Abstract:
INTRODUCTION AND HYPOTHESIS:Vaginal apical suspension is essential for the surgical treatment of pelvic organ prolapse (POP). We aim to evaluate whether the method of apical repair is associated with different re-operation rates for POP recurrence or surgical complications. METHODS:Population-based, retrospective cohort study of all Ontario women receiving primary apical POP repairs from 2003 to 2015. Primary exposure was the method of apical POP repair. Primary outcome was re-operation for recurrent POP, and secondary outcomes were surgical procedures for genito-intestinal (GI) or genitourinary (GU) complications, fistula repair, and mesh revision or removal. RESULTS:Forty-three thousand four hundred fifty-eight women were included. Overall, the number of mesh-based apical repairs decreased over time, while the number of native-tissue repairs slightly increased (p < 0.001). Multivariable Cox proportional hazards (Cox PH) analysis demonstrated a significant increase in repeat POP operations for transvaginal mesh apical repairs (adjusted HR 1.28 [95% CI: 1.10-1.48]), but not in abdominal mesh repairs (adjusted HR 0.96 [95% CI: 0.81-1.13]) compared with vaginal native tissue apical repairs. Overall risk of repeat surgery for fistulas or GI and GU complications remained low (< 0.5%). Risk of mesh removal or revision was 11.5-11.9%, with no difference between abdominal versus vaginal mesh on multivariable analysis (adjusted HR 0.99 [95% CI: 0.78-1.26]). CONCLUSIONS:Re-operation for recurrent POP is highest in transvaginal mesh apical repairs; however, this risk did not differ between abdominal mesh and vaginal native tissue apical repairs. GI and GU re-operations are rare. There is no difference in mesh removal or revision rates between abdominal and vaginal mesh repairs.
journal_name
Int Urogynecol Jjournal_title
International urogynecology journalauthors
Wu YM,Reid J,Chou Q,MacMillan B,Leong Y,Welk Bdoi
10.1007/s00192-018-3792-2subject
Has Abstractpub_date
2019-04-01 00:00:00pages
537-544issue
4eissn
0937-3462issn
1433-3023pii
10.1007/s00192-018-3792-2journal_volume
30pub_type
杂志文章abstract:INTRODUCTION AND HYPOTHESIS:Little is known about dynamic cell-matrix interactions in the context of pathophysiology and treatments for pelvic organ prolapse (POP). This study sought to identify differences between fibroblasts from women with varying degrees of prolapse in reaction to mechanical stimuli and matrix subs...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-013-2069-z
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Vacuum-assisted vaginal delivery (VAVD) is considered a major risk factor for obstetric anal sphincter injuries (OASIS). However, it is difficult to estimate its true contribution to the occurrence of OASIS, as its performance may be confounded by other determinants. Therefore, we aimed to evaluate the ass...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-020-04534-8
更新日期:2020-09-30 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The objective was to measure the effects of peroxisome proliferator-activated receptor delta (PPAR-delta) agonist and zinc sulfate (ZS) on vaginal smooth muscle cell (SMC) proliferation, tropoelastin production, and collagen production. METHODS:SMC cultures were performed from vaginal wall ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-012-1807-y
更新日期:2012-12-01 00:00:00
abstract::Obstetric fistula is the presence of a hole between a woman's genital tract and either the urinary or the intestinal tract. Better knowledge of the risk factors for obstetric fistula could help in preventing its occurrence. The purpose of this study was to assess the characteristics of obstetric fistula patients. We c...
journal_title:International urogynecology journal
pub_type: 杂志文章,评审
doi:10.1007/s00192-011-1622-x
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Standardized terminology for surgical procedures commonly performed to treat stress urinary incontinence in women is needed to facilitate research, clinical care, and teaching in female pelvic medicine and reconstructive surgery. METHODS:This report combines the input of members of the Amer...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-020-04237-0
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Our goal was to identify correlates of maximum urethral closure pressure (MUCP) and MUCP as a diagnostic test for stress urinary incontinence (SUI). METHODS:This study was a retrospective review of women with non-neurological referrals for urinary incontinence between1995 and 2006. RESULTS...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-012-1770-7
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Walking speed and carrying technique affect intra-abdominal pressure (IAP) in women. In this study, we tested the feasibility of monitoring IAP outside the laboratory environment and compared IAP while study participants were (1) carrying 13.6 kg (similar to a 3-month old in car seat) in six...
journal_title:International urogynecology journal
pub_type: 临床试验,杂志文章
doi:10.1007/s00192-014-2593-5
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Urinary dipsticks and culture analyses of a mid-stream urine specimen (MSU) at 105 cfu ml-1 of a known urinary pathogen are considered the gold standard investigations for diagnosing urinary tract infection (UTI). However, the reliability of these tests has been much criticised and they may ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-017-3472-7
更新日期:2018-07-01 00:00:00
abstract::The article "Impact of surgeon experience on routine prolapse operations", written by Emil Nüssler, Jacob Kjær Eskildsen, Emil Karl Nüssler, Marie Bixo, and Mats Löfgren, was originally published without open access. ...
journal_title:International urogynecology journal
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00192-017-3525-y
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Rectopexy and sacrocolpopexy can be performed concurrently to treat rectal and vaginal prolapse. We hypothesized that concurrent procedures might be associated with more complications than rectopexy and sacrocolpopexy alone. METHODS:Patients undergoing laparoscopic sacrocolpopexy or rectope...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-3699-y
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:World Health Organisation (WHO) data suggest that more than two million women and girls live with fistula and that an additional 50-100,000 are newly affected each year. In Tanzania, it has been estimated that there are between 1,200 and 3,000 new cases of obstetric fistula annually. METHOD...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-013-2185-9
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:We report 2-year data on the effectiveness and safety of the MiniArc single-incision sling in women with stress urinary incontinence. METHODS:This multi-center, prospective, single-arm, industry-sponsored study measured the effectiveness of the MiniArc sling via quantitative (cough stress t...
journal_title:International urogynecology journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00192-012-1734-y
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Support of the vaginal apex is paramount for a durable repair of pelvic organ prolapse (POP). Our aim is to assess national utilization of apical suspension procedures for the surgical treatment of complete POP. We hypothesize that there might be a high rate of apical suspension with advance...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-020-04342-0
更新日期:2020-06-08 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:This study aimed to explore gene expression and their regulatory mechanisms in etiology of stress urinary incontinence (SUI). METHODS:Tissue samples were taken from the paraurethral vaginal wall from three pairs of postmenopausal, age/body mass index/parity-matched SUI, and continent women ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1222-1
更新日期:2010-12-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:There seems to be a temporal association between increasing use of "hands off" the perineum in labour and reduced use of episiotomy with an increasing rate of anal sphincter injuries. We aimed to determine how common the practice of "hands off" the perineum is. METHODS:An observational post...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-011-1454-8
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Conflicting opinions on the effect of incontinence surgery on the prevalence of postoperative urgency symptoms exists. Our aim was to evaluate the prevalence of urgency symptoms preoperatively and during 3-year of follow-up in women undergoing mid-urethral sling procedures for stress inconti...
journal_title:International urogynecology journal
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00192-011-1511-3
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:despite claims of equivalence to the tension-free vaginal tape, a variety of suburethral slings have been introduced, with various modifications. Complications in certain synthetic slings and meshes have led to a recent FDA public health notification. METHODS:we report the case histories an...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1244-8
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:We evaluated outcomes of an inelastic retropubic sling in patients with intrinsic sphincteric deficiency (ISD). METHODS:This is a retrospective review of women diagnosed with ISD according to urodynamic parameters who underwent a retropubic suburethral sling surgery using a tape with minima...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-012-2007-5
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:High levels of androgens increase muscle mass. Due to the characteristics of hyperandrogenism in polycystic ovary syndrome (PCOS), it is plausible that women with PCOS may have increased pelvic floor muscle (PFM) thickness and neuromuscular activity levels compared with controls. The aim of this study was ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-015-2865-8
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:This study investigated perioperative and mid-term clinical outcomes after laparoscopic sacrocolpopexy (LSCP) with light titanium-coated polypropylene (TCP) mesh in a large group of patients affected by International Continence Society stage II-IV pelvic organ prolapse (POP). METHODS:This multicenter retr...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-019-04146-x
更新日期:2020-04-01 00:00:00
abstract::Vaginal hysterectomy is the oldest and least invasive of the hysterectomy techniques and fulfills the evidence-based requirements as the preferred route of hysterectomy for benign gynecologic disease. Currently, vaginal hysterectomy is commonly utilized for treating uterine prolapse, but despite proven safety and effe...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-014-2459-x
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The objective was to compare medium-term efficacy and safety of a partially absorbable mesh kit and native tissue repair in pelvic organ prolapse (POP). MATERIALS AND METHODS:Women with primary POP stage ≥ II were randomized to transvaginal trocar-guided partially absorbable mesh (81 women)...
journal_title:International urogynecology journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00192-018-3757-5
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The concurrence of vaginal cancer with irreducible uterine prolapse is rare. Reports about the management of vaginal cancer and concomitant irreducible prolapse are scanty in the literature, and there is no consensus on optimal treatment. In this video case report, we show surgical managemen...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-020-04263-y
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Currently, there is no global outcome assessment index in prolapse research. Patient Global Impression of Improvement (PGI-I) has only been validated in incontinence. Our aim was to validate its use following prolapse surgery. METHODS:Women with prolapse were recruited from waiting lists an...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-009-1069-5
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:a terminology and standardized classification has yet to be developed for those complications arising directly from the insertion of synthetic (prostheses) and biological (grafts) materials in female pelvic floor surgery. METHODS:this report on the above terminology and classification combi...
journal_title:International urogynecology journal
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00192-010-1324-9
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The aim of this study was to compare the results of repair of isolated, recurrent, posterior vaginal wall prolapse using standard posterior colporrhaphy versus non-absorbable polypropylene mesh in a routine health care setting. METHODS:This cohort study was based on prospectively collected ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-03856-y
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Hysterectomy can be performed during sacrocolpopexy, but there are limited studies comparing the effect of route of hysterectomy on adverse events. We hypothesized there would be no difference in adverse events or patient-reported outcomes in women who underwent minimally invasive sacrocolpo...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-3790-4
更新日期:2019-04-01 00:00:00
abstract::Pelvic reconstructive surgeons have suspected for over a century that childbirth-related trauma plays a major role in the aetiology of female pelvic organ prolapse. Modern imaging has recently allowed us to define and reliably diagnose some of this trauma. As a result, imaging is becoming increasingly important, since...
journal_title:International urogynecology journal
pub_type: 杂志文章,评审
doi:10.1007/s00192-011-1459-3
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Vaginal bulging is considered the key symptom for genital organ prolapse. The aim was to investigate the age-related prevalence and frequency of symptomatic pelvic organ prolapse (sPOP) and other pelvic floor symptoms in nonpregnant nullipara aged 25-64 years. METHODS:This national postal a...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-3684-5
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Laparoscopic sacral colpoperineopexy (LSCP) involves posterior graft extension to the perineum for improved posterior support. The objective of this study was to determine whether posterior measurements differed between those that had graft extension done abdominally (A-LSCP) or abdomino-vag...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1302-2
更新日期:2011-04-01 00:00:00