[Hyperparathyroidism simulating Creutzfeldt-Jakob disease].

Abstract:

:A 45 years-old woman presented with loss of initiative and memory, motivated cry and behaviour disturbance with childish traits, quickly progressive along 6 months until total apathy. An EEG showed periodic activity with bilateral triphasic waves against a flattened background activity suggesting Creutzfeldt-Jacob disease (CJD), but investigation for treatable causes of dementia disclosed hypercalcemia and hypophosphatemia. Further investigation showed a mass at the thyroid region that at surgery was identified as an oxyphilic cells adenoma. With electrolyte disturbance correction and posterior surgery there was normalization of both EEG and clinical status. Though it was previously reported mental confusion and EEG alteration associated with hyperparathyroidism we do not know of any previous case of confusion associated with periodic activity in EEG as in this disease. Hyperparathyroidism should be a differential diagnosis in every "de novo" case of CJD.

journal_name

Arq Neuropsiquiatr

authors

Bertolucci PH,Malheiros SF

doi

10.1590/s0004-282x1990000200019

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

245-9

issue

2

eissn

0004-282X

issn

1678-4227

journal_volume

48

pub_type

杂志文章
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    doi:

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