Regional blood-to-tissue transport in RT-9 brain tumors.

Abstract:

:Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental RT-9 brain tumors using 14C-alpha-aminoisobutyric acid (AIB) and quantitative autoradiographic techniques. The magnitude of K depends on the permeability, surface area, and blood flow of the tissue capillaries. The transfer rate constant was variable within tumor tissue (range 0.001 to 0.178 ml/gm/min) and depended on tumor size, location (intraparenchymal, meningeal, or choroid plexus associated), and to a lesser extent on necrosis and cyst formation. Brain adjacent to tumor had higher K values, particularly around larger tumors (0.004 to 0.014 ml/gm/min), than corresponding brain regions in the contralateral hemisphere (0.001 to 0.002 ml/gm/min). Estimates of the fractional extraction of AIB by intraparenchymal tumors were between 0.008 and 0.4 ml/gm/min. Values of fractional extraction in this range indicate that tumor capillaries are not freely permeable to this solute. The values of K measured with AIB in this study, for the most part, approximate the permeability-surface area product of tumor and brain capillaries. The experimental data suggest that the permeability-surface area characteristics of the microvasculature in small RT-9 tumors are similar to those of the host tissue, whereas the microvasculature of larger RT-9 tumors is influenced more by intrinsic tumor factors.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Molnar P,Blasberg RG,Horowitz M,Smith B,Fenstermacher J

doi

10.3171/jns.1983.58.6.0874

subject

Has Abstract

pub_date

1983-06-01 00:00:00

pages

874-84

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

58

pub_type

杂志文章
  • Bone morphogenetic protein-2 application by a poly(D,L-lactide)-coated interbody cage: in vivo results of a new carrier for growth factors.

    abstract:OBJECT:Growth factors such as bone morphogenetic protein-2 (BMP-2) have been proven to promote spine fusion and to overcome the disadvantages of an autologous bone graft. The optimum method to deliver such growth factors remains a matter of discussion. The purpose of this study was to determine the safety and efficacy ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2002.97.1.0040

    authors: Kandziora F,Bail H,Schmidmaier G,Schollmeier G,Scholz M,Knispel C,Hiller T,Pflugmacher R,Mittlmeier T,Raschke M,Haas NP

    更新日期:2002-07-01 00:00:00

  • Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-management.

    abstract:OBJECT:Neurointensivists are specialists trained to manage all aspects of the intensive care unit (ICU) stay of neurologically ill patients. No study to date has examined the role of neurointensivists specifically in subarachnoid hemorrhage (SAH) management. This study examined the use of a team-based neurointensivist ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.8.JNS09441

    authors: Josephson SA,Douglas VC,Lawton MT,English JD,Smith WS,Ko NU

    更新日期:2010-03-01 00:00:00

  • Delayed complication after Gamma Knife surgery for mesial temporal lobe epilepsy.

    abstract:OBJECT:Despite the controversy over the clinical significance of Gamma Knife surgery (GKS) for refractory mesial temporal lobe epilepsy (MTLE), the modality has attracted attention because it is less invasive than resection. The authors report long-term outcomes for 7 patients, focusing in particular on the long-term c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.2.JNS111296

    authors: Usami K,Kawai K,Koga T,Shin M,Kurita H,Suzuki I,Saito N

    更新日期:2012-06-01 00:00:00

  • The Wilhelm tell technique for anterior lumbar interbody fusion. Technical note.

    abstract::Experience indicates that stand-alone cages may lack the necessary stability to secure highly unstable motion segments at the lumbosacral junction. The authors have designed a special carbon fiber composite interbody cage that allows additional screw placement in anterior lumbar interbody fusion procedures performed a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2003.98.2.0222

    authors: Markwalder TM,Wenger M,Elsig JP,Laloux E

    更新日期:2003-03-01 00:00:00

  • Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas.

    abstract:OBJECT:Twenty-nine nonimmunocompromised patients with primary central nervous system (CNS) lymphoma were treated with high-dose methotrexate (MTX) therapy followed by irradiation. The authors investigated the correlation of infusion schedules with MTX penetration into cerebrospinal fluid (CSF), tumor response, and surv...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.2.0221

    authors: Hiraga S,Arita N,Ohnishi T,Kohmura E,Yamamoto K,Oku Y,Taki T,Sato M,Aozasa K,Yoshimine T

    更新日期:1999-08-01 00:00:00

  • Intracranial follicular dendritic cell sarcoma. Case report.

    abstract::Intracranial occurrence of follicular dendritic cell (FDC) sarcoma, a rare tumor derived from dendritic cells of the lymphoid follicle, has not yet been described. Therefore, the case of a 53-year-old man presenting with an intracranial mass invading the clivus is reported. The diagnosis of FDC sarcoma was confirmed b...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.6.1089

    authors: Hasselblatt M,Sepehrnia A,von Falkenhausen M,Paulus W

    更新日期:2003-12-01 00:00:00

  • Phase II study of nimustine, carboplatin, vincristine, and interferon-beta with radiotherapy for glioblastoma multiforme: experience of the Kyoto Neuro-Oncology Group.

    abstract:OBJECT:This Phase II study was performed to determine the safety, tolerability, and efficacy of combining nimustine (ACNU)-carboplatin-vincristine-Interferon-beta (IFNbeta) chemotherapy. METHODS:Ninety-seven patients with Karnofsky Performance Scale scores of 50 or greater were enrolled in the study. Nimustine (60 mg/...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.3.385

    authors: Aoki T,Takahashi JA,Ueba T,Oya N,Hiraoka M,Matsui K,Fukui T,Nakashima Y,Ishikawa M,Hashimoto N

    更新日期:2006-09-01 00:00:00

  • Neurosurgical decision making: personal and professional preferences.

    abstract:OBJECT:Physicians are often solicited by patients or colleagues for clinical recommendations they would make for themselves if faced by a clinical situation. The act of making a recommendation can alter the clinical course being taken. The authors sought to understand this dynamic across different neurosurgical scenari...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.11.JNS14400

    authors: Tanweer O,Wilson TA,Kalhorn SP,Golfinos JG,Huang PP,Kondziolka D

    更新日期:2015-03-01 00:00:00

  • Venous ischemia caused by dural arteriovenous malformation. Case report.

    abstract::A case is presented of tentorial dural arteriovenous malformation (AVM) associated with visual hallucinations and quadrant hemianopsia. Computerized tomography (CT) and magnetic resonance imaging showed an ischemic region, mainly affecting the white matter of the right occipital lobe, that was defined as an area of in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.80.3.0552

    authors: Kurata A,Miyasaka Y,Yoshida T,Kunii M,Yada K,Kan S

    更新日期:1994-03-01 00:00:00

  • Brainstem gangliogliomas: a retrospective series.

    abstract:OBJECT:The authors retrospectively analyzed data on brainstem gangliogliomas treated in their department and reviewed the pertinent literature to foster understanding of the preoperative characteristics, management, and clinical outcomes of this disease. METHODS:In 2006, the authors established a database of treated l...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.1.JNS121323

    authors: Zhang S,Wang X,Liu X,Ju Y,Hui X

    更新日期:2013-04-01 00:00:00

  • Venous outflow restriction as a predictor of cavernous sinus dural arteriovenous fistula obliteration after Gamma Knife surgery.

    abstract:OBJECTIVE:Gamma Knife surgery (GKS) obliterates 65%-87% of cavernous sinus dural arteriovenous fistulas (CSDAVFs). However, the hemodynamic effect on GKS outcomes is relatively unknown. The authors thus used the classification scheme developed by Suh et al. to explore this effect. METHODS:The authors retrospectively (...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.9.JNS182040

    authors: Wu CA,Yang HC,Hu YS,Wu HM,Lin CJ,Luo CB,Guo WY,Lee CC,Liu KD,Chung WY

    更新日期:2019-01-25 00:00:00

  • Prediction of survival in glioma patients by means of positron emission tomography.

    abstract::The aim of this study was to determine whether positron emission tomography (PET) with fluorine-18 (18F)-2-deoxyglucose (FDG) can be used as a prognostic test in patients with high-grade cerebral gliomas, regardless of the treatment given. Forty-five patients with astrocytoma Grade III or IV were included in this anal...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.6.0816

    authors: Patronas NJ,Di Chiro G,Kufta C,Bairamian D,Kornblith PL,Simon R,Larson SM

    更新日期:1985-06-01 00:00:00

  • Rupture of intracranial aneurysms during treatment with Guglielmi detachable coils: incidence, outcome, and risk factors.

    abstract:OBJECT:The aim of this study was to assess the incidence and outcome of procedure-related rupture of intracranial aneurysms in patients treated with Guglielmi detachable coils (GDCs) and to identify risk factors for this complication. METHODS:Procedure-related rupture occurred in seven of 264 treated aneurysms in 239 ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.94.2.0238

    authors: Sluzewski M,Bosch JA,van Rooij WJ,Nijssen PC,Wijnalda D

    更新日期:2001-02-01 00:00:00

  • Analysis of von hippel-lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity.

    abstract:OBJECT:Hemangioblastomas (HBs) occur sporadically or as a manifestation of von Hippel-Lindau (VHL) disease. In the majority of VHL-related HBs, inactivation of the VHL tumor suppressor gene (TSG), which is located on chromosome 3p25-26, is found. The VHL gene is assumed to be involved also in the development of sporadi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.4.0977

    authors: Gijtenbeek JM,Jacobs B,Sprenger SH,Eleveld MJ,van Kessel AG,Kros JM,Sciot R,van Calenbergh F,Wesseling P,Jeuken JW

    更新日期:2002-10-01 00:00:00

  • Frontal sinus approach to the orbit. Technical note.

    abstract::The authors have previously advocated a supraorbital approach to tumors of the orbit. In this paper, they describe a technique in which they take advantage of a large frontal sinus as a means of entering the orbit without the necessity of intracranial exposure, as required by the more conventional supraorbital approac...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.5.0811

    authors: Colohan AR,Jane JA,Newman SA,Maggio WW

    更新日期:1985-11-01 00:00:00

  • Cortical calculation localization using electrostimulation.

    abstract:OBJECT:A naming task has been used to spare cortical areas involved in language. In the present study, a calculation task was combined with electrostimulation mapping (awake surgery) to spare cortical areas involved in calculation in patients undergoing surgery for brain lesions. The organization of language and calcul...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.8.JNS17649

    authors: Roux FE,Boukhatem L,Draper L,Sacko O,Démonet JF

    更新日期:2009-06-01 00:00:00

  • Spinal cord injury.

    abstract:OBJECT:It is known that the spinal cord can sustain traumatic injury without associated injury of the spinal column in some conditions, such as a flexible spinal column or preexisting narrowed spinal canal. The purpose of this study was to characterize the clinical features and to understand the mechanisms in cases of ...

    journal_title:Journal of neurosurgery

    pub_type: 评论,信件

    doi:

    authors: Bhatoe HS

    更新日期:2001-04-01 00:00:00

  • Control of growth of vestibular schwannomas with low-dose Gamma Knife surgery.

    abstract:OBJECT:The treatment of solitary vestibular schwannomas by performing Gamma Knife surgery is well established. It has been reported that decreasing the surface dose reduces patient morbidity, especially facial weakness and numbness. The authors of this retrospective study examine patient data from a single center to de...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/sup.2006.105.7.154

    authors: Hudgins WR,Antes KJ,Herbert MA,Weiner RL,DeSaloms JM,Stamos D,Barker JL,Echt GA,Nichols TD,Schwarz DE

    更新日期:2006-12-01 00:00:00

  • Selective sacral rootlet neurectomy in the treatment of detrusor hyperreflexia. Technique and long-term results.

    abstract::Selective sacral neurectomy was performed in 12 patients with intractable urge incontinence of long duration (mean 12 years) caused by detrusor hyperreflexia. There was great variation in the innervation of the bladder, but resection of an S-3 root or rootlet was carried out in all patients. Six of the patients, who w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.2.0241

    authors: Tørring J,Petersen T,Klemar B,Søgaard I

    更新日期:1988-02-01 00:00:00

  • Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report.

    abstract::The authors report on the case of a 6-year-old boy who underwent resection of a midline cerebellar tumor. The boy was able to speak fluently after the operation. Magnetic resonance (MR) imaging showed that the right dentate nucleus had been partially removed along with the tumor, but that the left dentate nucleus rema...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.104.2.329

    authors: Kusano Y,Tanaka Y,Takasuna H,Wada N,Tada T,Kakizawa Y,Hongo K

    更新日期:2006-02-01 00:00:00

  • Anatomic variations of venous sinuses in the region of the torcular Herophili.

    abstract::In this study of 110 cranial cavities from adult cadavers, the superior sagittal sinus was found to divide into two channels. In most cases, the division was associated with a dural partition. Essentially, the variations as observed in this study could be grouped into three types: Type 1 includes those specimens in wh...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.1.0090

    authors: Bisaria KK

    更新日期:1985-01-01 00:00:00

  • Surgical treatment of falcotentorial meningiomas: a retrospective review of a single-institution experience.

    abstract:OBJECTIVE:Meningiomas at the falcotentorial junction represent a rare subgroup of complex meningiomas. Debate remains regarding the appropriate treatment strategy for and optimal surgical approach to these tumors, and surgical outcomes have not been well described in the literature. The authors reviewed their single-in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.4.JNS19208

    authors: Zhao X,Belykh E,Przybylowski CJ,Borba Moreira L,Gandhi S,Tayebi Meybodi A,Cavallo C,Valli D,Wicks RT,Nakaji P

    更新日期:2019-08-02 00:00:00

  • Clinical significance of the flow gap in carotid magnetic resonance angiography.

    abstract::Magnetic resonance (MR) angiography offers a safe, noninvasive alternative to conventional angiography in patients with suspected carotid stenosis; however, it tends to overestimate the severity of stenosis. Loss of the MR signal with a resulting flow gap is a frequent finding in cases of high-grade stenosis. The auth...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.3.0384

    authors: Heiserman JE,Zabramski JM,Drayer BP,Keller PJ

    更新日期:1996-09-01 00:00:00

  • The voice of art and the art of medicine. The 2002 presidential address.

    abstract::Vincent van Gogh's life, letters, and art are the framework for this existential speech about the nature of alienation, as well as its threat to humanity and to the artful practice of medicine. The honest, human voice expressed in van Gogh's art stands in opposition to alienation, which occurs when we divide the world...

    journal_title:Journal of neurosurgery

    pub_type:

    doi:10.3171/jns.2002.97.6.1261

    authors: Pelofsky S,Pelofsky R

    更新日期:2002-12-01 00:00:00

  • Endoscope-assisted retrosigmoid infralabyrinthine approach to jugular foramen tumors.

    abstract:OBJECTIVE:Removal of jugular foramen (JF) tumors usually requires extensive skull base approaches and is frequently associated with postoperative morbidities such as lower cranial nerve injury. The endoscope-assisted retrosigmoid infralabyrinthine approach is a relatively new approach to tumors extending into the bony ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.3.JNS142904

    authors: Samii M,Alimohamadi M,Gerganov V

    更新日期:2016-04-01 00:00:00

  • Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study.

    abstract::Clinical studies with transcranial Doppler suggest that the pulsatility of the flow velocity (FV) waveform increases when the distal cerebrovascular resistance (CVR) increases. To clarify this relationship, the authors studied animal models in which the resistance may be decreased in a controlled manner by an increase...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.84.1.0079

    authors: Czosnyka M,Richards HK,Whitehouse HE,Pickard JD

    更新日期:1996-01-01 00:00:00

  • Endoscopic extradural supraorbital approach to the temporal pole and adjacent area: technical note.

    abstract::The authors' initial experience with the endoscopic extradural supraorbital approach to the temporal pole and adjacent area is reported. Fully endoscopic surgery using the extradural space via a supraorbital keyhole was performed for tumors in or around the temporal pole, including temporal pole cavernous angioma, sph...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.3.JNS162228

    authors: Komatsu F,Imai M,Shigematsu H,Aoki R,Oda S,Shimoda M,Matsumae M

    更新日期:2018-06-01 00:00:00

  • Low-grade glioma surgery in eloquent areas: volumetric analysis of extent of resection and its impact on overall survival. A single-institution experience in 190 patients: clinical article.

    abstract:OBJECT:A growing number of published studies have recently demonstrated the role of resection in overall survival (OS) for patients with gliomas. In this retrospective study, the authors objectively investigated the role of the extent of resection (EOR) in OS in patients with low-grade gliomas (LGGs). METHODS:Between ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.8.JNS12393

    authors: Ius T,Isola M,Budai R,Pauletto G,Tomasino B,Fadiga L,Skrap M

    更新日期:2012-12-01 00:00:00

  • Epidural-cutaneous fistula in association with the Pott puffy tumor in an adolescent. Case report.

    abstract::The Pott puffy tumor is a subperiosteal abscess associated with underlying osteomyelitis, most often of the frontal bone in conjunction with frontal sinusitis. Intracranial sequelae can include epidural abscess, subdural empyema, intraparenchymal abscess, meningitis, and dural venous thrombophlebitis, all with resulta...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2006.105.3.235

    authors: Davidson L,McComb JG

    更新日期:2006-09-01 00:00:00

  • Comparison of clipping and coiling in elderly patients with unruptured cerebral aneurysms.

    abstract::OBJECTIVE The comparative effectiveness of the 2 treatment options-surgical clipping and endovascular coiling-for unruptured cerebral aneurysms remains an issue of debate and has not been studied in clinical trials. The authors investigated the association between treatment method for unruptured cerebral aneurysms and...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.1.JNS152028

    authors: Bekelis K,Gottlieb DJ,Su Y,O'Malley AJ,Labropoulos N,Goodney P,Lawton MT,MacKenzie TA

    更新日期:2017-03-01 00:00:00