Insight in schizophrenia: from conceptualization to neuroscience.

Abstract:

:Lack of insight into illness is a prevalent and distinguishing feature of schizophrenia, which has a complex history and has been given a variety of definitions. Currently, insight is measured and treated as a multidimensional phenomenon, because it is believed to result from psychological, neuropsychological and organic factors. Thus, schizophrenia patients may display dramatic disorders including demoralization, depression and a higher risk of suicide, all of which are directly or indirectly related to a lack of insight into their illness, and make the treatment difficult. To improve the treatment of people with schizophrenia, it is thus crucial to advance research on insight into their illness. Insight is studied in a variety of ways. Studies may focus on the relationship between insight and psychopathology, may view behavioral outcomes or look discretely at the cognitive dysfunction versus anatomy level of insight. All have merit but they are dispersed across a wide body of literature and rarely are the findings integrated and synthesized in a meaningful way. The aim of this study was to synthesize findings across the large body of literature dealing with insight, to highlight its multidimensional nature, measurement, neuropsychology and social impact in schizophrenia. The extensive literature on the cognitive consequences of lack of insight and the contribution of neuroimaging techniques to elucidating neurological etiology of insight deficits, is also reviewed.

authors

Ouzir M,Azorin JM,Adida M,Boussaoud D,Battas O

doi

10.1111/j.1440-1819.2012.02325.x

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

167-79

issue

3

eissn

1323-1316

issn

1440-1819

journal_volume

66

pub_type

杂志文章,评审
  • Psychological factors and survival after bone marrow transplantation in patients with leukemia.

    abstract::Psychological factors may be associated with the outcome of cancer treatment, including bone marrow transplantation (BMT). However, studies on the issue have provided controversial results. In the present study, effects of mood status on the outcome was studied through a follow-up period of 1-3 years as well as in sho...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2003.01084.x

    authors: Akaho R,Sasaki T,Mori S,Akiyama H,Yoshino M,Hagiya K,Nakagome K,Sakamaki H

    更新日期:2003-02-01 00:00:00

  • Effects of daytime activity on nocturnal sleep in the elderly.

    abstract::This study investigates the relationship between the level of daytime activities and nocturnal sleep in the elderly using the wrist actigraph and ambulatory polysomnograph system. Five male and five female subjects (mean age = 73.8+/-3.05 years; range 69-77 years) participated in this study. The level of daytime activ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2000.00691.x

    authors: Shirota A,Tamaki M,Hayashi M,Hori T

    更新日期:2000-06-01 00:00:00

  • Relation between social functioning and neurocognitive test results using the Optional Thinking Test in schizophrenia.

    abstract::The current study investigated the relationship between clinical evaluations of social functioning and neurocognitive test results, including various fluency tests for assessing divergent thinking, in patients with schizophrenia. The Optional Thinking Test (OTT) was used to measure the ability of individuals to concei...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2006.01461.x

    authors: Chino B,Mizuno M,Nemoto T,Yamashita C,Kashima H

    更新日期:2006-02-01 00:00:00

  • Involvement of nucleus accumbens dopaminergic transmission in acoustic startle: observations concerning prepulse inhibition in rats with entorhinal cortex lesions.

    abstract::The relationship between the entorhinal cortex and prepulse inhibition (PPI) as well as the nucleus accumbens dopaminergic participation in acoustic startle were examined in rats. After the entorhinal cortex was damaged bilaterally using ibotenic acid, a microdialysis probe was placed in the nucleus accumbens for dete...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2004.01281.x

    authors: Goto K,Ueki A,Iso H,Morita Y

    更新日期:2004-08-01 00:00:00

  • A novel method of time series analysis, and an application to the study of human sleep electroencephalogram.

    abstract::A new mathematical method was developed to analyze time series. Applications of this method to the delta component of all-night sleep electroencephalogram (EEG) revealed new variations with double-rapid eye movement (REM)-sleep interval. The proposed method entails repeated application of the least squares spectrum. F...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.1998.00450.x

    authors: Koga E,Tsuji Y

    更新日期:1998-10-01 00:00:00

  • Dissociation and alexithymia among men with alcoholism.

    abstract:AIM:The aim of the present study was to evaluate the relationship between alexithymia and dissociation among men with alcoholism. METHODS:Participants were 176 patients consecutively admitted to the inpatient unit of a addiction treatment center. The Toronto Alexithymia Scale, the Symptom Checklist-Revised, the Dissoc...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2007.01775.x

    authors: Evren C,Sar V,Evren B,Semiz U,Dalbudak E,Cakmak D

    更新日期:2008-02-01 00:00:00

  • What should non-US behavioral health systems learn from the USA?: US behavior health services trends in the 1980s and 1990s.

    abstract::Several countries, such as the USA, inadvertently created a different behavioral health payment system from the rest of medicine through the introduction of diagnostic-related group exemptions for psychiatric care. This led to isolation in the administration and delivery of care for patients with mental health and sub...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1819.2006.01500.x

    authors: Kishi Y,Kathol RG,McAlpine DD,Meller WH,Richards SW

    更新日期:2006-06-01 00:00:00

  • On the role of quantitative brain imaging in the differential diagnosis of speech disorders.

    abstract::We present the case of a 71-year-old woman with an 11-year history of slowly progressive decline of motor speech. Normal clinical investigations including routine magnetic resonance imaging (MRI) at 7, 8 and 10 years after the onset of speech dysfunction led to the suggestion of a psychogenic disorder. Extensive clini...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2002.00938.x

    authors: Tebartz van Elst LH,Juengling FD,Kassubek J,Schmidtke K,Thiel T,Ebert D,Dykierek P,Hüll M

    更新日期:2002-02-01 00:00:00

  • Reception of Kraepelin's ideas 1900-1960.

    abstract::Kraepelin's system of mental diseases has contributed substantially to the foundation of modern psychiatric diagnosis in the DSM-IV and ICD-10. Considering Kraepelin's influence in the creation of these diagnostic tools, the question arises as to how Kraepelin's contemporaries and successors reacted to his nosology. H...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1440-1819.2011.02226.x

    authors: Palm U,Möller HJ

    更新日期:2011-06-01 00:00:00

  • Post-traumatic growth of children affected by the Great East Japan Earthquake and their attitudes to memorial services and media coverage.

    abstract:AIMS:Post-traumatic growth (PTG) refers to positive changes that result from coping with a major life crisis or a traumatic event. Factors influencing PTG in youth have not been well characterized but could have a great impact on overall maturation. METHODS:Fourth to ninth graders (n = 3337) attending elementary or ju...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12379

    authors: Yoshida H,Kobayashi N,Honda N,Matsuoka H,Yamaguchi T,Homma H,Tomita H

    更新日期:2016-05-01 00:00:00

  • Study of image findings in rapid eye movement sleep behavioural disorder.

    abstract::To elucidate the cause of idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), magnetic resonance imaging and single-photon emission computed tomography of the brain were conducted on 20 patients with RBD. Blood flow in the upper portion of both sides of the frontal lobe and pons was significantly lower ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2002.00961.x

    authors: Shirakawa S,Takeuchi N,Uchimura N,Ohyama T,Maeda H,Abe T,Ishibashi M,Ohshima Y,Ohshima H

    更新日期:2002-06-01 00:00:00

  • Test-retest reliability of the Personality Diagnostic Questionnaire: Revised.

    abstract::We describe the test-retest reliability of the Personality Diagnostic Questionnaire: Revised (PDQ-R), which was developed to assess DSM-III-R personality disorders (PD). Thirty patients, diagnosed clinically with PD, filled out the PDQ-R twice at 1 month intervals after having undergone 8 weeks of treatment leading to...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1819.1997.tb02601.x

    authors: Uehara T,Sakado K,Sato T

    更新日期:1997-12-01 00:00:00

  • Prefrontal GABA and glutamate levels correlate with impulsivity and cognitive function of prescription opioid addicts: A 1 H-magnetic resonance spectroscopy study.

    abstract:AIM:Prescription opioids are psychoactive substances that can elicit many neuropsychological effects. There are no studies that directly demonstrate the effects of prescription opioid addiction (POA) on the human brain. This study aimed to quantify γ-aminobutyric acid (GABA) and glutamate (Glu) levels in the prefrontal...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12940

    authors: Li JN,Liu XL,Li L

    更新日期:2020-01-01 00:00:00

  • Hikikomori : Multidimensional understanding, assessment, and future international perspectives.

    abstract::Hikikomori, a severe form of social withdrawal, has long been observed in Japan mainly among youth and adolescents since around the 1970s, and has been especially highlighted since the late 1990s. Moreover, hikikomori-like cases have recently been reported in many other countries. Hikikomori negatively influences not ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:10.1111/pcn.12895

    authors: Kato TA,Kanba S,Teo AR

    更新日期:2019-08-01 00:00:00

  • Magnetic resonance imaging findings in patients with delusional disorder due to diffuse cerebrovascular disease: a report of seven cases.

    abstract::Delusions associated with cerebrovascular diseases have been sporadically reported. Although both psychiatrists and neurologists attempted to link delusions with anatomical locations of the brain lesion, comorbid psychiatric and neurological disorders make the interpretation of delusions difficult. The purpose of the ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2001.00798.x

    authors: Su KP,Hsu CY,Hsieh SC,Shen WW

    更新日期:2001-04-01 00:00:00

  • Psychiatric and psychological outcomes of Japanese living donors following liver transplantation.

    abstract::This study indexed the mental status in six living donor liver transplantations (LDLT) performed at the Juntendo University Hospital between 2005 and 2007. The donors' preoperative and postoperative psychiatric and psychological status was assessed using the Profile of Mood States (POMS) and the State-Trait Anxiety In...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2009.01992.x

    authors: Shibata N,Shimazaki H,Sano N,Kawasaki S,Arai H

    更新日期:2009-08-01 00:00:00

  • Treatment guidelines for geriatric mood disorders.

    abstract::The authors reviewed the literature on the pharmacotherapy of geriatric mood disorders. Based on the evidence available, we have proposed: (i) that although any antidepressant is assumedly equal in antidepressive efficacy, ones with weak anticholinergic and antialpha1 effects are preferable in geriatric patients; (ii)...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:

    authors: Oshima A,Higuchi T

    更新日期:1999-10-01 00:00:00

  • Serotonin syndrome during clomipramine monotherapy: comparison of two diagnostic criteria.

    abstract::Incidence of serotonin syndrome was determined by two different diagnostic criteria during clomipramine monotherapy. Incidence, determined by Sternbach's criteria, was 12.1% (8/66 patients), and that determined by the criteria of Dursun et al. was 3.0% (2/66 patients). The two patients who met the latter criteria also...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1819.1997.tb02365.x

    authors: Kudo K,Sasaki I,Tsuchiyama K,Akiyoshi J,Nagayama H,Fujii I

    更新日期:1997-02-01 00:00:00

  • Effects of transcranial direct current stimulation of prefrontal cortex on risk-taking behavior.

    abstract:AIM:Recent cognitive neuroscience research shows that noninvasive brain stimulation can modify a wide range of behaviors in healthy people. Such regulation effects on human behaviors provide new insights into the neurobiology of cognitive processes and establish causal brain-behavior relations. Here, we aimed to examin...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:10.1111/pcn.13025

    authors: Khaleghi A,Pirzad Jahromi G,Zarafshan H,Mostafavi SA,Mohammadi MR

    更新日期:2020-09-01 00:00:00

  • Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population.

    abstract::Interleukin-1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia. Recent genetic studies have revealed that the IL1 gene complex (IL,1 alpha, IL1, beta and IL1 receptor antagonist) wa...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2007.01671.x

    authors: Watanabe Y,Nunokawa A,Kaneko N,Muratake T,Koizumi M,Someya T

    更新日期:2007-08-01 00:00:00

  • Cognitive function and social abilities in patients with schizophrenia: relationship with atypical antipsychotics.

    abstract::Although atypical antipsychotics have been associated with improvements in cognitive function in schizophrenia, the neurochemical basis for such effects is not well understood. Candidate neurotransmitter systems primarily involve dopamine and serotonin. The current study explored this issue by examining the cognitive ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2006.01534.x

    authors: Tyson PJ,Laws KR,Flowers KA,Tyson A,Mortimer AM

    更新日期:2006-08-01 00:00:00

  • An attempt of radar chart expression of a self-rating scale for sleep disturbance.

    abstract::We made an attempt to express a complaint of sleep disturbance by a self-rating scale of radar chart mode. The questionnaire for sleep disturbance is made up of eight items. Each item was scored from grade 1 to 4. The score of each item was projected to the MY radar chart, designed by us. It is noted that this method ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1998.tb01009.x

    authors: Yamaguchi N,Matsubara S,Momonoi F,Morikawa K,Takeyama M,Maeda Y

    更新日期:1998-04-01 00:00:00

  • Relationship between personality disorder symptoms and temperament in the young male general population of South Korea.

    abstract::The aim of the present study was to identify the characteristics of temperament and character in personality disorder symptoms in the young male general population. A total of 585 male subjects from the same community were included in the study (mean age, 19.06 +/- 0.26 years). There was no difference in socioeconomic...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2007.01611.x

    authors: Ha JH,Kim EJ,Abbey SE,Kim TS

    更新日期:2007-02-01 00:00:00

  • Prolactin concentrations during aripiprazole treatment in relation to sex, plasma drugs concentrations and genetic polymorphisms of dopamine D2 receptor and cytochrome P450 2D6 in Japanese patients with schizophrenia.

    abstract:AIMS:The authors investigated the correlation between prolactin concentrations during aripiprazole treatment and various factors, including age, sex, plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, and genetic polymorphisms of dopamine D2 receptor (DRD2) and cytochrome P450(CYP)2D6...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2012.02391.x

    authors: Nagai G,Mihara K,Nakamura A,Suzuki T,Nemoto K,Kagawa S,Ohta I,Arakaki H,Kondo T

    更新日期:2012-10-01 00:00:00

  • Quality of life and related factors among cancer caregivers in China.

    abstract:AIMS:The present study was designed to investigate quality of life (QOL) among caregivers of cancer inpatients, and to explore the related factors with the long-term goal to improve QOL of cancer caregivers in China. METHODS:A cross-sectional study was performed during the period January-March 2008. Subjects comprised...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2010.02131.x

    authors: Lu L,Pan B,Sun W,Cheng L,Chi T,Wang L

    更新日期:2010-10-01 00:00:00

  • The central mechanism of hypothalamic-pituitary-adrenocortical system hyperfunction in depressed patients.

    abstract::While hypercortisolemia is commonly observed in depression, exactly where in the hypothalamic-pituitary-adrenocortical (H-P-A) axis this dysfunction arises remains undefined. In attempting to distinguish between central or peripheral locus of dysfunction, we studied in 12 patients (10 females, two males) with primary ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2000.00663.x

    authors: Jiang HK,Wang JY,Lin JC

    更新日期:2000-04-01 00:00:00

  • Different serum concentrations of steady-state valproic acid in two sustained-release formulations.

    abstract::Recently a new sustained-release formulation of valproic acid has been developed in Japan. The sustained-release mechanism of the new formulation was different from the conventional formulation. The aim of the present study was to compare the pharmacokinetic characteristics of valproic acid in two sustained-release fo...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2007.01656.x

    authors: Yasui-Furukori N,Saito M,Nakagami T,Niioka T,Sato Y,Fujii A,Kaneko S

    更新日期:2007-06-01 00:00:00

  • Internet addiction: Prevalence and relation with mental states in adolescents.

    abstract:AIM:Internet addiction disrupts the daily lives of adolescents. We investigated the prevalence of Internet addiction in junior high school students, elucidated the relation between Internet addiction and mental states, and determined the factors associated with Internet addiction in adolescents. METHODS:Junior high sc...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12402

    authors: Kawabe K,Horiuchi F,Ochi M,Oka Y,Ueno S

    更新日期:2016-09-01 00:00:00

  • Multicenter population-based study on the prevalence of early onset dementia in Japan: vascular dementia as its prominent cause.

    abstract:AIM:In Japan, the government and media have become aware of the issues of early onset dementia (EOD), but policies for EOD have not yet been established and support systems are inadequate. To provide practical data about EOD, a two-step postal survey was performed. METHODS:A questionnaire requesting information on EOD...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12127

    authors: Ikejima C,Ikeda M,Hashimoto M,Ogawa Y,Tanimukai S,Kashibayashi T,Miyanaga K,Yonemura K,Kakuma T,Murotani K,Asada T

    更新日期:2014-03-01 00:00:00

  • Typology of Internet gaming disorder and its clinical implications.

    abstract::Various perspectives exist regarding Internet gaming disorder. While the concept of behavioral addiction is gaining recognition, some view the phenomenon as merely excessive indulgence in online pastimes. Still, in recent years, complaints from patients or their family members about problems related to Internet use, p...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:10.1111/pcn.12457

    authors: Lee SY,Lee HK,Choo H

    更新日期:2017-07-01 00:00:00