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The impact of simulated birth trauma and ovariectomy on the gene expression of detrusor muscarinic receptors in female rats.

Abstract：

INTRODUCTION AND HYPOTHESIS:This study aims to investigate the effects of simulated birth trauma and ovariectomy on detrusor muscarinic receptors (M2 and M3), urethral neuronal nitric oxide synthase (nNOS), and estrogen receptor beta (ER beta). METHODS:Forty primiparous rats were equally divided into five groups: group A--delivery, group B--delivery plus ovariectomy, group C--delivery plus balloon dilatation for 2 h, group D--delivery plus balloon dilatation for 4 h, and group E--delivery plus balloon dilatation for 2 h plus ovariectomy. The gene expression of M2, M3, nNOS, and ER beta were assessed by reverse transcription polymerase chain reaction. RESULTS:Significant decreases in mRNA expression of M2 receptors and nNOS (P < 0.05), and a significant increase in M3 mRNA expression (P < 0.05) were observed in groups D and E when compared with group A. CONCLUSIONS:Ovariectomy following birth trauma may synergistically impact the function of urinary tract, this being possibly related to the modification of the gene expression of muscarinic receptors.

journal_name

Int Urogynecol J

journal_title

International urogynecology journal

authors

Long CY,Wu CH,Liu CM,Chen YH,Wang CL,Tsai EM

doi

10.1007/s00192-010-1159-4

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

1163-8

issue

9

eissn

0937-3462

issn

1433-3023

journal_volume

21

pub_type

杂志文章

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