The antemortem neurobehavior in fatal paramethoxymethamphetamine usage.

Abstract:

:Paramethoxymethamphetamine (PMMA) is an emerging and prevalent psychoactive drug with a structure analogous to amphetamine and related psychostimulants. However, the neurobehavioral effect is only studied in experimental animals and is barely mentioned in human. The authors report the antemortem neurobehavioral manifestations in 8 patients with PMMA use. There were 2 different antemortem presentations. The first group of patients showed delirium, hypertalkativity, and incoherence speech and then turned into convulsion and death. They did not exhibit the typical hyperdopaminergic movement disorder. The second group of patients gradually fell asleep and then suffered respiratory or cardiovascular collapse. The heart blood PMMA level was higher in the second group than in the first group of patients. Forensic autopsy showed variable findings, ranging from no remarkable change to significant pathological damage similar to serotonin syndrome in both groups of patients. PMMA seems to enhance serotoninergism than dopaminergism, and exerts a concentration-related dual effect on human.

journal_name

Subst Abus

journal_title

Substance abuse

authors

Chen WH,Chui C,Yin HL

doi

10.1080/08897077.2011.638736

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

366-72

issue

4

eissn

0889-7077

issn

1547-0164

journal_volume

33

pub_type

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