当前位置： SCI文献检索 > Journal of Cardiology期刊下所有文献 > CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort.

CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort.

Abstract：

BACKGROUND:Genetic regulation of plasma lipids has been shown to influence the risk of coronary artery disease (CAD). We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their association with CAD and circulating lipid levels in a representative cohort of Asian Indians selected from the Indian Atherosclerosis Research Study. METHODS:SNPs rs599839 and rs646776 were genotyped by Taqman assay in 1034 CAD patients (cases) and 1034 age- and gender-matched controls. Expression of CELSR2, PSRC1, and SORT1 genes was measured in 100 cases and 100 controls. Plasma levels of total cholesterol (TC), triglycerides, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol (LDL-c) were measured by enzymatic assay. RESULTS:Both rs646776 and rs599839 were in strong linkage disequilibrium (r = 0.98) and showed significant protective association with CAD (OR = 0.315, 95% CI 0.136-0.728, p<0.007 and OR = 0.422, 95% CI 0.181-0.981, p = 0.045, respectively). Haplotype TA showed 72% frequency and was associated with CAD (OR 0.77, 95% CI 0.67-0.88, p = 0.0002). PSRC1 gene expression was lower in the cases than in the controls (0.75 ± 0.405 versus 1.04 ± 0.622, p = 2.26 × 10(-4)). The homozygous variant and heterozygous genotypes showed 30% and 15% higher PSRC1 expression, respectively. Correspondingly, the minor alleles were associated with lower plasma TC and LDL-c levels. CONCLUSION:PSRC1 in the cholesterol gene cluster shows a significant association with CAD by virtue of the two SNPs, rs646776 and rs599839 that also regulate plasma cholesterol levels.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Arvind P,Nair J,Jambunathan S,Kakkar VV,Shanker J

doi

10.1016/j.jjcc.2014.02.012

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

339-46

issue

5

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(14)00067-7

journal_volume

64

pub_type

杂志文章

相关文献

Journal of Cardiology文献大全
  • [Effect of physical exercise training on graft patency after aortocoronary bypass grafting].

    abstract：:This study evaluated the effect of physical exercise training on graft patency after aortocoronary bypass grafting (ACBG). Patients who underwent ACBG were randomized into the training (17 patients, 43 grafts) and nontraining groups (18 patients, 45 grafts). Tissue plasminogen activator (TPA) antigen, TPA activity, pl...

    journal_title：Journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Kubo H,Ohshima H,Hirai H,Yabuki S,Machii K,Sato K,Ebine K

    更新日期：1993-01-01 00:00:00

  • Physical activity and progression of carotid intima-media thickness in patients with coronary heart disease.

    abstract：OBJECTIVE:We conducted the present study to determine the level of physical activity required to retard the progression of carotid intima-media thickness (IMT) in patients with coronary heart disease (CHD). PATIENTS AND MAIN OUTCOME MEASUREMENTS:The daily walking distance (km/day) of 40 patients with CHD (male/female ...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2008.02.005

    authors： Sato S,Makita S,Uchida R,Ishihara S,Majima M

    更新日期：2008-06-01 00:00:00

  • [Does dilatation of the sinotubular junction cause aortic regurgitation?: the use of the experimental model and preliminary result].

    abstract：:This study investigated the mechanism of aortic regurgitation caused by dilatation of the sinotubular junction. The canine model of dilatation of the sinotubular junction was used to observe coaptation of the aortic valve using direct imaging by endoscopy. Five adult mongrel dogs (body weight: 20-25 kg) were anestheti...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Furukawa K,Ohteki H,Doi K,Ohnishi H,Narita Y,Cao ZL,Itoh T

    更新日期：1998-01-01 00:00:00

  • Postconditioning attenuates early ventricular arrhythmias in patients with high-risk ST-segment elevation myocardial infarction.

    abstract：BACKGROUND:It has been demonstrated that postconditioning (postcon), brief episodes of ischemia during reperfusion period, in patients with ST-segment elevation myocardial infarction (STEMI) confers protection against ischemia-reperfusion injury and as a result, postcon might reduce infarct size. However, whether postc...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jjcc.2015.02.010

    authors： Araszkiewicz A,Grygier M,Pyda M,Rajewska J,Lesiak M,Grajek S

    更新日期：2015-06-01 00:00:00

  • Percutaneous revascularization of coronary chronic total occlusion: Toward a reappraisal of the available evidence.

    abstract：:Chronic total occlusion (CTO) is a challenging subset of coronary artery disease that is commonly encountered in real-world practice; it is associated with worse long-term prognosis. Observational studies suggest that percutaneous coronary intervention (PCI) for CTO is associated with reduction in myocardial ischemia ...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jjcc.2016.12.006

    authors： Karjalainen PP,Nammas W

    更新日期：2017-06-01 00:00:00

  • [Tricuspid regurgitation in mitral valve prolapse studied by two-dimensional color flow mapping].

    abstract：:To assess the incidence of tricuspid regurgitation (TR) in mitral valve prolapse (MVP), 96 patients with MVP and 23 normal control subjects were studied. Subjects in the MVP group were further classified as a group with mitral regurgitation (MR(+) group: 61 cases), and MR(-) group (35 cases). The presence of TR in eac...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Namiki A,Hirai H,Machii K,Ochiai M,Ohshima H,Tohma M,Kuwako K,Yamaguchi T,Toide H,Tohda E

    更新日期：1988-09-01 00:00:00

  • Accumulation of pericardial fat correlates with left ventricular diastolic dysfunction in patients with normal ejection fraction.

    abstract：BACKGROUND:Left ventricular diastolic dysfunction (LVDD) plays an important role in heart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot with possible paracrine or mechanical effects on the coronary cir...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2012.01.006

    authors： Konishi M,Sugiyama S,Sugamura K,Nozaki T,Matsubara J,Akiyama E,Utsunomiya D,Matsuzawa Y,Yamashita Y,Kimura K,Umemura S,Ogawa H

    更新日期：2012-05-01 00:00:00

  • [Cardiomyopathy showing progression from diffuse left ventricular hypertrophy to dilated phase associated with mitochondrial DNA point mutation A3243G: A case report].

    abstract：:A 44-year-old man was admitted to our hospital because of congestive heart failure. He had various symptoms caused by insulin-dependent diabetes mellitus, sensorineural deafness, Wolff-Parkinson-White syndrome and cardiomyopathy associated with mitochondrial DNA point mutation A3243G. Echocardiography had showed symme...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Ohmoto N,Fujiwara Y,Kibira S,Kobayashi M,Saito T,Miura M

    更新日期：2003-01-01 00:00:00

  • Serum syndecan-4 is a novel biomarker for patients with chronic heart failure.

    abstract：BACKGROUND:Syndecan-4 is a transmembrane heparan sulfate-carrying glycoprotein that mediates signal transduction pathways activated by growth factors and cell surface receptors, thereby modulating tissue regeneration, angiogenesis, and focal adhesion. The aim of the present study was to determine the clinical use of se...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2011.01.012

    authors： Takahashi R,Negishi K,Watanabe A,Arai M,Naganuma F,Ohyama Y,Kurabayashi M

    更新日期：2011-05-01 00:00:00

  • A case of transient mid-ventricular akinesia (a variant form of Takotsubo cardiomyopathy) followed with I-123-beta-metyl-iodophenyl pentadecanoic acid and I-123-meta-iodobenzyl-guanidine myocardial scintigraphy.

    abstract：:A 67-year-old woman without history of heart disease was admitted with chest oppression. Her electrocardiogram (ECG) at the time of admission showed ST segment elevation in leads V2-V6. Cardiac ultrasound revealed severe hypokinesis in mid to apical portion of anterior wall. Emergent coronary angiography showed normal...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2008.06.008

    authors： Moriya M,Naito K,Takahashi M,Ozoe A,Manabe T,Hosaka H,Suzuki M

    更新日期：2009-02-01 00:00:00

  • The value of cardiac magnetic resonance and distribution of late gadolinium enhancement for risk stratification of sudden cardiac death in patients with hypertrophic cardiomyopathy.

    abstract：BACKGROUND:The presence of late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcome and the extent of LGE predicts the increased risk of sudden cardiac death (SCD). Limited data exist regarding the distribution of LGE. We attempted to verify whether the presence o...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2015.07.020

    authors： Klopotowski M,Kukula K,Malek LA,Spiewak M,Polanska-Skrzypczyk M,Jamiolkowski J,Dabrowski M,Baranowski R,Klisiewicz A,Kusmierczyk M,Jasinska A,Jarmus E,Kruk M,Ruzyllo W,Witkowski A,Chojnowska L

    更新日期：2016-07-01 00:00:00

  • Evaluation of objective nutritional indexes as predictors of one-year outcomes after transcatheter aortic valve implantation.

    abstract：BACKGROUND:Objective nutritional indexes have been shown to predict prognoses in some clinical settings. We aimed to investigate the prognostic values of these indexes in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS:We retrospectively analyzed 95 consecutive patients who underwent TAVI a...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2019.02.017

    authors： Okuno T,Koseki K,Nakanishi T,Sato K,Ninomiya K,Tomii D,Tanaka T,Sato Y,Horiuchi Y,Koike H,Yahagi K,Komiyama K,Tanaka J,Aoki J,Yokozuka M,Miura S,Tanabe K

    更新日期：2019-07-01 00:00:00

  • [Recovery of severely decompensated hearts with a left ventricular assist device].

    abstract：:We evaluated the limits of recovery of decompensated hearts experimentally and clinically and studied the problems of applying a left ventricular assist device (LVAD). In the chronic experiments, 16 adult goats were studied as follows: Group I consisted of seven with left ventricular infarction in a 70-80% area of the...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Kinoshita M,Takano H,Taenaka Y,Nakatani T,Noda H,Tatsumi E,Yagura A,Sekii H,Sasaki E,Akutsu T

    更新日期：1990-01-01 00:00:00

  • Real clinical management of patients with isolated superior mesenteric artery dissection in Japan.

    abstract：BACKGROUND:Due to the rarity of this condition, clinical treatment and outcomes in isolated superior mesenteric artery dissection (ISMAD) patients remain unknown. The primary aim of this retrospective multicenter study was to elucidate the treatment strategies and in-hospital outcomes for ISMAD patients by using admini...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jjcc.2017.08.006

    authors： Mizuno A,Iguchi H,Sawada Y,Nomura H,Komiyama N,Watanabe S,Yoshikawa A

    更新日期：2018-02-01 00:00:00

  • Floppy mitral valve/mitral valve prolapse/mitral valvular regurgitation: effects on the circulation.

    abstract：:The floppy mitral valve prolapses into the left atrium in such a dynamic manner that the prolapsing floppy mitral valve becomes a space-occupying lesion within the left atrium. A significant result of the floppy mitral valve prolapsing into the left atrium during left ventricular systole is the development of a "third...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：

    authors： Boudoulas H,Wooley CF

    更新日期：2001-01-01 00:00:00

  • Novel KCNQ1 splicing mutation in patients with forme fruste LQT1 aggravated by hypokalemia.

    abstract：BACKGROUND:Several KCNQ1 splicing mutations have been identified in patients with type-1 long QT syndrome (LQT1). It was suggested that the clinical severity may differ according to the aberrant splicing products. There may be precipitating factors that cause cardiac events in those with a mild clinical phenotype (form...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2013.11.014

    authors： Imai M,Nakajima T,Kaneko Y,Niwamae N,Irie T,Ota M,Iijima T,Tange S,Kurabayashi M

    更新日期：2014-08-01 00:00:00

  • Low-dose dobutamine induces left ventricular mechanical dyssynchrony in patients with dilated cardiomyopathy and a narrow QRS: a study using real-time three-dimensional echocardiography.

    abstract：AIMS:The effects of inotropic agents on left ventricular (LV) synchrony in heart failure patients are still unknown. The purpose of this study was to investigate the effects of dobutamine on LV mechanical dyssynchrony and LV systolic performance in patients with dilated cardiomyopathy (DCM) and a narrow QRS using real-...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2012.12.012

    authors： Yagishita-Tagawa Y,Abe Y,Arai K,Yagishita D,Takagi A,Ashihara K,Shoda M,Naruko T,Itoh A,Haze K,Yoshikawa J,Hagiwara N

    更新日期：2013-04-01 00:00:00

  • Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.

    abstract：BACKGROUND:Although the Klotho gene is recognized as an aging-suppressor gene, the clinical significance of its soluble product, soluble Klotho, in coronary artery disease (CAD) has not been completely determined. The relationship between soluble Klotho and coronary artery calcification (CAC) was investigated in patien...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2020.11.014

    authors： Koga S,Ikeda S,Akashi R,Yonekura T,Kawano H,Maemura K

    更新日期：2020-12-07 00:00:00

  • Circulating levels of soluble Fas ligand and left ventricular remodeling after acute myocardial infarction (from the REVE-2 study).

    abstract：BACKGROUND:Apoptosis-related molecules may contribute to left ventricular (LV) remodeling after myocardial infarction (MI). To validate this hypothesis, we evaluated the relation between circulating plasma levels of soluble Fas ligand (sFas-L) and LV remodeling in patients post-MI. METHODS AND RESULTS:This prospective...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jjcc.2012.03.001

    authors： Fertin M,Bauters A,Pinet F,Bauters C

    更新日期：2012-08-01 00:00:00

  • [Infarct size related to the distribution and site of coronary artery lesions studied by the unfolded map technique using single photon emission computed tomography].

    abstract：:To assess the relative importance of the anatomical characteristics of the coronary artery distribution and the sites of the arterial stenoses in relation to infarct size, 21 patients with old myocardial infarction and angiographically-proven 90% or greater stenoses (AHA classification) of one of the major coronary ar...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Kamihata H,Kurimoto T,Shimada T,Karakawa M,Matsuura T,Ogura E,Hata T,Hamaguchi Y,Inada M,Nishiyama Y

    更新日期：1988-03-01 00:00:00

  • Overview of the pharmacological spasm provocation test: Comparisons between acetylcholine and ergonovine.

    abstract：:The spasm provocation tests of ergonovine and acetylcholine have been employed in the cardiac catheterization laboratory. Ergonovine acts through the serotogenic receptors, while acetylcholine acts through the muscarinic cholinergic receptors. Different mediators may have the potential to cause different coronary resp...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jjcc.2016.09.012

    authors： Sueda S,Kohno H,Ochi T,Uraoka T,Tsunemitsu K

    更新日期：2017-01-01 00:00:00

  • Bleeding risks associated with anticoagulant therapies after percutaneous coronary intervention in Japanese patients with ischemic heart disease complicated by atrial fibrillation: A comparative study.

    abstract：BACKGROUND:Current guidelines recommend early termination of triple therapy and the use of direct oral anticoagulants (DOAC) for non-valvular atrial fibrillation (NVAF) patients who undergo percutaneous coronary intervention (PCI), due to safety concerns. However, to date, real-world medication usage and safety outcome...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2020.08.008

    authors： Nakamura M,Yamashita T,Hayakawa A,Matsumoto T,Takita A,Hasegawa C,Uchino K,Sekine T,Iizuka T,Tanabe H,Kogure S

    更新日期：2021-02-01 00:00:00

  • [Non-invasive evaluation of coronary reperfusion using myoglobin: significance of quantitative and semi-quantitative latex agglutination methods].

    abstract：:We assessed the usefulness of myoglobin measured by latex agglutination methods as a parameter for successful reperfusion of the infarct-related artery. Plasma myoglobin levels were measured for 25 patients with acute myocardial infarction in whom thrombolysis and/or percutaneous transluminal coronary angioplasty (PTC...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Abe S,Arima S,Yamaguchi H,Atsuchi Y,Tahara M,Nakao S,Tanaka H,Maruyama I,Nomoto K,Ueno M

    更新日期：1991-01-01 00:00:00

  • A new disease entity: Atrial functional mitral regurgitation.

    abstract：:Functional mitral regurgitation (MR) has been traditionally known as secondary MR resulting from left ventricular (LV) dilatation and systolic dysfunction. However, deterioration of functional MR also relates to mitral annular (MA) dilatation. Furthermore, MA dilatation due to left atrial dilatation in patients with a...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jjcc.2020.12.002

    authors： Abe Y,Takahashi Y,Shibata T

    更新日期：2020-12-18 00:00:00

  • Factors influencing left atrial volume in treated hypertension.

    abstract：BACKGROUND:Left atrial (LA) enlargement has been documented to occur in hypertension (HT), and has been an index for evaluating the diastolic function of the left ventricle. Enlargement of the LA is one of the vital factors that induce heart failure and atrial fibrillation (AF) in patients with HT. METHODS AND SUBJECT...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jjcc.2012.02.011

    authors： Chen Y,Sato H,Watanabe N,Adachi T,Kodani N,Sato M,Takahashi N,Kitamura J,Sato H,Yamaguchi K,Yoshitomi H,Tanabe K

    更新日期：2012-08-01 00:00:00

  • Morphological characteristics in diabetic cardiomyopathy associated with autophagy.

    abstract：:Diabetic cardiomyopathy, clinically diagnosed as ventricular dysfunction in the absence of coronary atherosclerosis or hypertension in diabetic patients, is a cardiac muscle-specific disease that increases the risk of heart failure and mortality. Its clinical course is characterized initially by diastolic dysfunction,...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jjcc.2020.05.009

    authors： Kanamori H,Naruse G,Yoshida A,Minatoguchi S,Watanabe T,Kawaguchi T,Tanaka T,Yamada Y,Takasugi H,Mikami A,Minatoguchi S,Miyazaki T,Okura H

    更新日期：2021-01-01 00:00:00

  • [The influence of atrioventricular asynchronous contraction on left and right ventricular performance].

    abstract：:To investigate the influence of atrioventricular asynchronous contraction on left and right ventricular performance, pulsed Doppler echocardiographic studies were performed in 10 patients who received permanent pacemaker (VVI mode), but without significant heart disease except for complete heart block. After setting t...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Mizobuchi H,Tanigawa N,Komaki K,Ozawa Y

    更新日期：1992-01-01 00:00:00

  • Multifocal fibrosclerosis and IgG4-related disease involving the cardiovascular system.

    abstract：:The cardiovascular system may be involved as a target organ of multifocal fibrosclerosis, which may manifest as idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, inflammatory periarteritis, and inflammatory pericarditis. These pathological conditions can sometimes occur concomitantly. Idiopathic retro...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jjcc.2011.10.005

    authors： Ishizaka N,Sakamoto A,Imai Y,Terasaki F,Nagai R

    更新日期：2012-03-01 00:00:00

  • Efficacy of preoperative amino acid supplements on postoperative physical function and complications in open heart surgery patients: A study protocol for a randomized controlled trial.

    abstract：BACKGROUND:Elderly patients undergoing cardiac surgery often show poor nutritional status, muscle wasting, and sarcopenia, which are reported to affect postoperative functional recovery and incidence of complications. Amino acids are essential in maintaining nutritional status, synthesizing muscle protein, and promotin...

    journal_title：Journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jjcc.2019.03.011

    authors： Ogawa M,Yoshida N,Satomi-Kobayashi S,Tsuboi Y,Komaki K,Wakida K,Gotake Y,Inoue T,Tanaka H,Yamashita T,Sakai Y,Izawa KP,Takahashi M,Ogawa W,Hirata KI

    更新日期：2019-10-01 00:00:00

  • Sodium-Glucose Cotransporter-2 inhibitors are potential therapeutic agents for treatment of non-diabetic heart failure patients.

    abstract：:Despite recent developments in various therapies, heart failure remains a leading cause of morbidity and mortality worldwide. New pharmacological approaches are therefore needed to improve the outcomes of patients with heart failure. Diabetes mellitus is an important risk factor for heart failure, but until recently t...

    journal_title：Journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jjcc.2020.03.009

    authors： Nakagawa Y,Kuwahara K

    更新日期：2020-08-01 00:00:00