Abstract:
BACKGROUND:In the United States, pulmonary adenocarcinomas have recently replaced squamous cell carcinomas as the most frequent type of lung cancer encountered. The incidence of pulmonary adenocarcinoma continued to increase worldwide. METHOD:To determine the roles of the transforming growth factor-beta 1 (TGF-beta 1), and TGF-beta type I receptor (T beta R-I), and the TGF-beta type II receptor (T beta R-II) in the progression of a pulmonary adenocarcinoma, their respective expressions have been immunohistologically studied in specimens from 120 pulmonary adenocarcinoma patients. RESULT:The overall prognosis was significantly poorer for patients showing positive TGF-beta 1, T beta R-I, T beta R-II expressions than for patients who were negative to all three immunostainings (P < 0.01). Our multivariate analysis also revealed that a positive TGF-beta 1 response significantly affect prognosis (P < 0.05). CONCLUSIONS:TGF-beta 1, T beta R-I, and T beta R-II play important roles in tumor progression, and a positive TGF-beta 1 expression can serve as a pulmonary adenocarcinoma marker. T beta R-I and T beta R-II expressions are necessary for TGF-beta signal transduction.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Takanami I,Tanaka F,Hashizume T,Kodaira Sdoi
10.1002/(sici)1096-9098(199704)64:4<262::aid-jso3>subject
Has Abstractpub_date
1997-04-01 00:00:00pages
262-7issue
4eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199704)64:4<262::AID-JSO3>journal_volume
64pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The effects of isolated metastatic node dissection in the para-aortic region have not been established in colorectal cancer (CRC). The authors undertook to evaluate the role of para-aortic lymph node (PALN) dissection in CRC with isolated PALN metastasis. METHODS:Between January 1993 and Marc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21421
更新日期:2010-01-01 00:00:00
abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390103
更新日期:1988-09-01 00:00:00
abstract::A retrospective study of 74 cases of cancer of the mobile tongue and floor of the mouth, diagnosed between 1949 and 1975, with a two-year minimum follow-up was undertaken. The lesions were TNM staged, stages I and II accounting for 56 cases (76%) and stages III and IV accounting for 18 cases (24%). The analysis was ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100408
更新日期:1978-01-01 00:00:00
abstract::A study of the effectiveness of preoperative radiation as an adjuvant for surgery for patients with invasive bladder carcinoma revealed a subpopulation of patients having advanced disease who could not benefit from radiation treatment. The effect of such a group of patients on the efficiency of 2 common nonparametric ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100111
更新日期:1978-01-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24093
更新日期:2016-01-01 00:00:00
abstract::During the years 1975-1988, twenty lung cancer patients with symptomatic pericardial effusion were treated conservatively at our center. Echocardiography demonstrated small pericardial effusion in 2 patients, medium size effusion in 3 patients and large amount of fluid in 15 patients. Fifteen patients developed cardia...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450212
更新日期:1990-10-01 00:00:00
abstract::Evaluation of 135 consecutive patients was made for breast masses by the same surgeon and the patients were subsequently referred for ultrasound mammography of the breast after xeromammography revealed a "dysplastic" (DY) pattern only, with no evidence of malignancy. Three patients had carcinoma of the breast detected...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930190203
更新日期:1982-02-01 00:00:00
abstract:OBJECTIVES:To investigate the immunoreactivity of TTF-1 and PAX8 in neuroendocrine carcinoma of thymic (TNEC) and pulmonary origins (PNEC), and whether their immunophenotyping could be used to distinguish between NEC of the two sites, as well as prognosis of patients with TNEC. METHODS:Twenty-two cases of TNEC and 20 ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24393
更新日期:2016-11-01 00:00:00
abstract::Thirty-eight cases of advanced upper gastrointestinal cancer were assessed for their immune status prior to any form of therapy. Cell-mediated immunity, as tested by absolute lymphocyte count, T-cell count and delayed cutaneous hypersensitivity reactions to purified protein derivative and phytohemagglutinin showed sev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290113
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The diagnosis of invasive breast cancer is most commonly made on image-guided core biopsy (CB). The presence of extensive intraductal component (EIC), as identified on subsequent lumpectomy, is associated with an increased risk of positive margins and need for further surgery. CBs demonstratin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20242
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To describe the use of the mastoid skull post of a surgical image guidance system for image guided surgery and intraoperative navigation of the nasopharynx. This adaptation overcomes the limitations of a headset frame or head clamp and can be applied to open and closed surgery of the nasal cav...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21005
更新日期:2008-05-01 00:00:00
abstract::Correlations between levels of tissue polypeptide antigen (TPA) in serum and histologic stage or progression of cancer were studied in 94 patients with gastric cancer. Levels of TPA in serum from patients with cancerous invasion into the vein of the stomach wall (v-invasion) were elevated in parallel to the progressio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930410214
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Preoperative positivity of serum tumor markers has been reported to be a prognostic factor in several neoplasms. The aim of this longitudinal study was to evaluate the correlation between CEA, CA 19-9, and CA 72-4 preoperative serum levels and the site of recurrence after curative surgery for ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1163
更新日期:2001-12-01 00:00:00
abstract::Upper extremity malignancies have the potential to create significant functional impairment, and as such represent an opportunity for collaborative reconstruction to minimize potential morbidity. Given the increased complexity and array of potential reconstruction solutions, functional limb preservation is overwhelmin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24196
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Lymph node metastasis is the most important prognostic factor in patients with carcinoma of the penis. In this article, we have reviewed the outcome of the patients with pathologic node-positive carcinoma of the penis after groin dissection performed at the Cancer Institute (WIA) between 1987 and 1998. METH...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20414
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Mutation of the KRAS oncogene (mKRAS) in colorectal cancer has been associated with aggressive tumor biology, resistance to epidermal growth factor inhibitors, and decreased overall survival (OS). The aim of the current study was to analyze the association of mKRAS with pathologic complete response (pCR) and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26244
更新日期:2021-01-01 00:00:00
abstract::A survival study for squamous carcinomas of the distal esophagus treated by the Southern California Permanente Medical Group in the interval of 1954 to 1988 was undertaken. We found radiation therapy and surgery equally efficacious in terms of cure for patients without distant disease and performance status sufficient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460206
更新日期:1991-02-01 00:00:00
abstract::Forty-four consecutive cases of "early gastric cancer" were studied according to the macroscopic classification proposed by the Japanese Gastroenterological and Endoscopy Society and further analyzed in terms of growth patterns. The tumours were then classified into the small mucosal type, the superficially spreading ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510211
更新日期:1992-10-01 00:00:00
abstract::This is a retrospective review of 476 patients who had mastectomy for carcinoma of the breast during 1971-1980. There is a positive correlation of size of the primary tumor and the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma had a significantly higher incidence of nodal metastasis...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230105
更新日期:1983-05-01 00:00:00
abstract::Immunoproliferative small intestinal disease (IPSID), most common in Mediterranean countries, is characterized by lymphomatous infiltration of the small intestine and is usually associated with the synthesis of anomalous immunoglobulin alpha heavy chains. Flow cytometric analysis of DNA content, S phase fraction, and ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580106
更新日期:1995-01-01 00:00:00
abstract::An unusual case of Merkel cell carcinoma of the lower lip with metastasis to the submental nodes is presented. Clinical similarities and the histopathologic and prognostic differences between this tumor and basal or squamous cell carcinomas of the head and neck area are discussed and the current thoughts for treatment...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370212
更新日期:1988-02-01 00:00:00
abstract::This review evaluates the use of robotic-assisted laparoscopic surgery in the treatment of gynecologic malignancies and objectively evaluates the use of these systems in performing radical hysterectomies and surgical staging of gynecologic malignancies. The review focuses on surgical length, blood loss, complications,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.22080
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although race and socioeconomic status have been shown to affect outcomes in pancreatic ductal adenocarcinoma (PDAC), the impact of rural residence on the delivery of adjuvant therapy (AT) has not been studied. METHODS:Patients with resected PDAC were identified using the National Cancer Data...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25060
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To propose a distinct anatomical classification for the superior thyroid pole that may serve as a surgical landmark and could help reduce complications in thyroid surgery. MATERIALS AND METHODS:A comprehensive anatomical study based on existing literature and surgical observations. RESULTS:The proposed supe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23950
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23072
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:To investigate predictors of occult nipple-areolar complex (NAC) involvement in patients with carcinoma in situ (CIS) and to validate an online probability calculator (CancerMath; www.lifemath.net/cancer/breastcancer/nipplecalc/index.php). METHODS:Mastectomized patients with CIS (n = 104) were retrospective...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24768
更新日期:2017-12-01 00:00:00
abstract::The serum copper/zinc ratio was measured in 44 patients bearing primary large bowel malignancies. Measurements were repeated following removal of the primary tumour and again at the time of development of clinical evidence of cancer recurrence in order to evaluate the clinical value of the ratio to accurately reflect ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930210407
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pemetrexed is an appealing agent to use for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the optimal method of pemetrexed delivery still remains undefined. Using a murine model, we compared the use of open and closed abdomen techniques on the absorptio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24960
更新日期:2018-05-01 00:00:00
abstract::We investigated the incidence of thyroid nodules in female uremic patients on maintenance hemodialysis using a high-frequency sonographic scanner. In 47 (21.0%) of the 224 female normal controls and 33 (55.0%) of the 60 female patients, thyroid nodules were detected. The difference in these incidences between controls...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540405
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25485
更新日期:2019-08-01 00:00:00