Endothelial-dependent relaxant actions of carbachol and substance P in arterial smooth muscle.

abstract：:1. The effect of clofibrate (CFB), bezafibrate (BFB), and gemfibrozil (GFB) on plasma lipoprotein (VLDL and LDL) concentration, composition and resistance to copper-induced oxidation has been studied in male Sprague-Dawley rats after a 15 day treatment. 2. Plasma triglyceride levels were reduced by CFB (41%) and BFB (...

journal_title：British journal of pharmacology

authors： Vázquez M,Merlos M,Adzet T,Laguna JC

更新日期：1996-03-01 00:00:00

abstract：:1. The effects of methylflavonolamine hydrochloride (4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA) were investigated and compared with verapamil and papaverine on rabbit isolated aortic strips, which were contracted by noradrenaline, calcium and potassium. 2. Pre-incubation for 25 min wi...

journal_title：British journal of pharmacology

authors： Zhang MS,Zhou EF

更新日期：1988-08-01 00:00:00

abstract：:1. We studied the effect of intracellular angiotensin II (Ang II) and related peptides on rat aortic contraction, whether this effect is pharmacologically distinguishable from that induced by extracellular stimulation, and determined the Ca2+ source involved. 2. Compounds were delivered into the cytoplasm of de-endoth...

journal_title：British journal of pharmacology

authors： Brailoiu E,Filipeanu CM,Tica A,Toma CP,de Zeeuw D,Nelemans SA

更新日期：1999-03-01 00:00:00

abstract：:1. The action of the non-steroidal anti-inflammatory drugs (NSAID), sodium salicylate, aspirin, phenylbutazone and indomethacin was investigated on the migration of human polymorphonuclear cells (PMNs) and lymphocytes, using the system of migration of leucocytes from glass capillary tubes. 2. All NSAID produced a dose...

journal_title：British journal of pharmacology

authors： Brown KA,Collins AJ

更新日期：1978-11-01 00:00:00

abstract：:1. Two-electrode voltage clamp was used to study the effects of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and guanosine 3':5'-cyclic monophosphate (cyclic GMP) on voltage-dependent ion channels in salivary gland cells of the leech, Haementeria ghilianii. 2. Intracellular cyclic AMP specifically blocked delayed...

journal_title：British journal of pharmacology

authors： Everill B,Berry MS

更新日期：1995-09-01 00:00:00

abstract：:We have characterized the contribution of endothelial nitric oxide synthase (eNOS), cyclo-oxygenase (COX) and cytochrome P450 (CYP450) to the bradykinin (BK)- induced vasodilation in isolated hearts from wildtype (WT) and eNOS deficient mice (eNOS-/-). The endothelium-dependent vasodilation by bradykinin (BK, 1 microM...

journal_title：British journal of pharmacology

authors： Ding Z,Gödecke A,Schrader J

更新日期：2002-02-01 00:00:00

abstract：:1. Salmeterol, a novel, long-acting beta-adrenoceptor agonist, has been compared with isoprenaline and salbutamol for activity in vitro on a range of beta-adrenoceptor containing preparations from laboratory animals and man, and in vivo for bronchodilator activity in the conscious guinea-pig. 2. Salmeterol, like isopr...

journal_title：British journal of pharmacology

authors： Ball DI,Brittain RT,Coleman RA,Denyer LH,Jack D,Johnson M,Lunts LH,Nials AT,Sheldrick KE,Skidmore IF

更新日期：1991-11-01 00:00:00

abstract：:1. Experiments were designed to investigate the effects of the inducible nitric oxide synthase (iNOS) stimulator, lipopolysaccharide (LPS), on noradrenaline (NA) responses and on NOS activity and its expression in intact mesenteric resistance arteries (MRAs) from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR)...

journal_title：British journal of pharmacology

authors： Briones AM,Alonso MJ,Marín J,Balfagón G,Salaices M

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of tubulin-binding compounds, which act in part by inhibiting tumour angiogenesis, has become an integral strategy of tumour therapy. Recently, tubulysins were identified as a novel class of natural compounds of myxobacterial origin, which inhibit tubulin polymerization. As these compound...

journal_title：British journal of pharmacology

authors： Rath S,Liebl J,Fürst R,Ullrich A,Burkhart JL,Kazmaier U,Herrmann J,Müller R,Günther M,Schreiner L,Wagner E,Vollmar AM,Zahler S

更新日期：2012-11-01 00:00:00

abstract：:We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA). The purpose of this study was to determine the role of aldosterone in these AngII-induced vascular pathologies. Male apolipoprotein...

journal_title：British journal of pharmacology

authors： Cassis LA,Helton MJ,Howatt DA,King VL,Daugherty A

更新日期：2005-02-01 00:00:00

abstract：:1. The degree to which the RhoA kinase (ROK) blockers, Y-27632 (1 micro M) and HA-1077 (10 micro M), and the PKC blocker, GF-109203X (1 micro M), reduced force produced by carbachol, a muscarinic receptor agonist, and phenylephrine, an alpha-adrenoceptor agonist, was examined in rabbit stomach fundus smooth muscle. 2....

journal_title：British journal of pharmacology

authors： Ratz PH,Meehl JT,Eddinger TJ

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Skeletal muscle is the predominant site for glucose disposal and fatty acid consumption. Emerging evidence indicates that the crosstalk between adipose tissue and skeletal muscle is critical in maintaining insulin sensitivity and lipid homeostasis. The current study was designed to investigate wh...

journal_title：British journal of pharmacology

authors： Shen S,Liao Q,Zhang T,Pan R,Lin L

更新日期：2019-10-01 00:00:00

abstract：:1 Dose-related increases in airways resistance (Raw) and decreases in dynamic lung compliance (Cdyn) were recorded in guinea-pigs and rats following intravenous injection of propranolol and of the cardioselective beta-adrenoceptor blocking drugs, atenolol and practolol. 2 The bronchoconstriction reached a peak in 2 to...

journal_title：British journal of pharmacology

authors： Maclagan J,Ney UM

更新日期：1979-07-01 00:00:00

abstract：:The pharmacological activity of two natural bombesin-like peptides, alytesin and litorin, and 25 related synthetic peptides has been compared to that of bombesin. 2 The minimum length of the amino acid chain required for the first appearance of bombesin-like effects was represented by the C-terminal heptapeptide, and ...

journal_title：British journal of pharmacology

authors： Broccardo M,Falconieri Erspamer G,Melchiorri P,Negri L,de Castiglione R

更新日期：1975-10-01 00:00:00

abstract：:Effects of hypoxia on atrioventricular conduction were investigated in the Langendorff-perfused isolated heart of the rabbit with various extracellular calcium concentrations ([Ca2+]) as well as in the presence of verapamil, nifedipine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and chlorpromazine. The ...

journal_title：British journal of pharmacology

authors： Anno T,Kodama I,Shibata S,Toyama J,Yamada K

更新日期：1986-05-01 00:00:00

abstract：:G protein-coupled receptors are one of the most actively studied families of proteins. However, despite the ubiquity of protein dimerization and oligomerization as a structural and functional motif in biology, until the last decade they were generally considered as monomeric, non-interacting polypeptides. For the meta...

journal_title：British journal of pharmacology

authors： Milligan G

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Alogliptin, a highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances incretin action and pioglitazone enhances hepatic and peripheral insulin actions. Here, we have evaluated the effects of combining these agents in diabetic mice. EXPERIMENTAL APPROACH:Effects of short-term treatmen...

journal_title：British journal of pharmacology

authors： Moritoh Y,Takeuchi K,Asakawa T,Kataoka O,Odaka H

更新日期：2009-06-01 00:00:00

abstract：:1. Despite the observation of pharmacological responses to neuropeptide Y (NPY) in mammalian kidneys, there are species differences in the ease with which specific NPY binding sites can be demonstrated; we have investigated whether this can be explained by differential metabolism of NPY by a membrane-bound peptidase. ...

journal_title：British journal of pharmacology

authors： Price JS,Kenny AJ,Huskisson NS,Brown MJ

更新日期：1991-10-01 00:00:00

abstract：:1. The inflammatory response induced by poly-L-arginine in the rat hind-paw was studied both by measuring paw oedema and histologically. 2. The paw volume was measured with a hydroplethysmometer at 0.5, 1, 2, 4, 6 and 18 h after the subplantar injection of the polycation. Protein extravasation was evaluated with Evans...

journal_title：British journal of pharmacology

authors： Antunes E,Mariano M,Cirino G,Levi S,de Nucci G

更新日期：1990-12-01 00:00:00

abstract：:1. N(G)-monomethyl-L-arginine (L-NMMA) constricts human forearm resistance vasculature and selectively attenuates vasodilator responses to endothelium-dependent vasodilators. Incomplete inhibition of such responses could be due to an inadequate dose of L-NMMA or to NO-independent vasodilator mechanisms. 2. This study ...

journal_title：British journal of pharmacology

authors： Dawes M,Chowienczyk PJ,Ritter JM

更新日期：2001-11-01 00:00:00

abstract：:The effects of intravenous sufentanil and pre-administration of N-methyl-D-aspartate (NMDA) receptor antagonists were tested on a reflex triggered by C-fibre activation. The reflex was elicited by electrical stimulation of the sural nerve and recorded from the ipsilateral biceps femoris muscle in halothane anaesthetiz...

journal_title：British journal of pharmacology

authors： Adam F,Gairard AC,Chauvin M,Le Bars D,Guirimand F

更新日期：2001-08-01 00:00:00

abstract：:1. The inhibitory transmission in isolated preparations of cavernosal smooth muscle from human penis has been studied. 2. Electrical field stimulation (EFS; 2-64 pulses/train, 0.8 ms pulse duration, 10 Hz) evoked relaxation of preparations treated with guanethidine (50 microM). The EFS-evoked relaxations were atropine...

journal_title：British journal of pharmacology

authors： Pickard RS,Powell PH,Zar MA

更新日期：1991-11-01 00:00:00

abstract：:Chemotherapy-induced immune-suppression is a common, but potential detrimental, adverse reaction in patients undergoing treatment for cancer and strategies with capacity to boost the immune cell populations are needed. Physical exercise training is a potent regulator of immune cell viability and function and may serve...

journal_title：British journal of pharmacology

authors： Schauer T,Hojman P,Gehl J,Christensen JF

更新日期：2020-05-25 00:00:00

abstract：:I.c.v. self-administration of MDMA (0.01-2 micro g per infusion), alone and in combination with CP 55,940 (0.4 micro g infusion(-1)), was studied on an operant responding procedure. On the basis of individual preference for one of two levers, developed during training, rats were allowed to self-administer vehicle from...

journal_title：British journal of pharmacology

authors： Braida D,Sala M

更新日期：2002-08-01 00:00:00

abstract：:1. The effects of purinergic stimulation on action potential, force of contraction, 86Rb efflux and 45Ca uptake were investigated in guinea-pig left atria. 2. Adenosine exerted a negative inotropic effect which was antagonized by adenosine deaminase but enhanced by dipyridamole. 3. The negative inotropic effect of ade...

journal_title：British journal of pharmacology

authors： Jahnel U,Nawrath H

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Munich Wistar Frömter (MWF) rat strain represents an experimental model to study cardiovascular alterations under conditions of progressive albuminuria. The aim of this study was to evaluate the association between genetic predisposition to albuminuria and the development of arterial stiffnes...

journal_title：British journal of pharmacology

authors： Gil-Ortega M,García-Prieto CF,Ruiz-Hurtado G,Steireif C,González MC,Schulz A,Kreutz R,Fernández-Alfonso MS,Arribas S,Somoza B

更新日期：2015-09-01 00:00:00

abstract：:1. Measurements were made of the in vivo formation of inositol phosphates in the brains of C57/B1/601a mice treated acutely or chronically with lithium chloride (LiCl). 2. A single injection of LiCl (10 mEquiv kg-1, s.c.) 18 h before death increased the accumulation of [3H]-inositol phosphates ([3H]-Ins P's) in the br...

journal_title：British journal of pharmacology

authors： Whitworth P,Heal DJ,Kendall DA

更新日期：1990-09-01 00:00:00

abstract：:1. We studied the role of bradykinin (BK) and its active metabolite Des-Arg9-BK on noradrenaline release in association with the incidence of ventricular arrhythmias at reperfusion of the ischaemic myocardium. 2. Experiments were performed in Langendorff perfused isolated hearts of rats subjected to 30 min no flow fol...

journal_title：British journal of pharmacology

authors： Chahine R,Adam A,Yamaguchi N,Gaspo R,Regoli D,Nadeau R

更新日期：1993-02-01 00:00:00

abstract：:The development of myocardial and large vessel stiffness with aging underlies the development of diastolic heart failure and isolated systolic hypertension. Nonenzymatic reaction between glucose and proteins (Maillard reaction) leading to collagen crosslinking in the myocardium and arterial wall has been implicated in...

journal_title：British journal of pharmacology

authors： Aronson D

更新日期：2004-08-01 00:00:00

abstract：:1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46...

journal_title：British journal of pharmacology

authors： Hoult JR,Robinson C

更新日期：1983-01-01 00:00:00