Neutrophil accumulation is reduced during partial liquid ventilation.


OBJECTIVE:This study evaluates the ability of perflubron to inhibit pulmonary neutrophil accumulation during partial liquid ventilation (PLV) in the setting of acute lung injury. DESIGN:Randomized, controlled, nonblinded study. SETTING:Research laboratory at a university. SUBJECTS:Male, Sprague-Dawley rats (n = 120, 506 +/- 42 g). INTERVENTIONS:Animals were divided into eight groups (n = 15 in each group, of which n = 12 for myeloperoxidase content and n = 3 for histologic neutrophil counting): a) GV-CVF group, animals received gas ventilation (GV) with the induction of lung injury using cobra venom factor (CVF); b) PLV-CVF group, animals received partial liquid ventilation before the induction of lung injury; c) PEEP-CVF group, animals received positive end-expiratory pressure (PEEP) before the administration of cobra venom factor; d) CVF-PLV group, animals received partial liquid ventilation after cobra venom factor; e) CVF-PEEP group, animals received PEEP after cobra venom factor; f) PLV only group, animals received partial liquid ventilation only; g) GV only group, animals received gas ventilation only; and h) NVSBA group, nonventilated spontaneous breathing animals. MEASUREMENTS AND MAIN RESULTS:After the experimental period, total lung myeloperoxidase content was significantly decreased in the PLV-CVF (0.29 +/- 0.08, p = .02) and PEEP-CVF (0.34 +/- 0.04, p = .01) groups when compared with the GV-CVF group (0.62 +/- 0.07). When compared with the GV-CVF group, a trend toward a reduction in myeloperoxidase was observed in the CVF-PLV (0.42 +/- 0.05, p = .07) and the CVF-PEEP (0.39 +/- 0.06, p = .07) groups. When compared with the cobra venom factor only group (GV-CVF 47 +/- 2 neutrophils/high-power field), reductions in neutrophil count were observed in all groups (neutrophils/high-power field): PLV-CVF (20 +/- 2, p = .009); PEEP-CVF (24 +/- 1, p = .01); CVF-PLV (30 +/- 2, p = .03); and CVF-PEEP (37 +/- 1, p = .04). CONCLUSION:These data suggest that both partial liquid ventilation and PEEP result in a reduction in neutrophil accumulation in the setting of acute lung injury.


Crit Care Med


Critical care medicine


Colton DM,Till GO,Johnson KJ,Dean SB,Bartlett RH,Hirschl RB




Has Abstract


1998-10-01 00:00:00












  • Incidence and Mortality of Acute Respiratory Distress Syndrome in Children: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:Our understanding of the acute respiratory distress syndrome in children is limited, and literature is dominated by investigations in adult patients. Recent preclinical studies suggest that the susceptibility to and severity of acute respiratory distress syndrome in children could differ from that in adults....

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Schouten LR,Veltkamp F,Bos AP,van Woensel JB,Serpa Neto A,Schultz MJ,Wösten-van Asperen RM

    更新日期:2016-04-01 00:00:00

  • Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients-A Prospective Multicenter Study (IROI Study).

    abstract:OBJECTIVES:To identify the prevalence, risk factors, and outcomes of intra-abdominal hypertension in a mixed multicenter ICU population. DESIGN:Prospective observational study. SETTING:Fifteen ICUs worldwide. PATIENTS:Consecutive adult ICU patients with a bladder catheter. INTERVENTIONS:None. MEASUREMENTS AND MAIN...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Reintam Blaser A,Regli A,De Keulenaer B,Kimball EJ,Starkopf L,Davis WA,Greiffenstein P,Starkopf J,Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators.

    更新日期:2019-04-01 00:00:00

  • Acute hypercapnia increases the oxygen-carrying capacity of the blood in ventilated dogs.

    abstract:OBJECTIVE:To test the hypothesis that PaCO2 levels generated during permissive hypercapnia may enhance arterial oxygenation, when ventilation is maintained. DESIGN:Prospective study. SETTING:Research laboratory in a hospital. SUBJECTS:One group of eight mongrel dogs (four male; four female). INTERVENTIONS:The dogs ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Torbati D,Mangino MJ,Garcia E,Estrada M,Totapally BR,Wolfsdorf J

    更新日期:1998-11-01 00:00:00

  • Calorie sources and recovery from central nervous system ischemia.

    abstract:OBJECTIVES:Glucose is the primary substrate for the energy requirements of the nervous system. Nevertheless, administration of glucose to critically ill patients with central nervous system trauma may have adverse effects on their neurologic recovery. The purpose of this study was to evaluate the effects of other sourc...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Cherian L,Peek K,Robertson CS,Goodman JC,Grossman RG

    更新日期:1994-11-01 00:00:00

  • Urea removal during continuous hemodiafiltration.

    abstract:OBJECTIVE:To compare urea nitrogen removal by continuous hemodiafiltration vs. functional native kidneys in critically ill, septic patients receiving > 2 g of amino acids/kg body weight per day. DESIGN:Prospective, comparative, unblinded study. SETTING:Trauma critical care units of a Level I adult trauma hospital. P...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Frankenfield DC,Reynolds HN,Wiles CE 3rd,Badellino MM,Siegel JH

    更新日期:1994-03-01 00:00:00

  • Foreign-body pneumonitis associated with tracheostomy.

    abstract::Foreign-body aspiration in adults is usually associated with asphyxiation after aspiration of food particles. The present report documents a case of foreign-body aspiration that resulted from poor tracheostomy care in an alcoholic patient, and caused fulminant pneumonitis. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Brischetto MJ,Malouf J,Taylor RW

    更新日期:1984-08-01 00:00:00

  • Predictors of Intubation in Patients With Acute Hypoxemic Respiratory Failure Treated With a Noninvasive Oxygenation Strategy.

    abstract:OBJECTIVES:In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional oxygen therapy. Endotracheal intubation is frequently needed in these patients with a risk of delay, and early predictors of failure may help clinicians ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Frat JP,Ragot S,Coudroy R,Constantin JM,Girault C,Prat G,Boulain T,Demoule A,Ricard JD,Razazi K,Lascarrou JB,Devaquet J,Mira JP,Argaud L,Chakarian JC,Fartoukh M,Nseir S,Mercat A,Brochard L,Robert R,Thille AW,REV

    更新日期:2018-02-01 00:00:00

  • Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction.

    abstract:OBJECTIVES:Myocardial ischemia plays a central role in the development of right ventricular failure after acute pulmonary embolism. This study investigates whether pulmonary mediators act specifically on coronary tone and cardiac contractile function in acute pulmonary microembolization and whether such effects are alt...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Dschietzig T,Laule M,Alexiou K,Schrör K,Baumann G,Stangl K

    更新日期:1998-03-01 00:00:00

  • Association between intensive care unit-acquired dysglycemia and in-hospital mortality.

    abstract:OBJECTIVE:Our objective was to quantify the association between intensive care unit-acquired dysglycemia (hyperglycemia, hypoglycemia, and high variability) and in-hospital mortality. DESIGN:Retrospective, observational study. SETTING:eICU Research Institute participating hospitals with an active tele-ICU program bet...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Badawi O,Waite MD,Fuhrman SA,Zuckerman IH

    更新日期:2012-12-01 00:00:00

  • Acute asphyxia affects neutrophil number and function in the rat.

    abstract:OBJECTIVES:Previous studies in adults suggest that various types of physiologic stress appear to decrease phagocytic cell function. Adherence and chemotaxis of, and phagocytosis and bacterial killing by, neonatal neutrophils are altered compared with adult neutrophil function. Stresses encountered by the fetus and neon...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Beachy JC,Weisman LE

    更新日期:1993-12-01 00:00:00

  • Ventilatory support by tracheal gas insufflation and chest vibration during bronchoconstriction.

    abstract:OBJECTIVE:To determine whether chest wall vibration with tracheal gas insufflation during bronchoconstriction maintains gas exchange at lower airway and intrathoracic pressures than those that occur during positive pressure ventilation. DESIGN:Prospective study. SETTING:Experimental laboratory. SUBJECTS:Six anesthet...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Eckmann DM

    更新日期:2000-07-01 00:00:00

  • Ceramide mediates radiation-induced death of endothelium.

    abstract::The sphingomyelin (SM) pathway is an ubiquitous, evolutionarily conserved signaling system, analogous to conventional systems such as the cAMP and phosphoinositide pathways. Ceramide is generated from SM by the action of a neutral or acid SMase, or by de novo synthesis coordinated through the enzyme ceramide synthase....

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Lin X,Fuks Z,Kolesnick R

    更新日期:2000-04-01 00:00:00

  • Accuracy of intramucosal pH calculated from arterial bicarbonate and the Henderson-Hasselbalch equation: assessment using simulated ischemia.

    abstract:OBJECTIVES:To determine the accuracy of intramucosal pH (pHi) calculated using arterial bicarbonate instead of mucosal capillary bicarbonate in the Henderson-Hasselbalch equation. DESIGN:Simulation of progressive ischemia in mucosal capillary blood. SETTING:University research laboratory. SUBJECTS:Normal human blood...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Morgan TJ,Venkatesh B,Endre ZH

    更新日期:1999-11-01 00:00:00

  • Development and External Validation of an Online Clinical Prediction Model for Augmented Renal Clearance in Adult Mixed Critically Ill Patients: The Augmented Renal Clearance Predictor.

    abstract:OBJECTIVES:Augmented renal clearance might lead to subtherapeutic plasma levels of drugs with predominant renal clearance. Early identification of augmented renal clearance remains challenging for the ICU physician. We developed and validated our augmented renal clearance predictor, a clinical prediction model for augm...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Gijsen M,Huang CY,Flechet M,Van Daele R,Declercq P,Debaveye Y,Meersseman P,Meyfroidt G,Wauters J,Spriet I

    更新日期:2020-12-01 00:00:00

  • Perceptions of a critically ill patient experiencing therapeutic paralysis in an ICU.

    abstract::Prolonged therapeutic paralysis with pancuronium is commonly used in ICUs to facilitate mechanical ventilation of patients with respiratory failure. Sedation is usually given concomitantly to reduce patient discomfort, but assessment of its adequacy is made difficult by the paralysis. We recently cared for a former IC...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Parker MM,Schubert W,Shelhamer JH,Parrillo JE

    更新日期:1984-01-01 00:00:00

  • Cytochrome P450 3A4 activity after surgical stress.

    abstract:OBJECTIVE:To evaluate the relationship between the acute inflammatory response after surgical trauma and changes in hepatic cytochrome P450 3A4 activity, compare changes in cytochrome P450 3A4 activity after procedures with varying degrees of surgical stress, and to explore the time course of any potential drug-cytokin...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Haas CE,Kaufman DC,Jones CE,Burstein AH,Reiss W

    更新日期:2003-05-01 00:00:00

  • Laboratory evaluation and use of the Engström metabolic computer in the clinical setting.

    abstract::Laboratory evaluation and use of the Engström metabolic computer (EMC) in a clinical setting are described. The accuracy of the EMC was tested using an inert gas dilution technique. Mean errors in oxygen consumption (VO2) and CO2 production compared with predicted values were less than 2% of predicted, and generally l...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Regan CJ,Snowdon SL,Campbell IT

    更新日期:1990-08-01 00:00:00

  • Effects of inhaled nitric oxide in a rat model of Pseudomonas aeruginosa pneumonia.

    abstract:OBJECTIVE:Antimicrobial effects of nitric oxide (NO) have been demonstrated in vitro against a variety of infectious pathogens, yet in vivo evidence of a potential therapeutic role for exogenous NO as an antimicrobial agent is limited. Thus, we assessed the effects of inhaled NO on pulmonary infection, leukocyte infilt...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Webert KE,Vanderzwan J,Duggan M,Scott JA,McCormack DG,Lewis JF,Mehta S

    更新日期:2000-07-01 00:00:00

  • Exacerbation with granulocyte colony-stimulating factor of prior acute lung injury during neutropenia recovery in rats.

    abstract:OBJECTIVE:Neutropenia recovery may be associated with an increased risk of respiratory function deterioration. A history of pneumonia complicating neutropenia has been identified as the leading cause of adult respiratory distress syndrome during neutropenia recovery in patients receiving anticancer chemotherapy, sugges...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Azoulay E,Attalah H,Yang K,Herigault S,Jouault H,Brun-Buisson C,Brochard L,Harf A,Schlemmer B,Delclaux C

    更新日期:2003-01-01 00:00:00

  • Antibiotic dosing during sustained low-efficiency dialysis: special considerations in adult critically ill patients.

    abstract:OBJECTIVE:To address issues of antibiotic dosing during sustained low-efficiency dialysis by using available pharmacokinetic data, intermittent and continuous renal replacement therapy dialysis guidelines, and our experience with sustained low-efficiency dialysis. DATA RESOURCES:Published clinical trials, case reports...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Bogard KN,Peterson NT,Plumb TJ,Erwin MW,Fuller PD,Olsen KM

    更新日期:2011-03-01 00:00:00

  • Glycosylated recombinant human tumor necrosis factor binding protein-1 reduces mortality, shock, and production of tumor necrosis factor in rabbit Escherichia coli sepsis.

    abstract:OBJECTIVE:To examine the effect of glycosylated recombinant human tumor necrosis factor binding protein-1 (r-hTNF binding protein-1), the extracellular domain of the tumor necrosis factor receptor p55 produced in mammalian cells, in a rabbit model of circulatory shock due to Escherichia coli. DESIGN:Prospective, rando...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Porat R,Paddock HN,Schwaitzberg SD,Connolly RJ,Wilkens T,Dasch JR,Gascon MP,Hutchison JS,Ythier A,Wallach D

    更新日期:1995-06-01 00:00:00

  • Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis.

    abstract:OBJECTIVES:A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Meyer N,Harhay MO,Small DS,Prescott HC,Bowles KH,Gaieski DF,Mikkelsen ME

    更新日期:2018-03-01 00:00:00

  • A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs.

    abstract:OBJECTIVES:To characterize the landscape of process of care and safety outcomes for tracheal intubation across pediatric intensive care units BACKGROUND:Procedural process of care and safety outcomes of tracheal intubation across pediatric intensive care units has not been described. We hypothesize that the novel Nati...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Nishisaki A,Turner DA,Brown CA 3rd,Walls RM,Nadkarni VM,National Emergency Airway Registry for Children (NEAR4KIDS).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

    更新日期:2013-03-01 00:00:00

  • Hemorrhage and intracranial hypertension in combination increase cerebral production of thromboxane A2.

    abstract:BACKGROUND AND METHODS:To determine the effects of reduced cerebral perfusion pressures produced by hemorrhage alone or in combination with intracranial hypertension on thromboxane A2 (TxA2) production, we undertook a randomized study in 38 anesthetized, mongrel dogs. Animals were subjected to 30 mins of hemorrhagic sh...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Kong DL,Prough DS,Whitley JM,Taylor C,Vines S,Deal DD,DeWitt DS

    更新日期:1991-04-01 00:00:00

  • Evaluation of Institutional Review Board review and informed consent in publications of human research in critical care medicine.

    abstract:OBJECTIVE:To examine the frequency of obtaining Institutional Review Board (IRB) approval and informed consent in critical care research. DATA SOURCES AND DATA EXTRACTION:One-year retrospective review of original critical care research in humans published in seven journals, including American Journal of Respiratory an...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Matot I,Pizov R,Sprung CL

    更新日期:1998-09-01 00:00:00

  • Assessment of limb muscle strength in critically ill patients: a systematic review.

    abstract:OBJECTIVES:To determine the reliability of volitional and nonvolitional limb muscle strength assessment in critically ill patients and to provide guidelines for the implementation of limb muscle strength assessment this population. DATA SOURCES:The following computerized bibliographic databases were searched with MeSH...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Vanpee G,Hermans G,Segers J,Gosselink R

    更新日期:2014-03-01 00:00:00

  • Blood conservation in the intensive care unit.

    abstract:OBJECTIVE:To describe blood conservation strategies for critically ill patients. DATA SOURCES:By using a predefined strategy, we searched the electronic databases of Medline, EMBASE, CINAHL, the Cochrane database of systematic reviews, Cochrane central register of controlled trials, ACP Journal Club, Database of abstr...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Fowler RA,Berenson M

    更新日期:2003-12-01 00:00:00

  • Resolution of pneumothorax in neonates.

    abstract::The resolution time of pneumothorax in neonates requiring tube thoracotomy is not known. We found that 28%, 50%, and 83% of 54 pneumothoraces in 40 neonates resolved within 24, 96, and 168 h of tube thoracotomy, respectively. Pneumothoraces that persisted beyond 168 h were in infants requiring ventilatory assistance. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Bhatia J,Mathew OP

    更新日期:1985-05-01 00:00:00

  • A prospective study of the impact of patient preferences on life-sustaining treatment and hospital cost.

    abstract:OBJECTIVES:Ethicists advise that life-sustaining treatment decisions should be made in keeping with patient preferences. Until recently, there has been little systematic study of the impact of patient preferences on the use of various life-sustaining treatments or the consequent cost of hospital care. This prospective ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Danis M,Mutran E,Garrett JM,Stearns SC,Slifkin RT,Hanson L,Williams JF,Churchill LR

    更新日期:1996-11-01 00:00:00

  • Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study.

    abstract:BACKGROUND:The randomized two-way factorial Dressing Study (1,636 patients, 28,931 catheter days) showed that a chlorhexidine-impregnated sponge decreased the incidence of major catheter-related infections from 1.4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled ch...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验


    authors: Schwebel C,Lucet JC,Vesin A,Arrault X,Calvino-Gunther S,Bouadma L,Timsit JF

    更新日期:2012-01-01 00:00:00