Glioblastomas with oligodendroglial component have the same clinical phenotype as classical glioblastomas.

Abstract:

INTRODUCTION:Glioblastomas are the commonest primary brain tumour and are considered one of the most heterogeneous tumour types. The introduction of a glioblastoma with oligodendroglial component (GBM + O) in the latest WHO Classification of Tumours of the Central Nervous System (1) was to help with this. There has been conflicting evidence as to whether this tumour conferred a better prognosis than classical glioblastoma (GBM). The aim of this study was to study the clinical phenotype of these GBM + O tumours and compare it to the classical GBM. MATERIALS AND METHODS:All patients with histological evidence of a glioblastoma between 1st January 2007 and 31st January 2011 were identified from the Neuropathology Database. Clinical and radiological details were obtained for all patients. The overall survival of patients who were treated with chemoradiotherapy was obtained and the GBM + O cohort compared to the classical GBM cohort. RESULTS:Three hundred and ninety-six patients with newly diagnosed glioblastomas were identified: 294 (74.2%) had classical GBM and 102 (25.6%) had GBM + O. The two cohorts presented at a similar age (61.1 years GBM + O vs. 63.2 years GBM; P = 0.09) and were matched for sex and side of the tumour. GBM + O were more likely to be located in the frontal lobes (38.2% for GBM + O vs. 27.2% for GBM: P = 0.04). In the group that was treated with chemoradiotherapy the overall survival was similar (median survival GBM + O 361 days vs. 379 days GBM; Log Rank 0.61, P = 0.43). CONCLUSION:The presence of an oligodendroglial component does not confer any improvement in survival and has a similar clinical phenotype to classical GBMs.

journal_name

Br J Neurosurg

authors

Elmahdi A,Frary AJ,Scotton WJ,O'Donovan DG,Price SJ

doi

10.3109/02688697.2013.767315

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

419-24

issue

4

eissn

0268-8697

issn

1360-046X

journal_volume

27

pub_type

杂志文章
  • Thoracic spine ossified ligamentum flavum: single-surgeon experience of fifteen cases and a new MRI finding for preoperative diagnosis of dural ossification.

    abstract::Purpose: Ossification of ligamentum flavum (OLF) is an infrequent cause of thoracic spinal stenosis, mostly found in Japan and other East Asian countries, and uncommon in other populations. The incidence of dural ossification (DO) ranges from 11-62%. None of the previously described imaging findings can accurately dia...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2019.1670333

    authors: Prasad GL

    更新日期:2020-12-01 00:00:00

  • Speech arrest after sleeping on the left body side.

    abstract::Stroke like episodes can occur by cortical compression due to changes in intracranial pressure. We report a patient after left hemicraniectomy who presented transient speech arrest after sleeping on the left side. We propose that mechanical compression of the left inferior or superior frontal gyrus led to this episode...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2011.569037

    authors: Wojtecki L,Schnitzler A

    更新日期:2011-06-01 00:00:00

  • Carotico-cavernous fistula secondary to Varicella zoster?

    abstract::We describe the case of a previously well, 73-year-old male patient who presented with a spontaneous high flow, carotico-cavernous fistula, 1 month following an attack of herpes zoster. We postulate that the zoster virus was the underlying cause, given the history and time frame between the preceding shingles and the ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688691003634512

    authors: Amato-Watkins A,St George EJ,Saxena A,Bhattacharya J

    更新日期:2010-06-01 00:00:00

  • Management of veins during microvascular decompression for idiopathic trigeminal neuralgia.

    abstract:OBJECT:To summarize our experience in treating veins during microvascular decompression (MVD) procedures for idiopathic trigeminal neuralgia (TN). METHODS:A total of 210 patients who underwent single MVD for idiopathic TN were retrospectively studied. The offending vessels were summarized. The treatment choices for ve...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2018.1476674

    authors: Zhao X,Hao S,Wang M,Han C,Xing D,Wang C

    更新日期:2018-10-01 00:00:00

  • A clinical audit of neurosurgical bed usage.

    abstract:AIM:To investigate inefficiencies during patients' stay in neurosurgical beds. METHODS:A prospective audit of neurosurgical inpatients was conducted over approximately 2 months. We recorded the causes and duration of inappropriate delays, defined as actions requiring more that 24 h from initiation until completion. R...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690701649488

    authors: Chelvarajah R,Lee JK,Chandrasekaran S,Bavetta S

    更新日期:2007-12-01 00:00:00

  • Surgical-site infection surveillance in cranial neurosurgery.

    abstract:INTRODUCTION:Surgical-site infection (SSI) is associated with significant morbidity and mortality. Public Health England or PHE has published guidance on its surveillance, which is now mandatory in some specialities. We review how appropriate their programme is for monitoring SSI in cranial neurosurgery [CN]. METHOD:S...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2015.1071321

    authors: Davies BM,Jones A,Patel HC

    更新日期:2016-01-01 00:00:00

  • Prognostic value of OCT4 in primary intracranial germinoma: a single institute analysis of 31 cases.

    abstract::OCT4 expresses variably in primary intracranial germinomas. In this study, we tested our hypothesis that such variation of OCT4 is predictive of outcome in primary intracranial germinomas. Thirty-one histologically identified CNS germinoma patients were enrolled in our study. We collected medical data, immunohistochem...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2011.605483

    authors: Wanggou S,Jiang X,Yuan X,Ren C,Zeng Y,Li G,Li Q

    更新日期:2012-04-01 00:00:00

  • The management of cerebellar abscess since the introduction of CT scanning.

    abstract::Sixteen patients with surgical infection of the posterior fossa are presented. There were 14 patients with cerebellar abscess, one patient with a solitary posterior fossa subdural empyema, and another with a combined cerebellar abscess and subdural empyema. Two of the cerebellar abscess patients also had supratentoria...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688699408995113

    authors: Brydon HL,Hardwidge C

    更新日期:1994-01-01 00:00:00

  • Low rates of post-craniotomy surgical site infections in a developing country: surgical technique and results.

    abstract:INTRODUCTION:Although neurosurgical surgical site infections (SSI) exert a devastating price on the postoperative course of patients in the developing countries, literature is sparse on the subject from these regions. METHODS:This study is an audit of post-craniotomy SSI in a sub-Sahara African academic neurosurgical ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2017.1407746

    authors: Adeleye AO

    更新日期:2018-04-01 00:00:00

  • Post-operative infections of osteoplastic compared with free bone flaps.

    abstract::A retrospective study was performed to evaluate the rate of infection in free and osteoplastic bone flaps after craniotomy. Two hundred and two craniotomies were performed in 98 cases of tumour, 35 cases of trauma and 69 cases of vascular disease. The overall incidence of infection was 6.4% (13 cases). The infectious ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688699008993798

    authors: Rasmussen S,Ohrström JK,Westergaard L,Kosteljanetz M

    更新日期:1990-01-01 00:00:00

  • Chiari I malformation: surgical experience over a decade of management.

    abstract::Chiari malformations are a pathological continuum of hindbrain maldevelopment and Chiari I malformation (CMI) represents caudal decent of cerebellar tonsils. The surgery aims to relieve tonsillar compression with restoration of the normal cerebrospinal (CSF) flow dynamics. We report the salient features of our surgica...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690801894638

    authors: Kumar R,Kalra SK,Vaid VK,Mahapatra AK

    更新日期:2008-06-01 00:00:00

  • Cavernous malformation of the optic chiasm: case report.

    abstract::We report a 14-year-old boy with cavernous malformation of the optic chiasm. He had a 2-year history of gradually worsening visual disturbance. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a suprasellar mass, findings compatible with craniopharyngioma. The mass was biopsied and histological e...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690601000238

    authors: Muta D,Nishi T,Koga K,Yamashiro S,Fujioka S,Kuratsu J

    更新日期:2006-10-01 00:00:00

  • Middle cerebral artery atherosclerotic stenosis mimicking a cerebral aneurysm: pitfall in preoperative evaluation of cerebral aneurysms.

    abstract::We report a case of an aneurysm-like finding of MCA with severe atherosclerosis on standard radiological evaluation, which led us to plan surgical clipping. In particular, patients, whose modalities usually performed for preoperative assessment of cerebral aneurysms, such as DSA, 3D CTA and MRA, are insufficient. ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2011.633639

    authors: Shibahashi K,Kimura T,Morita A

    更新日期:2012-06-01 00:00:00

  • Racial differences between Maori and European New Zealanders in aneurysmal subarachnoid haemorrhage.

    abstract::Racial differences in the incidence and rate of rupture of intracranial aneurysms are well recognized. A retrospective study of racial differences between Maori and European New Zealanders presenting to the Auckland Regional Neurosurgical Unit between 1985 and 1990 was conducted. It was found that the incidence per 10...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688699309103475

    authors: Marks PV,Hope JK,Cluroe AD,Furneaux CE

    更新日期:1993-01-01 00:00:00

  • Lymphocytic and granulocytic hypophysitis: a single centre experience.

    abstract::Lymphocytic and granulocytic hypophysitis are rare pituitary masses. A series of five dealt with at a single centre is presented and discussed. Retrospective analysis of pathology records revealed the cases. Of pituitary mass lesions dealt with in this centre, 0.8% have the diagnosis. Five females presented, one pregn...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690120057664

    authors: Buxton N,Robertson I

    更新日期:2001-06-01 00:00:00

  • Trephine approach to anterior midline aneurysms--an initial communication.

    abstract::The outcome of two groups of patients wtih midline aneurysms exposed by two different approaches was compared. The initial results support a clinical impression that a trephine approach has the following advantages: (1) adequate exposure with the best possible anatomical orientation and (2) a reduced morbidity. ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688699008992743

    authors: Keogh AJ

    更新日期:1990-01-01 00:00:00

  • Photodynamic therapy of malignant brain tumours: a phase I/II trial.

    abstract::Twenty patients bearing malignant brain tumours (18 glioblastoma multiforme, one malignant meningioma, one melanoma metastasis) were treated 25 times with photodynamic therapy (PDT)--the combination of Hematoporophyrin derivative and light at 630 nm (40-120 J/cm2). Sixteen times the PDT was followed immediately by a s...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688698808992675

    authors: Kostron H,Fritsch E,Grunert V

    更新日期:1988-01-01 00:00:00

  • Cranial fasciitis of childhood: an incidental finding of a lytic skull lesion.

    abstract::We describe a case of cranial fascitis presenting as an incidental finding. A 2 1/2-year-old girl had skull radiographs performed after sustaining a minor head injury, which revealed a lytic skull lesion. We describe the salient features of the case and review the current literature of this rare benign inflammatory co...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1080/02688699745989

    authors: Boddie DE,Distante S,Blaiklock CT

    更新日期:1997-10-01 00:00:00

  • Regression of syringomyelia after removal of a posterior fossa epidermoid tumour.

    abstract::The case is reported of a 49-year-old man with a giant infratentorial extradural epidermoid tumour, with cervical syringomyelia and hydrocephalus, and partial protrusion of the cerebellar tonsils through the foramen magnum. The patient complained of symptoms of raised intracranial pressure and was admitted to our Depa...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688699647375

    authors: Sgaramella E,Perria C

    更新日期:1996-08-01 00:00:00

  • Intracranial malposition of a nasogastric tube following repair of choanal atresia.

    abstract::Intracranial penetration during attempted nasogastric intubation is a rare, often lethal occurrence. We report the inadvertent introduction of a nasogastric tube intracranially in a neonate following repair of unilateral choanal atresia. Following manual removal of the tube, the patient made a good recovery. ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688699943547

    authors: Nathoo N,Nadvi SS

    更新日期:1999-08-01 00:00:00

  • Posterior approach vertebrectomy in the thoracolumbar spine with expandable cage reconstruction: indications and techniques based on eight cases.

    abstract::We present a series of eight patients undergoing circumferential neural decompression and stabilization of the thoracolumbar spine via a single midline posterior approach, with complete vertebrectomy for a variety of indications. Four had primary tumours, two secondary tumours, one patient had tuberculosis and one had...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690701837273

    authors: Crocker M,James G,Ibrahim A,Thomas N,Chitnavis B

    更新日期:2008-04-01 00:00:00

  • Factors affecting diagnostic yield in needle biopsy for brain lesions.

    abstract:INTRODUCTION:We analyse the factors that are associated with the diagnostic yield of needle brain biopsy. MATERIAL AND METHODS:We present a retrospective series of 124 consecutive biopsies in a 30-month period. Patients' demographics (age, gender), lesion topography (side, location, depth), lesion characteristics (his...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2012.722239

    authors: Tsermoulas G,Mukerji N,Borah AJ,Mitchell P,Ross N

    更新日期:2013-04-01 00:00:00

  • Anterior sacral meningocele occurring in one family. An autosomal dominantly inherited condition.

    abstract::Anterior sacral meningocele is a rare congenital condition. Among 177 individuals familial occurrence was reported only seven times. In this report a family in which five members had anterior sacral meningoceles is presented and an autosomal dominant inheritance is suggested. ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688699009000683

    authors: Andersen C,Tange M,Bjerre P

    更新日期:1990-01-01 00:00:00

  • Complications of fixation to the occiput-anatomical and design implications.

    abstract::Internal fixation provides an increased immediate stability for the craniovertebral junction; however, there is no current consensus on the optimal method of occipitocervical (OC) fusion. In this report, we present 25 cases of craniovertebral instability treated with OC fusion by plates and screws instrumentation. The...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1080/02688690400022813

    authors: Lee SC,Chen JF,Lee ST

    更新日期:2004-12-01 00:00:00

  • Studies of regional subdural pressure gradients during craniotomy.

    abstract::We investigated subdural pressure gradients within the operative field of the exposed intact dura in 53 patients with space-occupying lesions during craniotomy. In 37 patients with supratentorial brain tumour paired measurements of subdural pressure were studied in either the same horizontal or vertical plane. In 16 p...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/026886900408414

    authors: Bundgaard H,Cold GE

    更新日期:2000-06-01 00:00:00

  • Laser-assisted flexible endoscopic fenestration of giant cyst of the septum pellucidum.

    abstract::The use of the flexible neuroendoscope and laser fenestration in the surgical management of a symptomatic cyst of cavum septum pellucidum is reported. Successful communication was established between the cyst cavity and the lateral ventricles using this technique. Satisfactory clinical and radiological improvement as ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688699550041179

    authors: Jackowski A,Kulshresta M,Sgouros S

    更新日期:1995-01-01 00:00:00

  • Post-operative spinal subdural extra-arachnoid hygroma causing cauda equina compression: a report of two cases.

    abstract::We present two cases of symptomatic, post-lumbar surgery cauda equina compression due to formation of a dissecting subdural extra-arachnoid cerebrospinal fluid (CSF) collection (hygroma) under tension. In both cases, a small inadvertent durotomy was sustained during the initial surgery. Surgical re-exploration confirm...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2011.625063

    authors: Singleton WG,Ramnarine D,Patel N,Wigfield C

    更新日期:2012-06-01 00:00:00

  • An assessment of how the anterior cerebral artery anatomy impacts ACoA aneurysm formation based on CFD analysis.

    abstract:OBJECTIVE:The aim of this study was to identify independent anatomic, morphologic and hemodynamic features of the ACoA (anterior communicating artery) complex that serve as risk factors for the occurrence of ACoA aneurysms. METHODS:Fifteen consecutive patients with 15 ACoA aneurysms were included. Computational fluid ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2020.1821867

    authors: Zhou G,Wang J,Liu W,Gu W,Su M,Feng Y,Qin B,Zhu Y

    更新日期:2020-09-29 00:00:00

  • Recurrent aneurysmal subarachnoid haemorrhage: incidence, timing and effects. A re-appraisal in a surgical series.

    abstract::A series of 510 patients with proven aneurysmal subarachnoid haemorrhage (SAH) is reported. The incidence of recurrent haemorrhage during the period awaiting surgery was 13.7%. There was no significant difference in incidence between good and poor grade patients. Following rebleeding there was an immediate mortality o...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688698808999657

    authors: O'Neill P,West CR,Chadwick DW,Conway M,Foy PM,Maloney P,Pickard JD,Spillane JA,Shaw MD

    更新日期:1988-01-01 00:00:00

  • Predictors for delayed ventriculoperitoneal shunt placement after external ventricular drain removal in patients with subarachnoid hemorrhage.

    abstract:OBJECTIVE:Hydrocephalus after subarachnoid hemorrhage (SAH) requires temporary cerebrospinal fluid (CSF) drainage using an external ventricular drain (EVD). This drain is removed if patients pass a clamp trial, or a ventriculoperitoneal shunt (VPS) is placed. Little is known about the risk factors for delayed VPS place...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2014.967753

    authors: Lewis A,Irvine H,Ogilvy C,Kimberly WT

    更新日期:2015-04-01 00:00:00