Spectrum of activity of levofloxacin against nontuberculous mycobacteria and its activity against the Mycobacterium avium complex in combination with ethambutol, rifampin, roxithromycin, amikacin, and clofazimine.

abstract：:The effect of rifampin on cutaneous hypersensitivity was studied in 11 tuberculous patients. A suppressive effect was noted in eight patients, five of whom developed a negative response to the strength of purified protein derivative to which they had been shown to be previously sensitive. In one instance complete aner...

journal_title：Antimicrobial agents and chemotherapy

authors： Mukerjee P,Schuldt S,Kasik JE

更新日期：1973-12-01 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats. VCM administered intr...

journal_title：Antimicrobial agents and chemotherapy

authors： Qu S,Dai C,Lang F,Hu L,Tang Q,Wang H,Zhang Y,Hao Z

更新日期：2018-12-21 00:00:00

abstract：:The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Esc...

journal_title：Antimicrobial agents and chemotherapy

authors： Iizaka Y,Higashi N,Ishida M,Oiwa R,Ichikawa Y,Takeda M,Anzai Y,Kato F

更新日期：2013-03-01 00:00:00

abstract：:A series of 1-cyclopropyl-8-methoxy-quinazoline-2,4-diones was synthesized and evaluated for lowering the ratio of the antimicrobial MIC in gyrase resistance mutants to that in the gyr(+) (wild type) using isogenic strains of Escherichia coli. Dione features that lowered this ratio were a 3-amino group and C-7 ring st...

journal_title：Antimicrobial agents and chemotherapy

authors： German N,Malik M,Rosen JD,Drlica K,Kerns RJ

更新日期：2008-11-01 00:00:00

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spre...

journal_title：Antimicrobial agents and chemotherapy

authors： Escudero JA,San Millan A,Catalan A,de la Campa AG,Rivero E,Lopez G,Dominguez L,Moreno MA,Gonzalez-Zorn B

更新日期：2007-02-01 00:00:00

abstract：:Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Burkholder E,Davis AT

更新日期：1980-03-01 00:00:00

abstract：:We studied the effects of two N,N'-bis(benzyl)-substituted polyamine analogs on the capacities of Trypanosoma cruzi to invade and multiply within a mammalian host cell. At concentrations as low as 1 microM, these compounds reduced significantly the infectivity of the parasite for rat heart myoblasts in a time-dependen...

journal_title：Antimicrobial agents and chemotherapy

authors： Majumder S,Kierszenbaum F

更新日期：1993-10-01 00:00:00

abstract：:In this paper, we present the biochemical and biological evaluation of N-arylmethyl-substituted iminoribitol derivatives as potential chemotherapeutic agents against trypanosomiasis. Previously, a library of 52 compounds was designed and synthesized as potent and selective inhibitors of Trypanosoma vivax inosine-adeno...

journal_title：Antimicrobial agents and chemotherapy

authors： Berg M,Kohl L,Van der Veken P,Joossens J,Al-Salabi MI,Castagna V,Giannese F,Cos P,Versées W,Steyaert J,Grellier P,Haemers A,Degano M,Maes L,de Koning HP,Augustyns K

更新日期：2010-05-01 00:00:00

abstract：:Serious Enterococcus faecalis infections usually require combination therapy to achieve a bactericidal effect. In orthopedic infections, the prognosis of enterococcal etiology is considered poor, and the use of aminoglycosides is questioned. The ampicillin-ceftriaxone combination has recently been accepted as alternat...

journal_title：Antimicrobial agents and chemotherapy

authors： Euba G,Lora-Tamayo J,Murillo O,Pedrero S,Cabo J,Verdaguer R,Ariza J

更新日期：2009-10-01 00:00:00

abstract：:9-Deoxy-Delta(9),Delta(12)-13,14-dihydro-prostaglandin D(2) (Delta(12)-PGJ(2)), a natural cyclopentenone metabolite of prostaglandin D(2), is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Pica F,Palamara AT,Rossi A,De Marco A,Amici C,Santoro MG

更新日期：2000-01-01 00:00:00

abstract：:The aim of the study was to identify the plasmid-encoded factors contributing to the emergence and spread of epidemic IncI1-Iγ plasmids obtained from Escherichia coli and Salmonella enterica isolates from animal and human reservoirs. For this, 251 IncI1-Iγ plasmids carrying various extended-spectrum β-lactamase (ESBL)...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith H,Bossers A,Harders F,Wu G,Woodford N,Schwarz S,Guerra B,Rodríguez I,van Essen-Zandbergen A,Brouwer M,Mevius D

更新日期：2015-09-01 00:00:00

abstract：:A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

journal_title：Antimicrobial agents and chemotherapy

authors： Kadlec K,Schwarz S

更新日期：2010-02-01 00:00:00

abstract：:The discovery of antibiotics in the last century is considered one of the most important achievements in the history of medicine. Antibiotic usage has significantly reduced morbidity and mortality associated with bacterial infections. However, inappropriate use of antibiotics has led to emergence of antibiotic resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Ghosh D,Veeraraghavan B,Elangovan R,Vivekanandan P

更新日期：2020-01-27 00:00:00

abstract：:Malaria control is hindered by the evolution and spread of resistance to antimalarials, necessitating multiple changes to drug policies over time. A comprehensive antimalarial drug resistance surveillance program is vital for detecting the potential emergence of resistance to antimalarials, including current artemisin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lucchi NW,Komino F,Okoth SA,Goldman I,Onyona P,Wiegand RE,Juma E,Shi YP,Barnwell JW,Udhayakumar V,Kariuki S

更新日期：2015-12-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:The resistance of Mycobacterium tuberculosis to isoniazid (INH) is largely linked to suppression of a catalase-peroxidase enzyme (KatG) that activates INH. In the absence of KatG, antioxidant protection is provided by enhanced expression of the peroxiredoxin AhpC, which is itself reduced by AhpD, a protein with low al...

journal_title：Antimicrobial agents and chemotherapy

authors： Koshkin A,Zhou XT,Kraus CN,Brenner JM,Bandyopadhyay P,Kuntz ID,Barry CE 3rd,Ortiz de Montellano PR

更新日期：2004-07-01 00:00:00

abstract：:The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gopal R,Kim YG,Lee JH,Lee SK,Chae JD,Son BK,Seo CH,Park Y

更新日期：2014-01-01 00:00:00

abstract：:The pharmacokinetics of the antifungal pradimicin derivative BMS 181184 in plasma of normal, catheterized rabbits were characterized after single and multiple daily intravenous administrations of dosages of 10, 25, 50, or 150 mg/kg of body weight, and drug levels in tissues were assessed after multiple dosing. Concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Sein T,Petraitis V,Petraitiene R,Callender D,Gonzalez CE,Giri N,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-10-01 00:00:00

abstract：:Hypermutable Pseudomonas aeruginosa strains are prevalent in patients with cystic fibrosis and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens have not been optimized against such strains using mechanism-based modeling (MBM) and the hollow-fiber infection model (HFIM). The PAO1 wild-t...

journal_title：Antimicrobial agents and chemotherapy

authors： Landersdorfer CB,Rees VE,Yadav R,Rogers KE,Kim TH,Bergen PJ,Cheah SE,Boyce JD,Peleg AY,Oliver A,Shin BS,Nation RL,Bulitta JB

更新日期：2018-03-27 00:00:00

abstract：:The emergence of pneumococci resistant to penicillin and other agents prompted us to evaluate intravenous vancomycin for the therapy of pneumococcal meningitis, which has an overall mortality of 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven pneumococcal meningitis and positive in...

journal_title：Antimicrobial agents and chemotherapy

authors： Viladrich PF,Gudiol F,Liñares J,Pallarés R,Sabaté I,Rufí G,Ariza J

更新日期：1991-12-01 00:00:00

abstract：:In order to probe the structure and function of the mycobacterial catalase-peroxidase enzyme (KatG), we employed a genetic approach using dominant-negative analysis of katG merodiploids. Transformation of Mycobacterium bovis BCG with various katG point mutants (expressed from low-copy-number plasmids) resulted in redu...

journal_title：Antimicrobial agents and chemotherapy

authors： DeVito JA,Morris S

更新日期：2003-01-01 00:00:00

abstract：:A remarkably high rate of adverse events is associated with the use of trimethoprim-sulfamethoxazole in patients with human immunodeficiency virus type 1 infection. We examined the efficacies of sulfonamides alone in the prevention of Pneumocystis carinii pneumonitis, with the assumption that at least some of the adve...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes WT,Killmar J

更新日期：1996-04-01 00:00:00

abstract：:beta-Lactamase identification by colony hybridization with 32P-labeled DNA probes for TEM-1, SHV-1, OXA-1, OXA-2, PSE-1, PSE-2, and PSE-4 was compared with isoelectric focusing in 122 clinical isolates making a variety of enzyme types. All strains producing a probe-type enzyme gave a positive hybridization reaction. C...

journal_title：Antimicrobial agents and chemotherapy

authors： Huovinen S,Huovinén P,Jacoby GA

更新日期：1988-02-01 00:00:00

abstract：:A structurally diverse library of 93 lipophilic di- and tricyclic diaminopyrimidine derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) cloned from human and bovine isolates of Cryptosporidium parvum (J. R. Vásquez et al., Mol. Biochem. Parasitol. 79:153-165, 1996). In parallel...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RG,Rosowsky A

更新日期：2001-12-01 00:00:00

abstract：:Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4 Candida tropicalis and 4 Candida dubliniensis strains, using the neutropenic mouse invasive candidiasis model. The area under the concentration-time cur...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Andes DR

更新日期：2019-10-22 00:00:00

abstract：:One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption. Here, we present MGIs, a new series of Mycobacterium tuberculosis gy...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanco D,Perez-Herran E,Cacho M,Ballell L,Castro J,González Del Río R,Lavandera JL,Remuiñán MJ,Richards C,Rullas J,Vázquez-Muñiz MJ,Woldu E,Zapatero-González MC,Angulo-Barturen I,Mendoza A,Barros D

更新日期：2015-04-01 00:00:00

abstract：:Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with t...

journal_title：Antimicrobial agents and chemotherapy

authors： Markantonis SL,Markou N,Fousteri M,Sakellaridis N,Karatzas S,Alamanos I,Dimopoulou E,Baltopoulos G

更新日期：2009-11-01 00:00:00