Abstract:
:Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with 99mTc-pertechenate and 67Ga in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days +30, +60 and +100 post transplant. Major salivary glands uptake and clearance of 99mTc-pertechenate results did not demonstrate any functional differences between pre- versus post transplant periods. Results of the 67Ga scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day +100 after HPCT.
journal_name
Bone Marrow Transplantjournal_title
Bone marrow transplantationauthors
Coracin FL,Pizzigatti Correa ME,Camargo EE,Peterson DE,de Oliveira Santos A,Vigorito AC,Borba Oliveira G,de Brito Eid KA,Zulli R,De Souza CAdoi
10.1038/sj.bmt.1705351subject
Has Abstractpub_date
2006-05-01 00:00:00pages
955-9issue
10eissn
0268-3369issn
1476-5365pii
1705351journal_volume
37pub_type
杂志文章abstract::Knowledge of the vital role of adenosine deaminase in lymphatic tissues has led to the development of enzyme inhibitors for treatment of lymphoid neoplasms. Deoxycoformycin is a potent ADA inhibitor and has been shown to be active in acute lymphoblastic leukemia at high doses but associated with unpredictable toxicity...
journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bmt.1703125
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,多中心研究
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/bmt.2010.318
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/bmt.2008.348
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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