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Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT.

Abstract：

:To prospectively assess whether periodic chest health surveillance is beneficial for the early detection of bronchiolitis obliterans syndrome (BOS) in children after allo-SCT. Children up to 18 years of age receiving allo-SCT from September 2009 to September 2011 were included. Surveillance consisted of the following: a 7-item respiratory system questionnaire of cough, wheeze and shortness of breath; focused physical examination; and pulmonary function test (PFT) conducted before SCT and at 1, 3, 6, 9, 12, 18 and 24 months after SCT. Thirty-nine patients were enrolled. Five children developed BOS at a median time of 192 days (range 94-282). Positive response comparisons between the BOS group vs the non-BOS group were NS for history questionnaire (P=0.2), heart rate (P=0.3), respiratory rate (P=0.3) and oxygen saturation monitoring (P=0.8). Differences between the two groups for chest auscultation and PFT were statistically significant (P=0.03 and P=0.01, respectively). However, chest auscultation in the BOS group was only positive after BOS diagnosis. PFT reduction was evident in the asymptomatic phase (BOS group 33%; non-BOS group 4.5%, P=0.01). Changes in PFT, but not history/physical examination, allow the early detection of BOS in children after SCT. Our study is limited by the small sample size.

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

Gassas A,Craig-Barnes H,Dell S,Doyle J,Schechter T,Sung L,Egeler M,Palaniyar N

doi

10.1038/bmt.2012.228

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

814-8

issue

6

eissn

0268-3369

issn

1476-5365

pii

bmt2012228

journal_volume

48

pub_type

临床试验,杂志文章

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