Abstract:
BACKGROUND:Subclinical thyroid disease is associated with abnormal cardiovascular haemodynamics and increased risk of heart failure. The burden of raised/low thyroid stimulating hormone (TSH) levels amongst South Asian (SA) and African-Caribbean (AC) minority groups in the UK is not well defined. Given that these groups are particularly susceptible to CVD, we hypothesised that STD would reflect abnormal cardiac function and heightened cardiovascular risk in these ethnic groups. METHODS:We examined SA (n=1111, 56% male, mean age 57.6 yrs) and AC (n=763, 44% male, mean age 59.2 yrs) participants from a large heart failure screening study. Euthyroidism is defined as TSH (0.4 - 4.9 mlU/l), subclinical hypothyroidism is defined as a raised TSH with normal serum free thyroxine (FT4) concentrations (9-19 pmol/l). Subclinical hyperthyroidism is defined as a low TSH with both FT4 and free triiodothyronine (FT3) concentrations within range (2.6-5.7 pmol/l). RESULTS:Across ethnic groups, prevalence of subclinical hypothyroidism was 2.9% (95% CI 2.1-3.7), and of hyperthyroidism was 2.0% (1.4-2.7). Hyperthyroidism was more common amongst SA compared to AC (2.8% vs. 0.9%, P=0.017), while rates of subclinical hypothyroidism were similar. On multivariate analysis of variations in subclinical thyroid function, ethnicity was not independently significant. CONCLUSION:The prevalence of subclinical thyroid disorders amongst SA and AC minority groups in Britain reflects levels reported in other populations. The clinical cardiovascular significance of subclinical thyroid disease is unclear, and it does not appear to be ethnically specific.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Gill PS,Patel JV,Chackathayil J,Webster C,Davis RC,Hughes E,Lip GYdoi
10.1016/j.ijcard.2013.08.030subject
Has Abstractpub_date
2013-10-15 00:00:00pages
5218-20issue
6eissn
0167-5273issn
1874-1754pii
S0167-5273(13)01555-6journal_volume
168pub_type
杂志文章abstract:BACKGROUND:The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary cohort of PCI treated patients, which would: predict 30 day mortality; provid...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.02.085
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Since the body of evidence addressing the coagulation derangements caused by Coronavirus disease (COVID-19) has been constantly growing, we investigated whether pre-hospitalization oral anticoagulation (OAC) or in-hospital heparin treatment could have a protective role among COVID-19 patients. METHOD:In thi...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2020.09.001
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Chronic kidney disease is now regarded as a risk factor for cardiovascular disease. The impact of occupational or non-occupational physical activity (PA) on moderate decreases of renal function is uncertain. OBJECTIVES:We aimed to identify the potential association of PA (occupational and leisure-time) on e...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.09.102
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:Premature acute myocardial infarction (AMI) is a rare disease carrying significant morbidity and mortality. Existing data on outcome in these patients is based on retrospective analysis of angiographic reports or refer to time periods with incomparable treatment regimes, making them unusable for risk assessm...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2017.03.146
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Sports activity has been associated with the development of atrial arrhythmias. Atrial fibrillation (AF) is frequently observed after successful ablation for atrial flutter. Sports activity as a risk factor for AF development after flutter ablation has not been studied. METHODS:We analyzed outcome in 137 ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.02.043
更新日期:2006-02-08 00:00:00
abstract::Reversible vascular obstructive lesions, i.e. pseudostenoses, may pose significant threats to interventional cardiologists as they can be mistaken for obstructive lesions and prompt inappropriate revascularization procedures. We hereby report for the first time in the literature a case of external iliac artery pseudos...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2004.02.007
更新日期:2005-05-25 00:00:00
abstract:RATIONALE:Sirtuin (SIRT3), a major nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase in mitochondria, declines with aging and its ablation is associated with accelerated development of cardiovascular diseases. However, the role of SIRT3 in coronary microvascular function and post-MI recovery has not been...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.04.092
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND:The number and age demographic of the future Fontan population is unknown. METHODS:Population projections were calculated probabilistically using microsimulation. Mortality hazard rates for each Fontan recipient were calculated from survivorship of 1353 Fontan recipients in the Australia and New Zealand Fon...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.05.035
更新日期:2016-09-15 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to compare the atrial proteome of subjects with AF versus controls with sinus rhythm (SR). Our aim was to identify novel...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.04.036
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:Inflammation is a major contributor to atherosclerotic vascular disease. Inflammatory parameters such as C-reactive protein (CRP) and Interleukin-6 (IL-6) have been shown to be strong predictors of cardiovascular events. The association between preoperative inflammatory parameters and early graft occlusion a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.09.004
更新日期:2007-08-09 00:00:00
abstract:BACKGROUND:The underlying molecular mechanisms of the remodeling after myocardial infarction (MI) remain unclear. The purpose of this study was to investigate the role of a survival pathway (PI3K/Akt) and an apoptosis pathway (calcineurin/BAD) in the remodeling after MI in a large animal model. METHODS:Ten Dorset hybr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.10.107
更新日期:2013-06-05 00:00:00
abstract::A 60-year-old male patient with ischemic cardiomyopathy experienced an electrical storm 1 month after implantation of an internal cardioverter-defibrillator. Recurrent life-threatening episodes of ventricular tachycardia persisted despite maximal antiarrhythmic theraphy with amiodarone, metoprolol and mexiletine. Afte...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2003.11.033
更新日期:2005-03-18 00:00:00
abstract:BACKGROUND:The lack of an accurate noninvasive method for assessing right ventricular (RV) volume and function has been a major deficiency of two-dimensional (2D) echocardiography. The aim of our study was to test the feasibility of single-beat full-volume capture with real-time three-dimensional echo (3DE) imaging sys...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2013.06.088
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:It has been controversial whether routine screening for depression should be recommended in all patients with acute coronary syndrome (ACS) due to lack of evidence for psychiatric as well as for cardiac outcomes. This study aimed to evaluate the result of screening for treatment and subsequent treatment of d...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2015.04.164
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Questions persist regarding the ability of drug-eluting stents (DES) to inhibit intimal growth in the long-term. METHODS:We prospectively enrolled 766 lesions treated with DES that underwent angiographic examination at 6 months and 2 years after stenting. Lesions with 6-month restenosis (>50% of visual sten...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2010.08.032
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Association of valvular heart disease and lipid profile might be important as in the case of aortic stenosis. However, it has not been so far considered in detail the probable association of other valvular diseases, particularly of mitral stenosis (MS) with lipid profile. In our study, we aimed to search pos...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.10.003
更新日期:2006-10-10 00:00:00
abstract::Cardiovascular disease and major cardiovascular events represent main cause of death in both acute and chronic kidney disease patients. Kidney and heart failure are common and frequently co-exist; this organ - organ interaction, also called organ cross-talk led to well-known definition of cardiorenal syndrome (CRS). H...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.11.156
更新日期:2017-01-15 00:00:00
abstract::A 66-year-old man presented with myocardial infarction. Chest X-ray showed a large mediastinal mass. Aortic dissection was suggested by a past history of chest trauma, but the mass was in a very atypical site. Dissection of an abnormally placed right-sided descending aorta was confirmed by computed tomography. The aor...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90174-x
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Tetralogy of Fallot (ToF) patients face an increased risk of sudden cardiac death late after repair. Heart rate turbulence (HRT) indices are well-known predictors of sudden cardiac death. We aimed to estimate whether HRT is impaired in repaired ToF patients compared to healthy controls and relate those HRT p...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.03.096
更新日期:2009-07-10 00:00:00
abstract:OBJECTIVE:To investigate plasma tumor necrosis factor (TNF)alpha, tumor necrosis factor alpha soluble receptor I, interleukin-1beta and neopterin concentrations as markers of monocyte activation in patients with heart failure. STUDY DESIGN:The group consisted of patients with heart failure due to dilated cardiomyopath...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(97)00332-x
更新日期:1998-02-28 00:00:00
abstract:INTRODUCTION:We derived a risk-assessment model for predicting mortality after coronary artery bypass surgery from patient data from the 1990s and examined the model's accuracy in predicting early mortality in more contemporary patients. We also examined the accuracy of a completely new model and an older model recalib...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.02.005
更新日期:2011-06-02 00:00:00
abstract:BACKGROUND:Few data are available about safety of second generation drug eluting stents in an all-comer ST elevation myocardial infarction (STEMI) population. We sought to investigate the predictors and clinical implications of 1-year stent thrombosis (ST) in patients with STEMI, included in the EXAMINATION trial. MET...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2013.03.036
更新日期:2013-10-03 00:00:00
abstract::Gossypiboma, a term used to describe a mass within the body composed of a cotton matrix which usually refers to a retained surgical sponge, is a rare complication of cardiac surgery. We report one case revealed by the recurrence of the anginal symptoms after successful myocardial revascularisation surgery. The preoper...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00003-0
更新日期:1999-07-31 00:00:00
abstract::Antipsychotic agents are known to be associated with a long QT interval and torsade de pointes. We report a 69 year old female who suffered from a syncopal attack at a psychiatric hospital and was referred to our center. Torsade de pointes with a long QT interval (QTc=680 ms) was observed on the 12 lead ECG in the eme...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.060
更新日期:2007-06-12 00:00:00
abstract:BACKGROUND:Exertional dyspnea is a frequent limiting symptom in patients with chronic heart failure. Furthermore, dyspnea and a plateau in VO(2) (oxygen consumption) at peak exercise often co-exist in chronic heart failure, especially in patients with severe regurgitant valvular heart disease (RVHD), their relevance to...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.02.015
更新日期:2005-03-30 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Patients with AF and chronic kidney disease(CKD) encountered increased risks of stroke, bleeding, morbidity, and overall mortality. Oral anticoagulation in these populations definitely enhances major bleeding but the benefit of stroke reduction remained inconclusive.The aim of this study is to...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.068
更新日期:2021-01-15 00:00:00
abstract::Myocardial stunning has not been described in patients with cerebrovascular accidents. We present a patient in whom inferior wall hypokinesis, ST-segment elevations and Q waves developed after acute right hemisphere ischemic stroke. Total recovery ensued within 5 days. Coronary vasospasm induced by stroke-related symp...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(96)02879-3
更新日期:1997-02-01 00:00:00
abstract::A 54-year-old woman without organic heart disease presented with presyncopal symptoms during work. A decreased cardiac output was demonstrated by haemodynamic measurements during exercise. Treatment with fludrocortisone and ephedrine was initiated with a good haemodynamic and symptomatic result. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90255-4
更新日期:1990-01-01 00:00:00
abstract:AIMS:To assess the efficacy of autologous biological pacing function by autograft of gene-transferred mesenchymal stem cells in a porcine model of complete heart block. METHODS AND RESULTS:Fourteen healthy young male pigs were randomized into active group (n=8) and control group (n=6). Porcine MSCs were transfected wi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.06.012
更新日期:2013-10-09 00:00:00
abstract::There is controversy about the influence of QT dispersion on the incidence of early ventricular arrhythmias in patients with acute myocardial infarction (AMI). The QT and QTc dispersion (QTd, QTcd) between two groups of patients with AMI were compared: 39 patients with early sustained ventricular tachycardia or ventri...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0167-5273(97)00226-x
更新日期:1997-12-19 00:00:00