Intravesical therapy in superficial bladder cancer.

Abstract:

OBJECTIVE:To identify the appropriate characteristics of superficial bladder cancer that allow the physician to predict tumor behavior. METHODS:We analyzed 1,745 patients with primary superficial bladder cancer with regard to disease and patient characteristics. RESULTS:With the characteristics we found, the population can be described and prognostic factors can be found. Moreover, with the use of these factors, it appears to be possible to predict tumor behavior on a group level. Prediction on an individual level, however, remains far from ideal. CONCLUSIONS:Three treatment options can be chosen: follow-up after initial transurethral resection, additional instillations with intravesical chemotherapy, or instillations with bacillus Calmette-Guerin (BCG). In case instillations are indicated, most (but not all) superficial bladder cancer trials show superiority of BCG over intravesical chemotherapy, although at the cost of more side effects. However, with intravesical BCG, it seems possible to influence the natural history of superficial bladder cancer, which means that we can delay progression and improve survival.

journal_name

Urology

journal_title

Urology

authors

Witjes JA,Mulders PF,Debruyne FM

doi

10.1016/0090-4295(94)90211-9

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

2-5; discussion 6

issue

2 Suppl

eissn

0090-4295

issn

1527-9995

journal_volume

43

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • Genomic characterization of testis cancer: association of alterations with outcome of clinical stage 1 mixed germ cell nonseminomatous germ cell tumor of the testis.

    abstract:OBJECTIVE:To identify genomic markers that are reliable in predicting lymph node metastases in clinical stage 1 non-seminomatous germ cell tumors (NSGCTs). METHODS:Comparative genomic array technology was used to identify regions of genomic amplification or deletion in clinical stage 1 NSGCTs. Twelve stage 1 mixed ger...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.02.026

    authors: Mohamed GH,Gelfond JA,Nicolas MM,Brand TC,Sarvis JA,Leach RJ,Johnson-Pais TL

    更新日期:2012-08-01 00:00:00

  • In Vivo Evaluation of a Novel Pigtail Suture Stent.

    abstract:OBJECTIVE:To compare pressure, dilation, and histology in a porcine model after stenting with a pigtail suture stent (PSS)-where the ureteral and bladder component consists of a suture and a double J (DJ) stent. METHODS:Twelve pigs were studied with a PSS (4.8F/MiniJFil®) and DJ stent (4.8F/RocaJJ Soft) inserted in bo...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.11.031

    authors: Majdalany SE,Aldoukhi AH,Jung H,Mehra R,Roberts WW,Ghani KR

    更新日期:2020-11-27 00:00:00

  • Tumor-size breakpoint for prognostic stratification of localized renal cell carcinoma.

    abstract:OBJECTIVES:To identify an optimal tumor-size breakpoint to distinguish between two groups with different prognoses in a large cohort of patients with localized renal cell carcinoma (RCC). METHODS:We reviewed the clinical records of 813 patients who had undergone surgical treatment for localized RCC from 1976 to 2000. ...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2003.09.081

    authors: Ficarra V,Prayer-Galetti T,Novara G,Bratti E,Zanolla L,Dal Bianco M,Artibani W,Pagano F

    更新日期:2004-02-01 00:00:00

  • Ureteroscopic diagnosis of intraluminal metastatic rectal carcinoma.

    abstract::Ureteral obstruction resulting from metastatic adenocarcinoma is almost always extrinsic in nature. In contrast, true intraluminal metastases are extremely rare. With this report, we document the videoendoscopic appearance of true intraluminal ureteral metastases from metastatic rectal cancer confirmed with histopatho...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(97)00072-1

    authors: Fazeli-Matin S,Levin HS,Streem SB

    更新日期:1997-06-01 00:00:00

  • Prostate cancer presenting with malignant ascites: signet-ring cell variant of prostatic adenocarcinoma.

    abstract::A case of prostate cancer presenting with malignant ascites as the sole clinical manifestation is reported. The clinical course simulated occult gastrointestinal malignancy. At the histologic level, the tumor had a signet-ring morphology. Detailed immunocytochemical and ultrastructural studies, however, confirmed the ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(92)90259-y

    authors: Catton PA,Hartwick RW,Srigley JR

    更新日期:1992-05-01 00:00:00

  • Muscarinic receptor antagonists in the treatment of overactive bladder.

    abstract::A wealth of clinical evidence supports the view that muscarinic receptor antagonists are effective in the treatment of overactive bladder. However, treatment-limiting adverse effects such as dry mouth, constipation, and blurred vision have restricted the usefulness of previously available agents, such as oxybutynin. A...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/s0090-4295(99)00492-6

    authors: Chapple CR

    更新日期:2000-05-01 00:00:00

  • Interobserver variability limits exact preoperative staging by computed tomography in bladder cancer.

    abstract:OBJECTIVE:To evaluate the agreement between radiologic staging of bladder cancer using multidetector row computed tomography (CT) and histopathologic staging and estimate the influence of interobserver variability of the CT findings as a potential limitation of this imaging modality. The available data on the value of ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.01.040

    authors: Tritschler S,Mosler C,Tilki D,Buchner A,Stief C,Graser A

    更新日期:2012-06-01 00:00:00

  • Renal primitive neuroectodermal tumor in childhood with intracardiac extension.

    abstract::Primary primitive neuroectodermal tumors of the kidney are exceptionally rare and usually affect children and young adults. We report the first pediatric case of renal primitive neuroectodermal tumor presenting with tumor extension along the inferior vena cava to the right ventricle. This case highlights that when con...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2006.02.032

    authors: Sellaturay SV,Arya M,Cuckow P,Anderson J,McHugh K,Sebire NJ

    更新日期:2006-08-01 00:00:00

  • Posterior urethral valves presenting as venous obstruction.

    abstract::A patient with posterior urethral valves presented with unilateral lower leg ecchymosis and edema. He initially had significant renal function impairment. The ecchymosis and edema resolved after appropriate therapy, and his renal function returned to normal. ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(91)80015-y

    authors: Bauchner H,Cranley W,Vinci R

    更新日期:1991-07-01 00:00:00

  • Acute renal failure in sickle cell trait.

    abstract::Acute renal failure and a syndrome characteristic of acute renal vein thrombosis developed in a patient with sickle trait and gram-negative bacteremia. It is suggested that intrarenal vaso-occlusion by sickled erythrocytes produced signs and symptoms typical of renal vein thrombosis and contributed to the severity of ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(75)90716-5

    authors: Frascino JA,Grabstald H

    更新日期:1975-08-01 00:00:00

  • Dissemination of carcinoma: unusual complication of percutaneous nephrostomy.

    abstract::Percutaneous nephrostomy is a safe and highly effective means of urinary diversion. We report a case of unusual complications: severe peritonitis and massive intraperitoneal dissemination of carcinoma. ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(85)90497-2

    authors: Chiang MS,Wise HA 2nd

    更新日期:1985-04-01 00:00:00

  • Arterial embolization of bleeding pseudoaneurysm caused by percutaneous renal biopsy.

    abstract::A pseudoaneurysm of a primary branch of the renal artery with massive hemorrhage developed in a patient who underwent percutaneous needle renal biopsy. He was treated successfully by embolization of the artery with gelatin sponge (Gelfoam). ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(79)90508-9

    authors: Uretzky G,Shapiro A,Ring E

    更新日期:1979-09-01 00:00:00

  • Simple urodynamic evaluation of incontinent elderly female nursing home patients. A descriptive analysis.

    abstract::We present a descriptive analysis of the functional, mental, and urodynamic status of a population of incontinent elderly female nursing home patients. One hundred fifty-five intermediate care female patients with a mean age of 85.5 years were identified as being incontinent of urine at least once daily. After urologi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(91)80220-2

    authors: Dennis PJ,Rohner TJ Jr,Hu TW,Igou JF,Yu LC,Kaltreider DL

    更新日期:1991-02-01 00:00:00

  • Serum androgen levels in men: impact of health status and age.

    abstract:OBJECTIVES:To investigate the impact of health status on androgen levels in men and to assess the age-related changes in androgen levels. METHODS:Sera were obtained from 526 men (age 20 to 89 years) participating in a health screening project and 35 men selected according to the SENIEUR protocol, which excludes those ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(02)02252-5

    authors: Schatzl G,Madersbacher S,Temml C,Krenn-Schinkel K,Nader A,Sregi G,Lapin A,Hermann M,Berger P,Marberger M

    更新日期:2003-03-01 00:00:00

  • Herpes simplex virus type 1 mutant HF10 oncolytic viral therapy for bladder cancer.

    abstract:OBJECTIVES:To investigate the antitumor effects of the oncolytic herpes simplex virus (HSV) type 1 mutant HF10 on human and murine bladder cancer cells (T24 and MBT-2) in vitro and in immunocompetent mouse models. METHODS:In vitro viral oncolytic activity and the replication ability of HF10 were measured in T24 and MB...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2005.05.041

    authors: Kohno S,Luo C,Goshima F,Nishiyama Y,Sata T,Ono Y

    更新日期:2005-11-01 00:00:00

  • Sexual function after male radical cystectomy in a sexually active population.

    abstract:OBJECTIVES:To assess sexual dysfunction in sexually active men after radical cystectomy (RC) and to determine whether sildenafil citrate can improve erectile dysfunction after surgery. METHODS:The baseline and follow-up data from 49 sexually active male patients (mean age 57.8 +/- 9.1 years) undergoing RC (1995 to 200...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.05.056

    authors: Zippe CD,Raina R,Massanyi EZ,Agarwal A,Jones JS,Ulchaker J,Klein EA

    更新日期:2004-10-01 00:00:00

  • Bilateral Circum-scrotal Z-plasties for Creation of Single Scrotal Sac in Cloacal Exstrophy With Widely Divergent Scrotal Sacs.

    abstract::Significant number of patients with cloacal exstrophy variants present with poorly developed scrotum. Widely divergent hypoplastic scrotal sacs pose a technical challenge for scrotal reconstruction. We describe a technique of bilateral Z-plasty for the creation of single scrotal sac in a patient with widely divergent,...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2015.04.053

    authors: Dangle PP,Billmire D,Schneck F,Grunwaldt LJ

    更新日期:2015-10-01 00:00:00

  • Multiple, Synchronous Lesions of Differing Histology Within the Same Testis: Ultrasonographic and Pathologic Correlations.

    abstract:OBJECTIVE:To describe ultrasound (US) and pathologic findings in 11 patients with multiple, synchronous lesions of different histology within the same testis. MATERIALS AND METHODS:We reviewed US and pathologic findings in 11 patients with multiple, synchronous lesions of different histology within the same testis. Le...

    journal_title:Urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.urology.2018.07.040

    authors: Cicero C,Bertolotto M,Hawthorn BR,Trambaiolo Antonelli C,Sidhu PS,Ascenti G,Nikolaidis P,Dudea S,Toncini C,Derchi LE

    更新日期:2018-11-01 00:00:00

  • Activated Akt prevents antitumor activity of gefitinib in renal cancer cells.

    abstract:OBJECTIVES:To investigate the mechanism of gefitinib resistance in renal cell carcinoma (RCC) cells. Although epidermal growth factor receptor (EGFR) is frequently overexpressed in RCC, gefitinib, a tyrosine kinase inhibitor of EGFR, has only a limited antitumor effect on RCC. METHODS:The effects of gefitinib on the a...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.12.058

    authors: Kuroda K,Horiguchi A,Sumitomo M,Asano T,Ito K,Hayakawa M,Asano T

    更新日期:2009-07-01 00:00:00

  • Occult stress urinary incontinence and the effect of vaginal vault prolapse on abdominal leak point pressures.

    abstract:OBJECTIVES:To compare the difference in abdominal leak point pressures (ALPPs) between patients with large cystoceles and severe vaginal vault prolapse and to assess the frequency of occult stress urinary incontinence (SUI) in these groups. METHODS:A total of 24 adult female patients with pelvic prolapse underwent pro...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)00856-6

    authors: Gallentine ML,Cespedes RD

    更新日期:2001-01-01 00:00:00

  • Solifenacin may improve sleep quality in patients with overactive bladder and sleep disturbance.

    abstract:OBJECTIVE:To examine the effect of solifenacin for not only overactive bladder symptoms but also sleep disturbance. Nocturia and urgency are independent factors for sleep disturbance. METHODS:Fifteen male patients with overactive bladder symptoms and sleep disturbance were enrolled in this study. The overactive bladde...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2011.04.020

    authors: Takao T,Tsujimura A,Yamamoto K,Fukuhara S,Nakayama J,Matsuoka Y,Miyagawa Y,Nonomura N

    更新日期:2011-09-01 00:00:00

  • Endoscopic silicone injection for female stress urinary incontinence due to intrinsic sphincter deficiency: impact of coexisting urethral mobility on treatment outcome.

    abstract:OBJECTIVES:To evaluate periurethral silicone injection in the treatment of female stress urinary incontinence due to intrinsic sphincter deficiency (ISD) and assess whether coexisting urethral hypermobility has an impact on treatment outcome. METHODS:A total of 29 female patients with stress urinary incontinence under...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(02)01996-9

    authors: Grdal M,Tekin A,Erdoan K,Sengr F

    更新日期:2002-12-01 00:00:00

  • The effect of partial bladder outlet obstruction on carbonyl and nitrotyrosine distribution in rabbit bladder.

    abstract:OBJECTIVES:Recent evidence indicates that ischemia and reperfusion (free radical generation) are major etiologic factors in the rabbit bladder subjected to partial outlet obstruction. The current investigation was designed to determine the time course of damage caused by reactive oxygen species (ROS) and reactive nitro...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2007.09.047

    authors: Juan YS,Lin WY,Kalorin C,Kogan BA,Levin RM,Mannikarottu A

    更新日期:2007-12-01 00:00:00

  • Hemostatic laparoscopic partial nephrectomy: initial experience with the radiofrequency coagulation-assisted technique.

    abstract:OBJECTIVES:The techniques for hemostasis after renal tumor excision have limited the widespread application of laparoscopic partial nephrectomy (LPN). To improve hemostasis and aid visualization, we report our experience with a novel radiofrequency coagulation (RFC) technique for LPN. METHODS:Ten patients underwent RF...

    journal_title:Urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0090-4295(01)01086-x

    authors: Gettman MT,Bishoff JT,Su LM,Chan D,Kavoussi LR,Jarrett TW,Cadeddu JA

    更新日期:2001-07-01 00:00:00

  • Evaluation of a no-needle penile injector: a preliminary study evaluating tissue penetration and its hemodynamic consequences in the rat.

    abstract:OBJECTIVES:Intracavernous needle injection is an effective delivery method for pharmacotherapy of erectile dysfunction. Needle phobia, pain, and concern about local tissue injury have stimulated the search for new, less invasive means of inducing penile erection. In this preliminary communication, we evaluate a jet inj...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/S0090-4295(97)00541-4

    authors: Seyam RM,Bégin LR,Tu LM,Dion SB,Merlin SL,Brock GB

    更新日期:1997-12-01 00:00:00

  • Renal vein ligation in absence of vena caval obstruction.

    abstract::This is a report of a patient whose left renal vein was ligated in the course of a right nephrectomy for a large Wilms tumor, in the presence of an unobstructed vena cava and without established venous collateral circulation. It would appear that even with sudden obstruction to venous outflow the left kidney can devel...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(80)90478-1

    authors: Tucci P,Diagonale AM,Visani S,Gentile RL

    更新日期:1980-04-01 00:00:00

  • Laparoscopic techniques applied to open surgery: sliding-clip renorrhaphy.

    abstract:OBJECTIVES:To describe our initial experience with the laparoscopic technique of sliding-clip renorrhaphy applied to open surgery for small renal masses. METHODS:Knotless renorrhaphy with the sliding-clip technique is performed by securing suture with Hem-o-lok clips slid under tension against the renal capsule and lo...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.10.025

    authors: Gorin MA,Ramanathan R,Leveillee RJ

    更新日期:2011-03-01 00:00:00

  • Bladder neck contracture after antegrade fulguration of posterior urethral valves--unusual long-term complication.

    abstract::Bladder neck contracture after antegrade fulguration of posterior urethral valves has not been reported in English studies to date to the best of our knowledge. A couple of reports have mentioned late-onset bladder neck contracture after retrograde valve fulguration. The present case report describes an unusual compli...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.07.071

    authors: Sinha RJ,Singh V,Dalela D,Sankhwar SN

    更新日期:2009-04-01 00:00:00

  • Risk factors for male lower urinary tract symptoms: the role of metabolic syndrome and androgenetic alopecia in a Latin American population.

    abstract:OBJECTIVE:To evaluate the association of male lower urinary tract symptoms (LUTS) with metabolic syndrome (MetS) and androgenetic alopecia in a Latin American population. METHODS:We enrolled 907 patients for prospective evaluation at a single institution. LUTS were evaluated with the International Prostate Symptom Sco...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2013.03.001

    authors: Barbosa JA,Muracca E,Nakano E,Paranhos M,Natalino R,Cordeiro P,Srougi M,Antunes AA

    更新日期:2013-07-01 00:00:00

  • Delayed presentation in posterior urethral valve: long-term implications and outcome.

    abstract:OBJECTIVES:To analyze the effect of delayed presentation of posterior urethral valves in children. METHODS:We divided 194 children with posterior urethral valve (PUV) who underwent surgical ablation into group I (less than 2 years old) and group II (greater than 2 years old) according to age at presentation. We analyz...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2007.09.037

    authors: Ansari MS,Singh P,Mandhani A,Dubey D,Srivastava A,Kapoor R,Kumar A

    更新日期:2008-02-01 00:00:00