Chemokine and chemokine receptors: a comparative study between metastatic and nonmetastatic lymph nodes in breast cancer patients.

abstract：:Patients with hypogammaglobulinemia have recurrent infections and fail to produce protective antibodies. In order for B cells to mature into antibody producing cells, several other cell types such as macrophages and helper T lymphocytes must be involved. They secrete several mediators such as interleukin-1 (IL-1), IL-...

journal_title：European cytokine network

authors： Matheson DS,Hart LJ,Webb BT,Yeoh E,Ling ZD,Junker AK,Tingle AJ

更新日期：1993-07-01 00:00:00

abstract：:The levels of hematopoietic growth factors in patients receiving intensive chemotherapy for malignant disorders were investigated using a variety of approaches. Firstly, serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), G-CSF and Flt3-ligand (Flt3L) were examined in acute leukemia patients wit...

journal_title：European cytokine network

authors： Bruserud O,Foss B,Petersen H

更新日期：2001-04-01 00:00:00

abstract：:Previously, we demonstrated that in vitro treatment of B16F10 murine melanoma cells with interleukin-2 (IL-2) enhances proliferation and metastasis. To further investigate the role played by IL-2 in human melanomas, we studied the expression of IL-2/IL-2 receptor and the effect of IL-2 on the proliferation of melanoma...

journal_title：European cytokine network

authors： García-Vázquez MD,Boyano MD,Cañavate ML,Gardeazabal J,de Galdeano AG,López-Michelena T,Ratón JA,Izu R,Díaz-Ramón JL,Díaz-Pérez JL

更新日期：2000-12-01 00:00:00

abstract：:Tumor growth and invasion are not only the result of malignant transformation but are also dependent on environmental influences from surrounding stroma, extracellular matrix (ECM), local cytokines and systemic hormones. We have investigated the influence of ECM components on three human breast cancer cell lines of di...

journal_title：European cytokine network

authors： Hirtenlehne K,Pec M,Kubista E,Singer CF

更新日期：2002-04-01 00:00:00

abstract：:Since the initial discovery of endothelial progenitor cells (EPC), and their promise in increasing angiogenesis and vasculogenesis, a myriad of papers have highlighted their potential application in experimental and clinical neovascularization and in tissue engineering. However, promising reports are contrasted by oth...

journal_title：European cytokine network

authors： Verloop RE,Koolwijk P,van Zonneveld AJ,van Hinsbergh VW

更新日期：2009-12-01 00:00:00

abstract：:Erythroid nuclear cells have been shown to exert regulatory effects on immunopoiesis. We have reported that some of these influences might be mediated via soluble factors secreted by nuclear erythroid cells. In this report we describe our estimate of the cytokine gene expression in cells isolated from individual eryth...

journal_title：European cytokine network

authors： Sennikov SV,Eremina LV,Samarin DM,Avdeev IV,Kozlov VA

更新日期：1996-12-01 00:00:00

abstract：:Interleukin-9 (IL-9) is a Th2 cytokine whose overexpression is associated with asthma and T cell lymphomagenesis. All the IL-9 activities studied so far are mediated by a specific hemopoietin receptor that activates a Jak/STAT pathway. Searching for genes specifically modulated by IL-9, we observed that the 24P3 mRNA ...

journal_title：European cytokine network

authors： Orabona C,Dumoutier L,Renauld JC

更新日期：2001-03-01 00:00:00

abstract：:The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data. We will also present results of transcriptome analyses, which have highlighted different categories of LIF targets, identified ...

journal_title：European cytokine network

authors： Trouillas M,Saucourt C,Guillotin B,Gauthereau X,Taupin JL,Moreau JF,Boeuf H

更新日期：2009-06-01 00:00:00

abstract：:Multiple studies have shown that the cytokine leukemia inhibitory factor (LIF) is protective of the myocardium in the acute stress of ischemia-reperfusion. All three major intracellular signaling pathways that are activated by LIF in cardiac myocytes have been linked to actions that protect against oxidative stress an...

journal_title：European cytokine network

authors： Zouein FA,Kurdi M,Booz GW

更新日期：2013-03-01 00:00:00

abstract：:In order to examine the specificity of cytokine production during coronary artery bypass graft (CABG) surgery, we serially measured serum levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF), in twenty patients ...

journal_title：European cytokine network

authors： Fujiwara T,Seo N,Murayama T,Hirata S,Kawahito K,Kawakami M

更新日期：1997-03-01 00:00:00

abstract：:A panel of monoclonal antibodies against the soluble IL-6 receptor was used to search for linear epitopes by a Pepscan analysis. Two such epitopes were found and the corresponding peptides were synthesized chemically. The peptides were active to inhibit the IL-6 dependent growth of human multiple myeloma cell line and...

journal_title：European cytokine network

authors： Halimi H,Eisenstein M,Oh JW,Revel M,Chebath J

更新日期：1995-05-01 00:00:00

abstract：:We investigated the serum concentration of the tumour necrosis factor (TNF) family ligands (TNF-alpha and TNF-beta) and their soluble receptors (sTNF-R p55 and sTNF-R p75) in 66 patients with rheumatoid arthritis (RA) and 14 healthy subjects as a control group, using an enzyme-linked immunosorbent assay (ELISA). We ex...

journal_title：European cytokine network

authors： Robak T,Gladalska A,Stepień H

更新日期：1998-06-01 00:00:00

abstract：:Pathogenic mechanisms of brain microvascular injury were studied in an experimental model of cerebral malaria (CM). The lesion, leading to perivascular microhemorrhages, is due to cytokine overproduction, and is associated with the sequestration of macrophages and parasitized erythrocytes in cerebral venules. In this ...

journal_title：European cytokine network

authors： Grau GE,Tacchini-Cottier F,Vesin C,Milon G,Lou JN,Piguet PF,Juillard P

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. METHODS:Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate th...

journal_title：European cytokine network

authors： Bloch F,Charmeteau B,Tovey M,Meritet JF,Desaint C,Launay O,Lebon P

更新日期：2016-09-01 00:00:00

abstract：:No biological parameter is currently available as a specific marker of multiple sclerosis (MS) activity. The aim of this study was to determine whether an evolution of the neurological disability is associated with a modified profile of cytokine production. Clinical disease activity was quantitated by the Kurtzke's ex...

journal_title：European cytokine network

authors： Chofflon M,Juillard C,Juillard P,Gauthier G,Grau GE

更新日期：1992-11-01 00:00:00

abstract：:Measurements of cytokines in cell culture supernatants are widely used to evaluate the immune response. Cytokine levels in secretomes are usually quantified using enzyme-linked immunosorbent assays (ELISA), which have easy, sensitive, specific, rapid, cost-effective, and reproducible protocols. To our knowledge, the s...

journal_title：European cytokine network

authors： G O,R G,N E

更新日期：2014-06-01 00:00:00

abstract：:Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance induction. Tolerance can be mediated by immature and semi-mature DCs expressing low levels of...

journal_title：European cytokine network

authors： Salazar L,Aravena O,Contreras-Levicoy J,Pesce B,Catalan D,Zuniga R,Iruretagoyena M,Kalergis AM,Aguillón JC

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the present study was to investigate the protective effect of β-carotene on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rat. Forty male rats were randomly divided into sham, control (I/R injury) and three β-carotene-pretreated groups. To induce the I/R lesions, the c...

journal_title：European cytokine network

authors： Seyyed Ali M,Neisi N,Darbor M,Hassanpour M,Makvandi M,Solgi G

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Fibroproliferative diseases are common causes of morbidity and mortality. Interleukin-15 (IL-15) is a pleiotropic cytokine with multiple effects on cells of the immune system. Although IL-15 is also expressed in mesenchymal cells, its effects on the development of fibrosis are unknown. We have previously desc...

journal_title：European cytokine network

authors： Wuttge DM,Wildt M,Scheja A,Westergren-Thorsson G

更新日期：2010-09-01 00:00:00

abstract：:Leptin may support the proliferation and hinder the apoptosis of tumor cells. Although leptin expression has been studied in several human tumors, its potential clinical significance remains uncertain in patients with gastric carcinoma. Furthermore, the majority of available findings have been determined from preclini...

journal_title：European cytokine network

authors： Tas F,Karabulut S,Erturk K,Duranyildiz D

更新日期：2018-06-01 00:00:00

abstract：:Recently there has been great interest in the ex vivo expansion and/or purging of human bone marrow cells prior to transplantation in order to obtain a long-lasting restoration of normal hematopoiesis and freedom from relapse. Long-term human bone marrow cultures (LTHBMC) represent the best available approximation of ...

journal_title：European cytokine network

authors： Hassan HT,Biermann B,Zander AR

更新日期：1996-04-01 00:00:00

abstract：:Toll-like receptor (TLR)-4 is an important pattern recognition receptor for Candida albicans, playing a role in innate host defense. We investigated whether there is an association between the TLR4 Asp299Gly or TLR4 Thr399Ile polymorphism, and the occurrence of Candida bloodstream infection. We performed a case-contro...

journal_title：European cytokine network

authors： Van der Graaf CA,Netea MG,Morré SA,Den Heijer M,Verweij PE,Van der Meer JW,Kullberg BJ

更新日期：2006-03-01 00:00:00

abstract：:The aim of the study was to evaluate a possible effect of atorvastatin on renal interleukins (ILs) and prostaglandin E2 (PGE2) in type 1 diabetic rats. Thirty-two male rats from a local Wister-derived strain were included in this prospective study and were classified into four groups. Each group consisted of eight ani...

journal_title：European cytokine network

authors： Maraqa AD

更新日期：2016-11-01 00:00:00

abstract：:Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to investigate whether human endothelial cells (EC) and, by way of comparison, monocytes express MCP-3 and its regulation by pro...

journal_title：European cytokine network

authors： Polentarutti N,Introna M,Sozzani S,Mancinelli R,Mantovani G,Mantovani A

更新日期：1997-09-01 00:00:00

abstract：:Thrombopoietin (TPO), the primary physiological regulator of platelet production, was initially thought to be a lineage-specific factor acting predominantly on megakaryocytopoiesis. Detailed studies establish that this cytokine mediates biological effects on a broad spectrum of hematopoietic progenitor cells, includin...

journal_title：European cytokine network

authors： Wendling F,Vainchenker W

更新日期：1998-09-01 00:00:00

abstract：:In a recent phase I study of inhalative, human natural interleukin-2 (hnIL-2) treatment of pulmonary metastases from previously resected solid tumors (mainly renal carcinoma), we have reported that this treatment resulted in an increased accessory function of alveolar macrophages (AM) [1]. Encouraged by these data, we...

journal_title：European cytokine network

authors： Gaede KI,Zissel G,Schwuléra U,Struff WG,Lorenz J,Aulitzky WE,Zipfel P,Schrum S,Schlaak M,Huber C,Müller-Quernheim J

更新日期：1997-12-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA); h...

journal_title：European cytokine network

authors： Bagheri Y,Babaha F,Falak R,Yazdani R,Azizi G,Sadri M,Abolhassani H,Shekarabi M,Aghamohammadi A

更新日期：2019-09-01 00:00:00

abstract：:A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have prov...

journal_title：European cytokine network

authors： Numerof RP,Dinarello CA,Asadullah K

更新日期：2005-06-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology and several cytokines have been implicated in its pathogenesis and onset. Our objective was to determine the profile of pro and anti-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-23, IFN-, TNF-α, IL-10 in autoimmune hepatitis and their ass...

journal_title：European cytokine network

authors： Chaouali M,Ben Azaiez M,Tezeghdenti A,Yacoubi-Oueslati B,Ghazouani E,Kochkar R

更新日期：2020-12-03 00:00:00

abstract：:Cells sensitive to the cytocidal effect of tumor necrosis factor (TNF) were protected against this effect when growth in the presence of elevated concentrations of tryptophan. Several other indole derivatives also provided protection against TNF cytotoxicity. Most effective were indole itself and its monomethyl deriva...

journal_title：European cytokine network

authors： Yuhas Y,Holtmann H,Shemer-Avni Y,Sarov I,Wallach D

更新日期：1990-03-01 00:00:00