Abstract：
:Multiple studies have shown that the cytokine leukemia inhibitory factor (LIF) is protective of the myocardium in the acute stress of ischemia-reperfusion. All three major intracellular signaling pathways that are activated by LIF in cardiac myocytes have been linked to actions that protect against oxidative stress and cell death, either at the level of the mitochondrion or via nuclear transcription. In addition, LIF has been shown to contribute to post-myocardial infarction cardiac repair and regeneration, by stimulating the homing of bone marrow-derived cardiac progenitors to the injured myocardium, the differentiation of resident cardiac stem cells into endothelial cells, and neovascularization. Whether LIF offers protection to the heart under chronic stress such as hypertension-induced cardiac remodeling and heart failure is not known. However, mice with cardiac myocyte restricted knockout of STAT3, a principal transcription factor activated by LIF, develop heart failure with age, and cardiac STAT3 levels are reported to be decreased in heart failure patients. In addition, endogenously produced LIF has been implicated in the cholinergic transdiffrentiation that may serve to attenuate sympathetic overdrive in heart failure and in the peri-infarct region of the heart after myocardial infarction. Surprisingly, therapeutic strategies to exploit the beneficial actions of LIF on the injured myocardium have received scant attention. Nor is it established whether the purported so-called adverse effects of LIF observed in isolated cardiac myocytes have physiological relevance in vivo. Here we present an overview of the actions of LIF in the heart with the goal of stimulating further research into the translational potential of this pleiotropic cytokine.
journal_name
Eur Cytokine Netwjournal_title
European cytokine networkauthors
Zouein FA,Kurdi M,Booz GWdoi
10.1684/ecn.2013.0335subject
Has Abstractpub_date
2013-03-01 00:00:00pages
11-9issue
1eissn
1148-5493issn
1952-4005pii
ecn.2013.0335journal_volume
24pub_type
杂志文章,评审abstract：:Interleukin-7 (IL-7) is a γ-chain cytokine that plays a key role in T cell development and homeostasis by signaling through its cognate receptor, IL-7R or CD127, and inducing T cell survival and/or proliferation. Owing to its ability to promote CD4+ T cell homeostasis, IL-7 has elicited significant interest as a poten...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2010.0205
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:Fibroproliferative diseases are common causes of morbidity and mortality. Interleukin-15 (IL-15) is a pleiotropic cytokine with multiple effects on cells of the immune system. Although IL-15 is also expressed in mesenchymal cells, its effects on the development of fibrosis are unknown. We have previously desc...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2010.0202
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Increased vascularity due to neo-angiogenesis is an essential part of airway remodelling. Vascular endothelial growth factor (VEGF), CD34 and von Willebrand's factor (FvW) are known angiogenic markers. Angiogenesis and airway remodelling has been documented in asthma but not in allergic rhinitis. OBJECTIVE:...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:The severity of pulmonary dysfunction and subsequent development of chronic lung disease (CLD) in preterm neonates depends on several factors, among them oxygen administration. The aim of this report is to compare the effects of high-frequency, oscillatory ventilation (HFOV) versus synchronized, intermittent,...
journal_title：European cytokine network
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2005-09-01 00:00:00
abstract：:Measurements of cytokines in cell culture supernatants are widely used to evaluate the immune response. Cytokine levels in secretomes are usually quantified using enzyme-linked immunosorbent assays (ELISA), which have easy, sensitive, specific, rapid, cost-effective, and reproducible protocols. To our knowledge, the s...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2014.0353
更新日期：2014-06-01 00:00:00
abstract：:The clinical evaluation and management of impacted third molars remain challenging. The aim of the present study was to investigate possible associations between follicular tissue cytokines and radiographic manifestations of impacted third molar. The population included 72 patients who underwent surgical extraction of...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0286
更新日期：2011-06-01 00:00:00
abstract：:In this in vitro study, the influence of serum-concentration, heat inactivation of the serum and the origin of the serum on the responsiveness of cultured human umbilical vein endothelial cells (HUVEC) to immunological challenges was investigated. Addition of human serum during stimulation with 1 microgram/ml bacteria...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:We analysed the specific effects of IL-1beta immunoneutralization on the expression of IL-6 in different pure cultures of neurones and glia after both experimental subliminal hypoxia and recovery. Whereas the IL-1beta-deprivation signal induced a decrease in IL-6 expression and release of normoxic neurones, it provoke...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：:Cells sensitive to the cytocidal effect of tumor necrosis factor (TNF) were protected against this effect when growth in the presence of elevated concentrations of tryptophan. Several other indole derivatives also provided protection against TNF cytotoxicity. Most effective were indole itself and its monomethyl deriva...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Recently there has been great interest in the ex vivo expansion and/or purging of human bone marrow cells prior to transplantation in order to obtain a long-lasting restoration of normal hematopoiesis and freedom from relapse. Long-term human bone marrow cultures (LTHBMC) represent the best available approximation of ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:The cytokines tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors p55 and p75, and interleukin 6 (IL-6) are involved in host defense against several microbiological agents, in the process of inflammation and also in body weight regulation. In the present study, we sought to assess the influence of age, gend...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Demyelination is the main pathological feature of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. Tumor necrosis factor-alpha (TNF-alpha) can cause myelin damage and contribute to MS pathogenesis. We measured plasma and cerebrospinal fluid (CSF) levels of TNF-alpha and its solubl...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Chronic fibroproliferative diseases are an important cause of morbidity and mortality in the world. Fibrotic diseases occur in a large variety of vital organs, and the process of fibrosis seems common to all tissues. In all of fibrotic reactions, the underlying cellular and molecular mechanisms involve leukocyte infil...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2008.0127
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Lymph nodes (LNs) are among the first sites of tumor metastasis. The expression of chemokines and chemokine receptors in LNs are involved in cancer prognosis and are considered to be good predictors of tumor progression. The main aim of this study was to assess the expression of important, tumor-promoting ch...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2012.0310
更新日期：2012-07-01 00:00:00
abstract：AIM:The aim of this study was to investigate the relationship between four circulating adipocytokines (apelin, vaspin, visfatin, adiponectin) and markers of insulin sensitivity, in the context of polycystic ovary syndrome (PCOS) in adolescents. SUBJECTS AND METHODS:48, obese, adolescent girls (mean age: 15.6±3.4 years...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0279
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:In vitro studies have shown that oxidized, low density lipoprotein (ox-LDL) stimulates macrophages to release interleukin-6 (IL-6) and interleukin-1β (IL-1β). In this study, we aimed to investigate the correlation between ox-LDL and IL-6 and IL-1β levels in the peripheral circulation of patients with type ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0282
更新日期：2011-06-01 00:00:00
abstract：:Cytokines play an important role in the mechanisms resulting in ultraviolet B-induced immunosuppression. They play a crucial role in the induction of local as well as systemic immunomodulatory events. Ultraviolet B irradiation directly induces the release of cytokines in the epidermis, resulting in complex and diverse...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-01 00:00:00
abstract：:The aim of the study was to evaluate a possible effect of atorvastatin on renal interleukins (ILs) and prostaglandin E2 (PGE2) in type 1 diabetic rats. Thirty-two male rats from a local Wister-derived strain were included in this prospective study and were classified into four groups. Each group consisted of eight ani...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2016.0384
更新日期：2016-11-01 00:00:00
abstract：:Atopic dermatitis (AD) is an inflammatory disorder of the skin characterized by an impaired immune response. Several effector T cell subsets, such as pro-inflammatory cells like Th9, Th17 and Th22 cells, expressing high levels of IL-9, IL-17 and IL-22, together with the anti-inflammatory, immuno-modulating Treg cells ...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2013.0333
更新日期：2013-03-01 00:00:00
abstract：:Apoptosis is a major mechanism for reducing acute inflammation by elimination of unwanted cellular responses causing tissue damage and monocytes (Mo) and macrophages (Mo) play an important role in these processes. Therefore, in the following we summarize how these cells may contribute to regulation of apoptosis of oth...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:Interleukin-1 (IL-1) has been implicated in the pathogenesis of rheumatoid arthritis (RA). IL-1alpha gene polymorphism was analysed for the exon V and promoter region in 51 patients with destructive and 47 with non-destructive RA, as well as in 94 controls. The two biallelic polymorphisms in the promoter region and th...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Specific binding sites for TNF-alpha in mouse and rat brain, spleen and pituitary gland have been visualized and characterized, using quantitative autoradiography. Mouse recombinant 125I-TNF-alpha has been used as a radioligand. In the spleen, TNF-alpha binding sites were highly concentrated in the white pulpe of mous...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. METHODS:We genotyped 123 very low birth weight (VLBW) infants for the tumour necros...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA); h...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2019.0434
更新日期：2019-09-01 00:00:00
abstract：:The effects of IL-3, GM-CSF and IL-5 on the expression of CD23 (Fc epsilon RII), CD25 (IL-2R/p55) and CD4 on an eosinophilic cell line (EoL-3) were investigated by flow cytometry. A separate incubation with IL-3, GM-CSF or IL-5 alone, did not induce the expression of CD23, CD25, or CD4. However, a sequential incubatio...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The immune effector response to Plasmodium falciparum infection involves a finely-tuned interplay between different cell types and cytokines. However, the processes by which they mediate the development of clinical immunity, in areas of different endemicity, are poorly understood. We analyzed circulating levels of pro...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2010.0208
更新日期：2010-12-01 00:00:00
abstract：:The levels of hematopoietic growth factors in patients receiving intensive chemotherapy for malignant disorders were investigated using a variety of approaches. Firstly, serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), G-CSF and Flt3-ligand (Flt3L) were examined in acute leukemia patients wit...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:TNF-alpha and TNF-beta are both involved in inflammation which regulates homeostasis in adults. We examined the mRNA expression of TNF-alpha and TNF-beta in murine embryonal carcinoma (EC) cell lines (PCC3, PCC4, ECA2 and F9) and trophoblast cell line (PL/B6) using a combined system of reverse transcription and polyme...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Patients with hypogammaglobulinemia have recurrent infections and fail to produce protective antibodies. In order for B cells to mature into antibody producing cells, several other cell types such as macrophages and helper T lymphocytes must be involved. They secrete several mediators such as interleukin-1 (IL-1), IL-...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:In the central nervous system, cytokine-primed microglia play a pivotal role in host defence against parasite infections. In this study, the effect of recombinant (r) prolactin (rPRL) and rIFN-gamma on A. castellanii infection in murine microglia was examined. Priming of microglia with rPRL and rIFN-gamma synergistica...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
