Abstract:
PURPOSE:To determine predictors of clot dissolution in patients undergoing catheter-directed urokinase thrombolysis for peripheral arterial occlusion (PAO). MATERIALS AND METHODS:The study included 103 patients with limb-threatening symptoms of embolism lasting 14 days or less and resulting from embolism (n = 20) or thrombosis (n = 83). Successful lysis was defined as restitution of antegrade flow with less than 20% diameter reduction by residual thrombus. Stepwise logistic regression was used to analyze the data. RESULTS:Relevant clinical variables were diabetic status (odds ratio, 0.75; P = .04 for diabetic patients), conduit type (1.25; P = .04 for native artery and 1.51; P = .02 for prosthetic graft), and number of arterial segments involved (1.60; P = .02 for one level and 1.42; P = .03 for two levels). Important procedural variables included intrathrombus positioning of catheter ports (odds ratio, 7.40; P = .001) and guide wire passage through the occlusion (3.10; P = .003). Absolute thrombus volume was nonpredictive but correlated with reperfusion time (P = .02) and infusion time (P = .01). CONCLUSION:Predictive parameters may help in the selection of candidates with PAO for thrombolytic therapy.
journal_name
Radiologyjournal_title
Radiologyauthors
Ouriel K,Shortell CK,Azodo MV,Guiterrez OH,Marder VJdoi
10.1148/radiology.193.2.7972780subject
Has Abstractpub_date
1994-11-01 00:00:00pages
561-6issue
2eissn
0033-8419issn
1527-1315journal_volume
193pub_type
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