Biological evaluation of biopsies from adult cerebral astrocytomas: cell-growth/cell-suicide ratios and their relationship to patient survival.

abstract：:Aerobic glycolysis is a characteristic in cancers that is important for cancer cell proliferation. Emerging evidence shows that long non-coding RNA (LncRNA) participates in glucose metabolism and cell proliferation in cancer. This study explored the effect of LncRNA: SNHG9 in glioblastoma. The mRNA expression of SNHG9...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhang H,Qin D,Jiang Z,Zhang J

更新日期：2019-10-01 00:00:00

abstract：:Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant ...

journal_title：Journal of neuropathology and experimental neurology

authors： McKay EC,Beck JS,Khoo SK,Dykema KJ,Cottingham SL,Winn ME,Paulson HL,Lieberman AP,Counts SE

更新日期：2019-05-01 00:00:00

abstract：:It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade ...

journal_title：Journal of neuropathology and experimental neurology

authors： Al-Hajri A,Al-Mughairi S,Somani A,An S,Liu J,Miserocchi A,McEvoy AW,Yousry T,Hoskote C,Thom M

更新日期：2017-12-01 00:00:00

abstract：:To understand neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease (sAD), we performed functional genomics analysis and analyzed messenger RNA (mRNA) expression by quantitative reverse transcription-polymerase chain reaction of 22 genes involved in neuroinflammation-like resp...

journal_title：Journal of neuropathology and experimental neurology

authors： López-González I,Schlüter A,Aso E,Garcia-Esparcia P,Ansoleaga B,LLorens F,Carmona M,Moreno J,Fuso A,Portero-Otin M,Pamplona R,Pujol A,Ferrer I

更新日期：2015-04-01 00:00:00

abstract：:Recent studies highlight the importance of BRAF alterations resulting in mitogen activated protein kinase (MAK/ERK) pathway activation in low-grade CNS tumors. We studied 106 low-grade CNS neoplasms in a cohort of primarily pediatric patients to identify the prevalence and clinicopathologic significance of these alter...

journal_title：Journal of neuropathology and experimental neurology

authors： Lin A,Rodriguez FJ,Karajannis MA,Williams SC,Legault G,Zagzag D,Burger PC,Allen JC,Eberhart CG,Bar EE

更新日期：2012-01-01 00:00:00

abstract：:Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). To determine whether oxidative damage is an early- or end-stage event in the process of neurod...

journal_title：Journal of neuropathology and experimental neurology

authors： Nunomura A,Perry G,Aliev G,Hirai K,Takeda A,Balraj EK,Jones PK,Ghanbari H,Wataya T,Shimohama S,Chiba S,Atwood CS,Petersen RB,Smith MA

更新日期：2001-08-01 00:00:00

abstract：:Nemaline myopathy is the most common congenital myopathy and is caused by mutations in various genes such as ACTA1 (encoding skeletal α-actin). It is associated with limb and respiratory muscle weakness. Despite increasing clinical and scientific interest, the molecular and cellular events leading to such weakness rem...

journal_title：Journal of neuropathology and experimental neurology

authors： Lindqvist J,Cheng AJ,Renaud G,Hardeman EC,Ochala J

更新日期：2013-06-01 00:00:00

abstract：:Selenoprotein P (Sepp1) is involved in selenium homeostasis. Mice with a deletion of Sepp1, replacement of it by the shortened form Sepp1(Delta240-361), or deletion of its receptor apolipoprotein E receptor 2 develop severe neurologic dysfunction when fed low-selenium diet. Because the brainstems of Sepp1(-/-) mice ha...

journal_title：Journal of neuropathology and experimental neurology

authors： Valentine WM,Abel TW,Hill KE,Austin LM,Burk RF

更新日期：2008-01-01 00:00:00

abstract：:The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the mo...

journal_title：Journal of neuropathology and experimental neurology

authors： McKee AC,Kosik KS,Kennedy MB,Kowall NW

更新日期：1990-01-01 00:00:00

abstract：:We describe a family with a rapidly progressive neurodegenerative disorder characterized by amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) but with unusual neuropathologic features that include pallidoluysionigral degeneration. The proband presented with primary progressive aphasia that evolved ...

journal_title：Journal of neuropathology and experimental neurology

authors： Portera-Cailliau C,Russ C,Brown RH Jr,Budson AE,Vonsattel JP,Folkerth RD,Corbo JC

更新日期：2007-07-01 00:00:00

abstract：:In attempting to control the pain of disseminated carcinoma, a variety of agents has been injected intrathecally. This report deals with the neuropathologic changes in spinal roots and spinal cord of four patients into whose lumbar sacs 100 to 285 ml of distilled water was infused. Survival following the procedure ra...

journal_title：Journal of neuropathology and experimental neurology

authors： Kelly JM,Asbury AK,King JS

更新日期：1975-09-01 00:00:00

abstract：:To determine if central nervous system (CNS) microvessel endothelial cells express class II major histocompatibility complex (MHC) molecules in early demyelinating lesions in humans, cerebral white matter (WM) biopsies from patients with acute inflammatory/demyelinating conditions, including 4 with multiple sclerosis ...

journal_title：Journal of neuropathology and experimental neurology

authors： van der Maesen K,Hinojoza JR,Sobel RA

更新日期：1999-04-01 00:00:00

abstract：:Fibrosis is the main cause of irreversible nerve damage in leprosy. Phenotypic changes in Mycobacterium leprae (ML)-infected Schwann cells (SCs) have been suggested to mediate this process. We found that SC line cultures stimulated with ML upregulated transforming growth factor-β1 (TGF-β1), and that TGF-β1 or ML induc...

journal_title：Journal of neuropathology and experimental neurology

authors： Petito RB,Amadeu TP,Pascarelli BM,Jardim MR,Vital RT,Antunes SL,Sarno EN

更新日期：2013-04-01 00:00:00

abstract：:Vanishing white matter disease (VWM) is a progressive cavitating disease of central white matter due to a deficiency of the translation initiation factor eIF2B. Oligodendrocytes appear to be numerically increased in some white matter areas, while decreased in others. We compared oligodendrocytes of cerebral, cerebella...

journal_title：Journal of neuropathology and experimental neurology

authors： Van Haren K,van der Voorn JP,Peterson DR,van der Knaap MS,Powers JM

更新日期：2004-06-01 00:00:00

abstract：:Bcl-2, a cell death suppressor protein, is expressed during brain development but is largely down-regulated in the adult central nervous system. We previously reported strong expression of bcl-2 in small, "oligodendrocyte-like" cells (OLC) found in glioneuronal hamartias. These hamartias are microscopic cell rests fou...

journal_title：Journal of neuropathology and experimental neurology

authors： Yachnis AT,Roper SN,Love A,Fancey JT,Muir D

更新日期：2000-02-01 00:00:00

abstract：:The role of regenerating axons in the restructuring of the endoneurium into minifascicles after peripheral nerve injury was investigated. Endoneurial changes were studied in the control distal stumps of crushed rat sciatic nerves and in the distal nerve stumps in which, in addition to other cellular elements, the orig...

journal_title：Journal of neuropathology and experimental neurology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：1994-11-01 00:00:00

abstract：:The periaqueductal gray (PAG) plays a central role in the integration of defense responses to threatening or stressful stimuli. Little is known about the neurochemical development of the human PAG around the time of birth, when the fetus makes the transition to extrauterine life and independent defense responses are n...

journal_title：Journal of neuropathology and experimental neurology

authors： Reddy SC,Panigrahy A,White WF,Kinney HC

更新日期：1996-04-01 00:00:00

abstract：:In the central nervous system, tuberous sclerosis complex (TSC) is characterized by a range of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and subependymal giant cell astrocytomas (SEGAs). Recent studies have implicated an important role for the TSC genes TSC1 and TSC2, in a sig...

journal_title：Journal of neuropathology and experimental neurology

authors： Chan JA,Zhang H,Roberts PS,Jozwiak S,Wieslawa G,Lewin-Kowalik J,Kotulska K,Kwiatkowski DJ

更新日期：2004-12-01 00:00:00

abstract：:Loss of chromosome 1p/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p/19q deletion based on the high degree of correlation between both parameters in o...

journal_title：Journal of neuropathology and experimental neurology

authors： Buckley PG,Alcock L,Heffernan J,Woods J,Brett F,Stallings RL,Farrell MA

更新日期：2011-03-01 00:00:00

abstract：:Neurofibromatosis 2 (NF2), a dominantly inherited disorder, is typically manifested as bilateral vestibular Schwannomas and predisposes to other nervous system tumors. Vestibular Schwannomas also occur sporadically but the onset is usually at an older age. Surgical and histological studies have shown that vestibular S...

journal_title：Journal of neuropathology and experimental neurology

authors： Antinheimo J,Haapasalo H,Seppälä M,Sainio M,Carpen O,Jääskeläinen J

更新日期：1995-11-01 00:00:00

abstract：:The relevance of cerebral amyloid angiopathy (CAA) to the pathogenesis of Alzheimer disease (AD) and dementia in general emphasizes the importance of developing novel targeting approaches for detecting and treating cerebrovascular amyloid (CVA) deposits. We developed a nanoparticle-based technology that uses a monoclo...

journal_title：Journal of neuropathology and experimental neurology

authors： Poduslo JF,Hultman KL,Curran GL,Preboske GM,Chamberlain R,Marjańska M,Garwood M,Jack CR Jr,Wengenack TM

更新日期：2011-08-01 00:00:00

abstract：:Deletions on the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) are molecular hallmark lesions of oligodendroglial tumors. Ever since oligodendroglial tumors with 1p and 19q deletions were shown to respond to chemotherapy, neuropathologists have been facing increasing requests for such molecula...

journal_title：Journal of neuropathology and experimental neurology

authors： Hartmann C,Mueller W,Lass U,Kamel-Reid S,von Deimling A

更新日期：2005-01-01 00:00:00

abstract：:Rupture of a saccular intracranial aneurysm (sIA) is often fatal. Thus, early detection of rupture-prone sIAs is vital. Myeloperoxidase (MPO), derived mainly from neutrophils, associates with sIA rupture, and therefore its role in sIA pathogenesis warrants further studies. We analyzed MPO and its association with othe...

journal_title：Journal of neuropathology and experimental neurology

authors： Ollikainen E,Tulamo R,Lehti S,Hernesniemi J,Niemelä M,Kovanen PT,Frösen J

更新日期：2018-06-01 00:00:00

abstract：:Prolonged deprivation of vitamin B12 in rhesus monkeys produced changes in the central nervous system that were indistinguishable topographically and histologically from those of human subacute combined degeneration. Ultrastructural studies of early lesions of the spinal cord disclosed a degeneration of myelin charact...

journal_title：Journal of neuropathology and experimental neurology

authors： Agamanolis DP,Victor M,Harris JW,Hines JD,Chester EM,Kark JA

更新日期：1978-05-01 00:00:00

abstract：:Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a...

journal_title：Journal of neuropathology and experimental neurology

authors： Horvath R,Fu K,Johns T,Genge A,Karpati G,Shoubridge EA

更新日期：1998-05-01 00:00:00

abstract：:The abundant axonal microtubule-associated protein tau regulates microtubule and actin dynamics, thereby contributing to normal neuronal function. We examined whether mice deficient in tau (Tau(-/-)) or with high levels of human tau differ from wild-type (WT) mice in their susceptibility to neuroaxonal injury in exper...

journal_title：Journal of neuropathology and experimental neurology

authors： Weinger JG,Davies P,Acker CM,Brosnan CF,Tsiperson V,Bayewitz A,Shafit-Zagardo B

更新日期：2012-05-01 00:00:00

abstract：:Older adults with intact cognition before death and substantial Alzheimer disease (AD) lesions at autopsy have been termed "asymptomatic AD subjects" (ASYMAD). We previously reported hypertrophy of neuronal cell bodies, nuclei, and nucleoli in the CA1 of the hippocampus (CA1), anterior cingulate gyrus, posterior cingu...

journal_title：Journal of neuropathology and experimental neurology

authors： Iacono D,Resnick SM,O'Brien R,Zonderman AB,An Y,Pletnikova O,Rudow G,Crain B,Troncoso JC

更新日期：2014-04-01 00:00:00

abstract：:Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term "nodo-paranodopathy" was first applied to some "axonal Guillain-Barré syndrome" subtypes, then extended to ca...

journal_title：Journal of neuropathology and experimental neurology

authors： Vallat JM,Magy L,Corcia P,Boulesteix JM,Uncini A,Mathis S

更新日期：2020-03-01 00:00:00

abstract：:Glioblastoma (GBM), representing WHO grade IV astrocytoma, is a relatively common primary brain tumor in adults with an exceptionally dismal prognosis. With an incidence rate of over 10 000 cases in the United States annually, the median survival rate ranges from 10-15 months in IDH1/2-wildtype tumors and 24-31 months...

journal_title：Journal of neuropathology and experimental neurology

authors： Richardson TE,Patel S,Serrano J,Sathe AA,Daoud EV,Oliver D,Maher EA,Madrigales A,Mickey BE,Taxter T,Jour G,White CL,Raisanen JM,Xing C,Snuderl M,Hatanpaa KJ

更新日期：2019-06-01 00:00:00

abstract：:In situ hybridization (ISH) for JC virus (JCV) is generally applied for the diagnosis of progressive multifocal leukoencephalopathy (PML). To explore the usefulness of immunohistochemistry (IHC) for JCV early proteins, 14 paraffin-embedded postmortem brain specimens with histologic features compatible with PML were te...

journal_title：Journal of neuropathology and experimental neurology

authors： Muñoz-Mármol AM,Mola G,Fernández-Vasalo A,Vela E,Mate JL,Ariza A

更新日期：2004-11-01 00:00:00