Abstract：
:Oxybutynin chloride is primarily indicated for the treatment of overactive bladder syndrome (OAB). It remains the most widely prescribed compound for OAB in the world. OAB is defined as the presence of urinary urgency, usually accompanied by daytime urinary frequency and nocturia, with or without urgency urinary incontinence, in the absence of infection or other identifiable etiology. This is a significant problem for men and women said to affect over 33 million adults in the USA, with the prevalence increasing with age. These symptoms can alter quality of life, with both physical and psychological impairment, as well as cause significant financial burden including the cost of sanitary supplies and decreased work productivity. Both pharmacological and non-pharmacological methods may be employed to aid in the treatment of OAB. The mainstay of treatment for OAB relies on pharmacological management, most specifically treatment with antimuscarinic medications. These medications are thought to prevent involuntary bladder contractions and/or urgency by inhibiting the muscarinic receptors within the urothelium and detrusor muscle. Currently, there are six different medications approved by the US Food and Drug Administration (FDA) for the treatment of OAB, with more than nine formulations including immediate- and extended-release tablets, transdermal patch and gel, vaginal ring, and suppository. This review will focus specifically on oxybutynin chloride, which has been used to treat OAB for four decades in numerous formulations.
journal_name
Int Urogynecol Jjournal_title
International urogynecology journalauthors
Jirschele K,Sand PKdoi
10.1007/s00192-012-1915-8subject
Has Abstractpub_date
2013-04-01 00:00:00pages
595-604issue
4eissn
0937-3462issn
1433-3023journal_volume
24pub_type
杂志文章,评审abstract：:The number of women suffering from pelvic floor disorders (PFD) is likely to grow significantly in the coming years with a growing older population. There is an urgent need to investigate factors contributing to the development of PFD and develop preventative strategies. We have reviewed the literature and analyzed re...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-011-1530-0
更新日期：2012-02-01 00:00:00
abstract：:Bladder dysfunction is a very prevalent disorder and often refractory to behavioral and pharmacologic therapies. Sacral nerve stimulation is an approved method of managing urinary urgency, frequency, urge incontinence, and urinary retention. Alternative approaches to neuromodulation are being developed. The purpose of...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-010-1282-2
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESES:There is no consensus regarding pregnancy after mid-urethral sling (MUS) operation, and some clinicians recommend postponing the MUS operation if a woman considers further pregnancies or routinely suggest cesarean section as the delivery method after MUS operations. Our primary aim was to as...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-020-04497-w
更新日期：2021-01-01 00:00:00
abstract：:We report a case of vesicocervical fistula following intrauterine device (Lippes loop) erosion following insertion 45 years ago. Vesicocervical fistula was suspected clinically. Ultrasound and magnetic resonance imaging confirmed the presence of a foreign body. Biopsy and magnetic resonance imaging were performed to r...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-015-2667-z
更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:No previous studies have investigated the efficacy of mirabegron 50 mg as the first-line therapy in OAB patients. Hence, the primary objective of this study was to evaluate the efficacy of mirabegron in treatment-naive patients in comparison with those who had discontinued antimuscarinic the...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-016-3219-x
更新日期：2017-07-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Surgical treatment of stress urinary incontinence in women using a synthetic midurethral tape has become a standard procedure. One of the complications observed postoperatively are lower urinary tract symptoms (LUTS). The aim was to analyze the role of introital ultrasound in the identificat...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3837-6
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:We present a video reviewing the key steps involved in safe anterior cul-de-sac entry during vaginal hysterectomy, including tips for troubleshooting difficult cases such as: uterine procidentia, cervical elongation, and multiple prior cesarean sections. METHODS:Anterior cul-de-sac entry is...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-018-3646-y
更新日期：2018-08-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The effect of incontinence pessaries for urine incontinence (UI) has previously been described in studies from high-income countries, where they have been documented to reduce urinary leakage significantly. However, there is a profound literature gap in these data in low- and middle-income c...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-019-03980-3
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:No clear consensus exists on the selection of patients with pelvic organ prolapse (POP) for surgery. There is a need to preoperatively identify candidates who will benefit from surgery as there is no strict correlation between POP anatomical abnormalities and changes in symptoms and quality ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-017-3423-3
更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Depression is more common in patients with urinary incontinence (UI). Drug or rehabilitation therapy have been shown to be effective in reducing urgency UI (UUI) symptoms, but whether these treatments can ameliorate the negative impact of UUI on the psychological aspects of quality of life i...
journal_title：International urogynecology journal
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00192-013-2116-9
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVES:Nocturia is the number of times urine is passed during main sleep. This definition tells us that it is a need to void; it does not tell us what triggers it. The aim of this study is to report bladder sensations that wake up women with nocturia (N). Descriptions of sensations in relation to various overactive...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-020-04257-w
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The impact of surgery on pelvic floor muscle (PFM) function remains uncertain. There is a pressure differential along the length of the vagina, influenced by surrounding active and passive tissue structures, giving rise to a pressure profile. The aim of this study is to determine if an intra...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-020-04576-y
更新日期：2020-11-16 00:00:00
abstract：AIM:A retrospective study of vesicouterine fistulae managed from 1996 to 2011 analyzed the incidence, symptomatology, diagnosis, and surgical outcome. PATIENTS & METHODS:During the study period, 17 patients were managed, of whom 14 underwent abdominal repair and three underwent vaginal repair. Mean patient age was 31....
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-012-1798-8
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Urinary dipsticks and culture analyses of a mid-stream urine specimen (MSU) at 105 cfu ml-1 of a known urinary pathogen are considered the gold standard investigations for diagnosing urinary tract infection (UTI). However, the reliability of these tests has been much criticised and they may ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-017-3472-7
更新日期：2018-07-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The objective was to identify risk factors for postpartum anatomic pelvic organ prolapse (aPOP) by comparing women with and without aPOP at 6 weeks postpartum with regard to pelvic floor measurements antepartum and obstetrical characteristics. METHODS:We carried out a prospective observatio...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3650-2
更新日期：2019-03-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Ureteral injury during gynecological surgery can be managed in a variety of ways, from endoscopic stent placement to ureteroneocystotomy with accompanying psoas hitch and/or Boari flap. The majority of these occur during hysterectomy; therefore, gynecologic surgeons may not be as familiar wi...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-020-04627-4
更新日期：2021-01-06 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:In the developed world, urethrovaginal fistulas are most the likely the result of iatrogenic injury. These fistulas are quite rare. Proper surgical repair requires careful dissection and tension-free closure. The objective of this video is to demonstrate the identification and surgical corre...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-016-3111-8
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:To report 12-year experience with replacing transvaginal mesh (TVM) with fascia lata autograft. METHODS:This was a chart review of TVM removal and replacement with a fascia lata autograft placement by a single surgeon between 2005 and 2017. The Pelvic Organ Prolapse Quantification (POP-Q) system before and ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-019-03957-2
更新日期：2019-09-01 00:00:00
abstract：:We report a case of enterococcus lumbar osteomyelitis that developed after post-operative pyelonephritis. A 78-year-old G2P2 with Stage III uterovaginal prolapse and genuine stress urinary incontinence who underwent laparoscopic-assisted vaginal hysterectomy, high uterosacral ligament suspension, tension-free vaginal ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-012-1836-6
更新日期：2013-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim of this study was to assess the efficacy of using transvaginal mesh to correct uterine prolapse by hysteropexy. METHODS:This was a single-center, prospective study of 40 subjects with bothersome uterine prolapse. Inclusion criteria were bothersome perception of a vaginal bulge on Pe...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-020-04590-0
更新日期：2020-11-11 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Different techniques of mesh placement for cystocele repair are known. Our goal was to compare anatomical and functional outcomes of three different techniques of mesh placement over a 3-year follow-up. METHODS:Between March 2003 and June 2004, 230 patients (stage 2-4 pelvic organ prolapse ...
journal_title：International urogynecology journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00192-011-1650-6
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:This study aims to investigate the effects of simulated birth trauma and ovariectomy on detrusor muscarinic receptors (M2 and M3), urethral neuronal nitric oxide synthase (nNOS), and estrogen receptor beta (ER beta). METHODS:Forty primiparous rats were equally divided into five groups: grou...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-010-1159-4
更新日期：2010-09-01 00:00:00
abstract：INTRODUCTION:In July 2011, the US Food and Drug Administration (FDA) issued a safety communication regarding serious complications associated with surgical mesh for pelvic organ prolapse, prompting increased media and public attention. This study sought to analyze internet search activity and news article volume after ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-016-3040-6
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim of this study was to retrospectively assess the extent and severity of the post-operative complications associated with the Pinnacle Pelvic Floor Repair Kit. METHODS:This is a descriptive analysis of 23 consecutive women who had a prolapse repair with either an anterior (n = 19) or ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-013-2156-1
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim of this study was to compare the results of pelvic organ prolapse repair using a capturing device-guided transvaginal mesh in a single- vs multicenter setting. METHODS:One hundred and twelve women operated by two surgeons at one center (2-year follow-up) were compared with 207 women...
journal_title：International urogynecology journal
pub_type： 杂志文章,多中心研究
doi：10.1007/s00192-017-3364-x
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:This time-series analysis was carried out to determine if the use of the EPISCISSORS-60®, episiotomy scissors specifically designed to achieve a cutting angle of 60°, would continue to sustain obstetric anal sphincter injuries (OASIS) reductions at our hospital 2 years after its introduction...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-019-04201-7
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Vaginal apical suspension is essential for the surgical treatment of pelvic organ prolapse (POP). We aim to evaluate whether the method of apical repair is associated with different re-operation rates for POP recurrence or surgical complications. METHODS:Population-based, retrospective coho...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3792-2
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Determine if women with fibromyalgia report increased bother from pelvic organ prolapse compared with women without fibromyalgia. METHODS:We performed a cross-sectional study of women with symptomatic prolapse on consultation with a private urogynecology practice within a 46-month period. A...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-013-2280-y
更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Laparoscopic sacral colpoperineopexy (LSCP) involves posterior graft extension to the perineum for improved posterior support. The objective of this study was to determine whether posterior measurements differed between those that had graft extension done abdominally (A-LSCP) or abdomino-vag...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-010-1302-2
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim of this study was to compare pelvic floor muscle strength (PFMS) and the prevalence of urinary incontinence (UI) and pelvic organ prolapse(POP) in women with and without diastasis recti abdominis (DRA) at 6-8 weeks postpartum. METHODS:Three hundred and ten women underwent routine ex...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-019-04005-9
更新日期：2020-02-01 00:00:00
