Dextroamphetamine as a treatment for depression and low energy in AIDS patients: a pilot study.

Abstract:

:This report documents findings from an open trial of dextroamphetamine in the treatment of depression and low energy in AIDS patients. Dextroamphetamine offers the potential for rapid onset of effect and activation properties, both of which are important to persons with late stage HIV illness. Primary inclusion criteria included having a DSM-III-R depressive disorder, debilitating low energy, CD4 cell count below 200 cells/mm3, and no history of drug dependence. The trial consisted of open treatment in a 6-week protocol, with indefinite follow-up. Twenty-four men entered the study, 18 of 19 (95%) patients who completed at least 6 weeks of treatment reported substantial improvement with regard to both mood and energy at a median dosage of 10 mg/day. These results suggest that dextroamphetamine is a potentially effective, fast acting antidepressant treatment for this population and call for a larger, controlled trial.

journal_name

J Psychosom Res

authors

Wagner GJ,Rabkin JG,Rabkin R

doi

10.1016/s0022-3999(96)00366-2

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

407-11

issue

4

eissn

0022-3999

issn

1879-1360

pii

S0022399996003662

journal_volume

42

pub_type

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