Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia.


:Transplantation of T- and B-cell depleted allografts from haploidentical family donors was evaluated within a prospective phase II trial in children with acute lymphoblastic leukaemia, acute myeloid leukaemia and advanced myelodysplastic syndrome (n = 46). 20 patients had active disease; 19 patients received a second or third stem cell transplantation (SCT). Toxicity-reduced conditioning regimens consisted of fludarabine or clofarabine (in active disease only), thiotepa, melphalan and serotherapy. Graft manipulation was carried out with immunomagnetic microbeads. Primary engraftment occurred in 88%, with a median time to reach >1·0 × 10⁹/l leucocytes, >20 × 10⁹/l platelets and >0·1 × 10⁹/l T-cells of 10, 11 and 50 days, respectively. After retransplantation, engraftment occurred in 100%. Acute graft-versus-host disease (GvHD) grade II and III-IV occurred in 20% and 7%, chronic GvHD occurred in 21%. Both conditioning regimens had comparable toxicity. Transplant-related mortality (TRM) was 8% at one year and 20% at 5 years. Event-free survival at 3 years was: 25% (whole group), 46% (first, second or third complete remission [CR], first SCT) vs. 8% (active disease, first SCT) and 20% (second or third SCT, any disease status). This approach allows first or subsequent haploidentical SCTs to be performed with low TRM. Patients in CR may benefit from SCT, whereas the results in patients with active disease were poor.


Br J Haematol


Lang P,Teltschik HM,Feuchtinger T,Müller I,Pfeiffer M,Schumm M,Ebinger M,Schwarze CP,Gruhn B,Schrauder A,Albert MH,Greil J,Urban C,Handgretinger R




Has Abstract


2014-06-01 00:00:00












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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Sakariassen KS,Nieuwenhuis HK,Sixma JJ

    更新日期:1985-03-01 00:00:00

  • Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kaplan R,Gabbeta J,Sun L,Mao GF,Rao AK

    更新日期:2000-12-01 00:00:00

  • Secondary T-acute lymphoblastic leukaemia mimicking blast crisis in chronic myeloid leukaemia.

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    pub_type: 杂志文章


    authors: Dawson L,Slater R,Hagemeijer A,Langerak AW,Willemze R,Kluin-Nelemans JC

    更新日期:1999-07-01 00:00:00

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    abstract::Previously thought to be best described as a plasma cell disorder, Waldenström macroglobulinaemia (WM) is now understood to be a distinct clinicobiological entity. WM shares B-cell origin and certain other features with both chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM). WM and CLL arise from B-cells a...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: McMaster ML,Caporaso N

    更新日期:2007-12-01 00:00:00

  • Recent advances in the understanding of inherited sideroblastic anaemia.

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Camaschella C

    更新日期:2008-10-01 00:00:00

  • The relevance of alpha-naphthyl acetate esterases to various monocyte functions.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Oertel J,Hagner G,Kastner M,Huhn D

    更新日期:1985-12-01 00:00:00

  • Abnormal tryptic peptide from the spectrin alpha-chain resulting from alpha- or beta-chain mutations: two genetically distinct forms of the Sp alpha I/74 variant.

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    pub_type: 杂志文章


    authors: Lecomte MC,Gautero H,Garbarz M,Boivin P,Dhermy D

    更新日期:1990-11-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


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    更新日期:2019-07-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Ossenkoppele GJ,van de Loosdrecht AA,Schuurhuis GJ

    更新日期:2011-05-01 00:00:00

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    authors: Merup M,Spasokoukotskaja T,Einhorn S,Smith CI,Gahrton G,Juliusson G

    更新日期:1996-03-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cantù-Rajnoldi A,Invernizzi R,Biondi A,Banfi P,Zoia A,De Fazio P,Polli N

    更新日期:1989-11-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Walley AJ,Ellis I,Harris A

    更新日期:1995-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Awada H,Mahfouz RZ,Durrani J,Kishtagari A,Jagadeesh D,Lichtin AE,Hill BT,Hamilton BK,Carraway HE,Nazha A,Majhail NS,Sobecks R,Visconte V,Kalaycio M,Sekeres MA,Maciejewski JP

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Bogner C,Dechow T,Ringshausen I,Wagner M,Oelsner M,Lutzny G,Licht T,Peschel C,Pastan I,Kreitman RJ,Decker T

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    authors: Bae J,Song W,Smith R,Daley J,Tai YT,Anderson KC,Munshi NC

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ramot B,Brok-Simoni F,Chweidan E,Ashkenazi YE

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Sancho JM,Pujol M,Fernández F,Soler M,Manzano P,Feliu E

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    pub_type: 杂志文章


    authors: Stowell KM,Figueiredo MS,Brownlee GG,Jones P,Bolton-Maggs PH

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    authors: Erslev AJ,Caro J,Kansu E,Silver R

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    pub_type: 杂志文章,多中心研究


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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Lee S,Kim DW,Kim YJ,Park YH,Min CK,Lee JW,Min WS,Kim CC

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Rajan SK,Espina BM,Liebman HA

    更新日期:2005-06-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Keraly CL,Coëffier E,Tencé M,Borrel MC,Benveniste J

    更新日期:1983-03-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Crawford DH,Francis GE,Wing MA,Edwards AJ,Janossy G,Hoffbrand AV,Prentice HG,Secher D,McConnell I,Kung PC,Goldstein G

    更新日期:1981-10-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hunt BJ

    更新日期:2020-11-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Rasmussen T,Jensen L,Honoré L,Andersen H,Johnsen HE

    更新日期:1999-12-01 00:00:00

  • Primary thrombocythaemia associated with systemic mastocytosis: a report of five cases.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Le Tourneau A,Gaulard P,D'Agay MF,Vainchencker W,Cadiou M,Devidas A,Haioun C,Clauvel JP,Audouin J,Diebold J

    更新日期:1991-09-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Montes R,Ruiz de Gaona E,Martínez-González MA,Alberca I,Hermida J

    更新日期:2006-04-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Sobota A,Sabharwal V,Fonebi G,Steinberg M

    更新日期:2015-09-01 00:00:00