Abstract：
:Zinc oxide nanoparticles (ZnO NPs) are one of the most abundantly used nanomaterials in consumer products and biomedical applications. As a result, human exposure to these NPs is highly frequent and they have become an issue of concern to public health. Although toxicity of ZnO NPs has been extensively studied and they have been shown to affect many different cell types and animal systems, there is a significant lack of toxicological data for ZnO NPs on the nervous system, especially for human neuronal cells and tissues. In this study, the cytotoxic and genotoxic effects of ZnO NPs on human SHSY5Y neuronal cells were investigated under different exposure conditions. Results obtained by flow cytometry showed that ZnO NPs do not enter the neuronal cells, but their presence in the medium induced cytotoxicity, including viability decrease, apoptosis and cell cycle alterations, and genotoxicity, including micronuclei production, H2AX phosphorylation and DNA damage, both primary and oxidative, on human neuronal cells in a dose- and time-dependent manner. Free Zn(2+) ions released from the ZnO NPs were not responsible for the viability decrease, but their role on other types of cell damage cannot be ruled out. The results obtained in this work contribute to increase the knowledge on the genotoxic and cytotoxic potential of ZnO NPs in general, and specifically on human neuronal cells, but further investigations are required to understand the action mechanism underlying the cytotoxic and genotoxic effects observed.
journal_name
Environ Intjournal_title
Environment internationalauthors
Valdiglesias V,Costa C,Kiliç G,Costa S,Pásaro E,Laffon B,Teixeira JPdoi
10.1016/j.envint.2013.02.013subject
Has Abstractpub_date
2013-05-01 00:00:00pages
92-100eissn
0160-4120issn
1873-6750pii
S0160-4120(13)00061-5journal_volume
55pub_type
杂志文章abstract：:Persistent organic pollutants (POPs) accumulate in the food web of the Great Lakes ecosystem, causing concern that these chemicals play a role in the decline of avian species such as colonial-nesting waterbirds. In this study, samples from four life stages of the common tern (Sterna hirundo), a threatened species in N...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2020.106065
更新日期：2020-11-01 00:00:00
abstract：:South Africa is the largest user of pesticides in sub-Saharan Africa and many studies have highlighted the occurrence of pesticides in water resources. Poor management of water treatment facilities in combination with a relatively high dependency on untreated water from boreholes and rivers creates the potential for e...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2013.10.001
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Limited studies have investigated the association between prenatal and early childhood phthalate exposures and thyroid function among children. OBJECTIVES:To investigate the association between early life phthalate exposure and thyroid function among school-age children, considering both prenatal and early ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2020.105782
更新日期：2020-08-01 00:00:00
abstract：:Di(2-ethylhexyl) phthalate (DEHP) is one of the common phthalate plasticizers used primarily in soft polyvinyl chloride, which is a plastic polymer that makes up the total weight of goods from 1% up to 40% in many consumer products. The aims of this study were to examine the urinary DEHP metabolites in South Korean ch...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2013.01.007
更新日期：2013-04-01 00:00:00
abstract：:Understanding cities comprehensively as systems is a costly challenge and is typically not feasible for policy makers. Nevertheless, focusing on some key systemic characteristics of cities can give useful insights for policy to advance health and well-being outcomes. Moreover, if we take a coevolutionary systems view ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2016.04.014
更新日期：2016-09-01 00:00:00
abstract：:To examine the levels of PCDD/DFs pollution in environmental samples in the vicinity of various incinerators, the levels of PCDD/DFs in air and soil samples collected near 17 incinerators and stack emission gases were investigated between 2003 and 2006. A total of 434 soil, 28 stack emission gas, and 38 air samples we...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2007.08.002
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Evidence suggests that living near blue spaces such as the coast, lakes and rivers may be good for health and wellbeing. Although greater levels of physical activity (PA) may be a potential mechanism, we know little about the types of PA that might account for this. OBJECTIVES:To explore the mediating role ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105016
更新日期：2019-10-01 00:00:00
abstract：:There is an increased awareness that medicinal products for human use may cause negative effects in the environment. In Sweden a voluntary environmental classification system for drugs has been established in collaboration between producers, authorities and the public health care, and used for five years. The idea is ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2008.12.008
更新日期：2009-07-01 00:00:00
abstract：:Low-dose organochlorine (OC) pesticides have recently been associated with type 2 diabetes in several non-Asian general populations. As there is currently epidemic type 2 diabetes in Asia, we investigated the associations between OC pesticides and type 2 diabetes in Koreans. Among subjects who participated in a commun...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2010.02.012
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Blood lead levels (BLLs) were measured in the adult Inuit population of Nunavut, Northern Canada, during the Inuit Health Survey (IHS) in 2007-2008. Approximately 10% of the adult participants had BLL over the Health Canada's guidance of 100μg/L. OBJECTIVES:1) To repeat the measurement of BLL among the IHS ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2014.06.004
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The city of Port Pirie in South Australia has been a world leading centre for lead and zinc smelting and processing since 1889 that continues to cause contamination of its environment and resident population. This study quantifies the effect of lead and SO2 emissions from Nyrstar Port Pirie Pty Ltd's smelter...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.01.062
更新日期：2019-06-01 00:00:00
abstract：:This article reports an environmental health study on risk identification. It discusses risk factors linked to rural work and pesticide contact in a restricted geographic area and shows the necessity of improving rural workers' health in the central part of Sao Paulo State. The municipality of Bariri, which is the cas...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2005.02.002
更新日期：2005-07-01 00:00:00
abstract：:Total urinary phthalate metabolites (the free plus glucuronidated forms) have been frequently measured in the general population. However, data are limited on the free forms which may be more bioactive, especially for sensitive population such as pregnant women. Here the data gap was addressed by measuring concentrati...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2015.12.004
更新日期：2016-03-01 00:00:00
abstract：:Landfills are reservoirs of antibiotics, heavy metals, disinfectants and other emerging contaminants, and they are closely associated with the increasing prevalence of antibiotic-resistance genes (ARGs). In this study, two classes of clinical use antibiotics, i.e., fluoroquinolones (FQs) and β-lactams (BLs), twelve su...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2018.02.002
更新日期：2018-04-01 00:00:00
abstract：:Based on a theoretical revision of the social vulnerability concept, this article proposes a scheme of vulnerability indicators within the human environment focused on different aetiology risks. An adaptation of this generic scheme of vulnerability factors is set for the specific field of aquifer contamination risk, a...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2008.08.005
更新日期：2009-02-01 00:00:00
abstract：:Driven by the growing demand for food products of animal origin, industrial livestock and poultry production has become increasingly popular and is on the track of becoming an important source of environmental pollution in China. Although concentrated animal feeding operations (CAFOs) have higher production efficiency...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2017.07.003
更新日期：2017-10-01 00:00:00
abstract：:A wide range of organic pollutants (OPs) are emitted from the road and traffic environment and transported with road runoff to receiving waters. To provide an understanding of the transport routes of OPs in the environment, an investigation was carried out with the aim to determine whether OPs are transported with nan...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105140
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Benzotriazoles (BTRs) and benzothiazoles (BTHs) are emerging contaminants with potential insulin modulation activities. Pregnancy exposure to BTs (BTRs and BTHs) may be a risk factor for the development of gestational diabetes mellitus (GDM). However, epidemiological studies are limited. OBJECTIVES:We prosp...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105360
更新日期：2020-02-01 00:00:00
abstract：:The insect repellent diethyltoluamide (DEET) is among the most frequently detected organic chemical contaminants in water across a wide range of geographies from around the world. These observations are raising critical questions and increasing concerns regarding potential environmental relevance, particularly when th...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2016.09.004
更新日期：2016-11-01 00:00:00
abstract：:Fifty women residing in and around New Delhi, India and identified to have benign (25 nos.) and malignant (25 nos.) breast lesions were studied for the first time to access the association between environmental exposure to lead and risk of breast cancer and to determine the potential of changes in trace elements conce...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2006.02.002
更新日期：2006-07-01 00:00:00
abstract：:Water embodied in traded commodities is important for water sustainability management. This study provides insight into China's water footprint and virtual water trade using three specific water named Green, Blue and Grey. A multi-region input-output analysis at national and sectoral analysis levels from the years 199...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2018.09.011
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Children from farming families have less allergies than their peers. Consumption of farm milk or unpasteurized milk has been shown to explain (part of) the farming effect or protect against allergies independent of farming status. OBJECTIVES:We investigated whether the protective effect of farm milk consump...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2008.04.003
更新日期：2008-11-01 00:00:00
abstract：:Due to their biological, chemical and physical actions, earthworms can be directly employed within bioremediation strategies to promote biodegradation of organic contaminants. Earthworms have been shown to aerate and bioturbate soils and improve their nutritional status and fertility, which are variables known to limi...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2008.02.013
更新日期：2008-10-01 00:00:00
abstract：:Given the ongoing studies on the adverse effects of organophosphate ester (OPE) flame retardants and plasticizers on human health, there is an increasing scientific interest in the risk of exposure to OPEs via dietary intake. Using peer-reviewed literature published up to 2018, this review surveyed and compiled the av...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2019.03.009
更新日期：2019-06-01 00:00:00
abstract：:Caenorhabditis elegans is a free-living soil nematode that is commonly used as a model for toxicity tests. The aim of this study was to investigate the toxicity of seven organic pollutants: four azaarenes (quinoline, acridine, phenazine, and 1,10-phenanthroline), short-chain chlorinated paraffins, and two organochlori...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2007.03.001
更新日期：2007-08-01 00:00:00
abstract：:High antibiotic releases from manufacturing facilities have been identified as a risk factor for antibiotic resistance development in bacterial pathogens. However, the role of antibiotic pollution in selection and transferability of antibiotic resistance genes (ARGs) is still limited. In this study, we analyzed efflue...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.04.007
更新日期：2019-09-01 00:00:00
abstract：:Domoic acid (DA) is a neurotoxin that is naturally produced by phytoplankton and accumulates in seafood during harmful algal blooms. As the prevalence of DA increases in the marine environment, there is a critical need to identify seafood consumers at risk of DA poisoning. DA exposure was estimated in recreational raz...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2017.01.006
更新日期：2017-04-01 00:00:00
abstract：:Organophosphate flame retardants (PFRs) are used as additives in plastics and other applications such as curtains and carpets as a replacement for brominated flame retardants. As such, exposure to PFR mixtures is widespread, with children being more vulnerable than adults to associated health risks such as allergies a...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105003
更新日期：2019-10-01 00:00:00
abstract：:Information on arsenic (As) speciation in solid materials is critical for many environmental studies concerned with As stability and/or mobility in natural As-impacted soils and mining or industrial sites contaminated by As. The investigation of these systems has provided evidence for a number of secondary As minerals...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2009.07.004
更新日期：2009-11-01 00:00:00
abstract：:Polycyclic aromatic compounds (PACs), including polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (oxy-PAHs), are common environmental pollutants known to cause health effects in humans and wild-life. In particular, vertebrate cardiovascular development and function are sensitive to PACs. However, the intera...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2020.105913
更新日期：2020-10-01 00:00:00
