Fenpropimorph affects uptake of uracil and cytosine in Saccharomyces cerevisiae.


:Fenpropimorph was shown to inhibit the accumulation of the pyrimidine bases uracil and cytosine from the growth media in Saccharomyces cerevisiae. Uracil prototrophs of S. cerevisiae were more resistant to the growth-inhibitory effects of fenpropimorph than were uracil auxotrophs. High concentrations of uracil rescued fenpropimorph-treated uracil auxotrophs, and cytosine, which is accumulated by a separate mechanism, could also support growth of treated uracil auxotrophs. Fenpropimorph caused a significant decrease in the uptake of radiolabeled uracil, which was not due to accumulation of ergosta-8,14-dienol (ignosterol) in the treated cultures. Radiolabeled cytosine uptake was unaffected by drug treatment in a wild-type strain but was inhibited in a sterol mutant, in which ergosterol was absent from the cell. The role of fenpropimorph in causing membrane dysfunction through a mechanism other than altered sterol metabolism is discussed.


Crowley JH,Lorenz RT,Parks LW




Has Abstract


1994-05-01 00:00:00












  • Potential use of WR6026 as prophylaxis against transfusion-transmitted American trypanosomiasis.

    abstract::Since transmission of Chagas' disease by the insect vector is under control in Brazil, transmission by blood transfusion is acquiring special relevance in areas where the disease is endemic and also in countries whose populations are free of infection but that are receiving immigrants from areas where the disease is e...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chiari E,Oliveira AB,Prado MA,Alves RJ,Galvão LM,Araujo FG

    更新日期:1996-03-01 00:00:00

  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450.

    abstract::The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in compa...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Asai K,Tsuchimori N,Okonogi K,Perfect JR,Gotoh O,Yoshida Y

    更新日期:1999-05-01 00:00:00

  • Pharmacodynamics of daptomycin in a murine thigh model of Staphylococcus aureus infection.

    abstract::Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of daptomycin for S. aureus using in vitro methods and the Craig (W. A. Craig, J. Redington, and S. C. Ebert, J. Antimicrob. Chemot...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Louie A,Kaw P,Liu W,Jumbe N,Miller MH,Drusano GL

    更新日期:2001-03-01 00:00:00

  • Susceptibility to PNU-140690 (Tipranavir) of human immunodeficiency virus type 1 isolates derived from patients with multidrug resistance to other protease inhibitors.

    abstract::In our study we examined the anti-human immunodeficiency virus type 1 (anti-HIV-1) activity of a novel HIV-1 protease inhibitor, PNU-140690 (tipranavir), against patient-derived isolates resistant to multiple other protease inhibitors (PIs). The aim of our experiments was to investigate the genotypes and the in vitro ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rusconi S,La Seta Catamancio S,Citterio P,Kurtagic S,Violin M,Balotta C,Moroni M,Galli M,d'Arminio-Monforte A

    更新日期:2000-05-01 00:00:00

  • Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam.

    abstract::Among 730 Escherichia coli, 438 Klebsiella pneumoniae, and 141 Proteus mirabilis isolates obtained between September 2000 and September 2001 in seven hospitals in Ho Chi Minh City, Vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cao V,Lambert T,Nhu DQ,Loan HK,Hoang NK,Arlet G,Courvalin P

    更新日期:2002-12-01 00:00:00

  • Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.

    abstract::The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted significant scientific interest as models for targeting and management o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Parisot J,Carey S,Breukink E,Chan WC,Narbad A,Bonev B

    更新日期:2008-02-01 00:00:00

  • Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis.

    abstract::The efficacy of a new class of drugs for Pneumocystis carinii pneumonitis was demonstrated. 566C80, a hydroxynaphthoquinone, administered orally in a dose of greater than or equal to 100 mg/kg of body weight per day prophylactically prevented P. carinii pneumonitis in 90% or more of rats, while all untreated control a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hughes WT,Gray VL,Gutteridge WE,Latter VS,Pudney M

    更新日期:1990-02-01 00:00:00

  • Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli.

    abstract::Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conf...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cagliero C,Mouline C,Cloeckaert A,Payot S

    更新日期:2006-11-01 00:00:00

  • Effects of two magainin peptides on eicosanoid release from rat peritoneal macrophages.

    abstract::Magainins are novel polycationic peptides with broad-spectrum antimicrobial activity, including activity against gram-negative bacteria. Gram-negative bacteremia can elicit endotoxic shock that is associated with the increased formation of eicosanoids. Inhibition of eicosanoid synthesis has been shown to improve the o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Matera G,Cook JA,Geisel J,Ashton SH,Wise WC,Focá A,Berkowitz BA,Halushka PV

    更新日期:1993-03-01 00:00:00

  • Fluid and pharmacological dynamics in a subcutaneous chamber implanted in rats.

    abstract::Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gardner WG,Prior RB,Perkins RL

    更新日期:1973-08-01 00:00:00

  • Characterization of the antimonial antileishmanial agent meglumine antimonate (glucantime).

    abstract::Meglumine antimonate (Glucantime), a drug of choice for the treatment of leishmaniasis, is produced by the reaction of pentavalent antimony with N-methyl-D-glucamine, a carbohydrate derivative. We investigated the structure and composition of meglumine antimonate, which remain poorly understood, despite 50 years of us...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Roberts WL,McMurray WJ,Rainey PM

    更新日期:1998-05-01 00:00:00

  • In vitro activities of five fluoroquinolone compounds against strains of Streptococcus pneumoniae with resistance to other antimicrobial agents.

    abstract::Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to multiple antibiotics did not affect the organism's susceptibility to the fluoroquinolones. The fluoroquinolones with in vitro...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Barry AL,Fuchs PC,Brown SD

    更新日期:1996-10-01 00:00:00

  • ICESp1116, the genetic element responsible for erm(B)-mediated, inducible resistance to erythromycin in Streptococcus pyogenes.

    abstract::ICESp1116, responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, was comprehensively characterized, and its chromosomal integration site was determined. It displayed a unique mosaic organization consisting of a scaffold, related to TnGallo1 from Streptococcus gallolyticus, with ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Brenciani A,Tiberi E,Morici E,Oryasin E,Giovanetti E,Varaldo PE

    更新日期:2012-12-01 00:00:00

  • Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study.

    abstract::Clostridium difficile causes antibiotic-associated diarrhea and is a major public health concern. Current therapies disrupt the protective intestinal flora, do not reliably prevent recurrent infections, and will be decreasingly effective should less susceptible strains emerge. CRS3123 is an oral agent that inhibits ba...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nayak SU,Griffiss JM,Blumer J,O'Riordan MA,Gray W,McKenzie R,Jurao RA,An AT,Le M,Bell SJ,Ochsner UA,Jarvis TC,Janjic N,Zenilman JM

    更新日期:2017-07-25 00:00:00

  • Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria.

    abstract::Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significan...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vieira JLF,Rivera JGB,de Sena LWP,Ferreira MVD

    更新日期:2020-02-21 00:00:00

  • Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.

    abstract::A survey of 1,203 Escherichia coli isolates from 44 hospitals in Taiwan revealed that 136 (11.3%) isolates were resistant to fluoroquinolones and that another 261 (21.7%) isolates had reduced susceptibility. Resistance was more common in isolates responsible for hospital-acquired (mostly in intensive care units) infec...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: McDonald LC,Chen FJ,Lo HJ,Yin HC,Lu PL,Huang CH,Chen P,Lauderdale TL,Ho M

    更新日期:2001-11-01 00:00:00

  • Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci.

    abstract::The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rodrigues M,McBride SW,Hullahalli K,Palmer KL,Duerkop BA

    更新日期:2019-10-22 00:00:00

  • A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.

    abstract::Sordarin and its derivatives are antifungal compounds of potential clinical interest. Despite the highly conserved nature of the fungal and mammalian protein synthesis machineries, sordarin is a selective inhibitor of protein synthesis in fungal organisms. In cells sensitive to sordarin, its mode of action is through ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Botet J,Rodríguez-Mateos M,Ballesta JP,Revuelta JL,Remacha M

    更新日期:2008-05-01 00:00:00

  • Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.

    abstract::Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein. DNA sequencing showed these mutations to be Ser-83----Ala and Gln-106----Arg. The mutant proteins were overproduced and purified, and...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hallett P,Maxwell A

    更新日期:1991-02-01 00:00:00

  • Pharmacodynamics of gemifloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model of infection.

    abstract::The pharmacodynamics of gemifloxacin against Streptococcus pneumoniae were investigated in a dilutional pharmacodynamic model of infection. Dose fractionation was used to simulate concentrations of gemifloxacin in human serum associated with 640 mg every 48 h (one dose), 320 mg every 24 h (two doses), and 160 mg every...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: MacGowan AP,Rogers CA,Holt HA,Wootton M,Bowker KE

    更新日期:2001-10-01 00:00:00

  • Decreased permeation of cephalosporins through the outer membrane of Escherichia coli grown in salicylates.

    abstract::Escherichia coli K-12 cells grown in 1 to 5 mM sodium salicylate (SAL) or acetylsalicylate show increased phenotypic resistance to various antibiotics (J. L. Rosner, Proc. Natl. Acad. Sci. USA 82:8771-8774, 1985), including cephalosporins (this study). To determine whether these effects are caused by a decreased uptak...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Foulds J,Murray DM,Chai T,Rosner JL

    更新日期:1989-04-01 00:00:00

  • Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders.

    abstract::Four pre-exposure prophylaxis (PrEP) users with gastro-intestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite a self-reported high adherence, trough plasma tenofovir concentrations (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Calcagno A,Dal Conte I,Cattaneo D,Testi R,Mistrangelo M,Gervasoni C,de Nicolò A,Bonora S,D'Avolio A,Di Perri G

    更新日期:2020-10-26 00:00:00

  • Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California.

    abstract::Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pandori M,Barry PM,Wu A,Ren A,Whittington WL,Liska S,Klausner JD

    更新日期:2009-09-01 00:00:00

  • Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum.

    abstract::Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Quémard A,Lacave C,Lanéelle G

    更新日期:1991-06-01 00:00:00

  • Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection.

    abstract::Isoprinosine has been reported to decrease progression to AIDS, primarily by preventing Pneumocystis carinii pneumonia (PCP), in human immunodeficiency virus-infected patients, but the mechanism of action is unknown. para-Acetamidobenzoic acid (PAcBA), one component of isoprinosine, is structurally related to para-ami...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kovacs JA,Powell F,Voeller D,Allegra CJ

    更新日期:1993-06-01 00:00:00

  • Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem.

    abstract::BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obt...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pozzi C,De Luca F,Benvenuti M,Poirel L,Nordmann P,Rossolini GM,Mangani S,Docquier JD

    更新日期:2016-11-21 00:00:00

  • Preliminary method for direct quantification of colistin methanesulfonate by attenuated total reflectance Fourier transform infrared spectroscopy.

    abstract::Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain abo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Niece KL,Akers KS

    更新日期:2015-09-01 00:00:00

  • A Novel Actin Binding Drug with In Vivo Efficacy.

    abstract::Occidiofungin is produced by the soil bacterium Burkolderia contaminans MS14 and is structurally similar or identical to the burkholdines, xylocandins, and cepacidines. This study identified the primary cellular target of occidiofungin, which was determined to be actin. The modification of occidiofungin with a functio...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ravichandran A,Geng M,Hull KG,Li J,Romo D,Lu SE,Albee A,Nutter C,Gordon DM,Ghannoum MA,Lockless SW,Smith L

    更新日期:2018-12-21 00:00:00

  • Pharmacokinetics and pharmacodynamics of TBR-652, a novel CCR5 antagonist, in HIV-1-infected, antiretroviral treatment-experienced, CCR5 antagonist-naïve patients.

    abstract::TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of this study was to determine the pharmacokinetics (PK) and pharmacodynamics (PD) of TBR-652 in HIV-1-infected, antiretroviral treatment-experienced, CCR5 antagonist-naïve patients. A double-blind, placebo-controlled, randomized,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Marier JF,Trinh M,Pheng LH,Palleja SM,Martin DE

    更新日期:2011-06-01 00:00:00

  • Reactions catalyzed by purified L-glutamine: keto-scyllo-inositol aminotransferase, an enzyme required for biosynthesis of aminocyclitol antibiotics.

    abstract::Dialyzed extracts of the gentamicin producer Micromonospora purpurea catalyze reactions which represent transaminations proposed for 2-deoxystreptamine biosynthesis. To determine whether these transaminations were catalyzed by a single aminotransferase or by multiple enzymes, we purified and characterized an L-glutami...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lucher LA,Chen YM,Walker JB

    更新日期:1989-04-01 00:00:00