Abstract:
:The anodic and cathodic behavior of nisoldipine, 3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3 ,5-dicarboxylate, are reported. This drug belongs to the nitroaryl-1,4-dihydropyridine family, known as calcium channel antagonist and employed in therapeuticalls as peripheral and cerebral vasodilators, in the treatment of the arterial hypertension. The cathodic response corresponds to the reduction of the nitroaromatic group to generate the hydroxylamine derivative. The study by dc and d.p.p. reveals the appearance of four signals depending on pH: Signal I (pH 1-11.5) R - NO2 + 4H+ + 4e- --> R - NHOH + H2O; Signal II (pH 1-5) R - N+H2OH + 2H+ + 2e- --> RN+H3 + H2O; Signal III (pH > 11.5) R - NO2 + e- <--> R - NO2.-; Signal IV (pH > 11.5) R - NO2.- + 3e- + 4H+ --> R - NHOH. In contrast, the anodic response corresponds to the oxidation of the 1,4-dihydropyridine ring to generate the corresponding pyridine derivative. Both, cathodic (d.p.p.) and anodic signals (d.p.v.) were employed to develop analytical methodology for the determination of the drug. The repeatability of the measurements for both methods was adequate with R.S.D. of 1.4% (n = 10) and 2.1% (n = 10) for d.p.p. and d.p.v., respectively. Also recovery studies, 103.8% (R.S.D. 2.65%) by d.p.p. and 98.7% (R.S.D. 2.1%) by d.p.v. show that the accuracy and precision of the developed methods were adequate. The analytical methods were successfully applied to the determination of nisoldipine in both tablets and capsules. In addition, a preliminary study of the photostability of nisoldipine (using both UV and artificial day light) was completed. The identity of the main electroactive photodegradation products by GC with spectrometry detection is provided.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Alvarez-Lueje A,Naranjo L,Núñez-Vergara LJ,Squella JAdoi
10.1016/s0731-7085(97)00122-2subject
Has Abstractpub_date
1998-01-01 00:00:00pages
853-62issue
5eissn
0731-7085issn
1873-264Xpii
S0731708597001222journal_volume
16pub_type
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