GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.

Abstract:

:β1-adrenergic receptors (ADRB1) and Gαs proteins (GNAS) play important roles in the regulation of cardiac function. The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 61 heart failure patients completed a 6-month exercise-training programme. Left ventricular ejection fraction (LVEF), mitral inflow velocities (deceleration time, and E/A ratio) and exercise tolerance (METs) were assessed at baseline and following exercise training. There were no associations between the studied variants and LVEF or E/A ratio measured at baseline and after exercise training. Deceleration time of early mitral flow was higher at baseline in GNAS -1211G allele carriers compared with -1211A allele homozygotes (P<0.05). Exercise training attenuated deceleration time in -1211G allele carriers (P<0.05) but not in -1211A allele homozygotes. Moreover, ADRB1 389Gly homozygotes had a greater training-induced increase in exercise tolerance than 389Arg homozygotes (P=0.04). This study shows that the functional GNAS -1121 G/A polymorphism is associated with diastolic function at baseline and in response to exercise training in heart failure patients. Furthermore, our data suggest that ADRB1 Arg389Gly polymorphism may influence exercise tolerance.

journal_name

Int J Sports Med

authors

Alves AJ,Goldhammer E,Ribeiro F,Eynon N,Ben-Zaken Cohen S,Duarte JA,Viana JL,Sagiv M,Oliveira J

doi

10.1055/s-0032-1316365

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

274-80

issue

3

eissn

0172-4622

issn

1439-3964

journal_volume

34

pub_type

临床试验,杂志文章
  • Game Running Performance and Fitness in Women's Futsal.

    abstract::The study aimed to verify possible associations between game-play running performance and outcomes derived from fitness (running) tests in female futsal players. Sixteen women professional elite futsal players from a 1st division league team (19.2±2 years-old, 4.3±2.1 years of experience) participated. Firstly, a grad...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/a-1202-1496

    authors: Palucci Vieira LH,Arins FB,Guglielmo LGA,de Lucas RD,Carminatti LJ,Santiago PRP

    更新日期:2021-01-01 00:00:00

  • Relationships between perceived exertion and physiological variables during swimming.

    abstract::The relationships between perceived exertion and the physiological variables oxygen uptake (VO2), heart rate (HR) and blood lactate concentration (HLa) were studied in tethered swimming. Seven male and ten female subjects swam at five submaximal intensities. The degree of perceived exertion was measured both on the ca...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2007-973025

    authors: Ueda T,Kurokawa T

    更新日期:1995-08-01 00:00:00

  • CNTFR Genotype and Sprint/power Performance: Case-control Association and Functional Studies.

    abstract::The aim of this study was to investigate whether rs41274853 in the 3'-untranslated region of the ciliary neurotrophic factor receptor gene (CNTFR) is associated with elite sprint/power athletic status and assess its functional significance. A total of 211 Japanese sprint/power track and field athletes (62 internationa...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0035-1564257

    authors: Miyamoto-Mikami E,Fujita Y,Murakami H,Ito M,Miyachi M,Kawahara T,Fuku N

    更新日期:2016-05-01 00:00:00

  • Qt dispersion in soccer players during exercise testing.

    abstract::Screening for cardiac health should involve relevant parameters or indices that are easy and inexpensive to obtain. Various cardiac adaptation mechanisms develop during regular exercise that are affected by many factors, and these are reflected on a surface electrocardiogram. QT dispersion has been considered a surrog...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2003-45256

    authors: Kasikcioglu E,Kayserilioglu A,Yildiz S,Akhan H,Cuhadaroglu C

    更新日期:2004-04-01 00:00:00

  • Bone mineral density in Hispanic women: role of aerobic capacity, fat-free mass, and adiposity.

    abstract::Understanding the etiology of factors influencing bone mineral density (BMD) in Hispanic women for the prevention of osteoporosis was the aim of this investigation. Whole body BMD (WBBMD) of 39 Hispanic, premenopausal women aged 22 - 51 years was measured using dual-energy X-ray absorptiometry (DXA). Maximal aerobic c...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2004-815839

    authors: Afghani A,Abbott AV,Wiswell RA,Jaque SV,Gleckner C,Schroeder ET,Johnson CA

    更新日期:2004-07-01 00:00:00

  • Glucose response after a ten-week training in swimming.

    abstract::The present study investigated the difference in blood glucose concentration (Glu) response during an incremental swimming test before and after a ten-week training period and verified whether blood glucose threshold (GT) could be determined in competitive swimmers. 7 elite male university swimmers participated in thi...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0031-1279778

    authors: Sengoku Y,Nakamura K,Takeda T,Nabekura Y,Tsubakimoto S

    更新日期:2011-11-01 00:00:00

  • Basic neurophysiology of motor skills in sport: a review.

    abstract::The broad spectrum of skills in sport, with their high demands on strength, speed, endurance, coordination, and flexibility, represents one of the greatest challenges to human motor performances. However, the basic neurophysiological mechanisms in sport are not principally different from those in everyday motor acts. ...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1025805

    authors: Henatsch HD,Langer HH

    更新日期:1985-02-01 00:00:00

  • A new rating scale of perceived exertion based on subjective estimation of exhaustion time: a preliminary study.

    abstract::Perceived exertion has been investigated during incremental exercise to exhaustion with athletes, according to the 6-20 scale proposed by Borg (RPE, 1970) and a new scale based on the estimation of exhaustion time (t(lim)) (Estimated Time Limit or ETL, from 1 to 20; ETL= 21 - 2 n, with n = log2t(lim)). ETL increased l...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2007-971089

    authors: Garcin M,Vandewalle H,Monod H

    更新日期:1999-01-01 00:00:00

  • 12 weeks of simulated barefoot running changes foot-strike patterns in female runners.

    abstract::To investigate the effect of a transition program of simulated barefoot running (SBR) on running kinematics and foot-strike patterns, female recreational athletes (n=9, age 29 ± 3 yrs) without SBR experience gradually increased running distance in Vibram FiveFingers SBR footwear over 12 weeks. Matched controls (n=10, ...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0033-1353215

    authors: McCarthy C,Fleming N,Donne B,Blanksby B

    更新日期:2014-05-01 00:00:00

  • A wearable respiratory monitoring device--the between-days variability of calibration.

    abstract::The between-days variability in ascertained gain factors for calibration of a wearable respiratory inductance plethysmograph (RIP) and validity thereof for the repeated use during exercise were examined. Consecutive 5-min periods of standing still, slow running at 8 km·h(-1), fast running at 14 km·h(-1) (male) or 12 k...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0034-1385864

    authors: Heyde C,Mahler H,Roecker K,Gollhofer A

    更新日期:2015-01-01 00:00:00

  • Skeletal muscle characteristics of sprint cyclists and nonathletes.

    abstract::Muscle fiber distribution and muscle enzyme activity (m. vastus lat.) were investigated in 10 elite sprint cyclists and 12 nonathletes. The ratio of fast to slow muscle fibers was 2:3 in cyclists and 3:2 in nonathletes. The mean diameter of each muscle fiber type was significantly higher in the athletes. The mean enzy...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2008-1025778

    authors: Macková E,Melichna J,Havlícková L,Placheta Z,Blahová D,Semiginovský B

    更新日期:1986-10-01 00:00:00

  • Responses of serum androgenic-anabolic and catabolic hormones to prolonged strength training.

    abstract::Endocrine and neuromuscular effects of prolonged strength training were investigated in 21 strength-trained male subjects during the course of a 24-week progressive strength training and during a subsequent detraining period of 12 weeks. Maximal isometric leg extensor force increased by 19% (P less than 0.001) during ...

    journal_title:International journal of sports medicine

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-1025011

    authors: Alén M,Pakarinen A,Häkkinen K,Komi PV

    更新日期:1988-06-01 00:00:00

  • Physical performance and metabolic recovery among lean, healthy men following a prolonged energy deficit.

    abstract::Previous studies have demonstrated that full recovery from weight loss may take months or years. The present investigation examined short-term recovery (5 wks "post") of physical performance (muscular strength, muscular power, vertical jump), body composition, metabolic hormones (testosterone, luteinizing hormone, sex...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2007-972640

    authors: Nindl BC,Friedl KE,Frykman PN,Marchitelli LJ,Shippee RL,Patton JF

    更新日期:1997-07-01 00:00:00

  • A new index of coordination for the crawl: description and usefulness.

    abstract::This study analyzes stroke phases and arm and leg coordination during front crawl swimming as a function of swim velocity and performance level. Forty-three swimmers constituted three groups based on performance level. All swam at three different swim velocities, corresponding to the paces appropriate for the 800 m, 1...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2000-8855

    authors: Chollet D,Chalies S,Chatard JC

    更新日期:2000-01-01 00:00:00

  • Influence of varied tempo music on wheelchair mechanical efficiency following 3-week practice.

    abstract::The purpose of this study was to analyse adaptations in propulsion technique and gross efficiency in novice able-bodied subjects during the initial phase of learning hand-rim wheelchair propulsion to music. 22 able bodied participants performed wheelchair propulsion (1.1 m·s(-1)) followed by a VO(2) peak test on a whe...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0030-1268439

    authors: Goosey-Tolfrey VL,West M,Lenton JP,Tolfrey K

    更新日期:2011-02-01 00:00:00

  • Energy cost of riding bicycles with shock absorption systems on a flat surface.

    abstract::Bike shock absorption systems reduce the energy variation induced by terrain irregularities, leading to a greater comfort. However, they may also induce an increase in energy expenditure for the rider. More specifically, cross-country racers claim that rear shock absorption systems generate significant energy loss. Th...

    journal_title:International journal of sports medicine

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2001-16242

    authors: Nielens H,Lejeune TM

    更新日期:2001-08-01 00:00:00

  • Effect of sex on wasted left ventricular effort following maximal exercise.

    abstract::Wasted left ventricular effort (∆Ew) refers to work required of the left ventricle to eject blood that does not result in increased stroke volume and is related to left ventricular hypertrophy. Literature shows that men and women have differing ventricular and vascular responses to and following exercise. Our purpose ...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0032-1329990

    authors: Lane AD,Ranadive SM,Yan H,Kappus RM,Cook MD,Sun P,Woods JA,Wilund K,Fernhall B

    更新日期:2013-09-01 00:00:00

  • Effects of local vibration on bone loss in -tail-suspended rats.

    abstract::We investigated the effects of vibration (35 Hz, 45 Hz and 55 Hz) as countermeasure locally applied to unloading hind limbs on bone, muscle and Achilles tendon. 40 female Sprague Dawley rats were divided into 5 groups (n=8, each): tail-suspension (TS), TS plus 35 Hz/0.3 g vibration (TSV35), TS plus 45 Hz/0.3 g vibrati...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0033-1358468

    authors: Sun LW,Luan HQ,Huang YF,Wang Y,Fan YB

    更新日期:2014-06-01 00:00:00

  • Acute cardiorespiratory and metabolic responses during resistance exercise in the lactate threshold intensity.

    abstract::The aims were both to determine lactate and ventilatory threshold during incremental resistance training and to analyze the acute cardiorespiratory and metabolic responses during constant-load resistance exercise at lactate threshold (LT) intensity. Ten healthy men performed 2 protocols on leg press machine. The incre...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0031-1286315

    authors: de Sousa NM,Magosso RF,Pereira GB,Souza MV,Vieira A,Marine DA,Perez SE,Baldissera V

    更新日期:2012-02-01 00:00:00

  • Plantar flexion torque as a function of time of day.

    abstract::The possible peripheral and/or central origin in the mechanisms responsible for day-time fluctuation in maximal torque of the triceps surae muscle were investigated with a special emphasis on antagonist muscle coactivation. Eleven healthy male subjects (physical education students) took part in this investigation. The...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2005-837618

    authors: Guette M,Gondin J,Martin A,Pérot C,Van Hoecke J

    更新日期:2006-03-01 00:00:00

  • Serum zinc in athletes in training.

    abstract::Serum zinc was determined using atomic absorption spectrophotometry in 160 training athletes (57 females) in the morning at rest. In 23.3% of the male and 43% of the female athletes, serum Zn was lower than the limit accepted for the normal range (75 microgram/dl or 11.5 mumol/l). The average serum Zn (96.7 +/- 12.6 m...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034599

    authors: Haralambie G

    更新日期:1981-08-01 00:00:00

  • Nandrolone inhibits VEGF mRNA in rat muscle.

    abstract::Vascular endothelial growth factor (VEGF) is a key compound for induction of angiogenesis in both physiological and pathological conditions. The aim of this study was to investigate the effect of androgenic-anabolic steroids (AAS) administration on VEGF mRNA expression in the rat soleus muscle after jumping training. ...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0029-1234058

    authors: Paschoal M,de Cássia Marqueti R,Perez S,Selistre-de-Araujo HS

    更新日期:2009-11-01 00:00:00

  • Aerobic fitness influences the response of maximal oxygen uptake and lactate threshold in acute hypobaric hypoxia.

    abstract::We studied 12 highly trained athletes, 6 male ice-hockey players and 6 cross-country skiers (2 females, 4 males). All of them participated in a maximal electrically braked bicycle ergometer test in a hypobaric chamber at the simulated altitude of 3000m (520 mmHg) and in normobaric conditions two days apart in random o...

    journal_title:International journal of sports medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-972968

    authors: Koistinen P,Takala T,Martikkala V,Leppäluoto J

    更新日期:1995-02-01 00:00:00

  • Effects of a long-term training program of increasing intensity on the immune function of indoor Olympic cyclists.

    abstract::We have studied, on blood samples, the level of immunocompetence (concentration of immune cells, phagocytic process of polymorphonuclear neutrophils, proliferative response of lymphocytes to mitogens), the ascorbic acid content of such immunocompetent cells and the "stress hormone" status (cortisol, ACTH and beta-endo...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2007-972900

    authors: Ferrández MD,Maynar M,De la Fuente M

    更新日期:1996-11-01 00:00:00

  • Changes of white blood cell count during prolonged exercise.

    abstract::Leukocytosis was postulated to accompany short- and medium-length exercise; in this report, we have studied the changes in leukocyte count during and following prolonged exercise. White blood cell (WBC) counts were obtained in 15 endurance-trained subjects before, during, and at a recovery period after an ultralong ex...

    journal_title:International journal of sports medicine

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2008-1025664

    authors: Galun E,Burstein R,Assia E,Tur-Kaspa I,Rosenblum J,Epstein Y

    更新日期:1987-08-01 00:00:00

  • Comparison of arterial and venous blood lactate kinetics after short exercise.

    abstract::Seventeen healthy male volunteers participated in this study designed to compare arterial with both arterialized venous and venous lactate kinetics after short exercise. Blood samples drawn before, during, and after bicycle exercise were analyzed continuously for lactate. A mathematical function incorporating two expo...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2007-1024867

    authors: Oyono-Enguelle S,Gartner M,Marbach J,Heitz A,Ott C,Freund H

    更新日期:1989-02-01 00:00:00

  • Exercise Training Plus Sildenafil Treatment: Role on Autonomic and Inflammatory Markers.

    abstract::The current study aimed to determine the effects of sildenafil-associated aerobic exercise training (ET) on the physical performance, hemodynamic, autonomic and inflammatory parameters of rats. Male Wistar rats were randomly assigned to: sedentary rats placebo-treated (SP); sedentary rats sildenafil-treated (SS); trai...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/a-0633-9132

    authors: Leoni LAB,Fukushima AR,Rocha LY,Feriani DJ,Júnior HJC,Gambassi BB,Mostarda CT,Maifrino LBM,Rodrigues B

    更新日期:2018-10-01 00:00:00

  • Caffeine and taurine enhance endurance performance.

    abstract::Caffeine enhances endurance performance; however, its effect on accumulated lactate remains unclear. Conversely, taurine, which also enhances endurance performance, decreases accumulated lactate. In this study, the effect of combination of caffeine and taurine on endurance performance was assessed. Mice ran on a tread...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-0028-1104574

    authors: Imagawa TF,Hirano I,Utsuki K,Horie M,Naka A,Matsumoto K,Imagawa S

    更新日期:2009-07-01 00:00:00

  • The effect of marathon cycling on renal function.

    abstract::The stress of strenuous long-term exercise may alter renal function. Whether this is also true for marathon cycling is unknown so far. The purpose of this study was to evaluate renal function following competitive marathon cycling. We investigated 38-male, well-trained recreational cyclists credibly not taking any kin...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2003-38205

    authors: Neumayr G,Pfister R,Hoertnagl H,Mitterbauer G,Getzner W,Ulmer H,Gaenzer H,Joannidis M

    更新日期:2003-02-01 00:00:00

  • Hematological comparison of iron status in trained top-level soccer players and control subjects.

    abstract::The aim of the present study was to compare the iron status of 19 top-level soccer players and 20 male control subjects. All players showed no impairment of physical performance and had a dietary iron intake adequate to cover the iron losses. Serum iron, TIBC, % transferrin saturation and serum ferritin were not signi...

    journal_title:International journal of sports medicine

    pub_type: 杂志文章

    doi:10.1055/s-2007-1024712

    authors: Resina A,Gatteschi L,Giamberardino MA,Imreh F,Rubenni MG,Vecchiet L

    更新日期:1991-10-01 00:00:00