Neurobehavioral and neurologic outcome in long-term survivors of posterior fossa brain tumors: role of age and perioperative factors.


:We evaluated the neuropsychological and neurologic outcome of 15 long-term survivors of posterior fossa tumors who were treated between 1970 and 1984 with cranial irradiation (n = 15) and surgery (n = 14). The interval between diagnosis and evaluation ranged from 4 to 20 years (median = 10 years). Earlier age at diagnosis (< 6 years) was associated with an increased incidence of severe neurologic and neuropsychological sequelae. Hydrocephalus, obtundation, and tumor extension outside the vermis also were more prevalent in the younger group. Poor neurobehavioral outcomes in young children with posterior fossa tumors may be related to more aggressive tumor growth or complications of the initial therapy and not solely due to toxicity from craniospinal irradiation.


J Child Neurol


Chapman CA,Waber DP,Bernstein JH,Pomeroy SL,LaVally B,Sallan SE,Tarbell N




Has Abstract


1995-05-01 00:00:00












  • A 5-year-old male child with late infantile metachromatic leukodystrophy: a case report.

    abstract::Metachromatic leukodystrophy is a rare disorder of myelin metabolism. This degenerative disorder results from the accumulation of cerebroside sulfatide within the myelin sheath of central and peripheral nervous system, due to deficiency of aryl sulfatase A enzyme. We report a 5-year-old male child, who presented with ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Mahmood A,Chacham S,Reddy UN,Rao JN,Rao SP

    更新日期:2015-03-01 00:00:00

  • Acquired alexia with agraphia syndrome in childhood.

    abstract::The acquired alexia with agraphia syndrome is a conspicuous disorder of reading and writing in the absence of significant other language impairments that has mainly been recorded in adults. Pure cases are rare, with most patients displaying mild aphasic deficits. In children, acquired reading and writing disorders are...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Paquier PF,De Smet HJ,Mariën P,Poznanski N,Van Bogaert P

    更新日期:2006-04-01 00:00:00

  • Case report of pyruvate dehydrogenase deficiency with unusual increase of fats during ketogenic diet treatment.

    abstract::This article describes a case of pyruvate dehydrogenase deficiency in a 3-year-old boy who presented generalized hypotonia, severe psychomotor development delay, and generalized and partial seizures and was refractory to antiepileptic drugs. After the diagnosis, the patient was put on a ketogenic diet. Six months late...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Di Pisa V,Cecconi I,Gentile V,Di Pietro E,Marchiani V,Verrotti A,Franzoni E

    更新日期:2012-12-01 00:00:00

  • Study of nerve conduction and late responses in normal Chinese infants, children, and adults.

    abstract::Healthy Chinese individuals (n = 168), aged from 24 hours to 30 years, were studied to establish the following normal values: (1) motor conduction velocity, distal latency, amplitude, and F-wave velocity in the median, ulnar, tibial, and peroneal nerves; (2) H-reflex velocity and latency in the tibial nerve for all su...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Cai F,Zhang J

    更新日期:1997-01-01 00:00:00

  • Central nervous system Sjögren's syndrome in a child: case report and review of the literature.

    abstract::We describe a case of pediatric Sjögren's syndrome with progressive neurologic involvement. At age 4 years, she had been diagnosed with Melkersson-Rosenthal syndrome. After being stable with facial diplegia and swelling for 5 years, she acutely presented with diplopia, vertigo, and ataxia. Cranial magnetic resonance i...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Gottfried JA,Finkel TH,Hunter JV,Carpentieri DF,Finkel RS

    更新日期:2001-09-01 00:00:00

  • Longitudinally extensive optic neuritis in pediatric patients.

    abstract::Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Graves J,Kraus V,Soares BP,Hess CP,Waubant E

    更新日期:2015-01-01 00:00:00

  • High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial.

    abstract::This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. This was a randomized, double-blind study of riboflavin (200 mg daily) versus placebo in 48 children. The primary efficacy measure was the number of patients achieving a 50% or greater reduction in the number of migrai...

    journal_title:Journal of child neurology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: MacLennan SC,Wade FM,Forrest KM,Ratanayake PD,Fagan E,Antony J

    更新日期:2008-11-01 00:00:00

  • Intravenous immunoglobulin as adjunctive therapy for juvenile spasms.

    abstract::Intravenous immunoglobulin has been reported to be an effective treatment for infantile spasms. Juvenile spasms are electrically and clinically similar to infantile spasms but occur in a later age group. We retrospectively reviewed the charts of five children (aged 4.5-11.5 years) at our institution. Their primary sei...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Bingel U,Pinter JD,Sotero de Menezes M,Rho JM

    更新日期:2003-06-01 00:00:00

  • Secondary erythromelalgia successfully treated with intravenous immunoglobulin.

    abstract::Erythromelalgia is a rare condition characterized by episodic painful erythema and warmth often affecting, but not limited to, the distal extremities. This condition is notoriously difficult to treat. We report a young female patient with seronegative polyarthritis who presented with a 6-year history of recurrent bout...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Moody S,Pacheco S,Butler IJ,Koenig MK

    更新日期:2012-07-01 00:00:00

  • Spinal muscular atrophy: new thoughts on the pathogenesis and classification schema.

    abstract::We have established the first prospective, collaborative study of spinal muscular atrophy, the second most common neuromuscular disease of childhood. One hundred and forty-one patients have been evaluated on at least four occasions over a 3-year period. The patients have been grouped by age of onset, as well as by fun...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,多中心研究


    authors: Russman BS,Iannacone ST,Buncher CR,Samaha FJ,White M,Perkins B,Zimmerman L,Smith C,Burhans K,Barker L

    更新日期:1992-10-01 00:00:00

  • Large Artery Stroke in a Child With Hypoparathyroidism.

    abstract::The association of hypoparathyroidism and ischemic stroke is rare in childhood. We report an interesting case of an 11-year-old girl diagnosed to have hypoparathyroidism and presented with an acute-onset right hemiparesis. Investigations revealed large artery ischemic stroke and uncontrolled hypoparathyroidism. Pediat...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Dhawan SR,Jondhale SN,Sahu JK,Vyas S,Singhi PD

    更新日期:2015-07-01 00:00:00

  • Muscle fatigue in spinal muscular atrophy.

    abstract::We previously reported that patients with spinal muscular atrophy do not lose muscle strength over time as measured quantitatively. However, we noted that many patients with spinal muscular atrophy suffer from what they call fatigue. We wondered if we could measure fatigue during a single maximal voluntary contraction...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Iannaccone ST,White M,Browne R,Russman B,Buncher R,Samaha FJ

    更新日期:1997-08-01 00:00:00

  • Postinfectious encephalomyelitis: etiologic and diagnostic trends.

    abstract::Fifty cases of postinfectious encephalomyelitis admitted to our Pediatric Department during the period 1980 to 1997 were consecutively collected and reviewed. There were 28 males and 22 females. The age of onset ranged from 9 months to 14 years. The antecedent infections included measles (6 cases), rubella (5 cases), ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Hung KL,Liao HT,Tsai ML

    更新日期:2000-10-01 00:00:00

  • Ocular motor behavior of children with neurofibromatosis 1.

    abstract::Patients with neurofibromatosis 1 show neurocognitive deficits including abnormal visuospatial performance, but oculomotor behavior has not been studied. We recorded saccades in neurofibromatosis 1 and normal children, ages 6 to 12 years. Patients showed increased latency and diminished amplitude to more eccentric tar...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Lasker AG,Denckla MB,Zee DS

    更新日期:2003-05-01 00:00:00

  • Children with seizures: when can treatment be deferred?

    abstract::The decision whether or not to recommend chronic antiepileptic drug treatment for a child with seizures requires a risk-benefit analysis tailored to each individual case. Because all of the available antiepileptic medications have some potential adverse effects, the analysis may weigh in favor of a decision not to tre...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审


    authors: Wyllie E

    更新日期:1994-10-01 00:00:00

  • Blindness from late presenting undiagnosed pancraniosynostosis mimicking pseudotumor cerebri.

    abstract::We report the unique case of late-onset pancraniosynostosis presenting with rapid visual deterioration, without other symptoms of increased intracranial pressure. A 10-year-old girl had episodes of blurry vision for 1 month. Magnetic resonance imaging (MRI) demonstrated a borderline Chiari I malformation. Ophthalmolog...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Bonfield CM,Tamber MS,Losee JE

    更新日期:2014-08-01 00:00:00

  • Neurofibromatosis type 1: magnetic resonance imaging findings.

    abstract::The purpose of this study was to determine the locations and characterize the types of brain abnormalities noted on brain magnetic resonance imaging in patients with probable and definite neurofibromatosis type 1. Patients with definite neurofibromatosis type 1 (n = 17) were studied when clinically indicated, and pati...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: DiMario FJ Jr,Ramsby G,Greenstein R,Langshur S,Dunham B

    更新日期:1993-01-01 00:00:00

  • Speed-accuracy testing on the Apple iPad provides a quantitative test of upper extremity motor performance in children with dystonia.

    abstract::The currently available scales for quantitative measurement of the severity of childhood dystonia require human observer ratings and provide poor granularity in the scores for individual limbs. We evaluated the use of new-generation high-quality touchscreens (an iPad) according with the Fitts law, which is a mathemati...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Bertucco M,Sanger TD

    更新日期:2014-11-01 00:00:00

  • History of Joubert syndrome and a 30-year follow-up of the original proband.

    abstract::The 1960s were a period of great flowering in the recognition of neurologic disorders in children. The so-called ataxic cerebral palsies were an especially fertile field waiting for clarification. Congenital ataxia coupled with hyperpnea-apnea, abnormal eye movements, and retardation was identified as an autosomal-rec...

    journal_title:Journal of child neurology

    pub_type: 历史文章,杂志文章


    authors: Andermann F,Andermann E,Ptito A,Fontaine S,Joubert M

    更新日期:1999-09-01 00:00:00

  • Multicenter prospective study of children with sickle cell disease: radiographic and psychometric correlation.

    abstract::After obtaining familial informed consent, between January 1996 and July 1997, 173 children (5 to 15 years old) with sickle cell disease were enrolled in a prospective multicenter study using blood screening, transcranial Doppler ultrasonography (n = 143), cerebral magnetic resonance imaging (n = 144), and neuropsycho...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,多中心研究


    authors: Bernaudin F,Verlhac S,Fréard F,Roudot-Thoraval F,Benkerrou M,Thuret I,Mardini R,Vannier JP,Ploix E,Romero M,Cassé-Perrot C,Helly M,Gillard E,Sebag G,Kchouk H,Pracros JP,Finck B,Dacher JN,Ickowicz V,Raybaud C,Ponce

    更新日期:2000-05-01 00:00:00

  • Unilateral auditory neuropathy: case study.

    abstract::This article reports on an 11-year-old boy who was diagnosed with unilateral auditory neuropathy. After failing his annual medical and school hearing screenings, he was referred for audiologic testing, which identified a profound sensorineural hearing loss in his left ear that has remained stable for the past 3 1/2 ye...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Podwall A,Podwall D,Gordon TG,Lamendola P,Gold AP

    更新日期:2002-04-01 00:00:00

  • A novel MECP2 change in an indian boy with variant rett phenotype and congenital blindness: implications for genetic counseling and prenatal diagnosis.

    abstract::Mutations in MECP2 gene are the primary cause of Rett syndrome, a neurodevelopmental disorder that primarily affects girls, and affect 90% to 95% patients with classical Rett syndrome. MECP2 mutations, once thought to be lethal in males, now present a broad spectrum of clinical manifestations in males. This article re...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Khajuria R,Gupta N,Sapra S,Gulati S,Ghosh M,Kalra V,Kabra M

    更新日期:2011-02-01 00:00:00

  • Learning disabilities with and without attention-deficit hyperactivity disorder: parents' and teachers' perspectives.

    abstract::Our objective was to delineate the educational and behavioral differences between learning disabled children with and without attention-deficit hyperactivity disorder (ADHD). A restrospective (TROHOC) multimeasure comparative design was employed. Parents' and teachers' questionnaires (ANSER system) pertaining to atten...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Tirosh E,Berger J,Cohen-Ophir M,Davidovitch M,Cohen A

    更新日期:1998-06-01 00:00:00

  • The puzzle of apparent life-threatening events in a healthy newborn.

    abstract::Apneic neonatal seizures can present as apparent life-threatening events. We report a newborn with unexplained episodes of apnea associated with cyanosis and desaturation, starting on the first day postpartum. Biochemical tests were normal. Central nervous system infections as well as abnormalities of upper airways an...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Khajeh L,Cherian PJ,Swarte RM,Smit LS,Lequin MH

    更新日期:2014-07-01 00:00:00

  • Phantosmia during radiation therapy: a report of 2 cases.

    abstract::Phantosmia is an infrequently reported and poorly understood qualitative olfactory disorder characterized by the perception of a frequently unpleasant odor in the absence of an odorant stimulus. Peripheral phantosmia is hypothesized to involve abnormally active olfactory receptor neurons while central phantosmia is th...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Yang JC,Khakoo Y,Lightner DD,Wolden SL

    更新日期:2013-06-01 00:00:00

  • Epilepsy and electroencephalographic findings in pericentric inversion of chromosome 12.

    abstract::Epilepsy, together with mental retardation, represents a common manifestation of chromosomal aberrations. Specific electroencephalographic (EEG) and epileptic patterns have been described in several chromosomal disorders, such as Angelman's syndrome, Miller-Dieker syndrome, Wolf-Hirschhorn syndrome, and ring 20 syndro...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Grosso S,Pucci L,Farnetani M,Di Bartolo RM,Galimberti D,Mostardini R,Anichini C,Balestri M,Morgese G,Balestri P

    更新日期:2004-08-01 00:00:00

  • Reversible coma associated with prolonged high-dose phenobarbital therapy in bilateral Sturge-Weber syndrome.

    abstract::High-dose phenobarbital therapy is an effective treatment for refractory status epilepticus in children. The advantages of this therapy include milder adverse effects without limits for maximal phenobarbital levels or doses during the initial phase of treatment. However, little is known about the safety of continuing ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Wakamoto H,Nakamura Y,Ebihara T,Tokuda K,Ohmori H

    更新日期:2009-12-01 00:00:00

  • Computerized real-time neuromuscular sonography: a new application, techniques and methods.

    abstract::Diagnostic ultrasound has been extensively used for neurologic evaluation of cranial, vascular and spinal diseases. This study presents the techniques, methodology, and procedures for a new diagnostic application of ultrasound for evaluation of the neuromuscular system. In order to determine the optimum sonographic ch...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Fischer AQ,Stephens S

    更新日期:1988-01-01 00:00:00

  • Epilepsy, intelligence, and psychiatric disorders in patients with cerebellar hypoplasia.

    abstract::The cerebellum is involved in motor and cognitive functions and behavior. Its role in controlling epileptic seizures has been demonstrated in the literature. Genetic factors can enhance epilepsy susceptibility when the cerebellum is damaged. We examined the occurrence and features of epilepsy, intelligence, and psychi...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Parmeggiani A,Posar A,Scaduto MC,Chiodo S,Giovanardi-Rossi P

    更新日期:2003-01-01 00:00:00

  • Weinberg's syndrome: a disorder of attention and behavior problems needing further research.

    abstract::A subset of inattentive children have an underlying problem in sustaining wakefulness ("vigilance"). This disorder of vigilance, termed Weinberg's syndrome, is characterized by difficulty in maintaining wakefulness and alertness as evidenced by (among other symptoms) motor restlessness (fidgeting and moving about, yaw...

    journal_title:Journal of child neurology

    pub_type: 杂志文章


    authors: Brumback RA

    更新日期:2000-07-01 00:00:00