Fenpropimorph affects uptake of uracil and cytosine in Saccharomyces cerevisiae.

abstract：:Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significan...

journal_title：Antimicrobial agents and chemotherapy

authors： Vieira JLF,Rivera JGB,de Sena LWP,Ferreira MVD

更新日期：2020-02-21 00:00:00

abstract：:We studied eight strains of Escherichia coli resistant to high levels of trimethoprim that were isolated over a 6-week period in a commercial breeding flock of broilers. The strains originated from fecal samples and from a carcass immediately after slaughter. Seven of eight strains belonged to the same infrequent biot...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaslus-Dancla E,Gerbaud G,Lagorce M,Lafont JP,Courvalin P

更新日期：1987-05-01 00:00:00

abstract：:A potential strategy that can be used to combat the worldwide AIDS epidemic is the development of a vaginal microbicide that prevents the sexual transmission of human immunodeficiency virus type 1 (HIV-1). Certain CC chemokines, including RANTES, MIP-1alpha, and MIP-1beta, might facilitate the development of such micr...

journal_title：Antimicrobial agents and chemotherapy

authors： Kish-Catalone TM,Lu W,Gallo RC,DeVico AL

更新日期：2006-04-01 00:00:00

abstract：:Though the primary action of the cationic antibiotic polymyxin B is against the membrane of susceptible bacteria, severe morphological changes are detected in the cytoplasm. Using fluorescence microscopy and a mono-N-dansyl-polymyxin B derivative, we could demonstrate aggregations of the antibiotic with cellular mater...

journal_title：Antimicrobial agents and chemotherapy

authors： Schindler PR,Teuber M

更新日期：1975-07-01 00:00:00

abstract：:The MIC of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate of one per asexual cycle. To ensure the cure of malaria, the MIC must be exceeded until all parasites have been eliminated. The development of highly sensitive and accurate PCR quantitation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Hien TT,White NJ,Thuy-Nhien NT,Hoa NT,Thuan PD,Tarning J,Nosten F,Magnusson B,Jain JP,Hamed K

更新日期：2017-01-24 00:00:00

abstract：:Dengue virus (DENV) causes disease globally, with an estimated 25 to 100 million new infections per year. At present, no effective vaccine is available, and treatment is supportive. In this study, we identified BP2109, a potent and selective small-molecule inhibitor of the DENV NS2B/NS3 protease, by a high-throughput ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang CC,Hsieh YC,Lee SJ,Wu SH,Liao CL,Tsao CH,Chao YS,Chern JH,Wu CP,Yueh A

更新日期：2011-01-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis. C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance of C. difficile to β-lactam antibiotics allows the pathogen to replicate and cause d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandhu BK,Edwards AN,Anderson SE,Woods EC,McBride SM

更新日期：2019-12-20 00:00:00

abstract：:A basic, random copolymer of l-ornithine and l-leucine (OL; molar ratios 1:1) was bactericidal to a sensitive (S) strain of Staphylococcus aureus at low concentration. Resistant cells (R) were selected from the culture medium and, after serial transfers to solutions containing increasing amounts of the polymer, grew w...

journal_title：Antimicrobial agents and chemotherapy

authors： Shenfeld A,Flowers HM,Katchalski E

更新日期：1974-02-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) Tat and gp120 intriguingly share the feature of being basic peptides that, once released by HIV(+) cells, bind to polyanionic heparan sulfate proteoglycans (HSPGs) on target uninfected cells, contributing to the onset of AIDS-associated pathologies. To identify multitarget anti-HIV p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bugatti A,Urbinati C,Ravelli C,De Clercq E,Liekens S,Rusnati M

更新日期：2007-07-01 00:00:00

abstract：:Twenty-one adult patients hospitalized with lower respiratory tract infections due to Branhamella catarrhalis or Haemophilus influenzae or both were treated with the combination of oral amoxicillin and potassium clavulanate (Augmentin) in an open, noncomparative clinical trial. Diseases included pneumonia, empyema, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallace RJ Jr,Steele LC,Brooks DL,Luman JI,Wilson RW,McLarty JW

更新日期：1985-06-01 00:00:00

abstract：:Miconazole, a broad-spectrum antimycotic agent with some antibacterial activity, has recently become available for experimental parenteral use in the United States. Its efficacy as an anticandidal drug was tested in adult Wistar rats. A previously established infectious dose of 5 x 10(6)Candida albicans was intravenou...

journal_title：Antimicrobial agents and chemotherapy

authors： Balk MW,Crumrine MH,Fischer GW

更新日期：1978-02-01 00:00:00

abstract：:The biological availability of cefoxitin administered rectally in the form of suppositories was examined in six human subjects by a cross-over design. Four different suppository systems containing adjuvants expected to enhance the absorption of the drug were studied. The presence of sodium salicylate and a nonionic su...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis SS,Burnham WR,Wilson P,O'Brien J

更新日期：1985-08-01 00:00:00

abstract：:β-Lactams are often used to treat Helicobacter cinaedi infections; however, the mechanism underlying β-lactam resistance is unknown. In this study, we investigated β-lactam resistance in an H. cinaedi strain, MRY12-0051 (MICs of amoxicillin [AMX] and ceftriaxone [CRO], 32 and 128 μg/ml; obtained from human feces). Bas...

journal_title：Antimicrobial agents and chemotherapy

authors： Rimbara E,Mori S,Kim H,Suzuki M,Shibayama K

更新日期：2018-01-25 00:00:00

abstract：:The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

更新日期：2010-10-01 00:00:00

abstract：:Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats. VCM administered intr...

journal_title：Antimicrobial agents and chemotherapy

authors： Qu S,Dai C,Lang F,Hu L,Tang Q,Wang H,Zhang Y,Hao Z

更新日期：2018-12-21 00:00:00

abstract：:Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis of tuberculosis. The use of INH has increased over the past years, largely as a result of the coepidemic of human immunodeficiency virus infection. It is frequently given chronically to critically ill patients who are copre...

journal_title：Antimicrobial agents and chemotherapy

authors： Desta Z,Soukhova NV,Flockhart DA

更新日期：2001-02-01 00:00:00

abstract：:Infections caused by carbapenem-resistant KPC-producing Klebsiella pneumoniae are responsible for high rates of mortality and represent a major therapeutic challenge, especially when the isolates are also resistant to colistin. We used the checkerboard method to evaluate the synergistic activity of 10 antibiotic combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tascini C,Tagliaferri E,Giani T,Leonildi A,Flammini S,Casini B,Lewis R,Ferranti S,Rossolini GM,Menichetti F

更新日期：2013-08-01 00:00:00

abstract：:The in vitro susceptibility of 409 clinical isolates to HR 810, a new cephalosporin, was evaluated and compared with their susceptibility to aztreonam, cefazolin, ceftazidime, imipenem, moxalactam, piperacillin, and gentamicin. On a weight basis, the activity of HR 810 against gram-negative bacilli was equivalent or s...

journal_title：Antimicrobial agents and chemotherapy

authors： Bertram MA,Bruckner DA,Young LS

更新日期：1984-08-01 00:00:00

abstract：:The 72 Escherichia coli strains of the ECOR collection were examined for resistance to 10 different antimicrobial agents including ampicillin, tetracycline, mercury, trimethoprim, and sulfonamides. Eighteen strains were resistant to at least one of the antibiotics tested, and nearly 20% (14 of 72) were resistant to tw...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazel D,Dychinco B,Webb VA,Davies J

更新日期：2000-06-01 00:00:00

abstract：:Candida parapsilosis isolates occasionally display resistance in vitro to echinocandins and cause breakthrough infections to echinocandins. The degree of the in vivo cross-resistance among echinocandins and the fitness loss associated with caspofungin (CAS) resistance of C. parapsilosis are not well studied. We compar...

journal_title：Antimicrobial agents and chemotherapy

authors： Dimopoulou D,Hamilos G,Tzardi M,Lewis RE,Samonis G,Kontoyiannis DP

更新日期：2014-01-01 00:00:00

abstract：:The activities of ceftazidime-avibactam, ceftolozane-tazobactam, and comparators were evaluated for 733 isolates displaying resistance to broad-spectrum cephalosporins and carrying extended-spectrum β-lactamase (ESBL) genes detected by whole-genome sequencing analysis. Isolates were collected during 2017 in U.S. hospi...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Doyle TB,Mendes RE,Sader HS

更新日期：2019-06-24 00:00:00

abstract：:Low-level vancomycin-resistant Staphylococcus aureus (vancomycin-intermediate S. aureus [VISA] and heterogenous VISA [hVISA]) is increasingly reported and leads to glycopeptide treatment failure. Various phenotypic features have been reported for these isolates, but the genetic changes leading to hVISA and VISA have y...

journal_title：Antimicrobial agents and chemotherapy

authors： Howden BP,Johnson PD,Ward PB,Stinear TP,Davies JK

更新日期：2006-09-01 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated...

journal_title：Antimicrobial agents and chemotherapy

authors： Walochnik J,Duchêne M,Seifert K,Obwaller A,Hottkowitz T,Wiedermann G,Eibl H,Aspöck H

更新日期：2002-03-01 00:00:00

abstract：:The postantibiotic subminimum inhibitory concentration effect (PA SME) may simulate in vivo drug exposure more accurately than the postantibiotic effect (PAE) since subinhibitory concentrations of drug persist between antibiotic dosings. In this study, we compared the PAEs and PA SMEs of levofloxacin and ciprofloxacin...

journal_title：Antimicrobial agents and chemotherapy

authors： Licata L,Smith CE,Goldschmidt RM,Barrett JF,Frosco M

更新日期：1997-05-01 00:00:00

abstract：:We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto K,Yanagihara K,Sugahara K,Imamura Y,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Hirakata Y,Kamihira S,Kohno S

更新日期：2009-08-01 00:00:00

abstract：:A new procedure for determining the susceptibility of Treponema pallidum subsp. pallidum to antimicrobial agents was developed, utilizing a tissue culture system which promotes the in vitro multiplication of this organism. In the absence of antibiotics, T. pallidum (Nichols virulent strain) multiplied an average of 10...

journal_title：Antimicrobial agents and chemotherapy

authors： Norris SJ,Edmondson DG

更新日期：1988-01-01 00:00:00

abstract：:Heteroresistant (methicillin-resistant) and nonheteroresistant strains of Staphylococcus aureus were tested for their susceptibility to penicillinase-resistant penicillins at incubation temperatures of 37, 35, and 30 C. Susceptibilities were determined by agar dilution and by the standard Kirby-Bauer agar diffusion te...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Caruthers JQ,Baker CN

更新日期：1973-09-01 00:00:00

abstract：:Most methicillin-resistant Staphylococcus aureus (MRSA) isolates identified among blood isolates collected in Denmark between 1957 and 1970 belonged to either phage group III or the closely related 83A complex and had a PSTM antibiotype (resistance to penicillin [P], streptomycin [S], tetracycline [T], and methicillin...

journal_title：Antimicrobial agents and chemotherapy

authors： Gomes AR,Westh H,de Lencastre H

更新日期：2006-10-01 00:00:00

abstract：:Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An in vitro Bacillus subtilis well-agar diffusion assay was employed to test the hypothesis that himastatin was enzymatically inactivated. The activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mamber SW,Brookshire KW,Dean BJ,Firestone RA,Leet JE,Matson JA,Forenza S

更新日期：1994-11-01 00:00:00