Pro-oxidative, genotoxic and cytotoxic properties of uranyl ions.

Abstract:

:It is demonstrated that hydroxyl radicals and hydrogen peroxide are formed under the action of uranyl ions in aqueous solutions containing no reducing agents. In the presence of uranyl ions, formation of 8-oxoguanine in DNA and long-lived protein radicals are observed in vitro. It is shown that the pro-oxidant properties of uranyl at micromolar concentrations mostly result from the physico-chemical nature of the compound rather than its radioactive decay. Uranyl ions lead to damage in DNA and proteins causing death of HEp-2 cells by necrotic pathway. It is revealed that the uranyl ions enhance radiation-induced oxidative stress and significantly increase a death rate of mice exposed to sublethal doses of X-rays.

journal_name

J Environ Radioact

authors

Garmash SA,Smirnova VS,Karp OE,Usacheva AM,Berezhnov AV,Ivanov VE,Chernikov AV,Bruskov VI,Gudkov SV

doi

10.1016/j.jenvrad.2012.12.009

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

163-70

eissn

0265-931X

issn

1879-1700

pii

S0265-931X(12)00298-6

journal_volume

127

pub_type

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