Abstract：
:Osteoarthritis (OA) is the most common human joint disorder. Its complex pathogenesis remains poorly understood but appears multifactorial. To date, no specific pharmacological agent has been identified to alter the disease course of OA. Calcification of articular cartilage is a hallmark of OA and evidence suggests it contributes directly to joint degeneration. Calcium crystals are frequently found in OA synovial fluid but their exact role in the disease process is unclear. Basic calcium phosphate (BCP) crystals are the predominant crystal type found in OA and recent data indicate a pathogenic role for these crystals in OA. However, information on the exact frequency and distribution of BCP crystals vary considerably, mainly due to the lack of simple and reliable methods of detection. The purpose of this review is to describe the current available methods for detecting BCP crystals and to highlight their obvious advantages and limitations. Recent developments in the field are also discussed with particular reference to their potential clinical applicability. Improved methods of detection for BCP crystals could potentially aid the diagnosis of OA and the development of novel therapies.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
MacMullan P,McMahon G,McCarthy Gdoi
10.1016/j.jbspin.2010.10.008subject
Has Abstractpub_date
2011-07-01 00:00:00pages
358-63issue
4eissn
1297-319Xissn
1778-7254pii
S1297-319X(10)00284-8journal_volume
78pub_type
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