Abstract：
:Giant cell arteritis is a primary large-vessel vasculitis characterized by an arterial wall inflammation associated with intimal hyperplasia leading to arterial occlusion. Glucocorticoids remain the mainstay of giant cell arteritis treatment. However, relapses and glucocorticoid-related complications are frequent and therapeutic options for refractory giant cell arteritis are quite limited. Like tumor necrosis factor-α and interleukin-6, interleukin-1β is also highly expressed in inflamed arterial walls of patients with giant cell arteritis and may contribute in the pathogenesis of this disease. We report treatment of three cases of refractory giant cell arteritis successfully treated with anakinra, an interleukin-1 blockade therapy. Anakinra was effective for all patients, yielding improvement in their inflammation biomarkers and/or in their symptoms, as well as a disappearance of arterial inflammation in PET/CT for two of them.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Ly KH,Stirnemann J,Liozon E,Michel M,Fain O,Fauchais ALdoi
10.1016/j.jbspin.2013.06.004subject
Has Abstractpub_date
2014-01-01 00:00:00pages
76-8issue
1eissn
1297-319Xissn
1778-7254pii
S1297-319X(13)00156-5journal_volume
81pub_type
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