Pregnancy increases cardiovascular toxicity to cocaine.

Abstract:

:The effects of intravenous cocaine on heart rate and blood pressure were studied in pregnant and oophorectomized nonpregnant ewes. In response to intravenous cocaine doses of 1.0 and 2.0 mg/kg, both pregnant and nonpregnant ewes demonstrated dose-dependent increases in systolic, diastolic, mean arterial, and pulse pressures with return to baseline by 30 to 60 minutes after cocaine administration. However, at both doses (1.0 and 2.0 mg/kg) pregnant ewes demonstrated greater increases in mean arterial pressure (+29.6%, +48.7%) than nonpregnant ewes (+15.6%, +27.7%) during the first 5 minutes after cocaine administration. Thereafter the responses were similar. Thus pregnancy increases the cardiovascular toxicity to cocaine.

journal_name

Am J Obstet Gynecol

authors

Woods JR Jr,Plessinger MA

doi

10.1016/0002-9378(90)90424-6

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

529-33

issue

2

eissn

0002-9378

issn

1097-6868

pii

0002-9378(90)90424-6

journal_volume

162

pub_type

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