Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung.

Abstract:

:1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46619 did not affect accumulation and metabolism of prostaglandin F2 alpha under similar conditions. 3 The pulmonary disposition of thromboxane B2, which occurs by uptake into pulmonary cells or binding to a specific macromolecular component, is mediated by a mechanism distinct from that handling prostaglandin F2 alpha. The possible relevance of these findings to the pulmonary disposition of thromboxane A2 is discussed.

journal_name

Br J Pharmacol

authors

Hoult JR,Robinson C

doi

10.1111/j.1476-5381.1983.tb09366.x

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

85-8

issue

1

eissn

0007-1188

issn

1476-5381

journal_volume

78

pub_type

杂志文章
  • Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice.

    abstract::Although previous reports have suggested that the sigma 1 (sigma(1)) receptor may be involved in pain sensation, its specific site of action has not been elucidated. The aim of present study was to determine the role of the spinal sigma(1) receptor in formalin-induced pain behavior, spinal cord Fos expression and phos...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0706764

    authors: Kim HW,Kwon YB,Roh DH,Yoon SY,Han HJ,Kim KW,Beitz AJ,Lee JH

    更新日期:2006-06-01 00:00:00

  • Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.

    abstract:BACKGROUND AND PURPOSE:This study represents a novel characterisation of KCNQ-encoded potassium channels in the vasculature using a variety of pharmacological and molecular tools to determine their role in contractility. EXPERIMENTAL APPROACH:Reverse transcriptase polymerase chain reaction (RT-PCR) experiments were un...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0707284

    authors: Yeung SY,Pucovský V,Moffatt JD,Saldanha L,Schwake M,Ohya S,Greenwood IA

    更新日期:2007-07-01 00:00:00

  • Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol.

    abstract:BACKGROUND AND PURPOSE:Gain of function mutations in TRPC6 channels can cause autosomal dominant forms of focal segmental glomerulosclerosis (FSGS). Validated inhibitors of TRPC6 channels that are biologically active on FSGS-related TRPC6 mutants are eagerly sought. EXPERIMENTAL APPROACH:We synthesized new TRPC6-inhib...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.13977

    authors: Urban N,Neuser S,Hentschel A,Köhling S,Rademann J,Schaefer M

    更新日期:2017-11-01 00:00:00

  • The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor.

    abstract::Transient expression in COS-7 cells of the recombinant human 5-hydroxytryptamine (5-HT) h5-HT4(c) receptor isoform led to constitutive activity of the receptor. The 5-HT4 receptor antagonist 2-(cis-3,5-dimethylpiperidino)ethyl 4-amino-5-chloro-2-methoxybenzoate (ML10375) at 1 microM completely abolished the 5-HT (1 mi...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0702163

    authors: Blondel O,Gastineau M,Langlois M,Fischmeister R

    更新日期:1998-10-01 00:00:00

  • Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes.

    abstract::1. Sigma (sigma) receptors have generated a great deal of interest on the basis of their possible roles in various pathologies, including cytoprotection. Although the exact function of sigma-1 (sigma(1)) receptors is not yet known, their role in the regulation of intracellular Ca(2+) levels and sterol biosynthesis, fu...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0704626

    authors: Klouz A,Sapena R,Liu J,Maurice T,Tillement JP,Papadopoulos V,Morin D

    更新日期:2002-04-01 00:00:00

  • Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction.

    abstract::1. Repeated allergen challenge has been shown to increase the role of Rho-kinase in airway smooth muscle (ASM) contraction. We considered the possibility that active allergic sensitization by itself, that is, without subsequent allergen exposure, could be sufficient to enhance Rho-kinase-mediated ASM contraction. 2. G...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0705903

    authors: Schaafsma D,Gosens R,Bos IS,Meurs H,Zaagsma J,Nelemans SA

    更新日期:2004-10-01 00:00:00

  • An oxytocin receptor in anococcygeus muscles isolated from male mice.

    abstract::The nature of the neurohypophyseal peptide receptor in the anococcygeus muscles from male mice was investigated. The rank order of potency of naturally occurring peptides was oxytocin greater than Arg-vasotocin greater than Arg-vasopressin greater than Lys-vasopressin, which is similar to that found in the uterus and ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1986.tb09482.x

    authors: Gibson A

    更新日期:1986-05-01 00:00:00

  • Electrophysiological characterisation of tachykinin receptors in the rat nucleus of the solitary tract and dorsal motor nucleus of the vagus in vitro.

    abstract::1. Recent studies have shown antagonists at the NK1 subtype of receptor for tachykinins are antiemetics and suggested that this may result from blockade of tachykinin-mediated synaptic transmission at a central site in the emetic reflex. 2. We have used intracellular recording in vitro to study the pharmacology of tac...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0701482

    authors: Maubach KA,Jones RS

    更新日期:1997-11-01 00:00:00

  • Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury.

    abstract:BACKGROUND AND PURPOSE:The present study investigated whether the pathophysiological changes induced by burn and smoke inhalation are modulated by parenteral administration of Na(2)S, a H(2)S donor. EXPERIMENTAL APPROACH:The study used a total of 16 chronically instrumented, adult female sheep. Na(2)S was administered...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2009.00411.x

    authors: Esechie A,Enkhbaatar P,Traber DL,Jonkam C,Lange M,Hamahata A,Djukom C,Whorton EB,Hawkins HK,Traber LD,Szabo C

    更新日期:2009-11-01 00:00:00

  • Insulin resistance in penile arteries from a rat model of metabolic syndrome.

    abstract:BACKGROUND AND PURPOSE:Metabolic and cardiovascular abnormalities accompanying metabolic syndrome, such as obesity, insulin resistance and hypertension, are all associated with endothelial dysfunction and are independent risk factors for erectile dysfunction. The purpose of the present study was to investigate the vasc...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2010.00825.x

    authors: Contreras C,Sánchez A,Martínez P,Raposo R,Climent B,García-Sacristán A,Benedito S,Prieto D

    更新日期:2010-09-01 00:00:00

  • Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1.

    abstract::1 Endothelin-1 (ET-1), an endothelium-derived vasoactive peptide, participates in the regulation of endothelial function through mechanisms that are not fully elucidated. This study examined the impact of ET-1 on oxidative stress, apoptosis and cell proliferation in human umbilical vein endothelial cells (HUVEC). HUVE...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0706193

    authors: Dong F,Zhang X,Wold LE,Ren Q,Zhang Z,Ren J

    更新日期:2005-06-01 00:00:00

  • Modification of dyskinesias following the intrastriatal injection of prostaglandins in the rodent.

    abstract::The abilities of prostaglandin E1 (PGE1), PGE2, PGD2 and PGF2 alpha to antagonize striatal dopamine function were assessed following bilateral and unilateral injections into the striata of the rat and guinea-pig. Three tests were used to assess the effects of the bilateral injections, ability to antagonize dyskinetic ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1985.tb11095.x

    authors: Costall B,Holmes SW,Kelly ME,Naylor RJ

    更新日期:1985-08-01 00:00:00

  • Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.

    abstract::Two structurally distinct peptides, angiotensin IV and LVV-haemorphin 7, both competitive high-affinity inhibitors of insulin-regulated aminopeptidase (IRAP), were found to enhance aversion-associated and spatial memory in normal rats and to improve performance in a number of memory tasks in rat deficits models. These...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1476-5381.2011.01402.x

    authors: Albiston AL,Diwakarla S,Fernando RN,Mountford SJ,Yeatman HR,Morgan B,Pham V,Holien JK,Parker MW,Thompson PE,Chai SY

    更新日期:2011-09-01 00:00:00

  • Central involvement of kinin B1 and B2 receptors in the febrile response induced by endotoxin in rats.

    abstract::1. The effect of central injection of selective kinin B1 and B2 receptor antagonists on the febrile response induced by endotoxin (E. coli lipopolysaccharide, LPS) in rats was investigated. 2. Intracerebroventricular (i.c.v.) injection of a selective B2 receptor antagonist (Hoe-140, 8 nmol) reduced the early (0-2 h), ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0701110

    authors: Coelho MM,Oliveira CR,Pajolla GP,Calixto JB,Pelá IR

    更新日期:1997-05-01 00:00:00

  • A patch-clamp study of K(+)-channel activity in bovine isolated tracheal smooth muscle cells.

    abstract::1. Single smooth muscle cells were isolated from bovine trachealis by enzymic digestion. The properties of large conductance plasmalemmal K(+)-channels in these cells were studied by the patch-clamp recording technique. 2. Recordings were made from inside-out plasmalemmal patches when [K+] was symmetrically high (140 ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1991.tb12269.x

    authors: Green KA,Foster RW,Small RC

    更新日期:1991-04-01 00:00:00

  • nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety.

    abstract:BACKGROUND AND PURPOSE:Anxiety disorder is a common mental health disorder. However, there are few safe and fast-acting anxiolytic drugs available that can treat anxiety disorder. We previously demonstrated that the interaction of neuronal NOS (nNOS) with its carboxy-terminal PDZ ligand (CAPON) is involved in regulatin...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.15084

    authors: Zhu LJ,Shi HJ,Chang L,Zhang CC,Si M,Li N,Zhu DY

    更新日期:2020-08-01 00:00:00

  • Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes.

    abstract::BACKGROUND AND PURPOSE The Ca(2+) paradox is an important phenomenon associated with Ca(2+) overload-mediated cellular injury in myocardium. The present study was undertaken to elucidate molecular and cellular mechanisms for the development of the Ca(2+) paradox. EXPERIMENTAL APPROACH Fluorescence imaging was performe...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2010.00986.x

    authors: Kojima A,Kitagawa H,Omatsu-Kanbe M,Matsuura H,Nosaka S

    更新日期:2010-12-01 00:00:00

  • Different pharmacological characteristics in L6 and C2C12 muscle cells and intact rat skeletal muscle for amylin, CGRP and calcitonin.

    abstract::1. We compared the ability of rat amylin, rat calcitonin gene-related peptide (CGRP) and rat and salmon calcitonins to elevate cyclic AMP levels and to inhibit [U-14C]-glucose incorporation into glycogen in insulin-stimulated intact rat soleus muscle and in two cell lines derived from rodent skeletal muscle, L6 and C2...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1996.tb15270.x

    authors: Pittner RA,Wolfe-Lopez D,Young AA,Beaumont K

    更新日期:1996-03-01 00:00:00

  • Protective effect of exogenous nitrite in postoperative ileus.

    abstract:BACKGROUND AND PURPOSE:As the pathogenesis of postoperative ileus (POI) involves inflammation and oxidative stress, comparable to ischaemia/reperfusion injury which can be ameliorated with nitrite, we investigated whether nitrite can protect against POI and explored the mechanisms involved. EXPERIMENTAL APPROACH:We us...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.13255

    authors: Cosyns SM,Shiva S,Lefebvre RA

    更新日期:2015-10-01 00:00:00

  • Impairment in connective tissue mast cells degranulation in spontaneously hypertensive rats: stimulus dependent resistance.

    abstract::1. Microvascular permeability in the mesentery and consequent leakage of protein into the peritoneum of spontaneously hypertensive rats (SHR) and normotensive rats (NTR) was measured in vivo by the extravasation of Evans blue dye. 2. In sensitized NTR, challenge with antigen produced extensive increases in dye extrava...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0701875

    authors: Kwasniewski FH,Tavares de Lima W,Bakhle YS,Jancar S

    更新日期:1998-06-01 00:00:00

  • Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature.

    abstract::Pulmonary hypertension (PH) is defined by elevated mean pulmonary artery pressure following the pathological remodelling of small pulmonary arteries. An increase in right ventricular (RV) afterload results in RV hypertrophy and RV failure. The pathophysiology of PH, and RV remodelling in particular, is not well unders...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bph.13721

    authors: Maarman GJ,Schulz R,Sliwa K,Schermuly RT,Lecour S

    更新日期:2017-04-01 00:00:00

  • S-nitrosothiols as selective antithrombotic agents - possible mechanisms.

    abstract::S-nitrosothiols have a number of potential clinical applications, among which their use as antithrombotic agents has been emphasized. This is largely because of their well-documented platelet inhibitory effects, which show a degree of platelet selectivity, although the mechanism of this remains undefined. Recent progr...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1476-5381.2010.00670.x

    authors: Gordge MP,Xiao F

    更新日期:2010-04-01 00:00:00

  • G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling.

    abstract::Oestrogens are important sex hormones central to health and disease in both genders that have protective effects on the cardiovascular and metabolic systems. These hormones act in complex ways via both genomic and non-genomic mechanisms. The genomic mechanisms are relatively well characterized, whereas the non-genomic...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1476-5381.2011.01235.x

    authors: Nilsson BO,Olde B,Leeb-Lundberg LM

    更新日期:2011-07-01 00:00:00

  • Inhibitory effect of sodium cromoglycate on pulmonary responses to histamine administered after indomethacin in anaesthetized guinea-pigs.

    abstract::1. Histamine (2-4 micrograms kg-1 i.v.) increased airways resistance (Raw) and decreased dynamic lung compliance (Cdyn) in urethane-anaesthetized guinea-pigs. The effects on Raw were almost abolished by atropine (0.1 mg kg-1 i.v.) and reduced by vagal cooling (11-16 degrees C). 2. Histamine-induced changes in Raw and ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1988.tb11555.x

    authors: Mitchell HW

    更新日期:1988-06-01 00:00:00

  • Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.

    abstract:BACKGROUND AND PURPOSE:N-arachidonoyl-serotonin (AA-5-HT) is an inhibitor of fatty acid amide hydrolase (FAAH)-catalysed hydrolysis of the endocannabinoid/ endovanilloid compound, anandamide (AEA). We investigated if AA-5-HT antagonizes the transient receptor potential vanilloid-1 (TRPV1) channel and, as FAAH and TRPV1...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0707145

    authors: Maione S,De Petrocellis L,de Novellis V,Moriello AS,Petrosino S,Palazzo E,Rossi FS,Woodward DF,Di Marzo V

    更新日期:2007-03-01 00:00:00

  • Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice.

    abstract::1. The role of smooth muscle-derived lipoprotein lipase (LPL) that translocates to the endothelium surface on vascular dysfunction during atherogenesis is unclear. Thus, the role of vascular LPL on blood vessel reactivity was assessed in transgenic mice that specifically express human LPL in the circulatory system. 2....

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0704440

    authors: Esenabhalu VE,Cerimagic M,Malli R,Osibow K,Levak-Frank S,Frieden M,Sattler W,Kostner GM,Zechner R,Graier WF

    更新日期:2002-01-01 00:00:00

  • Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain.

    abstract::The ability of gamma-aminobutyric acid (GABA) to affect the release of [3H]-dopamine in rat brain synaptosomes prepared from corpus striatum, frontal cortex and hypothalamus and prelabelled with the radioactive catecholamine in the presence of desipramine was examined. GABA (10-300 microM) increased in a concentration...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1987.tb09004.x

    authors: Bonanno G,Raiteri M

    更新日期:1987-05-01 00:00:00

  • The effect of tyrosine nitration of L-type Ca2+ channels on excitation-transcription coupling in colonic inflammation.

    abstract:BACKGROUND AND PURPOSE:Excitation-transcriptional coupling involves communication between plasma membrane ion channels and gene expression in the nucleus. Calcium influx through L-type Ca(2+) channels induces phosphorylation of the transcription factor, cyclic-AMP response element binding protein (CREB) and downstream ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2009.00599.x

    authors: Kang M,Ross GR,Akbarali HI

    更新日期:2010-03-01 00:00:00

  • The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes.

    abstract:BACKGROUND AND PURPOSE:Cultured pre-adipocytes accumulate and metabolize zidovudine (ZDV), but its mode of accumulation into these cells is unclear. We investigated the mode of accumulation of [(3)H]-ZDV, and the impact of changes in external pH and modulators of drug transporters on its accumulation and metabolism. E...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2009.00552.x

    authors: Janneh O,Owen A,Bray PG,Back DJ,Pirmohamed M

    更新日期:2010-01-01 00:00:00

  • Mechanistic analysis of the function of agonists and allosteric modulators: reconciling two-state and operational models.

    abstract::Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of ac...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bph.12231

    authors: Roche D,Gil D,Giraldo J

    更新日期:2013-07-01 00:00:00