Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia.

abstract：:The addition of rituximab (R) to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy was a milestone in the development of front-line therapy for diffuse large B-cell lymphoma (DLBCL). R-CHOP and equivalent rituximab-containing anthracycline-based regimens are now widely accepted as the standard...

journal_title：British journal of haematology

authors： Gisselbrecht C

更新日期：2008-12-01 00:00:00

abstract：:A simple technique to separate erythrocytes from bone marrow by sedimentation under gravity after addition of hydroxyethyl starch is described. This method of removing red blood cells from the donor marrow was evaluated in 23 consecutive allogeneic bone marrow transplants between ABH-incompatible individuals. Infusion...

journal_title：British journal of haematology

authors： Ho WG,Champlin RE,Feig SA,Gale RP

更新日期：1984-05-01 00:00:00

abstract：:A study has been made of a number of haematological and haemorheological factors following venesection therapy. Haematocrit was very effectively reduced by the venesection regimen and led to a fall in whole blood viscosity in spite of the microcytosis that was eventually induced in all the subjects. No clinically sign...

journal_title：British journal of haematology

authors： Challoner T,Briggs C,Rampling MW,Thomas DJ

更新日期：1986-04-01 00:00:00

abstract：:Liposome-entrapped desferrioxamine was administered to iron-over-loaded 59Fe lavelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a sing...

journal_title：British journal of haematology

authors： Young SP,Baker E,Huehns ER

更新日期：1979-03-01 00:00:00

abstract：:The CS1 antigen provides a unique target for the development of an immunotherapeutic strategy to treat patients with multiple myeloma (MM). This study aimed to identify HLA-A2(+) immunogenic peptides from the CS1 antigen, which induce peptide-specific cytotoxic T lymphocytes (CTL) against HLA-A2(+) MM cells. We iden...

journal_title：British journal of haematology

authors： Bae J,Song W,Smith R,Daley J,Tai YT,Anderson KC,Munshi NC

更新日期：2012-06-01 00:00:00

abstract：:Despite its' central role, the precise mechanisms of the phosphoinositide 3-kinase/Akt (PI3K)/Akt pathway activation in acute myeloid leukaemia (AML) have not been elucidated. Recently, a recurrent novel AKT1 pleckstrin homology domain (PHD) mutation leading to membrane translocation, constitutive AKT activation and l...

journal_title：British journal of haematology

authors： Tibes R,Kornblau SM,Qiu Y,Mousses SM,Robbins C,Moses T,Carpten JD

更新日期：2008-02-01 00:00:00

abstract：:Low concentrations of collagen and anticardiolipin antibodies (ACLA), which were raised in rabbits by immunization with cardiolipin (CL), co-operatively activated human gel-filtrated platelets (GFP). GFP activated by adding ACLA 5 min prior to collagen (ACLA + Col) showed strong responses in cytosolic Ca2+ mobilizatio...

journal_title：British journal of haematology

authors： Wang L,Su CY,Chou KY,Wang CT

更新日期：2002-09-01 00:00:00

abstract：:Both atypical haemolytic uraemic syndrome (aHUS) and the HELLP syndrome (haemolytic anaemia, elevated liver enzymes, and low platelets) are thrombotic microangiopathies characterized by microvascular endothelial activation, cell injury and thrombosis. aHUS is a disease of complement dysregulation, specifically a gain ...

journal_title：British journal of haematology

authors： Fang CJ,Richards A,Liszewski MK,Kavanagh D,Atkinson JP

更新日期：2008-11-01 00:00:00

abstract：:Risk factors for acute graft-versus-host disease (GvHD) remain controversial. We performed uni- and multivariate statistical analyses on a series of 37 patients receiving a non-depleted allogeneic bone marrow transplant from an HLA-identical sibling donor for a haematological malignancy, in order to identify risk fact...

journal_title：British journal of haematology

authors： Bagot M,Mary JY,Heslan M,Kuentz M,Cordonnier C,Vernant JP,Dubertret L,Levy JP

更新日期：1988-12-01 00:00:00

abstract：:This study was designed to investigate the ability of long-term primary cultures of adult human hepatocytes to secrete the main haemostasis proteins. Factors II, V, VII, VIII, PIVKA-II (protein induced by vitamin K 1 absence or antagonist II), fibrinogen and antithrombin were quantified in culture medium by immunologi...

journal_title：British journal of haematology

authors： Biron-Andréani C,Bezat-Bouchahda C,Raulet E,Pichard-Garcia L,Fabre JM,Saric J,Baulieux J,Schved JF,Maurel P

更新日期：2004-06-01 00:00:00

abstract：:A multicentre modified World Health Organization (WHO)-type international sensitivity index (ISI) calibration has been performed at 10 European Concerted Action on Anticoagulation (ECAA) national laboratories using non-citrated whole-blood on two point-of-care test (POCT) prothrombin time (PT) monitor systems, CoaguCh...

journal_title：British journal of haematology

authors： Poller L,Keown M,Chauhan N,van Den Besselaar AM,Tripodi A,Jespersen J,Shiach C,Horellou MH,Dias D,Egberg N,Iriarte JA,Kontopoulou-Griva I,Otridge B

更新日期：2002-03-01 00:00:00

abstract：:A female patient with delayed haemolytic transfusion reaction due to anti-M antibody is described. Diagnosis was based on laboratory evidence of haemolysis and on characteristic serological findings. Anti-M was detected in the recipient's serum 7 d after the last transfusion episode. This alloantibody had not been pre...

journal_title：British journal of haematology

authors： Sancho JM,Pujol M,Fernández F,Soler M,Manzano P,Feliu E

更新日期：1998-10-01 00:00:00

abstract：:The growth of marrow fibroblasts from patients with myeloproliferative disorders (MPD) was investigated using platelet derived growth factor (PDGF) and human serum as mitogens in the presence of human plasma derived serum. The proliferation of fibroblasts in MPD patients was increased compared to normal individuals, e...

journal_title：British journal of haematology

authors： Kimura A,Katoh O,Kuramoto A

更新日期：1988-06-01 00:00:00

abstract：:This report describes a case of chronic myelomonocytic leukaemia (CMML) in whom a complete remission was achieved and sustained 15 months after treatment with 25-OH vitamin D3. No side-effects were observed. Although vitamin D1 has been used in the treatment of myelodysplastic syndromes, to our knowledge this is the f...

journal_title：British journal of haematology

authors： Mellibovsky L,Díez A,Aubia J,Nogues X,Pérez-Vila E,Serrano S,Recker RR

更新日期：1993-12-01 00:00:00

abstract：:The question as to whether autologous stem cell transplantation (SCT) after consolidation chemotherapy improves the probability of survival of patients with acute myeloid leukaemia (AML) in first remission has not been settled. Here, we present the results of a phase III study conducted in newly diagnosed adult AML pa...

journal_title：British journal of haematology

authors： Breems DA,Boogaerts MA,Dekker AW,Van Putten WL,Sonneveld P,Huijgens PC,Van der Lelie J,Vellenga E,Gratwohl A,Verhoef GE,Verdonck LF,Löwenberg B

更新日期：2005-01-01 00:00:00

abstract：:Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial c...

journal_title：British journal of haematology

authors： Hossfeld DK,Köhler S

更新日期：1979-02-01 00:00:00

abstract：:To evaluate the clinical significance of CD21S expression of diffuse large B-cell lymphoma (DLBCL) tumour cells, we compared their clinical features, immunophenotype, response to therapy and outcome in relation to CD21S expression. Between 1987 and 1999, frozen sections from 240 DLBCL cases were examined for CD21S exp...

journal_title：British journal of haematology

authors： Ogawa S,Yamaguchi M,Oka K,Taniguchi M,Ito M,Nishii K,Nakase K,Ohno T,Kita K,Kobayashi T,Shiku H

更新日期：2004-04-01 00:00:00

abstract：:β- thalassaemia is a disorder of globin gene synthesis resulting in reduced or absent production of the β-globin chain in red blood cells. In this study, haematopoietic stem cells were isolated from the peripheral blood of six transfusion dependent β-thalassaemia patients and six healthy controls. Following 7 and 14 d...

journal_title：British journal of haematology

authors： Forster L,McCooke J,Bellgard M,Joske D,Finlayson J,Ghassemifar R

更新日期：2015-07-01 00:00:00

abstract：:This study investigated the response of acute lymphoblastic leukaemia (ALL) cells to Wnt proteins. Accumulation of beta-catenin was measured by Western blotting and immunofluorescence microscopy. Reverse transcription polymerase chain reaction (RT-PCR) analysis of B-cell progenitor acute lymphoblastic leukaemia (ALL) ...

journal_title：British journal of haematology

authors： Khan NI,Bradstock KF,Bendall LJ

更新日期：2007-08-01 00:00:00

abstract：:Overexpression of manganese superoxide dismutase (MnSOD) has been postulated as one possible mechanism of protection from oxidative damage and free radicals. Doxorubicin treatment induces oxygen free radicals, leading to cytotoxicity and myelosuppression. The present study was performed to determine whether over-expre...

journal_title：British journal of haematology

authors： Suresh A,Guedez L,Moreb J,Zucali J

更新日期：2003-02-01 00:00:00

abstract：:We report stability of a clonal immunoglobulin heavy chain (IgH) gene rearrangement in a case of childhood acute lymphoblastic leukaemia (ALL) relapsing 17 years after completion of first-line therapy. Clonal stability was shown by polymerase chain reaction amplification of the hypervariable CDRIII region of IgH gene....

journal_title：British journal of haematology

authors： Frost L,Goodeve A,Wilson G,Peake I,Barker H,Vora A

更新日期：1997-09-01 00:00:00

abstract：:The integration of molecular and clinical information to tailor treatments remains an important research challenge in chronic lymphocytic leukaemia (CLL). This study aimed to identify genomic lesions associated with a poor outcome and a higher risk of histological transformation. A mono-institutional cohort of 147 cas...

journal_title：British journal of haematology

authors： Rinaldi A,Mian M,Kwee I,Rossi D,Deambrogi C,Mensah AA,Forconi F,Spina V,Cencini E,Drandi D,Ladetto M,Santachiara R,Marasca R,Gattei V,Cavalli F,Zucca E,Gaidano G,Bertoni F

更新日期：2011-09-01 00:00:00

abstract：:Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofarabine 5 × 40 mg/m(2) in combination with pegylated asparaginase (PEG-ASP) 1 × 2500 iu/m(2) in high risk ALL patients a...

journal_title：British journal of haematology

authors： Escherich G,Zur Stadt U,Zimmermann M,Horstmann MA,CoALL study group.

更新日期：2013-10-01 00:00:00

abstract：:We have investigated the potency of the C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene as a genetic risk factor in women with a history of early (12 weeks gestation) recurrent miscarriage (three or more consecutive pregnancy losses). Fifty-seven of the tota...

journal_title：British journal of haematology

authors： Holmes ZR,Regan L,Chilcott I,Cohen H

更新日期：1999-04-01 00:00:00

abstract：:We used minisatellite probes to analyse by DNA fingerprints the long-term engraftment (median 4.3 years, range 1-2) of 21 bone marrow transplantation recipients for severe aplastic anaemia. Patients received their graft from histocompatible siblings. They were conditioned with cyclophosphamide (150 mg/kg) and a 6GY th...

journal_title：British journal of haematology

authors： Keable H,Bourhis JH,Brison O,Lehn P,Schenmetzler C,Devergie A,Gluckman E

更新日期：1989-04-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, immunodeficiency and eczema. X-linked thrombocytopenia (XLT) is a mild form of WAS with isolated thrombocytopenia. Both phenotypes are caused by mutation of the Wiskott-Aldrich syndrome protein (WASP) gene. In this ...

journal_title：British journal of haematology

authors： Kajiwara M,Nonoyama S,Eguchi M,Morio T,Imai K,Okawa H,Kaneko M,Sako M,Ohga S,Maeda M,Hibi S,Hashimito H,Shibuya A,Ochs HD,Nakahata T,Yata JI

更新日期：1999-11-01 00:00:00

abstract：:Sézary syndrome and Mycosis fungoides are the most common forms of cutaneous T-cell lymphomas. To assess the response to different therapies especially in Sézary syndrome, it is helpful to monitor the percentage of circulating tumour cells in the blood. The use of T-cell receptor (TCR)-Vbeta specific monoclonal antibo...

journal_title：British journal of haematology

authors： Schwab C,Willers J,Niederer E,Ludwig E,Kündig T,Grob P,Burg G,Dummer R

更新日期：2002-09-01 00:00:00

abstract：:Pentose phosphate shunt activity was studied by the release of 14CO2 from 14C-1-glucose and 14C-2-glucose in the red cells of five patients with pyruvate kinase deficiency and found to be significantly decreased after new methylene blue stimulation when compared to high reticulocyte controls. Incubated Heinz body form...

journal_title：British journal of haematology

authors： Tomoda A,Lachant NA,Noble NA,Tanaka KR

更新日期：1983-07-01 00:00:00

abstract：:Cytokines and chemokines determine mobilisation of Langerhans cells and their dysregulation is implicated in the pathogenesis of Langerhans cell histiocytosis (LCH). Twenty point mutations of 12 different cytokine genes were studied in 41 Italian children, 15 with single-system (SS) and 26 with multi-system disease. T...

journal_title：British journal of haematology

authors： De Filippi P,Badulli C,Cuccia M,De Silvestri A,Dametto E,Pasi A,Garaventa A,del Prever AB,Todesco A,Trizzino A,Danesino C,Martinetti M,Aricò M

更新日期：2006-03-01 00:00:00

abstract：:International guidance has recently recommended serial proximal compression ultrasound (CUS) as first line imaging for suspected deep vein thrombosis (DVT). Single whole-leg CUS is a routine alternative diagnostic strategy that can reduce repeated attendances and identify alternative pathology. We conducted a prospect...

journal_title：British journal of haematology

authors： Horner D,Hogg K,Body R,Jones S,Nash MJ,Mackway-Jones K

更新日期：2014-02-01 00:00:00