Comparison of dopamine, dobutamine, and epinephrine in CPR.

Abstract:

:Two new catecholamines, dopamine and dobutamine, have found widespread use for cardiovascular support. The relative efficacy of these drugs in aiding resuscitation from cardiopulmonary arrest is unknown. Dogs were subjected to either asphyxial or fibrillatory cardiac arrest. Resuscitation was attempted with artificial ventilation, closed chest cardiac massage, and one of four iv drug protocols: dopamine, 40 mg; epinephrine, 1 mg; dobutamine, 50 mg; or no drug. The incidence of successful resuscitation from both asphyxial and fibrillatory arrest was significantly greater in groups receiving dopamine or epinephrine than in groups receiving dobutamine or no drug. There was no difference in success between the dopamine and epinephrine groups. The authors conclude that, in dogs, dopamine is a useful adjunct to CPR because of its alpha-adrenergic stimulating activity at high doses. Dobutamine does not appear to be of value as the initial therapy of cardiac arrest. If the response in man is similar to that in dogs, dopamine may provide an alternative to epinephrine during CPR.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Otto CW,Yakaitis RW,Redding JS,Blitt CD

doi

10.1097/00003246-198109000-00005

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

640-3

issue

9

eissn

0090-3493

issn

1530-0293

journal_volume

9

pub_type

杂志文章
  • Treatment of acute hyponatremia: ensuring the excretion of a predictable amount of electrolyte-free water.

    abstract:BACKGROUND:Hypertonic saline is the recommended therapy to shrink swollen brain cells in patients with acute hyponatremia accompanied by seizures. OBJECTIVES:In the absence of hypertonic saline, hypertonic mannitol will shrink the cell volume. Because mannitol is excreted rapidly, our aim was to ensure that it would b...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200006000-00037

    authors: Porzio P,Halberthal M,Bohn D,Halperin ML

    更新日期:2000-06-01 00:00:00

  • Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status: A Prospective Multicentric Cohort Study.

    abstract:OBJECTIVES:Anxiety results from the anticipation of a threat and might be associated with poor outcome in the critically ill. This study aims at showing that anxiety at admission in critically ill patients is associated with new organ failure over the first 7 days of ICU hospitalization independently of baseline organ ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004495

    authors: Mazeraud A,Polito A,Sivanandamoorthy S,Porcher R,Heming N,Stoclin A,Hissem T,Antona M,Blot F,Gaillard R,Chrétien F,Annane D,Bozza FAB,Siami S,Sharshar T,Groupe d’Explorations Neurologiques en Réanimation (GENER).

    更新日期:2020-10-01 00:00:00

  • Heart-lung interactions measured by electrical impedance tomography.

    abstract:OBJECTIVE:The clinical value of stroke volume variations to assess intravascular fluid status in critically ill patients is well known. Electrical impedance tomography is a noninvasive monitoring technology that has been primarily used to assess ventilation. We investigated the potential of electrical impedance tomogra...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3182227e65

    authors: Maisch S,Bohm SH,Solà J,Goepfert MS,Kubitz JC,Richter HP,Ridder J,Goetz AE,Reuter DA

    更新日期:2011-09-01 00:00:00

  • Pathophysiology of disseminated intravascular coagulation in sepsis.

    abstract::Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by intravascular fibrin formation occurring in the course of a variety of severe diseases. In gram-negative sepsis, endotoxin is the bacterial component eliciting a cascade of tissue factor dependent hypercoagulable reactions mediated b...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003246-200009001-00003

    authors: ten Cate H

    更新日期:2000-09-01 00:00:00

  • Attitudes and preferences of intensivists regarding the role of family interests in medical decision making for incompetent patients.

    abstract:OBJECTIVE:The role of family interests in medical decision making is controversial. Physicians who routinely treat incompetent patients may have preferred strategies for addressing family interests as they are encountered in surrogate medical decision making. We sought to determine how physicians view the role of famil...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000084805.15352.01

    authors: Hardart GE,Truog RD

    更新日期:2003-07-01 00:00:00

  • The impact of adding 1 month of intensive care unit training in a categorical internal medicine residency program.

    abstract:OBJECTIVE:To determine the impact of adding a month of critical care training in the postgraduate year (PGY)-2 on the critical care skills of PGY-3 residents. DESIGN:Prospective, nonrandomized. SETTING:The internal medicine (IM) residency program of a tertiary care medical center. STUDY SUBJECTS:The study subjects i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31819cc170

    authors: Mullon JJ,Gajic O,Gali B,Ficalora RD,Kolars JC,Afessa B

    更新日期:2009-04-01 00:00:00

  • Radial Artery Applanation Tonometry for Continuous Noninvasive Cardiac Output Measurement: A Comparison With Intermittent Pulmonary Artery Thermodilution in Patients After Cardiothoracic Surgery.

    abstract:OBJECTIVES:Radial artery applanation tonometry allows completely noninvasive continuous cardiac output estimation. The aim of the present study was to compare cardiac output measurements obtained with applanation tonometry (AT-CO) using the T-Line system (Tensys Medical, San Diego, CA) with cardiac output measured by i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000979

    authors: Wagner JY,Sarwari H,Schön G,Kubik M,Kluge S,Reichenspurner H,Reuter DA,Saugel B

    更新日期:2015-07-01 00:00:00

  • Lactated Ringer Is Associated With Reduced Mortality and Less Acute Kidney Injury in Critically Ill Patients: A Retrospective Cohort Analysis.

    abstract:OBJECTIVES:To assess the impact of the percentage of fluid infused as Lactated Ringer (%LR) during the first 2 days of ICU admission in hospital mortality and occurrence of acute kidney injury. DESIGN:Retrospective cohort. SETTING:Analysis of a large public database (Multiparameter Intelligent Monitoring in Intensive...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001948

    authors: Zampieri FG,Ranzani OT,Azevedo LC,Martins ID,Kellum JA,Libório AB

    更新日期:2016-12-01 00:00:00

  • Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults.

    abstract:OBJECTIVES:Patients requiring admission to an ICU may subsequently experience cognitive decline. Our objective was to investigate longitudinal cognitive trajectories in older adults hospitalized in ICUs. We hypothesized that individuals hospitalized for critical illness develop greater cognitive decline compared with t...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003829

    authors: Schulte PJ,Warner DO,Martin DP,Deljou A,Mielke MM,Knopman DS,Petersen RC,Weingarten TN,Warner MA,Rabinstein AA,Hanson AC,Schroeder DR,Sprung J

    更新日期:2019-08-01 00:00:00

  • Reporting of Sepsis Cases for Performance Measurement Versus for Reimbursement in New York State.

    abstract:OBJECTIVES:Under "Rory's Regulations," New York State Article 28 acute care hospitals were mandated to implement sepsis protocols and report patient-level data. This study sought to determine how well cases reported under state mandate align with discharge records in a statewide administrative database. DESIGN:Observa...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003005

    authors: Prescott HC,Cope TM,Gesten FC,Ledneva TA,Friedrich ME,Iwashyna TJ,Osborn TM,Seymour CW,Levy MM

    更新日期:2018-05-01 00:00:00

  • Endothelial cell apoptosis in sepsis.

    abstract:OBJECTIVE:To discuss a potential role for endothelial cell apoptosis in the pathogenesis of sepsis. DATA SOURCES:Studies published in biomedical journals and studies from the authors' laboratory. STUDY SELECTION:In vitro and in vivo studies of endothelial cell apoptosis in endotoxin and sepsis models. DATA EXTRACTIO...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003246-200205001-00009

    authors: Hotchkiss RS,Tinsley KW,Swanson PE,Karl IE

    更新日期:2002-05-01 00:00:00

  • A direct relationship between ionized calcium and arterial pressure among patients in an intensive care unit.

    abstract::Serum ionized calcium (Ca+2), creatinine, magnesium, phosphate, and arterial pH were measured in patients on admission to the medical ICU (MICU). Patients were classified into three groups: a) hypotensive (n = 38), those who received vasopressor support for frank hypotension; b) hypertensive (n = 21), those who requir...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198806000-00002

    authors: Desai TK,Carlson RW,Thill-Baharozian M,Geheb MA

    更新日期:1988-06-01 00:00:00

  • International study on microcirculatory shock occurrence in acutely ill patients.

    abstract:OBJECTIVES:Microcirculatory alterations are associated with adverse outcome in subsets of critically ill patients. The prevalence and significance of microcirculatory alterations in the general ICU population are unknown. We studied the prevalence of microcirculatory alterations in a heterogeneous ICU population and it...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000553

    authors: Vellinga NA,Boerma EC,Koopmans M,Donati A,Dubin A,Shapiro NI,Pearse RM,Machado FR,Fries M,Akarsu-Ayazoglu T,Pranskunas A,Hollenberg S,Balestra G,van Iterson M,van der Voort PH,Sadaka F,Minto G,Aypar U,Hurtado FJ,Mar

    更新日期:2015-01-01 00:00:00

  • The cardiac output from blood pressure algorithms trial.

    abstract:OBJECTIVE:The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous refe...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181930174

    authors: Sun JX,Reisner AT,Saeed M,Heldt T,Mark RG

    更新日期:2009-01-01 00:00:00

  • Intestinal nitric oxide output during reduced mucosal blood flow in healthy volunteers.

    abstract:OBJECTIVE:Nitric oxide regulates epithelial permeability and other properties of the intestinal mucosal barrier. It previously has been shown in animals that intestinal mucosal nitric oxide production is impaired during gut hypoperfusion. The study was performed to confirm the presence of intestinal mucosal nitric oxid...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000080489.67211.1F

    authors: Snygg J,Aneman A,Pettersson A,Fändriks L

    更新日期:2003-08-01 00:00:00

  • Spontaneous high systemic oxygen delivery increases survival rate in awake sheep during sustained endotoxemia.

    abstract:OBJECTIVE:To study the natural evolution of systemic oxygen delivery (Do2) and oxygen consumption (Vo2) in sheep infused with low or high doses of endotoxin. DESIGN:Prospective, controlled experimental study. SETTING:Animal research laboratory at a medical university. SUBJECTS:Twenty-nine chronically instrumented aw...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200002000-00035

    authors: Pittet JF,Pastor CM,Morel DR

    更新日期:2000-02-01 00:00:00

  • Core temperature measurement in the intensive care unit.

    abstract:OBJECTIVE:To compare three devices that measure core body temperature at the bedside in ICU patients. DESIGN:Prospective, consecutive sample. SETTING:Voluntary community teaching hospital. PATIENTS:Fifteen patients, 78 +/- 6 (SD) yrs of age, admitted to the medical ICU over a 5-month period who had pulmonary artery ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199106000-00015

    authors: Nierman DM

    更新日期:1991-06-01 00:00:00

  • Hemodynamic effects of colloid concentration in experimental hemorrhage: a comparison of Ringer's acetate, 3% dextran-60, and 6% dextran-70.

    abstract::Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198804000-00008

    authors: Schött U,Lindbom LO,Sjöstrand U

    更新日期:1988-04-01 00:00:00

  • Acute lung inflammatory response and injury after hemorrhagic shock are more severe in postpartum rabbits.

    abstract:OBJECTIVE:The acute respiratory distress syndrome may complicate postpartum hemorrhagic shock and resuscitation, but its mechanisms are not yet well defined. We studied the lung inflammatory response to postpartum hemorrhagic shock and resuscitation in a rabbit model and the role of the nuclear factor-κB pathway. DESI...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3182451c17

    authors: Sheng C,Yu YH,Zhao KS,Huang LP,Lodato RF,Wang ZJ,Wang CH,Wang SH,Zha DS

    更新日期:2012-05-01 00:00:00

  • Oxygen availability during hypothermic cardiopulmonary bypass.

    abstract::Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients fell from a preoperative value of 25.9 +/- 2.4 (SD) to 15.6 +/...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197705000-00007

    authors: Fisher A,Foëx P,Emerson PM,Darley JH,Rauscher LA

    更新日期:1977-05-01 00:00:00

  • Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension.

    abstract:OBJECTIVE:The administration of endotoxin to healthy humans reduces cerebral blood flow but its influence on dynamic cerebral autoregulation remains unknown. We considered that a reduction in arterial carbon dioxide tension would attenuate cerebral perfusion and improve dynamic cerebral autoregulation in healthy subjec...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3182474ca7

    authors: Brassard P,Kim YS,van Lieshout J,Secher NH,Rosenmeier JB

    更新日期:2012-06-01 00:00:00

  • A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury.

    abstract:OBJECTIVES:Administration of eicosapentaenoic acid and docosahexanoic acid, omega-3 fatty acids in fish oil, has been associated with improved patient outcomes in acute lung injury when studied in a commercial enteral formula. However, fish oil has not been tested independently in acute lung injury. We therefore sought...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CCM.0b013e318218669d

    authors: Stapleton RD,Martin TR,Weiss NS,Crowley JJ,Gundel SJ,Nathens AB,Akhtar SR,Ruzinski JT,Caldwell E,Curtis JR,Heyland DK,Watkins TR,Parsons PE,Martin JM,Wurfel MM,Hallstrand TS,Sims KA,Neff MJ

    更新日期:2011-07-01 00:00:00

  • Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury.

    abstract:OBJECTIVE:To investigate whether inhibition of cyclooxygenase-2, a critical component of the inflammatory pathway, is neuroprotective in a neonatal rat model of cerebral hypoxia-ischemia. The development of brain inflammation largely contributes to neonatal brain injury that may lead to a lifetime of neurologic deficit...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181cb1158

    authors: Fathali N,Ostrowski RP,Lekic T,Jadhav V,Tong W,Tang J,Zhang JH

    更新日期:2010-02-01 00:00:00

  • Procalcitonin and cytokine levels: relationship to organ failure and mortality in pediatric septic shock.

    abstract:BACKGROUND:Procalcitonin (PCT), a marker of bacterial sepsis, may also act as a mediator of the inflammatory response to infection, and thus influence outcome. OBJECTIVE:To investigate the relationship between PCT, interleukin (IL)-10, tumor necrosis factor (TNF), organ failure, and mortality in pediatric septic shock...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200007000-00068

    authors: Hatherill M,Tibby SM,Turner C,Ratnavel N,Murdoch IA

    更新日期:2000-07-01 00:00:00

  • Observational Research for Therapies Titrated to Effect and Associated With Severity of Illness: Misleading Results From Commonly Used Statistical Methods.

    abstract:OBJECTIVES:In critically ill patients, treatment dose or intensity is often related to severity of illness and mortality risk, whereas overtreatment or undertreatment (relative to the individual need) may further increase the odds of death. We aimed to investigate how these relationships affect the results of common st...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004612

    authors: de Grooth HJ,Girbes ARJ,van der Ven F,Oudemans-van Straaten HM,Tuinman PR,de Man AME

    更新日期:2020-12-01 00:00:00

  • Critical Care Bed Capacity in Asian Countries and Regions.

    abstract:OBJECTIVE:To assess the number of adult critical care beds in Asian countries and regions in relation to population size. DESIGN:Cross-sectional observational study. SETTING:Twenty-three Asian countries and regions, covering 92.1% of the continent's population. PARTICIPANTS:Ten low-income and lower-middle-income eco...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004222

    authors: Phua J,Faruq MO,Kulkarni AP,Redjeki IS,Detleuxay K,Mendsaikhan N,Sann KK,Shrestha BR,Hashmi M,Palo JEM,Haniffa R,Wang C,Hashemian SMR,Konkayev A,Mat Nor MB,Patjanasoontorn B,Nafees KMK,Ling L,Nishimura M,Al Bahrani

    更新日期:2020-05-01 00:00:00

  • Theaflavin, a black tea extract, is a novel anti-inflammatory compound.

    abstract:OBJECTIVE:Tea has been around for centuries, and its medicinal properties have been purported in the literature but never fully confirmed. Interleukin-8 is a principle neutrophil chemoattractant and activator in humans. We determined the effects of theaflavin, a black tea-derived polyphenol, on tumor necrosis factor-al...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000142661.73633.15

    authors: Aneja R,Odoms K,Denenberg AG,Wong HR

    更新日期:2004-10-01 00:00:00

  • Heat stress increases survival rates in lipopolysaccharide-stimulated rats.

    abstract:OBJECTIVE:To examine the hypothesis that heat stress applied after the administration of bacterial endotoxin is protective. DESIGN:Prospective, randomized, laboratory study. SETTING:University research laboratory. SUBJECTS:One hundred eleven adult male Sprague-Dawley rats (weight range 250 to 400 g). INTERVENTIONS:...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199710000-00025

    authors: Chu EK,Ribeiro SP,Slutsky AS

    更新日期:1997-10-01 00:00:00

  • Increased nuclear factor kappa B activation in critically ill patients who die.

    abstract:OBJECTIVES:To determine nuclear factor kappa B (NF-kappa B) activation in mononuclear and neutrophils from critically ill patients and to compare NF-kappa B activation with circulating concentrations of interleukin (IL)-6, IL-8, and soluble intercellular adhesion molecule (sICAM)-1. DESIGN:Observational study. SETTIN...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200004000-00022

    authors: Paterson RL,Galley HF,Dhillon JK,Webster NR

    更新日期:2000-04-01 00:00:00

  • Time course of platelet counts in critically ill patients.

    abstract:BACKGROUND:Although thrombocytopenia in the intensive care unit (ICU) is associated with a poorer outcome, the precise relationship between the time course of platelet counts and the mortality rate has not been well defined. OBJECTIVE:To describe the time course of the platelet count in relation to the mortality rate ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00003246-200204000-00005

    authors: Akca S,Haji-Michael P,de Mendonça A,Suter P,Levi M,Vincent JL

    更新日期:2002-04-01 00:00:00