Abstract：
:No biological parameter is currently available as a specific marker of multiple sclerosis (MS) activity. The aim of this study was to determine whether an evolution of the neurological disability is associated with a modified profile of cytokine production. Clinical disease activity was quantitated by the Kurtzke's expanded disability status scale (EDSS). Whole blood was stimulated with phytohemagglutinin (PHA) for 2 hours at 37 degrees C and the activated plasma was assayed for Tumor necrosis factor alpha (TNF-alpha) and Interleukin-1 beta (IL-1 beta). Relapsing-remitting MS patients enduring a relapse (RRMS, in relapse) (721 +/- 58 pg/ml, n = 27) and chronic progressive MS (CPMS) patients (516 +/- 33 pg/ml, n = 17) had an higher TNF-alpha production capacity as compared to healthy subjects (143 +/- 25 pg/ml, n = 17), RRMS, stable patients, (123 +/- 11 pg/ml, n = 26) or other neurological diseases (OND) without immunological or inflammatory disease in the peripheral immune compartment (131 +/- 24 pg/ml, n = 14) (t test: p < 0.0001). IL-1 beta production was also significantly higher but to a lesser extent in the same conditions. Concentration of TNF-alpha was also found to be significantly higher in the cerebrospinal fluid (CSF) of CPMS patients (199 +/- 7.8 pg/ml, n = 7, p < 0.0001) but also in RRMS, in relapse (149 +/- 5.7 pg/ml, n = 11, p < 0.05) as compared to RRMS, stable (130 +/- 4.4 pg/ml, n = 7) or OND without inflammatory or immunological disease of the central nervous system (CNS) (142 +/- 6.2 pg/ml, n = 8).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur Cytokine Netwjournal_title
European cytokine networkauthors
Chofflon M,Juillard C,Juillard P,Gauthier G,Grau GEsubject
Has Abstractpub_date
1992-11-01 00:00:00pages
523-31issue
6eissn
1148-5493issn
1952-4005journal_volume
3pub_type
杂志文章abstract：:A panel of monoclonal antibodies against the soluble IL-6 receptor was used to search for linear epitopes by a Pepscan analysis. Two such epitopes were found and the corresponding peptides were synthesized chemically. The peptides were active to inhibit the IL-6 dependent growth of human multiple myeloma cell line and...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND/AIM:The aim of the present study was to investigate the protective effect of β-carotene on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rat. Forty male rats were randomly divided into sham, control (I/R injury) and three β-carotene-pretreated groups. To induce the I/R lesions, the c...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2012.0317
更新日期：2012-10-01 00:00:00
abstract：:Cytokines play an important role in the regulation of homeostasis and inflammation. A de-regulated cytokine function can subsequently promote chronic inflammation. This is supported by clinical evidence showing the beneficial effect of inhibiting TNF-alpha through injection of antibodies and soluble receptor in disord...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:The effects of statins (3-hydroxy-3-methylglutaryl coenzyme A reductase-HMGR-inhibitors) on the inflammatory response remain unclear. HMGR is implicated in the mevalonate pathway, directly upstream of cholesterol biosynthesis. We studied the impairment by this pathway of cytokine production by peripheral bloo...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2009.0162
更新日期：2009-09-01 00:00:00
abstract：:The effects of IL-3, GM-CSF and IL-5 on the expression of CD23 (Fc epsilon RII), CD25 (IL-2R/p55) and CD4 on an eosinophilic cell line (EoL-3) were investigated by flow cytometry. A separate incubation with IL-3, GM-CSF or IL-5 alone, did not induce the expression of CD23, CD25, or CD4. However, a sequential incubatio...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Atopic dermatitis (AD) is an inflammatory disorder of the skin characterized by an impaired immune response. Several effector T cell subsets, such as pro-inflammatory cells like Th9, Th17 and Th22 cells, expressing high levels of IL-9, IL-17 and IL-22, together with the anti-inflammatory, immuno-modulating Treg cells ...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2013.0333
更新日期：2013-03-01 00:00:00
abstract：:Adoptive immunotherapy with immune effector cells has proved to be potent for treatment of tumors, however neither the attendant criteria for potential clinical efficacy of the injected cells, nor the method to prepare these cells are presently well established. Our procedure of collecting lymphocytes from biological ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Measurements of cytokines in cell culture supernatants are widely used to evaluate the immune response. Cytokine levels in secretomes are usually quantified using enzyme-linked immunosorbent assays (ELISA), which have easy, sensitive, specific, rapid, cost-effective, and reproducible protocols. To our knowledge, the s...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2014.0353
更新日期：2014-06-01 00:00:00
abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine which regulates the immune response, the acute-phase response, hematopoiesis and body energy balance. Genetic polymorphism at -174 position of IL-6 promoter has been recently reported to be linked with insulin resistance, however, with conflicting results. The C allele at...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：AIM:The aim of this study was to investigate the relationship between four circulating adipocytokines (apelin, vaspin, visfatin, adiponectin) and markers of insulin sensitivity, in the context of polycystic ovary syndrome (PCOS) in adolescents. SUBJECTS AND METHODS:48, obese, adolescent girls (mean age: 15.6±3.4 years...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0279
更新日期：2011-03-01 00:00:00
abstract：:In the central nervous system, cytokine-primed microglia play a pivotal role in host defence against parasite infections. In this study, the effect of recombinant (r) prolactin (rPRL) and rIFN-gamma on A. castellanii infection in murine microglia was examined. Priming of microglia with rPRL and rIFN-gamma synergistica...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:TNF-alpha and TNF-beta are both involved in inflammation which regulates homeostasis in adults. We examined the mRNA expression of TNF-alpha and TNF-beta in murine embryonal carcinoma (EC) cell lines (PCC3, PCC4, ECA2 and F9) and trophoblast cell line (PL/B6) using a combined system of reverse transcription and polyme...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Incubation of murine C2C12 myotubes with tumour necrosis factor-alpha (TNF-alpha) leads to significant changes in protein content and turnover, suggesting that the cytokine exerts direct effects in skeletal muscle. The effects of the cytokine on protein content show a clear bimodal behaviour. At low concentrations (1 ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:In the last few years, some surface molecules which preferentially associate with human Th1 or Th2 cells have been described. Th1-related molecules include CD26, membrane IFN-gamma, LAG-3, CCR5 and CXCR3, whereas CD62L, CD30, CCR3, CCR4, CCR8, and in a certain way even CXCR4, preferentially associate with human Th2 ce...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:Toll-like receptor (TLR)-4 is an important pattern recognition receptor for Candida albicans, playing a role in innate host defense. We investigated whether there is an association between the TLR4 Asp299Gly or TLR4 Thr399Ile polymorphism, and the occurrence of Candida bloodstream infection. We performed a case-contro...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:TNF-induced caspase activation is critically involved in both apoptosis and protection from cell necrosis. We have investigated the roles of the p55- and p75-TNF receptors (TNFR1 and TNFR2) in the induction of mouse L-M cell death in the presence of a caspase inhibitor (zVAD-fmk) and a transcription inhibitor (actinom...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:Erythroid nuclear cells have been shown to exert regulatory effects on immunopoiesis. We have reported that some of these influences might be mediated via soluble factors secreted by nuclear erythroid cells. In this report we describe our estimate of the cytokine gene expression in cells isolated from individual eryth...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：INTRODUCTION:Open, right-sided, transthoracic esophagectomy with one-lung ventilation (OLV) triggers a massive inflammatory reaction. The influence of the OLV on the inflammatory cascade is unclear. Data on the inflammatory response in the ventilated left and collapsed right lung, respectively, are scarce. The aim of t...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2009.0180
更新日期：2010-03-01 00:00:00
abstract：:Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance induction. Tolerance can be mediated by immature and semi-mature DCs expressing low levels of...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2007.0089
更新日期：2007-06-01 00:00:00
abstract：:Interaction between the CD40 ligand and its cognate receptor is known to affect various aspects of B-cell biology. Less is known about the biological consequences of B-cell signaling through tumor necrosis factor alpha (TNF-alpha) and its two receptors. We have used Ramos germinal center (GC)-derived Burkitt's lymphom...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. METHODS:We genotyped 123 very low birth weight (VLBW) infants for the tumour necros...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Pulmonary artery hypertension is a syndrome that shows similar clinical and pathophysiological features characterized by elevated pulmonary arterial pressure and resistance. There have been a series of hypotheses trying to describe the development of pulmonary artery hypertension; however, none of them perfectly expla...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2016.0386
更新日期：2017-03-01 00:00:00
abstract：:To determine the role of CD14 in lipopolysaccharide (LPS)-induced release of chemokines, 16 humans were injected with LPS (4 ng/kg) preceded (-2 h) by intravenous IC14, an anti-human CD14 monoclonal antibody, or placebo. LPS elicited increases in interleukin (IL)-8 concentrations in plasma and in lysates of red blood ...
journal_title：European cytokine network
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:The severity of pulmonary dysfunction and subsequent development of chronic lung disease (CLD) in preterm neonates depends on several factors, among them oxygen administration. The aim of this report is to compare the effects of high-frequency, oscillatory ventilation (HFOV) versus synchronized, intermittent,...
journal_title：European cytokine network
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2005-09-01 00:00:00
abstract：:The objective of the current study was to investigate the protective effects of hesperidin against oxidative stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into four equal groups (Control, TCDD, hesperidin and TCDD+hes...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2013.0337
更新日期：2013-06-01 00:00:00
abstract：:Chronic fibroproliferative diseases are an important cause of morbidity and mortality in the world. Fibrotic diseases occur in a large variety of vital organs, and the process of fibrosis seems common to all tissues. In all of fibrotic reactions, the underlying cellular and molecular mechanisms involve leukocyte infil...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2008.0127
更新日期：2008-06-01 00:00:00
abstract：:Interferon-gamma (IFN-gamma) is a lymphokine produced by activated T lymphocytes and NK cells, that plays an important role in host defense mechanisms by exerting pleiotropic activities on a wide range of cell types. Cellular responses to IFN-gamma are mediated by its heterodimeric cell surface receptor (IFN-gammaR), ...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：2001-03-01 00:00:00
abstract：:The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data. We will also present results of transcriptome analyses, which have highlighted different categories of LIF targets, identified ...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2009.0148
更新日期：2009-06-01 00:00:00
abstract：:Leptin may support the proliferation and hinder the apoptosis of tumor cells. Although leptin expression has been studied in several human tumors, its potential clinical significance remains uncertain in patients with gastric carcinoma. Furthermore, the majority of available findings have been determined from preclini...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2018.0408
更新日期：2018-06-01 00:00:00
abstract：:Thrombopoietin (TPO), the primary physiological regulator of platelet production, was initially thought to be a lineage-specific factor acting predominantly on megakaryocytopoiesis. Detailed studies establish that this cytokine mediates biological effects on a broad spectrum of hematopoietic progenitor cells, includin...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
