Abstract:
:Hepatic steatosis is one of the most common hepatic disorders in developed countries. The epidemic of obesity in developed countries has increased with its attendant complications, including metabolic syndrome and non-alcoholic fatty liver disease. Steatotic livers are particularly vulnerable to ischemia/reperfusion injury, resulting in an increased risk of postoperative morbidity and mortality after liver surgery, including liver transplantation. There is growing understanding of the molecular and cellular mechanisms and therapeutic approaches for treating ischemia/reperfusion injury in patients with steatotic livers. This review discusses the mechanisms underlying the susceptibility of steatotic livers to ischemia/reperfusion injuries, such as mitochondrial dysfunction and signal transduction alterations, and summarizes the clinical impact of steatotic livers in the setting of hepatic resection and liver transplantation. This review also describes potential therapeutic approaches, such as ischemic and pharmacological preconditioning, to prevent ischemia/reperfusion injury in patients with steatotic livers. Other approaches, including machine perfusion, are also under clinical investigation; however, many pharmacological approaches developed through basic research are not yet suitable for clinical application.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Tashiro H,Kuroda S,Mikuriya Y,Ohdan Hdoi
10.1007/s00595-013-0736-9subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1611-25issue
9eissn
0941-1291issn
1436-2813journal_volume
44pub_type
杂志文章,评审相关文献
SURGERY TODAY文献大全abstract:PURPOSE:Patients with Crohn's disease (CD) show a higher incidence of surgical site infections (SSIs) after bowel resection in comparison to other patient populations because CD patients commonly suffer from anemia, malnutrition, and immunosuppression. In comparison to conventional passive drainage, active drainage usi...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-017-1549-z
更新日期:2018-01-01 00:00:00
abstract::An 80-year-old woman was admitted to our hospital complaining of severe abdominal and back pain. Computed tomography (CT) showed an 8.5 x 7.0-cm infrarenal abdominal aortic aneurysm (AAA) with a large contained retroperitoneal hematoma. Known situs inversus totalis was reconfirmed by CT. Just after the CT examination,...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-007-3616-3
更新日期:2008-01-01 00:00:00
abstract::This study was undertaken to assess blood vessel invasion (BVI) and other histologic features to determine the best method of histologic prognosis in node-negative breast cancer patients. The prognostic significance of the clinico-pathological findings was evaluated in 70 patients with node-negative breast cancer amon...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311773
更新日期:1996-01-01 00:00:00
abstract::We report herein the unusual case of a man who was diagnosed as having sporadic medullary thyroid carcinoma (MTC) at the age of 29 years, and subsequently followed up for a period of 18 years. A total thyroidectomy with radical neck dissection was initially performed, followed by a stable interval of 16 years with reg...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02482271
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To minimize the parietal trauma associated with multiple surgical access sites, single-incision laparoscopic surgery for colectomy has been emerging with the improvements in instrumentation and surgical techniques. The purpose of this study was to compare the clinicopathological outcomes between single-incision...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-015-1154-y
更新日期:2016-03-01 00:00:00
abstract::Body composition was measured with bioelectric impedance analysis (BIA) in 30 patients with protein malnutrition following biliopancreatic diversion. Determinations were carried out prior to, during, and at the completion of intravenous nutritional support when the nutritional parameters had completely reverted to nor...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311363
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:The plasma D-dimer (D-dimer) level, a marker of hypercoagulation, has been reported to be associated with survival in several types of cancers. This retrospective study was conducted to evaluate the prognostic significance of the preoperative D-dimer level in patients with completely resected non-small cell lun...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-014-0894-4
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:This study explored the optimal suture materials for use in the peritoneal cavity based on the formation of adhesions and abscesses under clean and contaminated conditions. METHODS:The parietal peritoneum and muscle layer of rats were incised. The incision was followed by interrupted suturing in the clean grou...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-012-0249-y
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:Global DNA hypomethylation plays an important role in genomic instability and carcinogenesis. The long interspersed nucleotide element-1 (LINE-1) methylation level is a good surrogate marker of the global DNA methylation level. Previously, we demonstrated a strong relationship between LINE-1 hypomethylation and...
journal_title:Surgery today
pub_type: 杂志文章,评审
doi:10.1007/s00595-017-1539-1
更新日期:2017-12-01 00:00:00
abstract::Neuroendocrine tumors of the pancreas are being recognized with increasing frequency, not because the incidence has increased, but as a result of improvements in diagnostic tools such as radioimmunoassays for a variety of circulating peptides, and imaging methods that include positron emission tomography (PET) and imm...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950050182
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:As the incidence of HIV increases, the occupational risk of human immuno deficiency virus (HIV) infection also increases, leading to heightened anxiety within surgical practice. This study assessed the attitudes of surgeons treating HIV-infected patients. METHODS:Seventy surgical trainees working in two distri...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-011-0096-2
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the genetic mutation profiles of Japanese pancreatic ductal adenocarcinoma (PDAC) patients. METHODS:Next-generation sequencing was performed using FoundationOne® CDx on 17 PDAC patients who were treated by surgical resection at Kyushu University Hospital between Februar...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-020-02123-2
更新日期:2020-09-04 00:00:00
abstract::Three patients were treated for coronary artery-pulmonary artery fistula. Each was asymptomatic due to a coronary artery fistula. There was one instance each of myocardial infarction, mitral stenosis and a large closed ruptured aneurysm including a thrombus. All the fistulas were comprised of several small plexiform a...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311346
更新日期:1992-01-01 00:00:00
abstract::We studied the amounts of nuclear DNA in gastric cancer metastases histologically and cytochemically by flow cytometry, which was performed retrospectively on paraffin-embedded specimens from 95 patients. At surgery, all cases of aneuploid cancer were positive for lymph node metastases. Liver metastases were frequentl...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00308788
更新日期:1992-01-01 00:00:00
abstract::Papillary fibroelastoma is a rare, benign cardiac tumor that can cause multiple emboli. We report herein a case of papillary fibroelastoma developing from the chordae of the tricuspid valve which was detected by echocardiography and confirmed by surgical resection. To our knowledge, this is only the fifth documented c...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950050154
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:This study evaluated a better treatment for patients with obstructive colorectal cancer (CRC) that have a poor prognosis. METHOD:This study compared the outcomes of 138 patients with obstructive CRC, including 70 primary resections, 50 resections after bowel decompression using an ileus tube, and 18 delayed re...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-011-0116-2
更新日期:2012-12-01 00:00:00
abstract::This report presents the case of a common hepatic artery (CHA) pseudoaneurysm secondary to postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD), which was successfully treated using a coronary covered stent. A 70-year-old female underwent subtotal stomach-preserving PD for middle cholangiocarcinoma...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-012-0314-6
更新日期:2014-01-01 00:00:00
abstract::Because of the low incidence rate of combined hepatocellular-cholangiocarcinoma (combined HCC-CC), the clinicopathological features of a recurrent tumor of this disease remain to be elucidated. We describe a 47-year-old Japanese woman with a 5-cm diameter mass lesion in the liver. A hepatectomy and dissection of the l...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950200140
更新日期:2002-01-01 00:00:00
abstract::The relationship between a local hypercoagulable state and primary varicose veins of the lower legs was investigated by measuring the plasma levels of D-dimer (DD) and the thrombin-antithrombin-III complex (TAT) in 122 consecutive patients before treatment, and in 46 patients after surgical intervention and compressio...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00309958
更新日期:1996-01-01 00:00:00
abstract::We report herein the cases of two patients with Crohn's disease complicated by a psoas abscess. The first patient was a 29-year-old man who underwent definitive surgery after acute inflammation had been controlled by nutritional therapy. In the second patient, a 37-year-old man, the abscess required drainage under loc...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311604
更新日期:1996-01-01 00:00:00
abstract::Accurate localization of the tumor during robot-assisted laparoscopic surgery for rectal cancer is crucial. Several techniques have been described, but each has its shortcomings. We developed a new technique of near infrared ray-guided surgery (NIRGS) to localize the tumor accurately, using intra-operative colonoscopy...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-019-01864-z
更新日期:2020-02-01 00:00:00
abstract::A true aneurysm of the right aortic arch which accompanies various branching characteristics is very rare. We report herein the successful surgical treatment of an elderly patient found to have an Edwards type IIIB right aortic arch aneurysm encircling and compressing the trachea. The complete right aortic arch and ri...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02483972
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:The precise role of downstaging or bridge therapy for cirrhotic patients with hepatocellular carcinoma (HCC) beyond or within the Milan criteria (MC) before living donor liver transplantation (LDLT) remains undefined. METHODS:We conducted a single-center, retrospective cohort study of 40 cirrhotic patients wit...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-020-02095-3
更新日期:2020-08-07 00:00:00
abstract::The majority of leiomyosarcomas occur in the muscular layers of the gastrointestinal tract and uterus. Primary leiomyosarcomas rarely arise in the veins of the lower extremities. Primary leiomyosarcoma of the superficial femoral vein is extremely uncommon. We herein present a case of a 69-year-old man with a primary l...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-010-4507-6
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is still debate about the practicality of performing laparoscopic colectomy instead of open colectomy for patients with curable cancer, although laparoscopic surgery is now being performed even for patients with advanced colon cancer. We compared the long-term results of laparoscopic versus...
journal_title:Surgery today
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00595-012-0292-8
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:In the present study, we investigated the effect of troglitazone, a selective ligand and agonist of PPAR-gamma, on the metastatic potential of human colon cancer cells. METHODS:High- and low-PPAR-gamma expression clones of the colon cancer cell line, HT29, namely clones 21 and 3 respectively, were used. We inv...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950200049
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:The anatomical site of resected lobes may influence postoperative cerebral infarction. The objective of the current study was to determine if left upper pulmonary lobectomy is a risk factor for postoperative cerebral infarction. METHODS:This was a retrospective case-control study in patients undergoing pulmona...
journal_title:Surgery today
pub_type: 杂志文章,多中心研究
doi:10.1007/s00595-020-02032-4
更新日期:2020-11-01 00:00:00
abstract::This study was undertaken to determine whether or not the prostanoid metabolism contributes to peritonitis-induced early liver oxidant stress. Lipid peroxidation products, malondialdehyde (MDA) and conjugated dienes (CD), were used to monitor oxidant stress. The rats were given a 5-cc intraperitoneal (i.p.) injection ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02482968
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Several recent studies have evaluated the feasibility of the sentinel node (SN) concept for gastric cancer. The aim of our study was to investigate limited gastrectomy with SN basin dissection in SN navigation surgery (SNNS) for patients with early-gastric cancer located in the upper-third of the stomach. METH...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-019-1768-6
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:There is evidence that blood transfusion is associated with an increased rate of tumor recurrence. This study was conducted to assess the survival advantage of giving autologous blood instead of allogeneic blood during surgery for esophageal cancer. METHODS:We retrospectively analyzed 62 patients who underwent...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950200191
更新日期:2002-01-01 00:00:00