A randomized, open-label, phase I/II trial to investigate the maximum tolerated dose of the Polo-like kinase inhibitor BI 2536 in elderly patients with refractory/relapsed acute myeloid leukaemia.

abstract：:In HbSC disease, as in sickle cell anaemia, there is a spectrum of clinical severity. A reduced mean corpuscular volume and haemoglobin concentration, traits typical of thalassaemia, might retard sickling. We therefore ascertained the prevalence of alpha-thalassaemia in 53 adults with HbSC disease and related alpha-gl...

journal_title：British journal of haematology

authors： Steinberg MH,Coleman MB,Adams JG,Platica O,Gillette P,Rieder RF

更新日期：1983-11-01 00:00:00

abstract：:Despite the significance of red blood cell (RBC) alloimmunization, the lack of standardized registries in the US has prevented the completion of large studies. Data from 3·5 years of the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) recipient database, containing information from 12 hospitals, were ...

journal_title：British journal of haematology

authors： Karafin MS,Westlake M,Hauser RG,Tormey CA,Norris PJ,Roubinian NH,Wu Y,Triulzi DJ,Kleinman S,Hendrickson JE,NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

更新日期：2018-06-01 00:00:00

abstract：:Elevated plasminogen activator inhibitor 1 (PAI-1) levels are associated with venous thromboembolism, although their significance is unclear. PAI-1 levels are influenced by a PAI-1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI-1 activity. We investigated whether the 4G allele influence...

journal_title：British journal of haematology

authors： Visanji JM,Seargent J,Tahri D,Croft SA,Makris M,Preston FE,Peake IR,Daly ME

更新日期：2000-07-01 00:00:00

abstract：:The existence of two genetic variants (allotypes) of normal human factor IX is used for carrier detection in three families with severe and one with mild haemophilia B. By analysis of IX:Ag with two different monoclonal antibodies in 93 members of the families, allelic assignment is shown to be a complement in carrier...

journal_title：British journal of haematology

authors： Wallmark A,Ljung R,Nilsson IM

更新日期：1987-12-01 00:00:00

abstract：:Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell (HPC) transplant patients. Although it is now possible to collect much larger numbers of neutrophils (PMNs) from donors stimulated with granulocyte colony-stimulating factor + corticosteroids, the efficacy ...

journal_title：British journal of haematology

authors： Strauss RG

更新日期：2012-08-01 00:00:00

abstract：:Eleven patients are described in whom myelomatosis was complicated by the laboratory and clinical features of the hyperviscosity syndrome (HVS). The myeloma type was IgA in nine and IgG3 in two. In those patients with IgA myeloma the HVS was related to the presence of high molecular weight complexes in the serum. Remi...

journal_title：British journal of haematology

authors： Preston FE,Cooke KB,Foster ME,Winfield DA,Lee D

更新日期：1978-04-01 00:00:00

abstract：:Nd-HPFH are haematological conditions which are natural models to aid understanding of the haemoglobin (Hb) switch. In this paper we describe a new non-deletional hereditary persistence of fetal haemoglobin (nd-HPFH) associated with the highest Hb F level observed to date (up to 49% without haemopoietic stress). Seque...

journal_title：British journal of haematology

authors： Pissard S,M'rad A,Beuzard Y,Roméo PH

更新日期：1996-10-01 00:00:00

abstract：:We analysed the incidence of graft failure, graft-versus-host disease (GVHD) and relapse of leukaemia in 208 patients undergoing allogeneic bone marrow transplantation (BMT) for chronic myeloid leukaemia in chronic phase in eight transplant centres in Europe and the United States. 106 patients received unmanipulated d...

journal_title：British journal of haematology

authors： Apperley JF,Mauro FR,Goldman JM,Gregory W,Arthur CK,Hows J,Arcese W,Papa G,Mandelli F,Wardle D

更新日期：1988-06-01 00:00:00

abstract：:Patients with aplastic anaemia (AA) frequently develop paroxysmal nocturnal haemoglobinuria (PNH) as a late complication. We investigated the frequency of the development of PNH features including a glycosyl phosphatidylinositol (GPI) anchoring defect in 73 Japanese patients with AA. A deficient expression of CD59 was...

journal_title：British journal of haematology

authors： Azenishi Y,Ueda E,Machii T,Nishimura J,Hirota T,Shibano M,Nakao S,Kinoshita T,Mizoguchi H,Kitani T

更新日期：1999-03-01 00:00:00

abstract：:Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

journal_title：British journal of haematology

authors： Clark RE,Lee ES

更新日期：1995-06-01 00:00:00

abstract：:Amiodarone has been implicated as a cause of thrombocytopenia but the responsible mechanism is unknown. We performed studies in three patients to characterize the pathogenesis of this complication. No amiodarone-dependent, platelet-reactive antibodies were identified using conventional serological techniques. However,...

journal_title：British journal of haematology

authors： Sahud MA,Caulfield M,Clarke N,Koch R,Bougie D,Aster R

更新日期：2013-10-01 00:00:00

abstract：:A chromogenic factor Xa generation method has been developed for comparing the co-factor activity of factor VIII concentrates at physiological factor VIII concentrations (1 iu/ml). In the presence of thrombin all concentrates gave similar rapid rates of factor Xa generation, but in the absence of thrombin there were m...

journal_title：British journal of haematology

authors： Kemball-Cook G,Tubbs JE,Dawson NJ,Barrowcliffe TW

更新日期：1993-06-01 00:00:00

abstract：:The role of autologous stem cell transplantation (ASCT) and the optimal timing of such transplants in patients with follicular lymphoma (FL) remains contentious. We present a single-centre experience documenting the outcomes of 70 FL patients who underwent BEAM (carmustine, cytarabine, etopside, melphalan)-conditioned...

journal_title：British journal of haematology

authors： Kothari J,Peggs KS,Bird A,Thomson KJ,Morris E,Virchis AE,Lambert J,Goldstone AH,Linch DC,Ardeshna KM

更新日期：2014-05-01 00:00:00

abstract：:Platelet mass (mean platelet volume x platelet count) can be derived from data obtained from the routine full blood count and separates patients with myelodysplastic syndromes (MDS) at diagnosis into three distinct prognostic groups: low platelet mass group - median survival 5 months and 5-year survival 0%; intermedia...

journal_title：British journal of haematology

authors： Bowles KM,Warner BA,Baglin TP

更新日期：2006-10-01 00:00:00

abstract：:Eradication of Helicobacter pylori infection has been associated with the correction of thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). We have analysed the response to eradication of H. pylori in a series of 56 adult patients with chronic ITP. Forty patients had H. pylori infection (71%) ...

journal_title：British journal of haematology

authors： Jarque I,Andreu R,Llopis I,De la Rubia J,Gomis F,Senent L,Jiménez C,Martín G,Martínez JA,Sanz GF,Ponce J,Sanz MA

更新日期：2001-12-01 00:00:00

abstract：:Eight patients with aplastic anaemia associated with dyskeratosis congenita received allogeneic marrow grafts from either HLA-identical siblings (six patients) or HLA-matched unrelated donors (two patients). Patients who received marrow from HLA-identical siblings were conditioned with cyclophosphamide (140-200 mg/kg)...

journal_title：British journal of haematology

authors： Langston AA,Sanders JE,Deeg HJ,Crawford SW,Anasetti C,Sullivan KM,Flowers ME,Storb R

更新日期：1996-03-01 00:00:00

abstract：:Highly purified and cloned preparations of interleukin-1 (IL-1) were found to antagonize the capacity of erythropoietin (Epo) to stimulate the proliferation of mouse spleen and bone marrow erythroid precursor cells (EPC) in culture. Cloned murine IL-1 and purified and cloned human IL-1 alpha and IL-1 beta were approxi...

journal_title：British journal of haematology

authors： Schooley JC,Kullgren B,Allison AC

更新日期：1987-09-01 00:00:00

abstract：:To evaluate the clinical significance of CD21S expression of diffuse large B-cell lymphoma (DLBCL) tumour cells, we compared their clinical features, immunophenotype, response to therapy and outcome in relation to CD21S expression. Between 1987 and 1999, frozen sections from 240 DLBCL cases were examined for CD21S exp...

journal_title：British journal of haematology

authors： Ogawa S,Yamaguchi M,Oka K,Taniguchi M,Ito M,Nishii K,Nakase K,Ohno T,Kita K,Kobayashi T,Shiku H

更新日期：2004-04-01 00:00:00

abstract：:The presence of oestrogen receptors (ER) and type II oestrogen binding sites (type II EBS) have been investigated by a whole cell assay in seven cases of acute lymphoid leukaemia (ALL) and 16 cases of acute myeloid leukaemia (AML). ER were detected in 6/7 ALL patients with values ranging between 133 and 2268 sites/cel...

journal_title：British journal of haematology

authors： Larocca LM,Piantelli M,Leone G,Sica S,Teofili L,Panici PB,Scambia G,Mancuso S,Capelli A,Ranelletti FO

更新日期：1990-08-01 00:00:00

abstract：:Seven children (age range 1.8-11 years) with juvenile chronic myelomonocytic leukaemia (JCML) received an allogeneic bone marrow transplantation (BMT), four from an HLA-identical sibling and three from a matched unrelated donor. In the four children transplanted using an HLA-identical sibling, conditioning regimen inc...

journal_title：British journal of haematology

authors： Locatelli F,Pession A,Comoli P,Bonetti F,Giorgiani G,Zecca M,Taibi RM,Mongini ME,Ambroselli F,de Stefano P,Severi F,Paolucci G

更新日期：1996-01-01 00:00:00

abstract：:A novel long-term cultured interleukin (IL)-3-dependent human myelodysplastic cell line, MDS92, was shown to contain several myeloid-lineage cells such as neutrophils, macrophages, eosinophils, and a small number of megakaryocyte-lineage cells. Therefore this cell line possesses at least bipotential characteristics of...

journal_title：British journal of haematology

authors： Tohyama K,Tohyama Y,Nakayama T,Ueda T,Nakamura T,Yoshida Y

更新日期：1995-12-01 00:00:00

abstract：:The number of novel therapies for the treatment of myeloma is rapidly increasing, as are the clinical trials evaluating them in combination with other novel and established therapies. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are the most well known and studied classes of novel agents ta...

journal_title：British journal of haematology

authors： Wallington-Beddoe CT,Sobieraj-Teague M,Kuss BJ,Pitson SM

更新日期：2018-07-01 00:00:00

abstract：:T-cell large granular lymphocyte leukaemia (T-LGL) is a clonal disorder of T cells associated with neutropenia and anaemia. The clinical consequences are recurrent infections and transfusion dependence. The optimum treatment for severely affected patients remains to be defined. Current therapies require long-term admi...

journal_title：British journal of haematology

authors： Sternberg A,Eagleton H,Pillai N,Leyden K,Turner S,Pearson D,Littlewood T,Hatton C

更新日期：2003-02-01 00:00:00

abstract：:The primary pathophysiological event in sickling is the intracellular polymerization of deoxygenated haemoglobin S. Tucaresol (589C80;4[2-formyl-3-hydroxyphenoxymethyl] benzoic acid), a substituted benzaldehyde, was designed to interact with haemoglobin to increase oxygen affinity and has been shown to inhibit sicklin...

journal_title：British journal of haematology

authors： Arya R,Rolan PE,Wootton R,Posner J,Bellingham AJ

更新日期：1996-06-01 00:00:00

abstract：:Various techniques have been used to assess the flow properties of blood and blood cells in a range of clinical situations. Filtration through microfilters offers a single technique for measuring the flow properties of all cellular components of blood in one experiment but depends on an assumed ability to recognize ce...

journal_title：British journal of haematology

authors： Jones JG,Adams RA,Cook AM,Evans SA

更新日期：1999-01-01 00:00:00

abstract：:Investigations into the nature of the molecular interactions mediating the recognition of the haemopoietic progenitor cells by the haemopoietic stroma, indicate that ubiquitin mediates the binding between murine haemopoietic progenitors and the haemopoietic stroma. The adhesion of haemopoietic progenitors to anti-ubiq...

journal_title：British journal of haematology

authors： Parakh KA,Kannan K

更新日期：1993-06-01 00:00:00

abstract：:Hypercalcaemia complicating acute myelogenous leukaemia is a rare but well-recognized phenomenon. In most cases the pathogenetic mechanism causing the hypercalcaemia remains poorly understood. We recently studied in detail two patients with acute myelogenous leukaemia who developed hypercalcaemia during the course of ...

journal_title：British journal of haematology

authors： Gewirtz AM,Stewart AF,Vignery A,Hoffman R

更新日期：1983-05-01 00:00:00

abstract：:The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with blood group O than in people with non-O blood groups was demonstrated with both techniques. This difference could not be attributed to a difference in sex...

journal_title：British journal of haematology

authors： Caekebeke-Peerlinck KM,Koster T,Briët E

更新日期：1989-10-01 00:00:00

abstract：:UK National External Quality Assessment Service surveys indicate continuing problems in malaria diagnosis: inaccurate calculation of parasitaemia or failure to estimate it altogether, difficulty distinguishing Plasmodium vivax from P. ovale, reporting malaria parasites when none were present and misidentification of P...

journal_title：British journal of haematology

authors： Bailey JW,Williams J,Bain BJ,Parker-Williams J,Chiodini PL,General Haematology Task Force of the British Committee for Standards in Haematology.

更新日期：2013-12-01 00:00:00

abstract：:Peripheral blood and bone marrow mononuclear cells from 10 patients with newly diagnosed Waldenström's macroglobulinaemia were analysed for the presence of leucocyte differentiation antigens using flow cytometry. Most patients had circulating intracytoplasmic-mu cells that were positive for the B-cell specific antigen...

journal_title：British journal of haematology

authors： Kucharska-Pulczynska M,Ellegaard J,Hokland P

更新日期：1987-04-01 00:00:00