Relationship between interleukin-8 levels and myeloperoxidase activity in human gastric mucosa.

Abstract:

:Although interleukin (IL)-8 is well known as a chemotactic agent for neutrophil migration in vitro, the relationship between IL-8 activity and the degree of neutrophil infiltration in gastric mucosa is still unclear. In the present study, we investigated IL-8 and myeloperoxidase activity, a marker of neutrophil infiltration, in gastric antral mucosa using biopsy samples in 23 patients with no gastric lesions. The results indicate that there is a good correlation between IL-8 and myeloperoxidase activity (y = 0.173x + 13.9; r = 0.49, P < 0.01). Furthermore, IL-8 and myeloperoxidase activity are significantly higher in Helicobacter pylori-positive patients than in H. pylori-negative patients. In conclusion, an increase of IL-8 activity in the gastric mucosa causes increased neutrophil infiltration in human gastric mucosa and H. pylori infection accelerates these reactions in the mucosa.

authors

Sasayama Y,Kawano S,Tsuji S,Fusamoto H,Kamada T,Fukui H,Yoneda S,Okishio T

doi

10.1111/j.1440-1746.1997.tb00392.x

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

104-8

issue

2

eissn

0815-9319

issn

1440-1746

journal_volume

12

pub_type

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