Abstract：
:Patients with hypogammaglobulinemia have recurrent infections and fail to produce protective antibodies. In order for B cells to mature into antibody producing cells, several other cell types such as macrophages and helper T lymphocytes must be involved. They secrete several mediators such as interleukin-1 (IL-1), IL-4, IL-5, IL-6 and interferon-gamma (IFN-gamma). These factors, as recombinant mediators, were tested to assess their ability to correct the immunoglobulin production defect in vitro from pokeweed mitogen (PWM) stimulated cultures of peripheral blood mononuclear cells (PBMC) from 11 patients with hypogammaglobulinemia, and from 10 normals as controls. In general, PBMC from hypogammaglobulinemic patients secreted very little Ig in cultures, and no mediator induced a statistically significant increase in the secretion of any IgG subclass. When assessed on an individual basis, one patient demonstrated a variable pattern of increase in total IgG, IgG1, and IgG3, secretion induced by various mediators, to within one standard deviation of the average secretion of normal PBMC cultured in PWM. In the case of the normal cells, IL-4, IL-6 and IL-1 plus IL-4 were able to increase IgG2 secretion in culture with PWM. No increase in secretion of IgG1, IgG3 and IgG4 or total IgG was demonstrable however. Hence, although there is variability in responsiveness amongst the patients, there does not appear to be any one of these recombinant mediators which will correct the defect.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur Cytokine Netwjournal_title
European cytokine networkauthors
Matheson DS,Hart LJ,Webb BT,Yeoh E,Ling ZD,Junker AK,Tingle AJsubject
Has Abstractpub_date
1993-07-01 00:00:00pages
299-306issue
4eissn
1148-5493issn
1952-4005journal_volume
4pub_type
杂志文章abstract：:Interleukin-6 (IL-6) is used as a growth factor by various tumor cells. It binds to a gp80 specific receptor (IL-6R) and then to a gp130 transducing chain. Both receptor chains are released as soluble functional proteins which circulate in biological fluids. With a view to studying the physiological role of these solu...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Dendritic cells (DC) can be obtained from peripheral blood mononuclear cells (PBMC) by in vitro culture with IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-13 shares properties with IL-4 but its receptor does not involve the common gamma chain present in the receptor complex of IL-4 and other c...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:The aim of the study was to investigate the stimulatory effect of lipopolysaccharide (LPS) on IL-lalpha production in different compartments of term and preterm placental tissues. Homogenates from amnion, chorion, and from fetal (subchorionic placental tissues, maternal decidua, and mid-placental tissue before and aft...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. METHODS:Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate th...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2016.0378
更新日期：2016-09-01 00:00:00
abstract：:In this in vitro study, the influence of serum-concentration, heat inactivation of the serum and the origin of the serum on the responsiveness of cultured human umbilical vein endothelial cells (HUVEC) to immunological challenges was investigated. Addition of human serum during stimulation with 1 microgram/ml bacteria...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Cytokines play an important role in the mechanisms resulting in ultraviolet B-induced immunosuppression. They play a crucial role in the induction of local as well as systemic immunomodulatory events. Ultraviolet B irradiation directly induces the release of cytokines in the epidermis, resulting in complex and diverse...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-01 00:00:00
abstract：:IL-1beta is suspected to be involved in the diarrhea that always accompanies inflammatory bowel disease. This work was aimed at studying the in vivo effect of IL-1beta on the net absorption of fluid, Na(+) and Cl(-) from the rat colon, and at delineating its mechanism of action. Rats were injected i.p. with IL-1beta (...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Leishmania parasites persist in their vertebrate host after the treatment-induced clinical cure and in the asymptomatic infection. They confer resistance to reinfection but represent a risk of occurrence of acute leishmaniosis in immunosuppressed conditions. We examined the effects of prolonged dexamethasone administr...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：UNLABELLED:It is well known that alcoholics are prone to severe infections and that the immune system is impaired by chronic ethanol abuse. The aim of this study is to compare serum inflammatory mediators in response to sepsis in chronic alcoholic with sepsis, non-alcoholics with sepsis and non-infected alcoholics. ME...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0272_1
更新日期：2011-03-01 00:00:00
abstract：:We investigated the serum concentration of the tumour necrosis factor (TNF) family ligands (TNF-alpha and TNF-beta) and their soluble receptors (sTNF-R p55 and sTNF-R p75) in 66 patients with rheumatoid arthritis (RA) and 14 healthy subjects as a control group, using an enzyme-linked immunosorbent assay (ELISA). We ex...
journal_title：European cytokine network
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-06-01 00:00:00
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journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data. We will also present results of transcriptome analyses, which have highlighted different categories of LIF targets, identified ...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2009.0148
更新日期：2009-06-01 00:00:00
abstract：:The effects of various recombinant cytokines i.e. IL-1 alpha, IL-3, IL-4, IL-6, IFN-gamma, TNF-alpha and GM-CSF used either alone or in combination with IL-2, were investigated in this study. First, their capacity to induce killer cells from human PBL was examined by evaluating the degree of killing of human NK-sensit...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
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journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2018.0415
更新日期：2018-09-01 00:00:00
abstract：:We have recently shown that IL-10 represents an efficient stimulus for suppressor of cytokine signalling (SOCS)-3 mRNA expression in human neutrophils and PBMC. Herein, we identify cAMP-elevating agents such as prostaglandin E2 (PGE2), PGE1, forskolin, dibutyryl cAMP (dbcAMP) and cholera toxin as a novel class of agon...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Incubation of murine C2C12 myotubes with tumour necrosis factor-alpha (TNF-alpha) leads to significant changes in protein content and turnover, suggesting that the cytokine exerts direct effects in skeletal muscle. The effects of the cytokine on protein content show a clear bimodal behaviour. At low concentrations (1 ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Erythroid nuclear cells have been shown to exert regulatory effects on immunopoiesis. We have reported that some of these influences might be mediated via soluble factors secreted by nuclear erythroid cells. In this report we describe our estimate of the cytokine gene expression in cells isolated from individual eryth...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:We have previously shown that intrathymic (i.t.) injection of staphylococcal enterotoxin B (SEB) to mice induces both T cell clonal deletion and IL-2-dependent anergy. In the present study, we have used a quantitative RT-PCR to demonstrate that i.t. administration of SEB induced a significant decrease in the levels of...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Anticancer immunotherapy with cytokines is often limited by the occurrence of severe toxicity, particularly in older age groups, which are characterized by a reduced tolerance to antineoplastic therapies. We, and others, have recently demonstrated the efficacy of pulsing procedures with IL-2 as a new therapeutic strat...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:The aim of the study was to evaluate a possible effect of atorvastatin on renal interleukins (ILs) and prostaglandin E2 (PGE2) in type 1 diabetic rats. Thirty-two male rats from a local Wister-derived strain were included in this prospective study and were classified into four groups. Each group consisted of eight ani...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2016.0384
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journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2013.0337
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journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
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journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:Interleukin-7 (IL-7) is a γ-chain cytokine that plays a key role in T cell development and homeostasis by signaling through its cognate receptor, IL-7R or CD127, and inducing T cell survival and/or proliferation. Owing to its ability to promote CD4+ T cell homeostasis, IL-7 has elicited significant interest as a poten...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2010.0205
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journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Lymph nodes (LNs) are among the first sites of tumor metastasis. The expression of chemokines and chemokine receptors in LNs are involved in cancer prognosis and are considered to be good predictors of tumor progression. The main aim of this study was to assess the expression of important, tumor-promoting ch...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2012.0310
更新日期：2012-07-01 00:00:00
abstract：:The purpose of this study was to evaluate T-cell immunity markers using serial post-transplantation monitoring of cytokine-producing cells during the first post-transplant months for the prediction of acute rejection and potentially chronic rejection of kidney allograft. We followed 57 kidney allograft recipients for ...
journal_title：European cytokine network
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:TNF-induced caspase activation is critically involved in both apoptosis and protection from cell necrosis. We have investigated the roles of the p55- and p75-TNF receptors (TNFR1 and TNFR2) in the induction of mouse L-M cell death in the presence of a caspase inhibitor (zVAD-fmk) and a transcription inhibitor (actinom...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:RANK, RANKL, and OPG have well established regulatory effects on bone metabolism. RANK is expressed at very high levels on osteoclastic precursors and on mature osteoclasts, and is required for differentiation and activation of the osteoclast. The ligand, RANKL binds to its receptor RANK to induce bone resorption. RAN...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：2002-04-01 00:00:00
