Is mirabegron equally as effective when used as first- or second-line therapy in women with overactive bladder?

Abstract:

INTRODUCTION AND HYPOTHESIS:No previous studies have investigated the efficacy of mirabegron 50 mg as the first-line therapy in OAB patients. Hence, the primary objective of this study was to evaluate the efficacy of mirabegron in treatment-naive patients in comparison with those who had discontinued antimuscarinic therapy because of insufficient efficacy. METHODS:All consecutive women who had pure OAB symptoms (including urgency with or without urgency incontinence and frequency) for at least 3 months were considered for this study. Women were divided into two groups: women without any previous pharmacological treatment for OAB (group 1) and women with a previous history of failed antimuscarinics therapy (group 2). RESULTS:At 3-month follow-up, the objective results on the basis of the frequency-volume chart showed a significant improvement in both groups. Furthermore, a significant reduction in the Overactive Bladder Questionnaire Short Form (OABq-SF) score and in the Indevus Urgency Severity Scale (IUSS) questionnaire were reported in both groups. However, the improvement in objective and subjective outcomes was superior in group 1 to that in group 2. CONCLUSIONS:Mirabegron is efficacious in improving OAB symptoms in both naïve patients and those who discontinued primary antimuscarinic therapy; however, its efficacy is superior when prescribed as first-line therapy.

journal_name

Int Urogynecol J

authors

Serati M,Leone Roberti Maggiore U,Sorice P,Cantaluppi S,Finazzi Agrò E,Ghezzi F,Publication Committee of the Italian Society of Urodynamics.

doi

10.1007/s00192-016-3219-x

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

1033-1039

issue

7

eissn

0937-3462

issn

1433-3023

pii

10.1007/s00192-016-3219-x

journal_volume

28

pub_type

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