Introduction of trimethoprim: a mixed blessing.

Abstract:

:Trimethoprim recently has been released by the Food and Drug Administration (FDA) exclusively for the treatment of acute symptomatic uncomplicated bacterial urinary tract infections. The compound compares favorably with alternative standard agents, such as ampicillin and cephalexin, for the therapy of women with acute symptomatic urinary tract infections caused by Escherichia coli. Trimethoprim should not be prescribed for the pregnant woman. Indiscriminate administration of the drug could foster the emergence of strains resistant to trimethoprim and trimethoprim-sulfamethoxazole. Trimethoprim has not been approved by the FDA for the treatment of recurrent, bacterial urinary tract infections.

journal_name

Urology

journal_title

Urology

authors

Gleckman RA

doi

10.1016/0090-4295(81)90190-4

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

460-1

issue

5

eissn

0090-4295

issn

1527-9995

pii

0090-4295(81)90190-4

journal_volume

17

pub_type

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