Abstract:
:To date, the effects of long-term testosterone (T) administration on the human vagina are not completely understood. Thus, the aim of this study was to investigate the effects of long-term T treatment on vaginal tissue histology, estrogen receptor alpha (ERα) and beta (ERβ) expression and proliferation in female to male transsexual subjects (FtM). We compared vaginal samples from FtM subjects with those of premenopausal women (PrM) and postmenopausal women (M) not receiving any hormonal treatment for at least 2 years. Vaginal tissue samples from 16 FtM subjects treated with T (intramuscular injections of 100 mg Testoviron Depot/7-10 days for at least 1 year), undergoing sex reassignment surgery, and 16 PrM and 16 M subjects undergoing a vaginal hysterectomy for prolapse, were collected. For each sample, morphology, glycogen content, proliferation (ki-67), ERα and ERβ expression were evaluated. Vaginal samples from FtM showed a loss of normal architecture of the epithelium, intermediate and superficial layers were completely lost, and glycogen content was depleted. T administration resulted in a strong proliferation reduction when compared with both M and PrM subjects. Stromal and epithelial ERα as well as ERβ were significantly decreased in FtM when compared with PrM subjects. In conclusion, our data suggests that systemic T administration at supraphysiological dosage, determines profound changes in histomorphology and reduces ERs expression and proliferation of vaginal epithelium.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Baldassarre M,Giannone FA,Foschini MP,Battaglia C,Busacchi P,Venturoli S,Meriggiola MCdoi
10.1038/ijir.2013.9subject
Has Abstractpub_date
2013-09-01 00:00:00pages
172-7issue
5eissn
0955-9930issn
1476-5489pii
ijir20139journal_volume
25pub_type
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journal_title:International journal of impotence research
pub_type: 杂志文章
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journal_title:International journal of impotence research
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pub_type: 杂志文章,评审
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更新日期:2020-06-02 00:00:00
abstract::The objective was to study available evidence for ingredients of popular over-the-counter testosterone and erectile dysfunction (ED) supplements. The top 16 male testosterone and 16 ED supplements in the USA were identified from the most popular online retailers: A1 Supplements, Amazon, Vitamin Shoppe, and Walmart. In...
journal_title:International journal of impotence research
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journal_title:International journal of impotence research
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更新日期:2007-03-01 00:00:00
abstract::The objective was to describe funding sources and publication trends for the primary literature on Peyronie's disease (PD), including direct industry research support. A search of EMBASE, PubMed, Scopus, and Web of Science was performed to identify articles published from 2006 to 2018. Articles not published in Englis...
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更新日期:2021-01-01 00:00:00
abstract::In order to assess the effectiveness of sildenafil under routine conditions of use in primary care settings and to evaluate its impact on patient's life satisfaction and partner's satisfaction with treatment for erectile dysfunction (ED), an open, multicentre, observational, prospective study was designed in which 281...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:International journal of impotence research
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更新日期:2004-04-01 00:00:00
abstract::Routine removal of the reservoir in explanting a malfunctioning three-piece penile implant raises debates because that the retained reservoir has little risk of erosion and it often needs a second incision to remove the reservoir. We reported a case whose retained reservoir resulted in nonbacterial inflammation around...
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pub_type: 杂志文章
doi:10.1038/sj.ijir.3901402
更新日期:2006-05-01 00:00:00
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更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41443-018-0029-3
更新日期:2018-08-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
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journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-07-01 00:00:00
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更新日期:2005-01-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
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journal_title:International journal of impotence research
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doi:10.1038/sj.ijir.3901196
更新日期:2004-10-01 00:00:00
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更新日期:2005-05-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900823
更新日期:2002-04-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,meta分析
doi:10.1038/sj.ijir.3901479
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:Quality of life (QOL) data were used to evaluate the effects of self-administered intracavernosal injection of alprostadil for erectile dysfunction, when used for up to 18 months during a 13 country Phase III clinical trial. METHODS:The Duke Health Profile was used to measure patients' physical and psychoso...
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pub_type: 临床试验,杂志文章
doi:10.1038/sj.ijir.3900364
更新日期:1998-12-01 00:00:00