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The putrescine biosynthesis pathway in Lactococcus lactis is transcriptionally regulated by carbon catabolic repression, mediated by CcpA.

Abstract：

:Lactococcus lactis is the lactic acid bacterium most widely used by the dairy industry as a starter for the manufacture of fermented products such as cheese and buttermilk. However, some strains produce putrescine from agmatine via the agmatine deiminase (AGDI) pathway. The proteins involved in this pathway, including those necessary for agmatine uptake and conversion into putrescine, are encoded by the aguB, aguD, aguA and aguC genes, which together form an operon. This paper reports the mechanism of regulation of putrescine biosynthesis in L. lactis. It is shown that the aguBDAC operon, which contains a cre site at the promoter of aguB (the first gene of the operon), is transcriptionally regulated by carbon catabolic repression (CCR) mediated by the catabolite control protein CcpA.

journal_name

Int J Food Microbiol

journal_title

International journal of food microbiology

authors

Linares DM,del Río B,Ladero V,Redruello B,Martín MC,Fernández M,Alvarez MA

doi

10.1016/j.ijfoodmicro.2013.04.021

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

43-50

issue

1

eissn

0168-1605

issn

1879-3460

pii

S0168-1605(13)00207-9

journal_volume

165

pub_type

杂志文章

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