Abstract:
:Writing the variance of the Mantel-Haenszel estimator under the null of homogeneity and inverting the corresponding test, we arrive at an improved confidence interval for the common risk difference in stratified 2 × 2 tables. This interval outperforms a variety of other intervals currently recommended in the literature and implemented in software. We also discuss a score-type confidence interval that allows to incorporate strata/study weights. Both of these intervals work very well under many scenarios common in stratified trials or in a meta-analysis, including situations with a mixture of both small and large strata sample sizes, unbalanced treatment allocation, or rare events. The new interval has the advantage that it is available in closed form with a simple formula. In addition, it applies to matched pairs data. We illustrate the methodology with various stratified clinical trials and a meta-analysis. R code to reproduce all analysis is provided in the Appendix.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Klingenberg Bdoi
10.1002/sim.6122subject
Has Abstractpub_date
2014-07-30 00:00:00pages
2968-83issue
17eissn
0277-6715issn
1097-0258journal_volume
33pub_type
杂志文章abstract::A model is developed to estimate the effect of covariate imbalance on the size of a test of treatment efficacy in randomized clinical trials comparing two treatments when dispersion parameters are known. It is concluded that tests of homogeneity on the covariates should not be performed, that covariate imbalance is ju...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780080410
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7970
更新日期:2019-02-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780090707
更新日期:1990-07-01 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2000-02-29 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7051
更新日期:2016-12-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2021-01-30 00:00:00
abstract::Detecting safety signals in clinical trial safety data is known to be challenging due to high dimensionality, rare occurrence, weak signal, and complex dependence. We propose a new hierarchical testing approach for analyzing safety data from a typical randomized clinical trial. This approach accounts for the hierarchi...
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pub_type: 杂志文章
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2001-08-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3474
更新日期:2009-01-30 00:00:00
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pub_type: 杂志文章
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更新日期:2014-12-20 00:00:00
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更新日期:2017-09-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0258(19990915/30)18:17/18<2301:
更新日期:1999-09-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780110410
更新日期:1992-02-28 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3202
更新日期:2008-09-20 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.4780060602
更新日期:1987-09-01 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5405
更新日期:2012-11-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4426
更新日期:2012-09-28 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/sim.4780080908
更新日期:1989-09-01 00:00:00
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pub_type: 传,历史文章,杂志文章
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更新日期:1982-10-01 00:00:00
abstract::The sojourn time, time spent in the preclinical detectable phase (PCDP) for chronic diseases, for example, breast cancer, plays an important role in the design and assessment of screening programmes. Traditional methods to estimate it usually assume a uniform incidence rate of preclinical disease from a randomized con...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2005-12-30 00:00:00
abstract::The Wilcoxon-Mann-Whitney (WMW) test is often used to compare the means or medians of two independent, possibly nonnormal distributions. For this problem, the true significance level of the large sample approximate version of the WMW test is known to be sensitive to differences in the shapes of the distributions. Base...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3561
更新日期:2009-05-01 00:00:00
abstract::Modelling disease clustering over space and time can be helpful in providing indications of possible exposures and planning corresponding public health practices. Though a considerable number of studies focus on modelling spatio-temporal patterns of disease, most of them do not directly model a spatio-temporal cluster...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2424
更新日期:2006-03-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2260
更新日期:2006-03-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19970630)16:12<1391::aid-s
更新日期:1997-06-30 00:00:00
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