Fenpropimorph affects uptake of uracil and cytosine in Saccharomyces cerevisiae.

Abstract:

:Fenpropimorph was shown to inhibit the accumulation of the pyrimidine bases uracil and cytosine from the growth media in Saccharomyces cerevisiae. Uracil prototrophs of S. cerevisiae were more resistant to the growth-inhibitory effects of fenpropimorph than were uracil auxotrophs. High concentrations of uracil rescued fenpropimorph-treated uracil auxotrophs, and cytosine, which is accumulated by a separate mechanism, could also support growth of treated uracil auxotrophs. Fenpropimorph caused a significant decrease in the uptake of radiolabeled uracil, which was not due to accumulation of ergosta-8,14-dienol (ignosterol) in the treated cultures. Radiolabeled cytosine uptake was unaffected by drug treatment in a wild-type strain but was inhibited in a sterol mutant, in which ergosterol was absent from the cell. The role of fenpropimorph in causing membrane dysfunction through a mechanism other than altered sterol metabolism is discussed.

authors

Crowley JH,Lorenz RT,Parks LW

doi

10.1128/aac.38.5.1004

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

1004-7

issue

5

eissn

0066-4804

issn

1098-6596

journal_volume

38

pub_type

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