Abstract:
INTRODUCTION:We analyse the factors that are associated with the diagnostic yield of needle brain biopsy. MATERIAL AND METHODS:We present a retrospective series of 124 consecutive biopsies in a 30-month period. Patients' demographics (age, gender), lesion topography (side, location, depth), lesion characteristics (histology, volume, radiological enhancement), type of biopsy procedure (freehand, ultrasound guided, frameless and frame-based stereotactic) and the use of intraoperative histologic examination were correlated with the diagnostic rate. Descriptive statistics and a nominal logistic regression model were used to evaluate the factors influencing diagnostic yield. RESULTS:63 men and 61 women were included in the study with mean age 59.2 (range: 16-86). 55 were frame-based stereotactic biopsies, 33 were frameless stereotactic biopsies, 29 biopsies were performed under ultrasound guidance and 7 freehand. The diagnostic yield in our series is 93.5%. The gender, lesion topography, biopsy method, use of intraoperative histology and enhancement did not correlate with the diagnostic yield. Younger age had a negative impact on diagnostic yield. 6 out of 8 inconclusive biopsies were in non-glial lesions (p < 0.05). The odds of obtaining a positive diagnosis increased sevenfold with every cc increase in lesion volume. CONCLUSION:The age of the patient, the volume and the histology of the brain lesion had an impact on the diagnostic yield of needle biopsy. None of the other factors significantly influenced the diagnostic rate.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Tsermoulas G,Mukerji N,Borah AJ,Mitchell P,Ross Ndoi
10.3109/02688697.2012.722239subject
Has Abstractpub_date
2013-04-01 00:00:00pages
207-11issue
2eissn
0268-8697issn
1360-046Xjournal_volume
27pub_type
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