Abstract：
:The Human Genome Project has made it easier to genetically map and clone mutant genes which predispose to a great many human diseases. In addition to diseases inherited in a simple Mendelian fashion, there are many degenerative and infectious diseases, and sensitivities to environmental insults, in which the genetic make-up of an individual contributes to the course of the disease. Once a gene or genes associated with disease has been cloned, it is possible to design DNA-based diagnostics to detect altered forms of the gene which predispose to disease. The ability to predict the development of disease makes possible early intervention to limit the severity of a disease or to use gene therapy to cure inherited disorders.
journal_name
Prev Medjournal_title
Preventive medicineauthors
Gottesman MM,Collins FSdoi
10.1006/pmed.1994.1094subject
Has Abstractpub_date
1994-09-01 00:00:00pages
591-4issue
5eissn
0091-7435issn
1096-0260pii
S0091-7435(84)71094-2journal_volume
23pub_type
杂志文章abstract：:We conducted a health impact assessment (HIA) of cycling network expansions in seven European cities. We modeled the association between cycling network length and cycling mode share and estimated health impacts of the expansion of cycling networks. First, we performed a non-linear least square regression to assess th...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2017.12.011
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Data on smoking cessation and relapse for 6 yers of the Multiple Risk Factor Intervention Trial were evaluated in univariate and multivariate analyses to determine the relationship between variables measured at the beginning of the trial and smoking cessation and relapse for special intervention and usual ca...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章
doi：10.1016/0091-7435(91)90057-b
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) forms an increasing health problem. Despite smoking cessation improving the prognosis of the disease, many patients persist smoking. The present study presents the results of a smoking cessation counseling protocol in general practice (Smoking Cessation in patient...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2005.08.003
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Although numerous studies have examined repeat mammography, they provide limited information about actual patterns of women's behavior over time. METHODS:In this study, 128 asymptomatic women ages 50 to 75 who had had their first mammograms 15 to 27 months previously were interviewed to determine rates of r...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.1997.0163
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Studies on children and adolescents suggest a large increase in the role of snacking; however, little is know about changes in the snacking behavior of young adults. METHODS:USDA's nationally representative surveys from 1977-1978 to 1994-1996 are used to study snacking trends among 8,493 persons 19-29 years...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2000.0817
更新日期：2001-04-01 00:00:00
abstract：:The Scale-Up project introduced vaginal self-sampling and low-cost human papillomavirus (HPV) testing as the primary approach for cervical cancer screening in selected public health centers in Guatemala, Honduras, and Nicaragua. We evaluate the country-specific accomplishments in screening: target-coverage, triage, an...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2020.106076
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:We investigated associations of walking and other leisure-time physical activity (LTPA) with environmental characteristics and transportation modes in older Japanese adults. METHODS:This cross-sectional study in 2010-2011 used data from 421 community-dwelling older adults aged 65-85 years living in Kasama Ci...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.05.013
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:To guide the development of an AIDS prevention program for urban minority high school students, the authors investigated the prevalence of AIDS-risk behaviors, and the relative explanatory power of demographic, contextual, and cognitive correlates of these behaviors, among black and Hispanic students in thre...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.1993.1074
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:Little is known about the types of physical activity (PA) in which adolescent girls participate. Understanding this, along with examining specific psychosocial correlates of PA, may help guide the development of effective interventions to prevent the decline in PA in female youth. METHODS:2791 sixth grade gi...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2007.02.012
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:The objective of the study is to evaluate cross-sectional and longitudinal changes in children's commuting to school in a representative sample of a Brazilian city. METHODS:Two school-based studies were carried out in 2002 (n=2936; 7-10 years old) and 2007 (n=1232; 7-15 years old) in Florianopolis, Brazil. C...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.06.023
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:The objective of the study is to assess the socioeconomic status of the households affected by the tsunami of 2004 & to determine the factors associated with the recovery of household economic status. METHODS:The study was conducted in tsunami-affected areas in Malaysia in 2010-2011. A total of 193 household...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.12.024
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Elevated total homocysteine (tHcy) levels (>/= 15 micromol/L), resulting from enzyme or vitamin deficiency, increase risk for cardiac, cerebral, and peripheral vascular disease. This study examines tHcy levels in an Israeli population and the relationship to vitamin status and disease. The need for screening...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2003.09.001
更新日期：2003-12-01 00:00:00
abstract：:Both cigarette smoking and obesity are significant public health concerns and are associated with increased risk of early mortality. It is well established that the mesolimbic dopamine pathway is an important component of the reward system within the brain and is implicated in the development of addiction. Indeed, nic...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2016.08.009
更新日期：2016-11-01 00:00:00
abstract：:The intent of this study was to compare bicycle network connectivity for different types of bicyclists and different neighborhoods. Connectivity was defined as the ability to reach important destinations, such as grocery stores, banks, and elementary schools, via pathways or roads with low vehicle volumes and low spee...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2016.12.007
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Rapid health and nutrition transitional changes are resulting in greater prominence of non-communicable disease (NCD) in Latin America, particularly among the poor. OBJECTIVE:The study aims to examine the extent to which NCD pxfsrevails in Peru and the socioeconomic status (SES) as a risk factor. DESIGN:Be...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2005.06.001
更新日期：2005-09-01 00:00:00
abstract：:The North Karelia Youth Project was a 2-year intervention study aimed at preventing cardiovascular diseases risk factors among 13-year-old adolescents at the project's start. It was carried out during the years 1978 to 1980 in the county of North Karelia, Finland. The smoking prevention portion of the program was aime...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(86)90074-5
更新日期：1986-11-01 00:00:00
abstract：:Retirement is a major life-course transition that is closely related to changes in health. This study examined the dynamic impact of retirement on health and health behaviors, distinguishing an immediate change in the level of health at retirement and a change in the rate of change after retirement. We used panel data...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2017.04.007
更新日期：2017-07-01 00:00:00
abstract：:Health warnings are a promising strategy for reducing consumption of sugar-sweetened beverages (SSBs), but uncertainty remains about how to design warnings to maximize their impact. Warnings already implemented in Latin America use nutrient disclosures, while proposed U.S. warnings would describe the health effects of...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2019.02.010
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To determine what health behaviors patients choose to change in response to medical advice when they are given the potential net-present value (reduction in biological age) of modifying a behavior. METHODS:Baseline data for multiple health-risk behaviors that were recommended for change among 660 coronary an...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ypmed.2007.09.007
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To test a computer-delivered program for preventing substance use among adolescent girls. METHODS:Randomly, 916 girls aged 12.76+/-1.0 years and their mothers were assigned to an intervention arm or to a test-only control arm. Intervention-arm dyads engaged in exercises to improve the mother-daughter relatio...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2009.08.001
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To determine whether adherence to home exercise interventions for the prevention of falls in older adults relates to home exercise program characteristics and intervention efficacy. METHODS:In Australia (2011) a systematic literature search of four databases was conducted. Randomized controlled trials were i...
journal_title：Preventive medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ypmed.2012.07.007
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To examine physicians' beliefs about the pelvic examination and identify physician characteristics associated with routine use of this procedure in the United States. METHODS:A total of 1250 United States family/general practitioners, internists, and obstetrician/gynecologists who participated in the 2009 Do...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.03.012
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Neonatal abstinence syndrome (NAS) occurs following prenatal opioid exposure. It is characterized by signs and symptoms indicating central nervous system hyperirritability and autonomic nervous system, gastrointestinal tract, and respiratory system dysfunction. OBJECTIVE:This article: (1) briefly reviews NA...
journal_title：Preventive medicine
pub_type： 历史文章,杂志文章
doi：10.1016/j.ypmed.2015.07.017
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:This study explores the predisposing, enabling, and need-based factors associated with parents' or guardians' decision to have their child initiate, continue, and complete the human papillomavirus (HPV) vaccine. METHODS:Parents and guardians of children between the ages of 9 and 17years who completed the 20...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2016.01.010
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:We conducted a systematic review to investigate the cross-sectional and prospective associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age. METHODS:Ovid Medline, Embase, Web of Science and the Cochrane Libr...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2015.04.013
更新日期：2015-07-01 00:00:00
abstract：:Children and adolescents recently have become a group targeted for health promotion efforts. It is argued that early behavioral intervention will alter patterns of behavior that might place young people at increased risk for chronic diseases later in life. The Minnesota Heart Health Program is a longitudinal, communit...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(85)90064-7
更新日期：1985-05-01 00:00:00
abstract：:Despite tremendous gains in our understanding of the development of memory during the infancy period, relatively little is known about the neural bases of early memory. This is unfortunate, as elucidating the neurobiological mechanisms that mediate changes in memory would likely yield important insight into the concep...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1006/pmed.1998.0272
更新日期：1998-03-01 00:00:00
abstract：:Social inequities compromise health-related quality of life (HR-QoL) among women living with HIV (WLWH). Little is known about health impacts of intersecting stigma based on HIV status, race and gender among WLWH or potential mechanisms to promote HR-QoL. We tested pathways from multiple types of stigma (HIV-related, ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2017.12.018
更新日期：2018-02-01 00:00:00
abstract：:Chronic kidney disease (CKD) affects 15% of the US general population, and this rate is projected to increase. A healthy lifestyle is important for individuals with CKD to reduce risk for CKD progression and adverse heath events. Adults with CKD also have high rates of psychological distress, which may be associated w...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2019.06.007
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:Genetic tests for nicotine addiction susceptibility may someday offer preventive medicine specialists new tools to reduce smoking among adolescents. This paper examines adolescents' interest in, and reasons behind interest in, such testing and correlates of interest. METHODS:The sample included 211 healthy ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2005.09.007
更新日期：2006-01-01 00:00:00
