Enhancing nerve regeneration across a silicone tube conduit by using interposed short-segment nerve grafts.

Abstract:

:Isolated nerve segments may inherently contain all of the necessary factors required to support regeneration within a silicone tube conduit placed across a nerve gap. Thirty-six adult Lewis rats each weighing approximately 250 g were randomized into three groups. A sciatic nerve gap (13-15 mm in length) was bridged by an empty silicone tube (Group I), a silicone tube containing a short 2-mm interposed nerve segment (Group II), or a nerve autograft (Group III). At 16 weeks postoperatively, no regeneration was observed through the empty silicone tube. In contrast, regeneration across the silicone tube containing the isolated nerve segment was equivalent to that noted through nerve autografts as assessed by histological, electrophysiological, and functional criteria. Thus, an interposed nerve segment will extend the length of successful nerve regeneration through a silicone tube conduit.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Francel PC,Francel TJ,Mackinnon SE,Hertl C

doi

10.3171/jns.1997.87.6.0887

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

887-92

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

87

pub_type

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