Severe neonatal alloimmune thrombocytopenia due to anti-HPA-3a.

Abstract:

BACKGROUND AND OBJECTIVES:Neonatal alloimmune thrombocytopenia is usually attributable to HPA-la antibodies. We report a case of parental platelet antigen incompatibility associated with a severe neonatal thrombocytopenia secondary to alloimmunization to HPA-3a. MATERIALS AND METHODS:Platelet antibodies were detected by the monoclonal antibody-specific immobilization of platelet antigens, genotyping of the platelets by PCR, and HLA typing by serologic procedures and PCR. RESULTS:Genotyping of maternal and paternal platelets confirmed the incompatibility in the HPA-3a system. It is noteworthy that the mother is of the HLA type DRB3*0101, is ABO-incompatible with her husband, and also has HLA class I antibodies. CONCLUSION:Severe neonatal thrombocytopenia associated with HPA-3a alloimmunization is infrequent and all the factors mentioned above could have played a role in the severity of the disease.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Boehlen F,Kaplan C,de Moerloose P

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

201-4

issue

3

eissn

0042-9007

issn

1423-0410

pii

vox74201

journal_volume

74

pub_type

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