Abstract:
BACKGROUND:The main target site of action for the sedative clonidine (CLO), an α2 adrenoceptor agonist, has been considered to be the locus coeruleus (LC). However, previous reports suggest other sites of action of CLO than the LC. Our previous studies suggested that the neuronal activities in the perifornical area (Pef) could influence the sedative or the anesthetic level induced by anesthetics. Therefore, we examined whether microinjection of CLO into the Pef might induce sedation in rats. MATERIALS AND METHODS:Fifty-five Wistar rats were used. The cortical norepinephrine (NE) and acetylcholine (ACh) effluxes were detected using microdialysis and measured by high-performance liquid chromatography in samples collected every 20 minutes. First, we injected CLO (100, 300, and 1000 μg/kg cumulative doses) intraperitoneally (IP) and observed the changes in NE or ACh efflux. Second, we injected CLO (4.8 μg in 0.2 μL) or saline (0.2 μL) into the LC or the Pef and observed the changes in NE or ACh efflux for 2 hours. Finally, a sedative/anesthetic score was obtained after IP, LC or Pef microinjection of CLO. RESULTS:IP injection of CLO induced sedation and resulted in a dose-dependent attenuation of the cortical effluxes of both NE and ACh (P<0.001). Microinjection of CLO either into the LC or the Pef induced sedation and significantly decreased the cortical NE efflux (P<0.001). Cortical ACh efflux was significantly reduced by microinjection of CLO into the Pef but not by microinjection into the LC (P<0.05). CONCLUSION:The Pef and the LC are responsible for the sedative action of CLO in rats.
journal_name
J Neurosurg Anesthesioljournal_title
Journal of neurosurgical anesthesiologyauthors
Sakamoto H,Fukuda S,Minakawa Y,Sawamura Sdoi
10.1097/ANA.0b013e3182978ff0subject
Has Abstractpub_date
2013-10-01 00:00:00pages
399-407issue
4eissn
0898-4921issn
1537-1921pii
00008506-201310000-00005journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Glucocorticoids have been shown to alleviate ischemia-induced myocardial injury, while aggravating neuronal damage caused by ischemia. As energy failure is a predominant factor in cellular viability, we examined the effects of glucocorticoids on energy utilization in the mouse heart and brain. METHODS:Seven...
journal_title:Journal of neurosurgical anesthesiology
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doi:10.1097/ANA.0000000000000153
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abstract::Patients receiving anticonvulsants such as phenytoin or carbamazepine may be resistant to neuromuscular blocking agents. The authors report the response to rapacuronium bromide (1.5 mg/kg) in two adult patients; one receiving phenytoin and the other receiving carbamazepine. In both patients, there was a delay in achie...
journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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abstract::Brain tissue oxygen monitoring (P(ti)O2 (Neurotrend, Codman, Germany) was employed in addition to standard intracranial pressure (ICP) and cerebral perfusion pressure (CPP) monitoring in seven patients with severe neuronal damage of heterogeneous etiology. The correlation between P(ti)O2 changes and CPP fluctuations d...
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abstract::The use of sevoflurane is favored for its rapid onset and offset of anesthesia as well as good intraoperative titratability of the anesthetic. With regard to neuroanesthesia, the reported effects of sevoflurane on cerebral hemodynamics and cerebrospinal fluid dynamics are inconsistent. We used phase-contrast magnetic ...
journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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