Abstract：
INTRODUCTION AND HYPOTHESIS:Polypropylene is a base polymer used in biomaterial applications, including sutures and mesh products, for the treatment of pelvic organ prolapse, stress urinary incontinence, and hernia repairs. Previous studies have dismissed the value of formulation additives employed in polypropylene, and the importance and necessity of an effective mesh explant cleaning protocol when characterizing explanted devices. However, both are critical to understanding the alleged degradation of polypropylene-based meshes. METHODS:An effective, nondestructive, hydrolytic cleaning process, supplemented with light microscopy (LM), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) data, was used to evaluate 78 explanted Prolene meshes (with duration of implantation ranging from 0.4 to 11.7 years). RESULTS:The cleaning process exposed clean, unoxidized, nondegraded Prolene fibers with smooth surfaces and with no visible evidence of gradient-type or ductile damage. LM showed identical translucent and sometimes clear, cracked/flaking material on both blue and clear fibers, instead of clear cracked/flaking material on the clear fibers and blue cracked/flaking material on the blue fibers. FTIR confirmed progressive protein removal and loss of protein absorption intensity after each cleaning step. CONCLUSIONS:Our effective cleaning of explanted Prolene meshes and subsequent analyses showed that they did not degrade in vivo, confirming the in vivo stability of properly formulated polypropylene. Instead, the cracked layer that some researchers have identified as degraded Prolene is an adsorbed protein-formaldehyde coating, resulting from the well-established formalin-protein fixation process, which occurs immediately upon placing an explant in formalin.
journal_name
Int Urogynecol Jjournal_title
International urogynecology journalauthors
Thames SF,White JB,Ong KLdoi
10.1007/s00192-016-3131-4subject
Has Abstractpub_date
2017-02-01 00:00:00pages
285-297issue
2eissn
0937-3462issn
1433-3023pii
10.1007/s00192-016-3131-4journal_volume
28pub_type
杂志文章abstract：INTRODUCTION AND HYPOTHESIS:To describe the impact of native tissue vaginal reconstruction on pelvic anatomy using dynamic magnetic resonance imaging. METHODS:This prospective single-cohort observational study involved women undergoing native tissue reconstruction with intraperitoneal vaginal vault suspension for pelv...
journal_title：International urogynecology journal
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journal_title：International urogynecology journal
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journal_title：International urogynecology journal
pub_type： 共识发展会议,杂志文章
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更新日期：2013-11-01 00:00:00
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,meta分析,评审
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pub_type： 杂志文章
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abstract：INTRODUCTION AND HYPOTHESIS:Obstetric fistula, caused by traumatic delivery and patient lack of access to obstetric care, is an important public health concern in developing countries, particularly in Sub-Saharan Africa. This research focuses on the experience of women living with obstetric fistula in Burkina Faso as w...
journal_title：International urogynecology journal
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
